10.07.2015 Views

conductive hearing loss dictionary

conductive hearing loss dictionary

conductive hearing loss dictionary

SHOW MORE
SHOW LESS
  • No tags were found...

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

Studies 5instrument used for <strong>hearing</strong> screening prototype instrument. (2) To develop a prototypeinstrument that will demonstrate the feasibility of using WB-PR to address the standingwave problem.Website: http://crisp.cit.nih.gov/crisp/Crisp_Query.Generate_Screen• Project Title: ADENOIDECTOMY FOR OTITIS MEDIA IN 2/3 YEAR OLDCHILDRENPrincipal Investigator & Institution: Casselbrant, Margaretha L.; Professor; Children'sHosp Pittsburgh/Upmc Hlth Sys of Upmc Health Systems Pittsburgh, Pa 152132583Timing: Fiscal Year 2001; Project Start 01-FEB-1997; Project End 31-JAN-2005Summary: Efficacy of adenoidectomy for the treatment and prevention of otitis mediawith effusion has been shown for children four years and older. In their "ClinicalPractice Guidelines, Otitis Media with Effusion in Young Children", the Agency forHealth Care Policy and Research of the U.S. Department of Health and Human Servicesconcluded that "Adenoidectomy is not recommended for treatment of OME in a childage 1 through 3 years in the absence of specific adenoid pathology". This conclusion wasbased on the Panel's finding no clinical trials to support any judgement as to the efficacyof adenoidectomy in the primary management of otitis media with effusion in veryyoung children, coupled with the risk of postoperative bleeding. By means of a welldesigned large-scale randomized controlled trial, the efficacy of adenoidectomy andmyringotomy with and without tympanotomy tube insertion will be compared withthat of myringotomy and tympanotomy alone in reducing the morbidity of bilateralotitis media with effusion of at least 3 months's duration associated with <strong>hearing</strong> <strong>loss</strong>(>20 dB) in children ages 2 and 3 years. The primary outcome measure will bepercentage of time with middle ear effusion. Rates of episodes of acute otitis media,otorrhea, and otitis media with effusion, time to first recurrence, number of surgicalprocedures, treatment failures, <strong>hearing</strong> status, and other sequelae and complicationswill be recorded and compared among the three treatment groups. We estimate that 63evaluable subjects need to be entered in each treatment arm to have a 90 percent powerof detecting a benefit of at least 0.30 in percentage of time with middle ear effusion. Theoutcome of this trial should resolve the question of efficacy of adenoidectomy for otitismedia with effusion in this age group.Website: http://crisp.cit.nih.gov/crisp/Crisp_Query.Generate_Screen• Project Title: AGED MIDDLE EARPrincipal Investigator & Institution: Gratton, Michael A.; Otorhinolaryngology Head &Neck Surgery; University of Pennsylvania 3451 Walnut Street Philadelphia, Pa 19104Timing: Fiscal Year 2002; Project Start 15-SEP-2002; Project End 31-AUG-2004Summary: Loss of <strong>hearing</strong> with aging is a well known phenomenon called presbycusis.Presbycusis, historically and correctly, is largely attributed to hair cell and primaryneurons degeneration from unknown, though probably genetic, causes. This proposalargues that <strong>hearing</strong> <strong>loss</strong> in the elderly may also arise from age-related changes in the<strong>conductive</strong> apparatus of the middle ear. The evidence for age-related changes in thehuman middle-ear function is equivocal. This is most likely due to limitations in theway <strong>conductive</strong> <strong>hearing</strong> <strong>loss</strong> is assessed rather than anything else. Nevertheless, clearevidence can be found for structural changes in the <strong>conductive</strong> apparatus of both thehuman and animal middle ear. The aim of the present research is to develop an animalmodel that demonstrates the effects of aging on the structural and functional aspects ofthe middle ear. Such a model would then be employed to detail the consequences of

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!