The Genetic Mysteries of the Corneal Dystrophies The Genetic ...

Pre-Descemets Dystrophy• Fine, deep white posterior stromal opacities• Lie anterior to Descemets membrane• Autosomal dominant• No effect on visual acuityCentral Cloudy Dystrophy of Francois• Central opacity in stroma looks like cracked-iceor crocodile skin; glycosaminoglycan deposition• Visual acuity is usually normal• Appearance similar to crocodile shagreen, anage-related corneal change resulting in posteriorstromal deposition• Difficult to differentiate from crocodile shagreenin the late course of disease, especially ifbilateral15