Poster Sessions - Eurotox 2013

P08-25Effects of endocrine disruptors Bisphenol A and di(2-ethylhexyl) phthalate in acombination with 17 β-estradiol on apoptosis-related genes in the MCF-7 breastcancer cell lineMlynarcikova, Alzbeta; Havranek, Tomas; Fickova, MariaP08-26Effects of Formaldehyde exposure on human epithelial cells all along the respiratorytractGaëlle Bardet, Charles Persoz, Thomas Loret, Isabelle Momas, Sophie Achard, Nathalie SetaP08-27Effects of maternal exposure to di(2-ethylhexyl)phthalate (DEHP) during pregnancyon neonatal asthma susceptibilityLee, Kyoung-youl; Choi, Eun-youngP08-28Ellagic acid protects against cyclophosphamide induced acute lung injury in Wistarrats by inhibiting oxidative stress, NF-kB activation and inflammatory cellproduction.Saba and Sheikh RaisuddinP08-29Endocrine disruptor Bisphenol A toxicity study in testicular mitochondria of Swissalbino miceSameya Anjum and Sheikh RaisuddinP08-30Heavy metal burdens of public primary school children in Ibadan north-west localgovernment area, Nigeria related to playground soils and classroom dustsAdemuyiwa O., Akinwunmi F., Atobatele Z., Adewole O., Odekunle K., Arogundade L. and OdukoyaO.O.P08-31Hypothalamic-pituitary-adrenal axis activity is modified by perfluorooctane sulfonate(PFOS) exposure in adult male ratLafuente, Anunciacion; Pereiro, Natividad; Gomez-Limia, LuciaP08-32In vitro particulate matter toxicity relates to seasonal variability in chemicalcomposition.Osornio Vargas, Alvaro; Manzano-Leon, Natalia; Quintana-Belmares, Raul; Sanchez, Brisa; Sitarik,Alexandra; Serrano, Jesus; Vega, Elizabeth; Vazquez-Lopez, Ines; Rojas-Bracho, Leonora; Lopez-Villegas, Tania; Vadillo-Ortega, Felipe; De Vizcaya-Ruiz, Andrea; Rosas, Irma; Moran-Pineda,Marina; O'Neill, MarieP08-33Influence of media and N:P ratios on growth, microcystin production and geneexpression of a Microcystis aeruginosa strainBortoli, Stella; de Oliveira Silva, Diogo; A. Volmer, Dietrich; Pinto, Ernani

P08-34(Cancelled)P08-35Lack of Association Between Serum Prolactin and Lead ExposureAysegul Bacaksiz, Meside Gunduzoz, Sedat Abusoglu, Engin Tutkun, Hinc Yilmaz, Nilgun Giynas,Emine Gul AydinP08-36Mercury Levels in Placentas from Non-Exposed MothersTülin Söylemezoğlu, Zeliha Kayaaltı, Seda Kaya, Vugar Ali TürksoyP08-37Mercury-Resistant Bacteria from Tagus Estuary – Characterization and MercuryReduction PotentialNeusa L. L. Figueiredo, João Canário, Aida Duarte and Cristina CarvalhoP08-38Neurobehavioral Effects of Exposure to Environmental Chemicals and Caesium inDeveloping Offspring MiceIsabel Llovet, Daisy Lafuente, Sergio Gonzalo, Montserrat Bellés, José Luís Domingo, VictòriaLinaresP08-39NOEC versus EC10, reloaded on a recent show caseJung, Eunsoo; Wess, Ralf Arno; Schmidt, ThomasP08-40Oatp Expression profile in Danio rerio upon Microcystin-exposureSteiner, Konstanze; Karner, Tim; Dietrich, DanielP08-41Oxidative stress in birds: Effects of heavy metals and pharmaceuticalsOsickova J., Kovacova V., Pikula J., Bandouchova H., Kral J., Skochova H., Pohanka M., Novotny L.P08-42Particulate matter emissions from cigarettes under real life conditionMarik Gerecht, Daniel Müller, Johannes Schulze, David A GronebergP08-43Protective effects of N-acetyl cysteine with zinc and selenium on chronic mercuryinduced oxidative stress and DNA damage evaluation in rats.Deepmala Joshi and Deepak Kumar MittalP08-44Pulmonary cytotoxic in vitro studies of selected short-chain monocarboxylic acidspresent in indoor environmentsD. Lipsa, C. Cacho, P. Leva, J. Barrero-Moreno

P08-45Reconstituted human airway epithelium 3D-model to assess the impact of indoor airpollutants on the inflammatory response.Grellet, Sophie; Momas, Isabelle; Seta, Nathalie; Bardet, Gaëlle; Achard, SophieP08-46Reduced expression of genes for nuclear receptors RXRalpha and RXRbeta bybisphenol A in human mammary cancer cells (MCF7).Fickova M., Havranek T., Brtko J., Macejova D.P08-47Selected organotin halides: Toxicity versus nuclear retinoic acid/retinoid X receptorsand their co-regulators expression in breast cancer and leukemia cell linesBrtko, Julius; Macejova, Dana; Bialesova, Lucia; Fickova, Maria; Bohacova, Viera; Sulova, Zdena;Breier, Albert; Hunakova, LubaP08-48Studies on the red grape extract supplementation against mercuric chloride inducedtoxicity in rat erythrocytesKanti Bhooshan Pandey and Syed Ibrahim RizviP08-49Study of platinum group metals effects on lettuce plants (Lactuca sativa)Mikulaskova, H., Nemcova, B., Beklova, M.P08-50Study of the impact of platinum and palladium on representatives of soil fauna(Folsomia candida)Nemcova B., Bednarova I., Mikulaskova H., Beklova M.P08-51The effect of green tea extract on a-amanitin induced hepatotoxicity in a murinemodelPark, Yong JinP08-52The Importance of the Ecotoxicological Assessment for the Risk Management ofCosmetic IngredientsHauaji Zacarias, Cyro; Assanome, Karen; Queiroz, DianaP08-53The influence of methionine on the selected biochemical parameters andmorphological picture of the liver of rats intoxicated with sodium fluorideStawiarska-Pieta, Barbara; Helis, Agnieszka; Matelska, Sara; Grzegorzak, Natalia; Zalejska-Fiolka,Jolanta; Birkner, Ewa; Wyszynska, MagdalenaP08-54The organotin tributyltin and TNF-α induce 17β-hydroxysteroid dehydrogenase type3 expressionCornelia Fürstenberger, Roger Engeli and Alex Odermatt

P08-55The Regulation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced LungTumor Promotion by Estradiol in Female A/J MiceYing-Jan Wang, Rong-Jane Chen, Louis W. Chang, Yuan-Soon Ho, Chih-Hsiung Wu, Pinpin LinP08-56Toxicity and genotoxicity of the air polluted with compounds produced by heavyindustryH. Sezimová, K. Malachová, Z. RybkováP08-57Toxicity of microcystin-deficient Planktothrix strains due to chlorine and sulfatecontaining aeruginosinsKohler, Esther; Blom, Judith; Grundler, Verena; Häussinger, Daniel; Kurmayer, Rainer; Gademann,Karl; Pernthaler, JakobP08-58Toxicological Risk Assessment in Carbon Capture and Storage TechnologyHillebrand, Marcus; Pflugmacher, Stephan; Hahn, AxelP08-59Xenoestrogenic and dioxin-like activity in blood of East Greenland polar bears (Ursusmaritimus)Simon E. Erdmann, Rune Dietz, Christian Sonne, Thea Ø. Bechshøft, Katrin Vorkamp, Robert J.Letcher, Manhai Long, Eva C. Bonefeld-JørgensenP09: Food SafetyP09-01A preliminary assessment of dietary exposure to sulphites in Greek populationthrough wine consumptionIoannis N. Tsakiris, Manolis N. Tzatzarakis, Athanasios K. Alegakis, Paraskevi Mitlianga, KyriakakisMichalis, Polychronis Stivaktakis, Mathaios Kavvalakis, Vlachou Maria, Aristidis M. TsatsakisP09-02Activation of AhR and CYP1A1 induction by pelargonidin in primary humanhepatocytes and human cancer cell linesAlzbeta Kamenickova, Zdenek Dvorak, Eva Anzenbacherova, Pavel AnzenbacherP09-03Activity and Genetic Expression of Antioxidant Enzymes in Liver and Kidney of Ratsexposed to a Modified Clay and Its Migration ExtractJos A, Maisanaba S, Llana Ruíz-Cabello M, Gutiérrez-Praena D, Puerto M, Mate A, Pichardo S, JordáM, Aucejo S, Cameán A.P09-04Cytotoxicity Study in the Human Cell Line Caco-2 of Dipropyl Sulfide and DipropylDisulfide from Garlic Essential OilJos A, Llana Ruiz-Cabello M, Gutiérrez-Praena D, Pichardo S, Bermúdez JM, Aucejo S, Cameán AM

P09-05Cytotoxicity, Oxidative Stress and Genotoxicity of Two Novel Modified ClaysIntended to Food Packaging applications in the Human Cell Line HepG2Jos A, Maisanaba S, Houtman J, Puerto M, Jordá M, Aucejo S, Pichardo, S.P09-06Histological and Biochemical Study in Rats Subchronically Exposed to anOrganomodified Clay and its Migration ExtractJos A, Maisanaba S, Puerto M, Gutiérrez-Praena D, Moyano R, Blanco A, Pichardo S, Jordá M,Aucejo S, Cameán A.P09-07Study of the Basal Cytotoxicity and the Oxidative Stress Induction of Carvarcrol,Thymol, and their Mixture in the Human Cell Line Caco-2Cameán AM, Llana Ruiz-Cabello M, Gutiérrez-Praena D, Pichardo S, Jos A, Puerto M, Bermúdez JM,Aucejo SP09-08Aflatoxins and Fumonisins Contamination of Home-Made Food (Weanimix) fromCerel-Legume Blends for Children in GhanaKumi, Justice; Nicole, Mitchell; A. Asare, George; Dotse, Eunice; Kwaa, Freda; Phillips, Timothy;Ankrah, Nii-AyiP09-09Are house dust mite or shellfish allergic patients at risk when consuming foodcontaining mealworm proteins.Verhoeckx, KCM, van Broekhoven, S., Broekman, HCHP, den Hartog Jager, CF, Gaspari, M, de Jong,Govardus AH., Wichers, H, van Hoffen, E, Houben, GF, Knulst, ACP09-10Cadmium and Lead Levels Consumed by Patients with Oral Hospital DietsPrescriptionsJulia S. Manzoli de Sá; Isabela C Fernandes; Daniele C. F. Moreira; Marcelo A. Morgano; Késia D.Quintaes.P09-11Trace elements in tea leaves commercialized in BrazilRaquel F. Milani; Marcelo A. Morgano; Elisabete S. Saron; Fábio F. Silva; Solange CadoreP09-12Determination of Primary Aromatic Amines in Cold Water Extract of Colour PaperNapkin Samples by Liquid Chromatography-Tandem Mass SpectrometryOguzhan Yavuz, Sandro Valzacchi, Eddo Hoekstra and Catherine SimoneauP09-13Evidence for lipid signaling molecules in glycated protein preparations beingresponsible for the stimulation of inflammatory signaling in RAGE expressing cells –potential role of lysophosphatidic acidTimo Buetler, Hélia Latado, and Gabriele ScholzP09-14Hepatotoxic pyrrolizidine alkaloids - Molecular effects on the transcriptome in humanprimary hepatocytesLuckert, Claudia; Hessel, Stefanie; Lenze, Dido; Lampen, Alfonso

P09-15Induction of micronuclei and cytotoxic effects of ochratoxin A in Vero cellsJG Costa; AS Fernandes; PS Guerreiro; E Filipe, JP Miranda, M Castro and NG OliveiraP09-16Influence of the making and cooking pasta on enniatins contentsFont G., Serrano A.B., Tolosa J. and Ferrer E.P09-17Monitoring Alternaria mycotoxins and pesticide residues in tomato by dispersiveliquid-liquid microextraction coupled to gas chromatography-tandem massspectrometryFont G., Rodríguez-Carrasco, Y., Moltó J.C., Berrada, H.P09-18Influence of the Process Conditions on the Formation of 3-MCPD Esters in Palm OilKlicia A. Sampaio, Adriana P. Arisseto, Jose V. Ayala, Christian Stevens, Roberta Ceriani, RolandVerhé, Antonio J.A. MeirellesP09-19Liquid Chromatographic determination of histamine in traditionally salted, smokedand frozen fish with Relation to Microbial LoadM.M. Deabes, S.A. Ahmed, Hayam A. Mansour, Laila A. Mohamed, and Doha A. Salah El dinP09-20Mutagenicity studies of processed food items and ready-to-eat snacks in FinlandIyekhoetin Matthew Omoruyi and Raimo PohjanvirtaP09-21Nutritional and toxicological analyses of leaves and fruits of Solanum macrocarponLinn (Solanaceae) in Cotonou (Benin)Dougnon Victorien, Bankolé Honoré, Dougnon Jacques, Klotoé Jean-Robert, Edorh Patrick, LokoFrédéric, Boko MichelP09-22Safety Testing of New Ingredients in Infant Formula using Piglet as an Animal ModelAli S. Faqi, Adam D. Aulbach and Bjorn A. ThorsrudP09-23The scaling of allergenic products for the hazard characterisation of new proteinsKruizinga, AG; Klein Entink, RH; Blom, WM; Houben, GF; van Bilsen, JHMP09-24Toxicological, genotoxicological, antigenotoxicological, cytotoxicity and lifespanstudies of beer and some componentsMerinas-Amo, Maria Tania; Villalba-Benito, Leticia; Almagro-Berlanga, Rafael; Romero-Jimenez,Magdalena; Mateo-Fernandez, Marcos; Alonso-Moraga, Angeles; Calahorro-Nuñez, FernandoP09-25Withdrawal time of Fosfomycin in pigs and broiler chickens after oral andintramuscular administrationPérez, Denisa S.; Soraci, Alejandro L.; Tapia, María O.

P10-08The 4977 bp and 7436 bp Mitochondrial DNA Deletions in Workers with AcuteExposed to Iridium-192Esma Söylemez, Zeliha Kayaaltı, Dilek (Kaya) Akyüzlü, Engin Tutkun, Tülin SöylemezoğluP10-09Effects of Reduction of the Top Concentration Limit Used in the In VitroChromosomal Aberration TestMorita, Takeshi; Hatano, Akiko; Honma, MasamitsuP10-10Evaluation of Aromatic Amines in the EpiDermTM 3D Human Reconstructed SkinMicronucleus (RSMN) AssayHolland, Daniela; Barnett, Brenda; Aardema, Marilyn; Pfuhler, StefanP10-11Evaluation of In Vivo DNA Damaging and Oxidative Stress Effects of SertralineAyca Aktas, Dilek Battal, Mehmet Ali Sungur, Serap Yalin, Ela Kadıoglu, Ebru Derici Eker, NefiseOzlen Sahin, Sahan SaygiP10-12Exposure-response relationships in adolescents of the 2nd Flemish Environment andHealth Study: The correlation between polycyclic aromatic hydrocarbons (PAHs) andDNA damageEva Govarts, Carmen Franken, Gudrun Koppen, Elly Den Hond, Greet Schoeters,P10-13Genotoxic assessment of tobacco-specific nitrosamine mixtures using the in vitroγH2AX assayCarolina Garcia-Canton, Graham Errington, Clive MeredithP10-14Guajiru (Chrysobalanus icaco L.) fruit protects rat bone marrow erythrocytes againstdoxorubicin-induced DNA damageVinícius de Paula Venâncio, Mara Ribeiro de Almeida, Lívia Cristina Hernandes, Joana DarcCastania Darin, Marcella Camargo Marques, Adriana Zerlotti Mercadante, Maria Lourdes PiresBianchi, Lusânia Maria Greggi AntunesP10-15Modulating Effects of Pycnogenol on Sepsis Induced DNA Damage In the Liver andRenal Tissue Cells of RatsGökçe Taner, Sevtap Aydın, Merve Bacanlı, Tolga Şahin, A. Ahmet Başaran, Nurşen BaşaranP10-16Use of in vitro assays to assess the potential cytotoxic, genotoxic and antigenotoxiceffects of vanillic acidGökçe Taner, Deniz Özkan Vardar, Sevtap Aydın, Zeki Aytaç, Ahmet Başaran, Nurşen BaşaranP10-17New Study Design Considerations for Somatic and Germ Cell Analysis in the BigBlue ® Transgenic Rodent Mutation AssayRobert R. Young, David Bruning, Marilyn J. Aardema

P10-18Noncanonical activation of ATR-p53 axis by DNA-protein crosslinks controls celldeath responses to formaldehydeAnatoly Zhitkovich, Victor Wong, Jessica MorseP10-19Preclinical safety assessment of aqueous Gentiana lutea radix extractsTurek, Claudia; Mörbt, Nora; Felenda, Jennifer; Link, Kerstin; Christiane, Beckmann; Müller,Margit; Vögele, Peter; Stintzing, FlorianP10-20Predicting in vivo genotoxicity using mRNA and miRNA data from two in vitro livermodels.Linda Rieswijk, Daneida Lizarraga, Karen Brauers, Stan Gaj, Jos C. Kleinjans, and Joost H.M. vanDelftP10-21Retrospective study of false positive results in in vitro genotoxicity studiesHofman-Hüther, HanaP10-22Selected methyleugenol metabolites suppress topoisomerase I activity and diminishthe DNA-damaging properties of the DNA-topoisomerase poison camptothecin inhuman colon carcinoma cellsGroh, Isabel Anna Maria; Schröter, Anika; Marko, Doris; Esselen, MelanieP10-23The food dye Quinoline Yellow modulated mRNA transcriptional profile associatedto DNA damage signaling pathwayFarah Maria Drumond Chequer ; Vinícius de Paula Venâncio, Maria Lourdes Pires Bianchi, LusâniaMaria Greggi AntunesP10-24The ToxTracker assay: Unveiling the carcinogenic properties of chemicals.Giel Hendriks, Fabienne Calléja, Bruno Morolli, Bob van de Water and Harry Vrieling.P15: Methods in ToxicologyP15-013-month intravenous bolus injections via the femoral vein and an external access portin ratsPerron, Josee; Armer, Lynn; Tavcar, Robert; Forster, RoyP15-02A 4D lung multi-culture system which mimicking alveolar cellular organization tostudy the toxic potential of airborne particlesT. Serchi, S.G. Klein, A. Jehanno, S. Legay, S. Contal, J. Hennen, A.C. Gutleb, L. Hoffmann and B.Blömeke

P15-03A new culture system activating hepatic function of HepG2 cells utilizing a collagenvitrigel membrane chamber and its application to liver metabolism and toxicity assaysOshikata-Miyazaki Miyazaki, Ayumi; Ishida, Seiichi; Kuroda, Yukie; Takezawa, ToshiakiP15-04A novel approach for extrapolating toxicity in vivo by analyzing the behavior of stemcells cultured on TOSHI (tissue/organ sections for histopathology)-substrata derivedfrom experimental animals after exposing chemicalsTakezawa, ToshiakiP15-05A refined surgical technique for telemetry in group housed macaques (M. fascicularis)J. Luft, J. Sternberg, M. Fine; D. SarazanP15-06Assessment of benzene-induced hematotoxicity using a human-like hematopoieticlineage in NOD/Shi-scid-IL2Rγ null miceMasayuki Takahashi, Noriyuki Tsujimura, Tomoko Yoshino, Masahito Hosokawa, Tadashi Matunaga,Satoshi NakasonoP15-07Bovine Corneal Opacity and Permeability Test (BCOP) - an Appropriate in vitroAlternative Method for Evaluation of the Potential Ocular Corrosivity or SevereIrritancy of Nonpolar Substances?Weidmann, Katharina; Schmid, Sandra; Albrecht, Achim; Schleh, Carsten; Allingham, Philip; Leoni,Anne-LaureP15-08Construction of a mouse MA-10 Leydig cell line stably expressing a HSDB luciferasereporterRoger Engeli, Cornelia Fürstenberger and Alex OdermattP15-09Development and validation of a gas chromatography/mass spectrometry method forsimultaneous quantification of benzylpiperazine and its metabolites: application to apilot toxicokinetic study in miceM. Monteiro, M. Carvalho, M.L. Bastos and P. Guedes de PinhoP15-10Development of a Simple and Rapid Spectrophotometric Method for theQuantification of CarboxyhemoglobinAna Oliveira, Fernanda Sampaio-Silva, Félix Carvalho, Ricardo Silvestre, Ricardo Jorge Dinis-OliveiraP15-11Identification of psychoactive substances in “legal highs” marketed in PortugalAna Margarida Araújo, Maria de Lourdes Bastos, Márcia Carvalho, Félix Carvalho, Helena Gaspar,Ana Cardoso Matias, Paula Guedes de Pinho

P15-12Dose Determination of Particles for Air/Liquid Interface (ALI) Technique forToxicity Testing on Human Lung CellsTroeller S. and Linsel G.P15-13Extraction of Perfluorinated Alkyl Acids and Lipophilic Persistent Organic Pollutantsfrom Human SerumC. Bjerregaard-Olesen, R. Bossi, E.C. Bonefeld-JørgensenP15-14Flow-through versus static design for dermal absorption experiments in vitroK. Guth, M. Schäfer-Korting, E. Fabian, E. Haltner-Ukomadu, B. van Ravenzwaay, R. LandsiedelP15-15Following the Fate of Modified Microcystin-LRGrundler, Verena; Kohler, Esther; Faltermann, Susanne; Blom, Judith; Pernthaler, Jakob; Fent, Karl;Gademann, KarlP15-16Historical Control Data generated in a 2-Year Life Span Study in Wistar Rats(Crl:Wi(Han)) demonstrate a Reliable Model for Carcinogenicity StudiesPhilip Allingham, Anne-Laure Leoni, Achim Albrecht, Wolfram Riedel, Susan Gähler, GabrielePohlmeyer-Esch, Klaus WeberP15-17Implementation and establishment of blood toxicity protocol for use of pre-clinicaltesting of drugs. Studies in rats.Teles, Alessandra; Gorniak, SilvanaP15-18Local tolerance evaluation of fibrin and thrombin solution in a free-flap model in thejuvenile Sprague-Dawley ratColombo P, Neri MT, Carù F, Scarpellini M, Bacci M, Guarnieri C, Ali Youssef D, Riccardi E, Rosa BP15-19Novel formats for the comet assaySergey Shaposhnikov, Gunnar Brunborg, Amaya Azqueta, Isabel Gaivão, Andrew Smart, Andrew R.CollinsP15-20Predicted drug-induced bradycardia related cardio toxicity using a zebrafish in vivomodel is highly correlated with results from in vitro testsMyoung joo, Park; Dae-Seop, Shin; Sung- Hoon, Ahn; Myung Ae, BaeP15-21Predicting intramuscular discomfort with the Slug Mucosal Irritation assayAdriaens, Els; Lenoir, Joke; Remon, Jean Paul

P15-22Read-across approach for hazard assessment of fatty acid esters via investigating thelipase mediated hydrolysisLi, Qiang; Lee, Moung Sook; Jost, Martina; Höppner, Christoph; Kreiling, ReinhardP15-23Searching of Standard Comet Assay Parameters for Detecting Lymphocyte DNADamage Using Fourteen Different Test ConditionsEsma Söylemez, Zeliha Kayaaltı, Tülin SöylemezoğluP15-24SLIM: a smart way from innovations to humansMarc Teunis, Rob Vandebriel, Ruud Woutersen, Diane Kegler, Jan Raaijmakers, Jan van der Valk,Raymond Pieters, Cyrille KrulP15-25Substantive reduction of animal numbers on regulatory toxicology studies by usingmicrosampling or sample-sparing techniquesLawrence R, Mitchell D, Coleman DP15-26Successful continuous intravenous infusion in post-weaning juvenile ratsAllais, Linda; Gerhardy, Cécilia; Briffaux, Jean-Paul; Vignand, Philippe; David, Sylvie; Fant,PierluigiP15-27The evaluation of the embryotoxic chemicals by using undifferentiated humanembryonic stem cellsEui-Man Jung, Yeoul Choi, Hong-Seok Kang and Eui-Bae JeungP15-28The role of the transcutaneous electrical resistance test (TER) in the sequential testingstrategy aimed at evaluating dermal irritating and corrosive properties of chemicalsubstancesGruszka, Katarzyna; Mrzyk, Inga; Sornat, Robert; Kropidlo, Aneta; Drzewiecka, AgnieszkaP15-29The Threshold of Toxicological Concern as a Tool For The Safety Assessment ofCosmetic IngredientsAssanome, Karen; Queiroz, Diana; Zacarias, CyroP15-30Development of MISPE-MS/MS method for Cocaine and its metabolites in vitreoushumorRaquel M. T. Fernandes, Júlio César Santos Júnior, Carla Giane Loss, Nelci Fenalti Höehr, PedroCarlos Mollo Filho, Ruggero Bernardo Felice Guidugli and Marcos N. Eberlin

P16: OmicsP16-01A proteomic approach to investigate the modification in the proteome of thecytoplasmatic compartment of Balb/3T3 cells after exposure to gold nanoparticles(AuNPs)Hubert Chassaigne, Sabrina Gioria, Donatella Carpi, Antonietta Parracino, Paola Barboro andFrançois RossiP16-02Untargeted metabolomics in human health risk assessment of nanoparticles: dataprocessing workflow challengesHubert Chassaigne, Sabrina Gioria, Giorgio Tomasi, Agnieszka Kinsner-Ovaskainen, François Rossi,Claude GuillouP16-03Amiodarone: a metabolomic approach of different modes of action (MOAs) in ratsG. Montoya, V. Strauss, E. Fabian, H. Kamp, W. Mellert, T. Walk, R. Looser, M. Herold, G. Krennrich,E. Peter and B. van RavenzwaayP16-04Mechanistic explanation of different metabolomics patterns in rat plasma for thedifferentiation of direct thyroid hormone synthesis inhibitors and compoundsincreasing thyroid hormone clearanceG. Montoya, V. Strauss, E. Fabian, H. Kamp, W. Mellert, T. Walk, R. Looser, M. Herold, G. Krennrich,E. Peter and B. van RavenzwaayP16-05Application of metabolomics in vitro for identification of toxicological modes ofactionTzutzuy Ramirez, Natalie Bordag, Werner Mellert, Hennicke Kamp, Tilmann Walk, Ralf Looser andBennard van RavenzwaayP16-06Changes in Hepatic Gene Expression Induced by Various Statin Formulations inChimeric PXB-Mouse ® with Highly Humanized Liver Mikiro Nakashima, Hidehisa Tachiki, Hatsune Enomoto, Takashi Shimada and Shin-Ichiro NagatsukaP16-07Characterisation of novel Australian snake venom toxins as potential therapeuticagents.Liam St Pierre, Paul Masci, Kong-Nan Zhao, John De Jersey and Martin Lavin.P16-08Genetic Variations of DMT1 Gene and Blood Iron, Lead and Cadmium Levels inThalassemia PatientsTülin Söylemezoğlu, Zeliha Kayaalti, Derya Söylemez GökyerP16-09Human skin proteome: insights into chemical induced skin sensitisationZhu, Zheying; Fang, Min

P16-10Oxidative stress in carcinogenesis: a Toxicogenomics based comparison between liverand colon carcinoma cells.Deferme L, Briedé JJ, Cavill R, Kleinjans JCSP16-11Percellome Toxicogenomics application to Sick House Syndrome-level InhalationToxicity with Special Reference to Transcriptomic Response of Hippocampus.Jun Kanno, Ken-ichi Aisaki, Katsuhide Igarashi, Yuhji Taquahashi and Satoshi KitajimaP16-12Proteomic investigations into mechanisms of nephrotoxicity induced by 3-MCPD andits dipalmitate in rat kidneyS. Sawada, C. Meckert, J. Potkura, A. Oberemm, A. LampenP16-13Systems biology approach reveals a dose-dependent recovery of primary humanairway epithelium culture after exposure to cigarette smokeCarole Mathis, Stephan Gebel, Carine Poussin, Arnd Hengstermann, Dirk Weisensee, Alain Sewer,Vincenzo Belcastro, Sam Ansari, Sandra Wagner, Julia Hoeng, Manuel C. PeitschP16-14XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms in chronic obstructivepulmonary diseaseAyşegül Bacaksiz, Zeliha Kayaalti, Dilek (Kaya) Akyüzlü, Esma Söylemez, Gülseren Karabıyıkoğlu,Hatice Taslak, Tülin SöylemezoğluP17: Pesticide ToxicologyP17-01Analysis of hepatotoxic mixture effects of (tri)azole fungicides in a broad dose rangeHeise, T., Rieke, S., Schmidt, F., Ladwig, M., Haider, W., Kneuer, C., Pfeil, R., Niemann, L., Marx-Stoelting, P.P17-02Analysis of toxic heavy metals and pesticides in Mucuna pruriens by SpectroscopicmethodsSiddique NA, Mujeeb M, Ahmad S, Aamir M, Rshid MP17-03Combination effects of (tri)azole fungicides on the adrenal gland in vivoRieke S., Schmidt F., Heise T., Pfeil R., Ladwig, M., Haider, W., Hirsch-Ernst, KI., Niemann L., Marx-Stoelting, P.P17-04Concentration Addition Model to Assess Activation of the Pregnane X Receptor(PXR) by Pesticide Mixtures Found in the French DietG. de Sousa, A. Nawaz, R. Rahmani

P17-05Currently used pesticides and their mixtures affect the function of sex hormonereceptors and aromatase enzyme activityLisbeth Stigaard Kjeldsen, Mandana Ghisari and Eva Cecilie Bonefeld-JørgensenP17-06Establishment of cohort study for Agricultural worker exposured pesticides inKOREAMihye Jeong, Soon-Sung Hong, Kyung-Hun Park, Soo Jin LeeP17-07Evaluation of DNA damage and telomerase activity in liver and kidney after longterm rabbits exposure to chlorpyrifos.Vasilaki Fotini, Maravgakis Georgios, Stivaktakis Polychronis, Tsitsimpikou Christina, VakonakiElena, Fragkiadaki Persefoni, Kovatsi Leda, Christakis-Hampsas Maria, Emmanuel N. Kokkinakis,Tsatsakis M. AristidisP17-08Evaluation of organochlorine pesticides- mediated toxicity in vitro and amelioratingeffect of n-acetylcystein and curcuminManushi Siddarth, Sudip K Datta, Rafat S Ahmed, Om P Kalra, Basu D Banerjee and Ashok K TripathiP17-09In vitro - in vivo correlations for endocrine activity of a mixture of 5 currently usedpesticidesCamilla Taxvig, Niels Hadrup, Julie Boberg, Marta Axelstad, Rossana Bossi, Eva Cecilie BonefeldJørgensen & Anne Marie VinggaardP17-10Mechanism of action of the herbicide Paraquat mediated oxidative stress on erythroiddifferentiation pathway in bone marrow and spleen of miceBhardwaj, Nitin; Saxena, Rajiv KP17-11New biochemical and physiological aspects of chlorpyrifos neurotoxicityRosalovsky, Volodymyr; Salyha, YuriyP17-12Organophosphates used in agriculture and produce exportAikaterini N. Kokkinaki, Emmanuel N. Kokkinakis, Tzatzarakis Manolis, Fragkiadaki Persefoni,Tsakiris N. Ioannis, Vynias Dionisios, Georgios Maravgakis, Matthaios Kavvalakis, Aristidis M.TsatsakisP17-13Pesticide training as a major factor sustaining public health, during farming ofcertified produce.Aikaterini N. Kokkinaki, Emmanuel N. Kokkinakis, Georgia Tavladaki, Georgia Panagiotaki, SofiaNiniraki, Giannakoudakis Konstantinos, Tsakiris Ioannis, Kavvalakis P. Mathaios, Aristidis M.Tsatsakis

P17-14Potential ecotoxicity impact induced by plant protection products in Finnish cropfarmingK. Räsänen, T. Mattila, P. Porvari, S. KurppaP17-15The effect of glyphosate on the spontaneous motoric activity of rat isolated jejunumstripsMendel, Marta; Chlopecka, Magdalena; Dziekan, Natalia; Karlik, WojciechP17-16The role of microtubule on dithiocarbamate cytotoxicityEugene Gonzalez-Lopez and Shu-Yuan ChengP17-17Toxic effects of combined (tri)azole fungicides on prostate gland and testis in ratsSchmidt F, Rieke S, Heise T, Ladwig M, Haider W, Hirsch-Ernst KI, Niemann L, Pfeil R, Marx-Stoelting PP17-18Understanding the imidacloprid metabolism in long-term exposure through acomparative study of imidacloprid and its major metabolite levels in the urine andhair of intentionally exposed rabbitsMathaios P. Kavvalakis, Manolis N. Tzatzarakis, Stivaktakis Polychronis, Manolis Barbounis, MarinaGoumenou, Athanasios Alegakis, Elisavet Renieri, Dionisis Vynias, Aristidis M. TsatsakisClub CasinoP05: Computational ToxicologyP05-01A new approach based on QSAR based expert system and a quantitative read acrossmethodology to achieve better in silico genotoxicity assessment of drugs, impuritiesand metabolitesSuman Chakravarti, Roustem SaiakhovP05-02A quantitative weight-of-evidence approach used in decision support for safety andrisk assessmentJ.F. Rathmana, C. Yang, S. Boyerc, C. Hasselgrenc, H. ZhouaP05-03Assessing the inter-individual variability of toxicokinetic processes oftrichloroethylene (TCE) in humansOlie J.D.N., Boerleider R.Z., DeVries I., Meulenbelt J., Hunault C.C.P05-04Category Formation and Read-Across for Toxicity Prediction: A Review of theCurrent Status and Future DirectionsCronin, Mark; Enoch, Steven; Madden, Judith; Richarz, Andrea; Roberts, David

P05-05Data mining toxicity effects through an ontology approach to investigate toxicitymode of actionVessela Vitcheva, Chihae Yang, Aleksandra Mostrag-Szychtying, Mark Nelms, Petko Alov, SteveEnoch, Ivanka Tsakovka, James Rathman, Mark CroninP05-06Development of New COSMOS oRepeatDose and non-cancer Threshold ofToxicological Concern (TTC) Databases to Support Alternative Testing Methods forCosmetics Related ChemicalsChihae Yang, Massimo Ambrosio, Kirk Arvidson, Sue Barlow, Alan Boobis, Maria Checheva, MarkCronin, Susan Felter, Elena Fioravanzo, Heli Hollnagel, Dimitar Hristozov, Kristi Jacobs, DetlefKeller, Aleksandra Mostrag-Szylchtying, Mark Nelms, James Rathman, Andrea Richarz, IvankaTsakovska, Stephane Vidry, Vessela Vitcheva, Andrew WorthP05-07Development of Integrated In Silico Models for Toxicity Prediction Focussing onCosmetic IngredientsRicharz, Andrea-Nicole; Neagu, Daniel; Yang, Chihae; Fioravanzo, Elena; Péry, Alexandre; Worth,Andrew; Berthold, Michael; Cronin, MarkP05-8In Silico Workflows for Toxicity Prediction Implemented into KNIMERicharz, Andrea-Nicole; Enoch, Steven; Hewitt, Mark; Madden, Judith; Nelms, Mark; Przybylak,Katarzyna; Yang, Chihae; Berthold, Michael; Meinl, Thorsten; Ohl, Peter; Cronin, MarkP05-09Development of the KY-methods for used in toxicity predictionYuta, KohtaroP05-10External Validation of the Toxicological Categories in Hazard Evaluation SupportSystem Integrated Platform (HESS)Sakuratani, Yuki; Yamada, Takashi; Ikenaga, Yutaka; Yamada, Jun; Ohta, Satoshi; Hayashi, MakotoP05-11Generalized workflow for generating high quality in-silico models for off-targetmediated toxicityAnger, Lennart T.; Schleifer, Klaus-Juergen; Schrenk, Dieter; Rohrer, SebastianP05-12Human Bioaccumulation Potential Simulated in R and Implemented into KNIMEinterfaceAlicia Paini, José Vicente Sala Benito, Monika Gajewska, Andrew Worth, José Manuel ZaldivarComengesP05-13Modelling Chemically-Induced Cell Toxicity: an Open Source Implementation of aVirtual Cell Based Assay ModelAlicia Paini, José Vicente Sala Benito, Milena Mennecozzi, Monika Gajewska, Andrew Worth, JoséManuel Zaldivar Comenges

P05-14Identification of potential CMR substances under REACH by (Q)SAREva B. Wedebye, Nikolai G. Nikolov, Marianne Dybdahl, Sine A. Rosenberg, Jay R. NiemeläP05-15Integration of Omics Data and Systems Biology Modeling: Response of the NFE2L2Pathway in Human Renal Kidneys Cells exposed to Cyclosporine A in vitroJérémy Hamon, Paul Jennings, Frédéric Y. BoisP05-16Molecular Modelling of LXR Binding to Evaluate the Potential for Liver SteatosisE. Fioravanzo, A. Bassan, M.T.D. Cronin, S. Kovarich, C. Manelfi, A.-N. Richarz, I. Tsakovska, A.P.Worth.P05-17Multi-scale modeling for individualized spatiotemporal prediction of drug effectsJuan G. Diaz Ochoa, Joachim Bucher, Jens Niklas, Klaus MauchP05-18New strategies to develop chemical categories in the context of REACH - work inprogressBatke M, Bitsch A, Gundert-Remy U, Guetlein M, Helma Ch, Kramer S, Maunz A, Partosch F, SeelandM, Stahlmann RP05-19Pharmacophore-based virtual screening as a prioritization tool to assess mechanismbasedcardiotoxic effects of small organic moleculesDaniela Schuster, Michael Edtbauer, Jadel M. Kratz, Christina E. Mair, Steffen Hering, Judith M.RollingerP05-20Pharmacophore-based virtual screening in the search for endocrine disruptingchemicals - successful case studiesAnna Vuorinen, Alex Odermatt, Daniela SchusterP05-21Skin sensitization study by a new qualitative sttructure-toxicity relationships (QSTR)approach: K-step Yard Sampling (KY) methods.Sato, Kazuhiro; Kusaka, Yukinori; Yuta, KohtaroP05-22The Danish (Q)SAR Database Update ProjectNikolai G. Nikolov, Marianne Dybdahl, Sine A. Rosenberg, Eva B. WedebyeP05-23Toward better understanding of liver steatosis MoA: Molecular modelling study ofPPAR gamma receptorAl Sharif, Merilin; Alov, Petko; Cronin, Mark; Fioravanzo, Elena; Tsakovska, Ivanka; Vitcheva,Vessela; Worth, Andrew; Yang, Chihae; Pajeva, Ilza

Tuesday, September 3 rd , 2013Location:Auditorium Foyer: P12/01 - P14/28, P20/01 - P21/03Concert Hall: P18/01- P18/27, P23/01 - P25/28Club Casino: P19/01 - P19/17; P22/01 - P22/05Auditorium FoyerP12: In vitro ToxicologyP12-01A human 3D myocardial microtissue model for cardiotoxicity testingPhilippe Beauchamp, Irina Agarkova, Wolfgang Moritz, Jens Kelm, Christian ZuppingerP12-02A physiologically relevant HepG2 cell based 3D cell culture model for highthroughput toxicity studiesPrice, Leo; van de Water, Bob; van Delft, Joost; Commandeur, Jan; Braver, Michiel; Coonen,Maarten; Ramaiahgari, Sreenivasa; Jennen, Danyel; Meerman, JohnP12-03A Triple cell co-culture model of the air-blood barrier reconstructed from primaryhuman cellsJackson, George; Mankus, Courtney; Oldach, Jonathan; Child, Matthew; Spratt, Maureen;Kandarova, Helena; Ayehunie, Seyoum; Hayden, PatrickP12-04Air/Liquid Interface (ALI) technique for toxicity testing of gaseous compounds onhuman lung cellsTroeller S., Linsel G., Huettig N., Bauer M., Graebsch C., Smirnova L., Pirow R., Liebsch M., Berger-Preiß E., Kock, H., Oertel A., Ritter D., Knebel, J.P12-05Alternative in-vitro phototoxicity test using reconstructed skin model, KeraSkin ®Yang-Hwan Ryu, Su-Hyon LeeP12-06Development of a new reconstituted human cornea model to assess the eye irritationSu-Hyon Lee, Haeng-Sun Jung, Kyoung-Mi Jung, Kyoung-Min LimP12-07Evaluating the micronucleus induction potential for the genotoxicity assay using theKeraSkin ® human skin modelSu-Hyon Lee, Haeng-Sun Jung

P12-08Amphotericin B: relationship between nephrotoxicity and inhibition of PKA and p38MAPK signaling pathwaysFrança, F.D., Tagliati, C.A., Chaves, M.M.P12-09An automated system for a stable and reproducible long-term cultivation of epithelialcells at the air-liquid interface - the CULTEX ® LTC moduleMichaela Aufderheide, Jessica Rach, Niklas MöhleP12-10An in vitro model of the renal proximal tubule composed of small intestinalsubmucosa (SIS) and human kidney-derived cells (hKDCs)Hoppensack, Anke; Schanz, Johanna; Kazanecki, Christian; Colter, David; Walles, HeikeP12-11An investigation into the toxicity and genotoxicity of brominated flame retardants inSHSY-5Y cellsSostare, Jelena; Michelangeli, Francesco; Hodges, NikolasP12-12Analysis of the Validated Epiderm Skin Corrosion Test (EpiDerm SCT) and aPrediction Model for Sub-Categorization According to the UN GHS and EU CLP.Helena Kandarova, Silvia Letasiova, Tatiana Milasova and Mitchell KlausnerP12-13Arctigenin’s mode of toxicity in oxidative metabolizing cell lines.Virginie Riebel, Brecht K, Bonifacio A, Marcellin M, Couttet, P, Chibout SD, Pognan F, Wolf A, andUteng M.P12-14Are in vitro methods really useful for eye irritation assessment of children products?Fragoso Rocha, Bianca; Queiroz, Diana; Fonseca, Vitor; Lucena, Kaline; Sá-Rocha, VanessaP12-15Are structural analogues to bisphenol A a safe alternative?Rosenmai, Anna; Dybdahl, Marianne; Pedersen, Gitte Alsing; Pedersen, Mikael; van Vugt-Lussenburg, Barbara; Taxvig, Camilla; Vinggard, Anne MarieP12-16Bioengineered carbon-encapsulated magnetic nanoparticles as target antibodydelivery systems in glioma toxicityMonika A. Cywinska, Ireneusz P. Grudzinski, Anita Kosmider, Magdalena Poplawska, MichalBystrzejewski, Andrzej Cieszanowski, Agnieszka OstrowskaP12-17Cell cycle-related genes transcriptionally induced by the mycotoxin ZearalenoneVaccari, Monica; Perdichizzi, Stefania; Mascolo, Maria Grazia; Silingardi, Paola; Morandi, Elena;Rotondo, Francesca; Guerrini, Angela; Bergamini, Cecila; Colacci, Annamaria

P12-18Comparison of in silico and two in vitro high content screening approaches,phospholipidosis and lysosomal trapping, in predicting in vivo phopholipidosisFrost, Kerry; Bauch, Caroline; Ellis, Samantha; Woodhouse, Heather; Walker, PaulP12-19Cytotoxicity of Pycnogenol and Resveratrol in CHO and HeLa Cell LinesZehra Sarıgöl, Gökçe Taner, Sevtap Aydın, Merve Bacanlı, A.Ahmet Başaran, Nurşen BaşaranP12-20Determination of liver specific toxicities in rat hepatocytes by High Content Imagingduring 2-week multiple treatmentGermano, Davide; Uteng, Marianne; Couttet, Philippe; Grenet, Olivier; Chibout, Salah-Dine;Pognan, Francois; Wolf, ArminP12-21Development of a 3D suspension culture system of umbilical cord-derivedmesenchymal stromal cells (UCX ® ) for potential in vitro toxicological applicationsMiranda J.P., Filipe E., Filipe M., Teixeira M., Cipriano M., Barcia R., Cruz P., Cruz H., OliveiraN.G., Castro M., Santos J.M.P12-22In vitro cytotoxicity assessment using three-dimensional cell cultures of MCF10AcellsMiranda J.P., Cipriano M., Fernandes A.S., Castro M. and Oliveira N.G.P12-23Development-dependent inflammatory response elicited by the herbicide paraquat in3D neural culturesJenny Sandström von Tobel, Jorane Althaus, Julien Mermoud and Florianne Monnet-TschudiP12-24Effects of culture on polymer biomaterials on the cellular responses to chemicalsMiyajima-Tabata, Atsuko; Kato, Reiko; Sakai, Keiko; Matsuoka, AtsukoP12-25Effects of extended low-load operation of a non-DPF diesel engine on the relativetoxicity of its emissionsTopinka, Jan; Rossner, Pavel; Milcova, Alena; Schmuczerova, Jana; Rossnerova, Andrea; Pavlikova,Jitka; Ambroz, Antonin; Novakova, Zuzana; Svecova, Vlasta; Vojtisek-Lom, MichalP12-26Effects of neurotoxic compounds on functional three-dimensional neural tissuesderived from hESCs.L. Stoppini, I. Charvet, KH KrauseP12-27Effects of Neurotoxicity on Fipronil using human cell SH-SY5YYoung-Lim Kim, Mihye Jeong, Soo-Jin Park, Kyung-Hun Park, Jeong Eun Lee, Jae Hyun Park, HyunChul Koh

P12-28Effects of perfluoroalkyl acids on the function of the thyroid hormone and the arylhydrocarbon receptorLong, Manhai; Ghisari, Mandana; Bonefeld-Jørgensen, Eva C.P12-29Efficiency and efficacy of using a sophisticated 3D in vitro system of the humanepithelial airway barrier to gain insight into the hazard posed by nanomaterialsMartin J. D. Clift, Carola Endes, Dimitri Vanhecke, Peter Wick, Peter Gehr, Roel P. F. Schins, AlkePetri-Fink & Barbara Rothen-RutishauserP12-30Estimation of oral mucosa toxicity using 3-D reconstructed human oral tissue modelfor animal alternativeSun-A Cho, Yin-zhu Piao, Gi-baeg Nam, Ji Hoon Kim, Mee-ju Kim, Il-Hong Bae, Kwang-Mahn Kim,Jun-Cheol Cho, Kyeho ShinP12-31Evaluating the potential of utilizing human embryonic stem cell-derivedcardiomyocytes on multielectrode array as a pre-clinical cardiotoxicity assayClements, Mike; Roquemore, LizP12-32Evaluation of Biological Efficiency of Oxime Based Reactivators AgainstOrganophosphate Inhibited AChE: An In-vitro StudyBhanushree Gupta & Kallol K. GhoshP12-33Feasibility study of a new microfluidic device consisting in the coculture of intestinaland hepatic cellsThibault Bricks, Patrick Paullier, Marie-José Fleury, Franck Merlier, Eric LeclercP12-34High throughput screening of toxicological signaling pathways using in vitro 3Depithelial luciferase reporter modelsMankus, Courtney; Jackson, George; Armento, Alexander; Kandarova, Helena; Hayden, PatrickP12-35Importance of adaption-time to galactose-medium for accurate in vitro assessment ofmitochondrial toxicityK. Dernick, F. Boess, T. Singer, F. Schuler, A. Roth, S. KustermannP12-36Importance of reproducibility demonstration of the bio-engineered tissue models usedfor in vitro toxicity testing purposes.Silvia Letasiova, Michael Bachelor, Helena Kandarova, Paul Kearney, Mitchell KlausnerP12-37In Vitro Assessment of Adsorbents to Prevent Disruption of the Intestinal Barrier byMycotoxinsA Anadón, M A Martínez, I Ares, V Castellano, M Martínez, E Ramos, M R Martínez-Larrañaga and ARomero.

P12-38In Vitro Cytotoxicity And Genotoxicity Testing Using Upcyte® HepatocytesNörenberg, Astrid, Vera Sonntag-Buck, Nicola Hewitt, Stefan Heinz, Joris BraspenningP12-39In vitro effects of deoxynivalenol and β-Zearalenol alone and in combination onsteroidogenesis in bovine small granulosa cellsF. Pizzo, F. Caloni, N. Schreiber, M. Totty, L.J. SpicerP12-40In vitro effects of fumonisin B 1 on porcine granulosa cell steroidogenesis and geneexpressionC. Cortinovis, F. Caloni, N. Schreiber, L.J. SpicerP12-41In Vitro Modeling of Cytokine-Drug Interactions Using Micropatterned Co-Culturesof Primary Hepatocytes and Kupffer MacrophagesMichael McVay, Chitra Kanchagar, Salman R. Khetani and Okechukwu UkairoP12-42In vitro pituitary and thyroid cell proliferation assays and their relevance asalternatives to animal testingJomaa, Barae; Aarts, Jac M.M.J.G.; de Haan, Laura H.J.; Peijinenburg, Ad A.C.M.; Bovee, ToineF.H.; Murk, Albertinka J.; Rietjens, Ivonne M.C.M.P12-43In vitro studies on the neurotoxic effects of piperazine-derived designer drugs and3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")Popova, Dina; Forsblad, Andréas N. P.; Jacobsson, Stig O. P.P12-44Insights into mechanisms underlying inter-individual susceptibility to Drug-Induced-Liver-Injury (DILI) from data on in vitro exposure, transcriptomics and functionalityof cryopreserved human primary hepatocytes – The example of ChlorpromazineRichert L, Hewitt P, Blaauboer B, Bois F, Mueller S and Annaert PP12-45Interindividual variation in response to xenobiotic exposure established in precisioncuthuman liver slicesMarlon J.A. Jetten, Sandra M. Claessen, Cees H.C. Dejong, Agustin Lahoz, Danyel G.J. Jennen, JosC.S. Kleinjans, Joost H.M. van DelftP12-46Iron induced mitochondrial damage, which is blocked by LKB1 activationSang Chan Kim, Guang-Zhi Dong, Il Je Cho and Young Woo Kim,P12-47Roots of Erigeron annuus inhibits acute inflammatory response through NF-kBinactivationSang Chan Kim, Il Je Cho and Young Woo Kim

P12-48Kinetic Studies of Cholinesterase Reactivators with Organophosphate Inhibited AChERahul Sharma & Kallol K. GhoshP12-49Low concentration mixtures of MDMA and its major human metabolites inducesignificant toxicity to liver cells, both at physiological and hyperthermic conditionsDiana Dias da Silva, Elisabete Silva, Félix Carvalho, Helena CarmoP12-50Melatonin Protection against Type II Pyrethroid-Induced Cytotoxicity in SH-SY5Y,HepG2 and Caco-2 Human Cell LinesM R Martínez-Larrañaga, M A Martínez, I Ares, V Castellano, M Martínez, E Ramos, A Anadón, and ARomero.P12-51Microgravity spheroids as a reliable, long-term tool for predictive toxicology.Stephen J. Fey and Krzysztof WrzesinskiP12-52miRNA profiling as a tool for developmental neurotoxicity pathway analysis inhuman in vitro modelPrice, Anna; Fabbri, Marco; Sacco, Maria Grazia; Gribaldo, Laura; Pamies, David; Pallocca,GiorgiaP12-53MiRNA-210 modulates nickel-induced hypoxic responses by repressing the ironsulfurcluster assembly proteins ISCU1/2Mindi He, Lin Mao, Zhengping Yu, Zhou ZhouP12-54miRNomics, metabolomics and 3D neuronal differentiation of LUHMES progenitorcells as an in vitro model for DNT studies.L. Smirnova, G. Harris, H. Hogberg, S. Martos, and T. HartungP12-55Multicellular D Human Liver Microtissues for long-term toxicity testingSimon Messner, Paul Walker, Wolfgang Moritz, Jens M. KelmP12-56Multiple endpoint approach improves prediction of hepatotoxicityTruisi GL, Parmentier C, Richert L, Mueller SO, Hewitt PGP12-57Natural Ingredients in Sensitizing Formulations Inhibit the Response of SensitizationMarkers in Dendritic CellsN. Lambrechts, H. Witters, J. Hooyberghs, G. Schoeters

P12-58Optimization of the EpiOcular TM Eye Irritation Test for Hazard Identification andLabelling of Chemicals in Response to the Requirements of the EU CosmeticDirective and REACH LegislationYulia Kaluzhny, Helena Kandarova, Laurence d’Argembeau-Thornton, Jane De Luca, Patrick Hayden,Amy Hunter, Thoa Truong, and Mitchell Klausner.P12-59Organotypic human oral tissue models for toxicological studiesBridget Breyfogle, Silvia Letasiova, Patrick Hayden and Mitchell KlausnerP12-60Perfluorinated compounds affect the function of sex hormone receptorsKjeldsen, Lisbeth Stigaard; Bonefeld-Jorgensen, Eva CecilieP12-61Pharmacodynamic profiling of EGFR inhibitors in human keratinocytesBalavenkatraman KK, Vicart A, Couttet P, Ledieu D, Hopfer U, Rathfelder N, Bertschi B, GreutmannB, Marcellin M, Chibout SD, Lambert A, Moggs J, Pognan F, Wolf AP12-62Piperazine designer drugs present cytotoxicity to primary rat hepatocytesMarcelo Dutra Arbo, Simone Melega, Markus Schug, Regina Stöber, Jan Hengstler, Maria de LourdesBastos, Helena Carmo.P12-63Precision-cut intestinal slices as an in vitro model to predict NSAID induced intestinaltoxicityNiu, Xiaoyu; van der Bijl, Henk; Groothuis, Geny; de Graaf, IngeP12-64Prediction of Drug-Induced Liver Injury in Human with a Multiparametric Assay onthe HepaRG® Cell LineNelly Buron, Mathieu Porceddu, Célestin Roussel, Pierre Rustin, Sandrine Camus, Bernard Fromentyand Annie Borgne-SanchezP12-65Predictive Human Kidney-Specific In Vitro ModelsYao Li, Zay Yar Oo, Wei Seong Toh, and Daniele ZinkP12-66Prevalidation of the CULTEX ® method (BMBF project 0315710):The air-liquid interface exposure of human lung cells in the CULTEX ® Radial FlowSystem (RFS)Niklas Möhle, Dirk Steinritz, Christine Pohl, Sebastian Hoffmann, Michaela AufderheideP12-67Primary cells derived from the non-human primateS Grote-Wessels, R v Laer, B Niggemann

P12-68Protective effect of traditional African vegetable (Amaranthus hybridus) againstaflatoxin B 1 and/or fumonisin B 1 in a rat hepatoma cell-lineMohamed I.M. Ibrahim, Rialet Pieters, A.M. van der Walt, Cornelius C. Bezuidenhout, Skeina H.Abdel-Azeim, Mosaad, A. Abdel-wahhabP12-69Protective Effects of Boron Compounds against Metal Induced Genotoxicity in V79CellsAylin Üstündağ, Claudia Behm, Wolfram Föllmann, Yalçın Duydu, Gisela H. DegenP12-70Rat neuronal microtissues for toxicity testingDavid A. Fluri, Rosemarie Marchan, Simon Messner, Jan G. Hengstler and Jens M. KelmP12-71Relevance of in-vitro methods for the evaluation of eye and skin irritation/corrosionpotential of aliphatic tertiary aminesLi, Qiang; Kreiling, ReinhardP12-72Saussurea Lappa induce apoptosis in HL-60 cells via activation of JNK and inhibitionof ERK1/2Su Jin Kang, Sae Kwang Ku, Young Joon LeeP12-73Sestrin2 Induction by Nrf2 Is Essential for the Protection against Oxidative Damagein HepatocytesIl Je Cho, Young Woo Kim, Sung Hwan Ki, and Sang Chan KimP12-74Skin irritation using VitroDerm model for the personal care products classification:Internal validation processFicheux, Hervé; Catoire, Sophie; Lopez, FabiolaP12-75Systems-Toxicology Approach to Evaluate the Biological Impact of a Subset ofHarmful/Potentially Harmful Constituents of Tobacco SmokeIgnacio Gonzalez-Suarez, Carole Mathis, Emmanuel Guedj, Paul Walker, Samantha Ellis, HeatherWoodhouse, Remi Dulize, Sandra Wagner, Florian Martin, Nikolai Ivanov, Julia Hoeng, Manuel C.PeitschP12-76The effect of environmentally relevant concentration of selected PPCPs on fish celllinesJ. Kolarova, V. Zlabek, R. Grabic, O. Golovko, K. Grabicova, V. Burkina, T. RandakP12-77The effect of selected furanocoumarins on the spontaneous motoric activity of ratisolated intestine stripsMendel, Marta; Chlopecka, Magdalena; Dziekan, Natalia; Karlik, Wojciech; Skalicka-Wozniak,Krystyna

P12-78The gastrointestinal uptake of TiO2 nanoparticles and associated toxicityGitrowski, Constantinos; Al-Jubory, Aliaa; Handy, RichardP12-79The importance of understanding drivers of irritation in vivo for selection ofchemicals used in the development and evaluation of in vitro eye irritation assays:Cosmetics Europe analysisBarroso J, Alépée N, De Smedt A, De Wever B, Hibatallah, J, McNamee P, Mewes K, Millet M,Pfannenbecker U, Tailhardat M, Templier MP12-80The survival of murine dendritic cells is controlled by the transcriptional factor Nrf2in response to contact sensitizers.Zeina El Ali, Marc Pallardy and Saadia Kerdine-RömerP12-81The use of Real-Time Cell Analyzer (RTCA) in In Vitro ToxicologyS. Barcellini-Couget, G. de Sousa, R. RahmaniP12-82Toxicity of cadmium chloride in a 28-day repeated exposure human bronchialepithelial cell modelEmma Bishop, Damien Breheny, Debbie Dillon & Clive MeredithP12-83Trimetyltin promotes neuroinflammation and enhances 11β-hydroxysteroiddehydrogenase 1 expression in microglial cells isolated and in an histotypic contextBoonrat Chantong, Fanny Zuffery, Tania Dos Santos, Florianne Tschudi-Monnet and Alex OdermattP12-84Use of 'same donor' endothelial cells and PBMC in co-culture to detect cytokinestorm reactions to a TGN1412-like anti-CD28 antibody: A novel assay for biologicdrug safety screeningReed, Daniel; Gashaw, Hime; Bailey, Lucy; Paschalaki, Koralia; Starke, Richard; Randi, Anna;Hansel, Trevor; Mitchell, JaneP12-85Using transcriptomics from a human hepatocyte cell line to predict pesticidegenotoxicity and carcinogenicity: Comparing gene- and pathway-based classifiersCavill, Rachel; Brauers, Karen; Kleinjans, Jos; Briedé, Jacob-JanP12-86Utilization of Hormone Responsive Cell Lines for Identification of EndocrineDisrupting ChemicalsYama Abassi, Can Jin, Melinda Stampfl, Xiao Xu, Xiaobo WangP12-87Vaccinium Myrtillus extract protects against UVA- and UVB- induced damage inHaCaT keratinocytesCalo', Rossella; Lo Scalzo, Roberto; Marabini, Laura

P12-88Validation of high throughput 2D hepatocyte, micro-patterned co-cultured hepatocyte,and 3D hepatocyte spheroid models for prediction of rodent and human liver toxicityXiaoman Ang, Thomas Sachnik, Alex Odermatt, Adrian B. Roth, Claudia McGinnisP12-89Vitrigel-EIT (eye irritancy test) methods provide a brief assay system for estimatingthe changes of barrier function and architecture after exposing test chemicals to ahuman corneal epithelium modelYamaguchi, Hiroyuki; Kojima, Hajime; Takezawa, ToshiakiP13: Mechanisms of ToxicitiesP13-01“Ecstasy” impairs mitochondrial trafficking in hippocampal neurons by a Tauphosphorylation-dependent mechanism involving GSK3βDaniel José Barbosa, Romàn Serrat, Serena Mirra, Marti Quevedo, Elena Gomez de Barreda, JesúsÀvila, Eduarda Fernandes, Maria de Lourdes Bastos, João Paulo Capela, Félix Carvalho, andEduardo SorianoP13-02Alterations in Survivin and Caspase-3 Expressions after Hypericin Mediated PDT inHT-29 and Caco-2 CellsAysun Kiliç Süloğlu, Çağatay Karaaslan, Elif Karacaoğlu, Güldeniz SelmanoğluP13-03Association between δ-aminolevulinic Acid Dehydratase Polymorphism and PlacentalLead LevelsTülin Söylemezoğlu, Zeliha Kayaaltı, Dilek (Kaya) Akyüzlü, Esma Söylemez, Selda SertP13-04CAR-mediated, rodent-specific, mechanism of liver foci formation: evidence from 8-day KO mouse studyHoflack JC, Niederhauser U, Flint N, Lenz B, Herrmann A, Boess F, Singer T & Roth AP13-05Chronic Toxicity Study of benzaldehyde semicarbazone in rats: alterations in liverand bonesVieira, Andrea; Vieira, Rafael; Cassali, Geovanni; Galassi, Carolina; Beraldo, Heloisa; Taligati,CarlosP13-06Cobalt chloride speciation, mechanisms of cytotoxicity on human pulmonary cells,and synergistic toxicity with zincCarole Bresson, Carine Darolles, Asuncion Carmona, Céline Gautier, Nicole Sage, StéphaneRoudeau, Richard Ortega, Eric Ansoborlo, Véronique Malard

P13-07Dibutyltin blocks metabotropic glutamate receptor mGluR5 signaling resulting inincreased intracellular calcium and endoplasmic reticulum stress in mouse BV-2microglia cellsBoonrat Chantong and Alex OdermattP13-08Endocrine modulatory effects of cadmium and the molecular mechanism of actionImran Ali, Pauliina Damdimopoulou, Ulla Stenius and Krister HalldinP13-09Epoxyeicosatrienoic acids modulate amyloid precursor protein (APP) processing invitroMule, Nandkishor; Arand, Michael; Cronin, Annette; Kollar, Sarah; Marowsky, AnneP13-10Evaluation of Rats Liver Damage Degree Following Administration of DifferentAntituberculosis Medicines CombinationsS. Anisimova, G. Shayakhmetova, L. Bondarenko, A. Voronina, V. KovalenkoP13-11HLA haplotype determines hapten or p-i T cell reactivity to flucloxacillinWuillemin, Natascha; Adam, Jacqueline; Fontana, Stefano; Kraehenbuehl, Stephan; Yerly, Daniel;Pichler, Werner J.P13-12Increased Hypothalamic Dopaminergic Neuron Tyrosine Hydroxylase Expression inLean Wistar RatsSimon M. Plummer, Mariana Beltran, Laura Aitken, Mike Millar, Rolly Wiegand, and Jayne Wright.P13-13Interaction between mercury compounds and selenium and its effects on the activityand expression of thioredoxin and thioredoxin reductase in liver cells.Vasco Branco, Ana G. Santos, Juan Rodrigues, João Gonçalves, Jun Lu, Arne Holmgren, CristinaCarvalhoP13-14Interactions of signaling through the aryl hydrocarbon receptor and the β-cateninpathway in the regulation of CYP1A1 expressionAlbert Braeuning, Pascal Schulthess, Alexandra Löffler, Nils Blüthgen, Michael SchwarzP13-15Key scientific issues relevant to the identification and characterisation of endocrinedisrupting substances - Report of the Endocrine Disrupters Expert Advisory GroupSharon Munn, Marina GoumenouP13-16Mitochondrial impairment after mitoxantrone multi-administration to Male WistarratsFernando Remião, Luciana Grazziotin Rossato, Eliane Dallegrave, Marcelo Arbo, Renata Silva, RitaFerreira, Francisco Amado, Ricardo JorgeDinis-Oliveira, José Alberto Duarte, Maria de LourdesBastos, Carlos Palmeira, and Vera Marisa Costa

P13-17Modulation of sphingolipid metabolism and alterations of membrane proteins bydioxin- and non-dioxin-like toxicants in liver progenitor cellsM. Machala, J. Slavik, K Pencikova, J. VondracekP13-18Quercetin effectiveness in the prevention of pathological processes at the metabolicsyndromeRushchak, Volodymyr; Voronina, Alla; Shayakhmetova, Anna; Chashchyn, MykolaP13-19Polyphenolic compounds from Aronia melanocarpa berries protect from hydrogenperoxide accumulation in the bone tissue of cadmium-exposed ratsRoszczenko, Alicja; Brzóska, Malgorzata M.; Rogalska, JoannaP13-20Protective efficacy of selenite against lead-induced neurotoxicity in CaenorhabditiselegansVivian Hsiu-Chuan Liao, Wen-Hsuan Li, Yeu-Ching Shi, I-Ling TsengP13-21Protein Kinase C Inhibition Induced Steroid Hormonal Perturbation in Rat in vivoSchadt Heiko, Dincer Zuhal, Schwald Marianne, Dietz Audrey, Ledieu David, Cordier Andre, PapoutsiMaria, Junker Walker Ursula, Spence Fiona, Chibout Salah-Dine, Wolf Armin, Pognan FrancoisP13-22Quantum mechanical, In Vitro and In Vivo Evidence of the Involvement of Non-Bonding Nitrogen Interactions in Valine Derived β- amino ChalcogenidesWaseem Hassan, Senthil Narayanaperumal, Kashif Gul, Rogério de Aquino Saraiva,Antonio L. Braga, Oscar E.D. Rodrigues and João Batista Teixeira da RochaP13-23Structure-activity studies on the RXR agonist activity of organotinsNakanishi, Tsuyoshi; Hiromori, Youhei; Nishikawa, Jun-ichi; Nagase, HisamitsuP13-24Tributyltin-induced endoplasmic reticulum stress and its mechanismKotake, Yaichiro; Isomura, Midori; Masuda, Kyoichi; Miyara, Masatsugu; Okuda, Katsuhiro; Samizo,Shigeyoshi; Sanoh, Seigo; Hosoi, Toru; Ozawa, koichiro; Ohta, ShigeruP13-25Zinc supplementation protects from cadmium-induced oxidative stress in the brain ofratsBrzóska, Malgorzata M.; Rogalska, Joanna; Galazyn-Sidorczuk, Malgorzata

P14: Metabolism and kineticsP14-013D hepatocyte cultures: a useful tool in the study of Nevirapine bioactivation andtoxicityMiranda J.P., Pinheiro P.F., Marinho A.T., Harjivan S.G., Castro M., Pereira S.A., Antunes A.M.M.,Marques M.M.P14-02Consumption of foods containing cyanogenic glycosides: A study on bioavailabilityof cyanide in humansAbraham K, Buhrke T, Lampen AP14-03Determination of urinary butoxyacetic acid (2-BAA) in rat treated withdiethyleneglycoldibutylether (DEGDBE) for the purpose of read-across hazardassessmentLee, Moung Sook; Grimm, Andreas; Kreiling, ReinhardP14-04Differences in detoxification of the ultimate carcinogenic dihydrodiol epoxides ofbenzo[a]pyrene and dibenzo[a,l]pyrene in human Caco-2 cellsHessel, Stefanie; John, Andrea; Seidel, Albrecht; Lampen, AlfonsoP14-05Effect of maternal vitamin D receptor FokI single-nucleotide polymorphism on theplacental lead levelTülin Söylemezoğlu, Zeliha Kayaalti, Dilek (Kaya) Akyüzlü, Esma Söylemez, Deniz KocaP14-06Effects of single or repeated Bojungikkitang (BJIKT) administration, a polyherbalformula, on pharmacokinetics of gefitinib in ratsSoo-Jin Park, Jong-Dae Kim, Dae-Sung Hyun, Su-Yeon Cho, Sae-Kwang KuP14-07Effects of single or repeated Jaeumkanghwatang (JEKHT) administration, apolyherbal formula, on pharmacokinetics of tamoxifen in ratsSoo-Jin Park, Young-Sun Park, Sung-Hwan Park, Sang-Chan Kim, Su-Yeon Cho, Sae-Kwang KuP14-08Effects of single or repeated Kongjindan (KJD) administration, a polyherbal formula,on pharmacokinetics of donepezil in ratsSoo-Jin Park, Oh Dae Kwon, Dae-Kyoo Chung, Su-Yeon Cho, Sae-Kwang KuP14-09Effects of single or repeated Chungsinoryungsan (CSORS) administration, apolyherbal formula, on pharmacokinetics of perindopril in ratsSoo-Jin Park, Seok-Bong Kang, Ho-Sang Shon, Su-Yeon Cho, Sae-Kwang Ku

P14-10Effects of single or repeated Ijintanggamibang (IJTGMB) administration, apolyherbal formula, on pharmacokinetics of ondansetron in ratsSoo-Jin Park, Dae-Jun Kim, Ryu Hyun-Mo, Su-Yeon Cho, Sae-Kwang KuP14-11Effects of single or repeated Kongjindan (KJD) administration, a polyherbal formula,on pharmacokinetics of sorafenib in ratsSoo-Jin Park, Seung-Mo Kim, Chang Hyeong Lee, Sang-Chan Kim, Su-Yeon Cho, Sae-Kwang KuP14-12Experimental investigation of chrome accumulation kinetics in the animal organismGumarova Zh.Zh., Bekmukhambetov Ye.Zh., Jarkenov T.A.P14-13FRET-based analysis of the interaction between mEH and CYPAnette Orjuela, Michael ArandP14-14Genetic Variations of MT2A Gene are Associated with Arsenic Levels in BiologicalSamples of Individuals Occupationally Exposed to ArsenicDilek (Kaya) Akyüzlü, Zeliha Kayaaltı, Esma Söylemez, Vugar Ali Türksoy, Engin Tutkun, TülinSöylemezoğluP14-15Maternal hemochromatosis gene H63D single-nucleotide polymorphism and placentallead levelsDilek (Kaya) Akyüzlü, Zeliha Kayaaltı, Esma Söylemez, Sinem Işık, Tülin SöylemezoğluP14-16Interindividual Variability in Generating Acetaminophen Reactive Metabolite NAPQIby Various Human Liver and Kidney MicrosomesEge Arzuk, Burak Turna, Murat Sözbilen, Hilmi OrhanP14-17Metabolic and thermoregulatory effects of skin versus diet L-menthol treatmentAngelica Valente, Athanasios Z. Jamurtas, Eleutheria Theodoropoulou, Elena Vakonaki, MariaChristakis-Hampsas, Stavros Pantelakos, Manolis Tzatzarakis, Aristidis Tsatsakis, Andreas D. FlourisP14-18P-glycoprotein expression and activity are differently modulated by Colchicine inCaco-2 cells: in vitro and in silico studiesFernando Remião, Renata Silva, Vânia Vilas-Boas, Daniel José Barbosa, Andreia Palmeira, EmíliaSousa, Félix Carvalho, Maria de Lourdes Bastos and Helena CarmoP14-19Participation of Mammalian Gut Bacteria in Metabolism of NatumetoneAnzenbacherova, Eva; Anzenbacher, Pavel; Matuskova, Zuzana; Kolár, Milan; Tlaskalova-Hogenova,Helena

P14-20Pharmacokinetics and percutaneous absorption of benzophenone-3 from sunscreenformulations in ratsTae Hwan Kim, Sung Ha Ryu, Beom Soo Shin, Sun Dong Yoo, Kyu-Bong KimP14-21Pharmacokinetics and tissue distribution of acrylamide and its active metabolite,glycidamide in ratsKyu-Bong Kim, Sung Ha Ryu, Ji Won Kim, Beom Soo ShinP14-22Pharmacokinetics and tissue distribution of benzophenone-3, a UV filtering agent inratsTae Hwan Kim, Sung Ha Ryu, Beom Soo Shin, Sun Dong Yoo, Kyu-Bong KimP14-23Polyphenolic compounds from Aronia melanocarpa berries protect from cadmiumaccumulation in the liver and kidney of ratsBrzóska, Malgorzata M.; Galazyn-Sidorczuk, Malgorzata; Jurczuk, MariaP14-24Rational design of novel CYP2A6 inhibitorsRaunio, Hannu; Tani, Niina; Juvonen, Risto; Fashe, Muluneh; Leppänen, Jukka; Zhao, Bin; Miksys,Sharon; Tyndale, Rachel; Rahnasto-Rilla, MinnaP14-25Reactivity and risk assessment of CoA-conjugated carboxylic acid drugsMalin Darnell and Lars WeidolfP14-26Study of Intracellular Reaction and Diffusion Mechanism of Carcinogenic PAH:sUsing Non-Standard Compartment Modeling ApproachQasim A. Chaudhry, Michael HankeP14-27The role of rat and human CYP enzymes in okadaic acid-associated toxicityKolrep, Franziska; Hessel, Stefanie; Ehlers, Anke; Lampen, AlfonsoP14-28Toxicokinetics of sub-nanomaterials following oral administration for safetyevaluationHigashisaka, Kazuma; Uji, Miyuki; Yamaguchi, Manami; Mori, Takahide; Misato, Kazuki; Tsunoda,Shin-ichi; Yoshioka, Yasuo; Tsutsumi, YasuoP20: Risk AssessmentP20-01A case study of risk assessment in MalaysiaThannimalay, Letchumi

P20-02An In Vitro Model for Predicting Penetration of Polyethylene Glycols ([ 14 C]-PEG 7Phosphate) through Intact, Moderately and Highly Compromised SkinHelga Rothe, Swatee Dey, Leanne Page, Robert O’Connor, Sara Farahmand, Frank Toner, andShaoying ZhouP20-03Animal-Free Studies in Cosmetic Ingredient Industry: Perspective and Strategy after a10-Year ExperienceFicheux, Herve; Catoire, Sophie; Lopez, FabiolaP20-04Assessment of endocrine disrupting effects of inorganic arsenicGutu, Claudia Maria; Purdel, Carmen Nicoleta; Gubandru, Miriana; Ilie, Mihaela; Balalau, DanP20-05Assessment of health risks of high levels of arsenic in drinking water. The Romanianexperience.Nicola, Claudia; Ilie, Mihaela; Purdel, Nicoleta CarmenP20-06Asymmetric phthalates – a special case for risk assessmentUlrike Bernauer, Agnes Schulte, Monika Moeder, Steffi Schrader, Thorsten ReemtsmaP20-07Correlation between styrene concentration in saliva and blood samples for thebiological monitoring of occupational exposureMonica Gherardi, Giovanna Tranfo, Maria Pia Gatto, Andrea Gordiani, Enrico Paci, Bruno PapaleoP20-08Determination of operator’s external exposure to deltamethrin used in vector controlin French GuyanaNorvès, Benoit; Pontal, Pierre-GérardP20-09Development of cumulative and aggregate risk assessment models for human healthDalzell, Abigail; Glass, Richard; Kennedy, MarcP20-10Extrapolation of toxicology endpoint data in developing integrated human andenvironmental risk assessmentsDalzell, Abigail; Glass, RichardP20-11Dinitrosopiperazine (DNPZ) and N-nitrosopiperazine (NPZ): Toxicological propertiesand acceptable exposure levels for the general populationLedirac, Nathalie; Bossard, Camille; Bertomeu, Lisa; Pontal, Pierre-GérardP20-12EFSA’s Qualified Presumption of Safety (QPS) risk assessment approach reducestoxicological data requirementsRenata Leuschner, Rosella Brozzi, Frédérique Istace and Anne Theobald

P20-13Estimation of Benchmark Dose for Thyroid Hormone Levels in Rats Exposed toProlonged Cadmium IntoxicationAleksandra Buha, Zorica Bulat, Biljana Antonijević, Danijela Đukić-Ćosić, Vesna Jaćević, SlavicaVučinić, Vesna MatovićP20-14The Use of @Risk Software for Risk Assessment of Mercury Intake via Marine Foodamong Serbian PopulationBuha, Aleksandra; Filipovic, Angelina; Dumanovic, Jelena; Antonijevic, Evica; Curcic, Marijana;Jankovic, Saša; Nikolic, Dragica; Antonijevic, BiljanaP20-15Evaluating and comparing some current environmental toxicity prediction models forthe use of preparing for Korean Act on registration and evaluation of chemicalsKim, Kwang-Yon; Cha, Ji Young; No, Kyoung TaiP20-16Exposure data for family care productsGalonnier, Maude; Gomez-Berrada, Marie-Pierre; Guillou, Sonia; Rielland, Aurelie; De Javel,Dominique; Ferret, Pierre-JacquesP20-17Exposure to dish washing liquid evaluated in Brest university population: apreliminary study.A. Ramirez-Martinez, N. Wesolek, D. Parent-Massin, A.C. RoudotP20-18Facilitating the use of non-standard in vivo studies in health risk assessment - aproposal to improve evaluation criteria and reportingMolander, Linda; Beronius, Anna; Rudén, Christina; Hanberg, AnnikaP20-19Feasibility study: New selection rules for the TTC concept based on experimental andin silico dataHauge-Nilsen, Kristin; Keller, DetlefP20-20Human Biomonitoring of Parabens in Korean Children's UrineSeung-Youl Lee, Min-Sik Kyung, Song-Yi Park, Hee-Seok Lee, Min-Ki Shin, Ahra Ko, Ji-Young Kim,Sang-yub Kim, Young-Mi JangP20-21In vitro risk assessment of hypersensitivity-causing drugsBuenter, Antonia; Wuillemin, Natascha; Adam, Jacqueline; Yun, James; Yerly, Daniel; Dörig, Dario;Pecaric Petkovic, Tatjana; Pichler, Werner J.P20-22(Cancelled)P20-23International Training Programme in Health Risk AssessmentZilliacus, Johanna; Hanberg, Annika; Håkansson, Helen

P20-24Life-cycle toxicity assessment of Caenorhabditis elegans exposed to seleniumVivian H.-C. Liao, Wen-Hsuan Li, Yun-Ru JuP20-25Occupational Risk Assessment: threshold and non-threshold models for the mutageniceffect of epoxides and consequences for the determination of a virtual safe doseFröhlicher Mirjam, Sagelsdorf Peter, Arand Michael and Dollenmeier PeterP20-26Phytoestrogen aglycones but not glucuronides were found estrogenic in in vitromodelsLeeuwen, F. X. Rolaf van; Rietjens, Ivonne M. C. M.; Murk, Albertinka J.P20-27Post hoc ergo propter hoc? – the CIOMS scale to differentiate time and causalassociation in hepatotoxicityJohannes Schulze and Rolf TeschkeP20-28Probabilistic exposure assessment to nail cosmetics by French consumersMorisset, Typhaine; Ficheux, Anne-Sophie; Postic, Cindy; Chevillotte, Grégoire; Roudot, Alain-ClaudeP20-29Quantitative Risk Assessment for Infant and Children’s products based on ChildSpecific Exposure ConsiderationsKirsch, Taryn; Felter, SusanP20-30Refined animal toxicity testing using unequally sized dose groups and Benchmarkdose analysisÖberg, Mattias; Ringblom, Joakim; Kalantari, Fereshteh; Johanson, GunnarP20-31Risk and Nutritional Assessment of Toxic (Hg, Cd, Pb, Sn and As) and EssentialElements (Cu, Mn, Se and Zn) in Fish and Shellfish SamplesGil F, Olmedo P, Pla A, Hernández AF, Molina-Villalba IP20-32Risk assessment based on computer-aided and bibliographical methods of ahomeopathic preparation from Pulsatilla pratensis L. as an exampleMerz, Karl-Heinz; Jochims, Karin; Schrenk, DieterP20-33Risk assessment for hazardous substances contained in household product-cleaner andwet-tissuePark, KunHo; Park, Junghyun; Kim, Chan-Kook; Shin, Jihye; Lee, Jong-HyeonP20-34SAR- and analogue based safety assessments of cosmetic ingredientsPetry, Thomas; Jeronimo-Roque, Daniela; Tencalla, Francesca; Mishra, Sanghamitra

P20-35The PCB effect database: a tool for translational research and health risk assessmentHellgren, Dennis; Wu, Jianyao; Roos, Robert; Westerholm, Emma; Adfeldt-Still, Oliver; Andersson,Patrik; Halldin, Krister; Håkansson, HelenP20-36Toxicogenomics to group environmental chemicals in vitro?Ignarski, Alessa; Legradi, Jessica; Legler, Juliette; Segner, HelmutP20-37Toxicological evaluation of LASSBio-596: in vitro and in vivoAraujo, G.L.; Vieira, A.E.D., Barreiro, Eliezer J, Lima, Lidia M., Cardoso, C.N.; Emiliano, N.F.;Martins, M.T.; Souza, S.S.; Soares, S., Tagliati C. A.P20-38TTC: A new concept for inhalation exposureEscher, Sylvia; Tluczkiewicz, Inga; Kühne, Ralph; Ebert, Ralf-Uwe; Schüürmann, Gerrit;Mangelsdorf, IngeP21: Safety Assessment of MixturesP21-01A low dose chemical mixture modulates the effect of PFNA in male ratsHadrup, Niels; Skov, Kasper; Taxvig, Camilla; Frandsen, Henrik; Vinggaard, Anne MarieP21-02Hemostatic activity screening and skin toxicity of sap of Jatropha multifida L.(Euphorbiaceae) used in traditional medicine (Benin)Dougnon Tamègnon Victorien, Klotoé Jean Robert, Dougnon Tossou Jacques, Sègbo Julien, AtègboJean-Marc, Loko Frédéric, Dramane KarimP21-03Safety of green coffee oil in cosmetic formulations: from in vitro to clinical studiesTais A. L. Wagemaker,; Ana Sofia Fernandes,; Catarina Rosado; Patricia Rijo,; Patricia MaiaCampos; Luis M. Rodrigues,Concert HallP18: Regulatory ToxicologyP18-01A prototype for integrating toxicokinetics into the human health risk assessmentprocess for agrochemicals: sulfoxaflorTerry, Claire; Aggarwal, Manoj; McCoy, Alene; McFadden, Lisa; Bartels, Michael; Billington,RichardP18-02Mode of Action Analysis of Decreased Neonatal Rat Survival Induced by In UteroExposure to SulfoxaflorClaire Terry, Robert G. Ellis-Hutchings, Sue Marty, Reza J. Rasoulpour, Valerie Marshall, Edward W.Carney, and Richard Billington

P18-03Alternative Method in practice: postvalidation experience of the skin sensitization invitro test strategySusanne N. Kolle, Annette Mehling, Wera Teubner, Bennard van Ravenzwaay and Robert LandsiedelP18-04Applicability of in silico models for the prediction of the sensitization potential ofindustrial chemicalsWera Teubner, Annette Mehling, Paul Xaver Schuster, Katharina Guth, Andrew Worth, Julien Burton,Bennard van Ravenzwaay, Robert LandsiedelP18-05Assessment factors for susceptible populations analysis of airway response duringshort-term exposure to airborne chemicalsÖberg, Mattias; Johansson, Mia; Johanson, GunnarP18-06Assessment of the subchronic and developmental toxicity of sodium-dimethyl-5-sulphonatoisophthalate (CAS 3965-55-7) in a weight of evidence approachRoth, Thomas; Jensch, Udo; Volz, NadineP18-07Comparison of methods for calculation of carry-over limits and their values withoccupational exposure limitsLovsin Barle, Ester; Cudd, Margaret Amelia; Bechter, Rudolf; Gian Christian, WinklerP18-08Derivation of a Guidance Limit for Cadmium in Children’s Jewellery: HealthCanada’s PerspectiveJohn Field, Pierre Chantal, Sandra Wright, Paul Chowhan, Patricia Pelletier, Helen Ryan, andGordon BarrettP18-09Draize test for eye irritation: importance of the endpoints evaluated with regard to UNGHS / EU CLP classificationAdriaens, Els; Barroso, João; Eskes, Chantra; Hoffmann, Sebastian; McNamee, Pauline; Alépée,Nathalie; Bessou-Touya, Sandrine; De Smedt, Ann; de Wever, Bart; Pfannenbecker, Uwe; Tailhardat,Magalie; Kirmizidis, George; Zuang, ValérieP18-10Gender-related difference in the toxic susceptibility of rats to an ultraviolet absorber,2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole: a role of peroxisomeproliferator-activated receptor (PPAR) alphaOno, Atsushi; Hirata-Koizumi, Mutsuko; Ise, Ryota; Kato, Hirohito; Matsuyama, Takashi; Ema,Makoto; Hirose, AkihikoP18-11Trend Analysis of Body Weights, Survival, and Tumor Incidence, and the Effect ofBody Weight on the Incidence of Spontaneous Tumors in Tg.rasH2 MiceElbekai, Reem; Paranjpe, Madhav

P18-12Historical Control Data of Neoplastic Lesions in Transgenic CBYB6F1-Tg(HRAS)2Jic (Tg.rasH2) MiceParanjpe, Madhav; Elbekai, ReemP18-13HISTORICAL CONTROL DATABASE OF NON-NEOPLASTIC LESIONS INTRANSGENIC CBYB6F1-Tg(HRAS)2Jic (Tg.rasH2) MICEElbekai, Reem; Paranjpe, MadhavP18-14Improving the Quality of Cardiovascular and Respiratory Endpoints in ToxicologyStudiesCrome SJ, Broadmeadow A, Meecham KP18-15Legal principles for handling information deficits in REACHZetterberg, Charlotta; Nilsson, Charlotte; Håkansson, HelenP18-16Less is More: Better Toxicity Data from fewer Rodents using Plasma MicrosamplingAnne Eichinger-Chapelon, Daniela Zaugg, Georg Schmitt and Thomas SingerP18-17Likeliness of false positive finding in Local Lymph Node Assay withDiethyleneglycoldibutyletherLee, Moung Sook; Kreiling, ReinhardP18-18Non-animal approaches to assessing the skin sensitization endpoint under REACHThomas Petry, Nirmala Ranggasami and Francesca TencallaP18-19Non-experimental alternative methods for the hazard evaluation of cosmetics andchemicalsCarole Charmeau, Nathalie Ledirac, Laëtitia Fiévez-Fournier, Muriel Danten, Aurélie SevestreP18-20Overview of the Existing Regulations and Testing Programs for Endocrine ActiveChemicalsSimon Warren, Elaine Freeman, Julian ReddyP18-21Ranking of epoxy resin compounds based on their sensitising potencySchuhmacher-Wolz, Ulrike; Heine, Karin; Geier, Johannes; Kalberlah, FritzP18-22Relationship between mortality and dosage scheme as key issue in the design ofregulatory toxicological studies of different types of human insulin analogsKupny, Joanna; Mrzyk, Inga; Sornat, Robert; Drzewiecka, Agnieszka; Kropidlo, Aneta; Gruszka,Katarzyna; Szewczyk, Aleksandra; Pawlowska, Monika; Bogiel, Monika; Borowicz, Piotr

P18-23Reproductive toxicity of azole fungicides from a regulatory perspectiveMyöhänen K., Broeckaert F., Court Marques D., Lapenna S., Maggiore A., Spjuth L., Huuskonen H.P18-24Role of Post-Translational Modifications in a Function of Pregnane X ReceptorVavrova A., Vrzal R., Dvorak Z.P18-25Safety assessment of Hwangryunhaedok-tang: subchronic toxicity study in Crl:CDSprague Dawley ratsLee, Meeyoung; Seo, Changseob; Kim, Young bum; Shin, HyeunkyooP18-26Tumour and cumulative mortality information in oral tumorigenicity studies in theCD 1 mouse between 1995 and 2011Broadmeadow, Alan; Crome, Steve; Webley, Lisa; Taylor, IanP18-27Vaccines Europe reflection paper on the Safety Assessment of Residuals andContaminants in VaccinesDamsten, Micaela; Segal, Lawrence; Gould, Sarah; Finkelstein, Martin; Frantz, Christopher; Geuns,Ed; Herzyk, Danuta; Mulder, Mariska; Novicki, Deborah; Smith, ThomasP18-28A Global Collaborative Approach to Human Health Risk Assessment: The WHOChemical Risk Assessment NetworkKathy Hughes on behalf of the Initial Steering Group for the establishment of the WHO Chemical RiskAssessment Network, Health Canada, Ottawa, CanadaP23: Target Organ ToxicitiesP23-01‘Ecstasy’ and amphetamine neurotoxicity to cultured rat cortical neurons in acontinuous exposure modelSilvana da Costa Araújo, Vera Marisa Costa, Frederico C. Pereira, Eduarda Fernandes, Maria deLourdes Bastos, Félix Dias Carvalho, João Paulo Capela,P23-02A novel zebrafish model to predict organ toxicities in mammalsIngham, Philip; Wang, Xingang; Wang, Haishan; Kaur, Navrinder; Mathavan, Sinnakaruppan;Fowler, Stephen; Weiser, Thomas; Cohen, Stephen; McGinnis, ClaudiaP23-03Acrylamide induced chronic nephrotoxicity in ratsRaoufi, Ahmad, jamshidi, keivanP23-04Chloracne/MADISH-like cystic lesions after low-dose exposure to dioxin:A histological study of 43 casesNikolina Saxer-Sekulic, Gürkan Kaya, Jean-Hilaire Saurat, Olivier Sorg

P23-05Comparison of the accumulation of ochratoxin A residues in treated pig tissuesJelka Pleadina, Nina Peršia, Dragan Kovačevićb, Ana Vulića, Dinka MilićcP23-06Evaluation of zebrafish larvae as alternative test system to predict hepatotoxicityS. Verstraelen, A. Covaci, W. Maho, P. Berckmans, B. Peers, H. WittersP23-07Full-field electroretinogram recording in the Göttingen minipigHaag, Valérie; Forster, Roy; Augsburger, Anne-SandrineP23-08Gene expression of mitotic reorientation on rat prostate epithelial cells exposed tosubchronic testosteroneLiu, Xiang-yun; Xu, Li; Li, Lei; Cheng, Yi; Shao, Yue; Yang, Jian-yan; Sun, Zu-yueP23-09Heat shock protein 90 inhibitor, TAS-116, demonstrates favorable tissue distributionprofiles and leads to minimized ocular toxicityHitotsumachi, Hiroko; Kodama, Yasuo; Ohkubo, Shuichi; Besshi, Kazuhiko; Yonekura, Kazuhiko;Morita, Fumio; Hayashi, TaijiP23-10Histopathological findings, telomerase activity and oxidative stress in kidney tissueafter long-term rabbits exposure to turinabol and methanabolFragkiadaki Persefoni, Tsitsimpikou Christina, Vasilaki Fotini, Stivaktakis Polychronis, SegradakisJohn, Tsarouhas Konstantinos, Tzardi Maria, Kouretas Demetrios, Tsatsakis AristidisP23-11Lactoferrin enhances apoptosis and protects the liver in the rat thioacetamide-inducedliver fibrosisHegazy, Rehab; Hessin, Alyaa; Hassan, Azza; Yassin, Nemat; Kenawy, SanaaP23-12Neuroprotective effects of tomato seed extract against rotenone-induced oxidativeimpairments and neurotoxicity in miceGokul K and MuralidharaP23-13Neurotoxicity in vitro: assessment of the predictivity of neuronal networks coped tomicroelectrode arrays for identification of neurotoxicantsTzutzuy Ramirez, Timo Weisschu, Hans-Albrecht Hüner, Bennard van Ravenzwaay, Robert LandsiedelP23-14Pharmacological concentrations of mitoxantrone are able to transiently activatecaspases and dually modify glutathione pathways in HL-1 cellsVera Marisa Costa, João Paulo Capela, Maria de Lourdes Bastos, José Alberto Duarte, FernandoRemião and Félix Carvalho

P23-15Protective effects of sulforaphane on acetaminophen-induced hepatotoxicity in miceMasubuchi, Yasuhiro; Shiiki, Ayano; Matsumura, Astushi; Makita, MasahiroP23-16TCDD-induced sebaceous gland atrophy in mice: Kinetics of restoration followingend of treatmentFabienne Fontao, Frédérique Ino, Olivier Sorg, Jean-Hilaire SauratP23-17Study of Benzophenone Induced Oxidative Stress in the CytomorphologicalAlterations of Rat LungUma DuttaP24: Toxicology of NanomaterialsP24-01Acute and subchronic pulmonary toxicity of cerium oxide nanoparticles for safetyassessmentAlazne Domínguez, Carolina Aristimuño, Eneritz Arriaga, Amaia Aspiazu, Blanca Suárez-Merino andFelipe Goñi-de-CerioP24-02Amorphous Silica Nanoparticles Induce Autophagic Cell Death in HepG2 CellsTriggered by Reactive Oxygen SpeciesYongbo Yu, Junchao Duan, Yang Yu, Yang Li, Xiaomei Liu, Xianqing Zhou, Peili Huang, Zhiwei SunP24-03Assessment of oxidative stress and cytotoxicity of copper oxide nanoparticles inhuman skin epidermal cell line (HaCaT)Saud Alarifi, Daoud AliP24-04Biodistribution and toxicological effects of intranasally instilled polyamidoamine(PAMAM) dendrimers in BALB/c mouse brainTin-Tin Win-Shwe, Yoshika Kurokawa, Hiroshi Nitta, Seishiro Hirano, Hideko SoneP24-05Comparative Immunotoxicity on Physicochemical Properties of Single-WalledCarbon Nanotubes: in Vitro and in VivoSoyoung Lee, Dongwoo Khang, Sang-Hyun KimP24-06Ecotoxicity of engineered nanomaterials: known facts and data gapsJuganson, Katre; Ivask, Angela; Koitjärv, Meelika; Mortimer, Monika; Bondarenko, Olesja; Kasemets,Kaja; Kahru, AnneP24-07Effect of manufactured nanoparticles on allergen-induced sensitizationBirgit Baré, Nathalie Lambrechts, Hilda Witters, Peter Hoet, Inge Nelissen

P24-08Effects of zinc oxide nanoparticles on an in vitro model of the air-blood barrierR. Bengalli, M. Gualtieri, M. Camatini, C. Urani, P. ManteccaP24-09High-temperature calcined fullerene nanowhiskers and multi-wall carbon nanotubeshave abilities to induce IL-1beta secretion through NLRP3-dependent mechanism,depending on their lengthsNishimaki-Mogami, Tomoko; Cui, Hongyan; Wu, Weija; Okuhira, Keiichiro; Naito, Mikihiko;Nishimura, Tetsuji; Sakamoto, Yoshimitsu; Ogata, Akio; Maeno, Tomokazu; Inomata, Akiko; Nakae,Dai; Miyazawa, Kun'ichi; Hirose, AkihikoP24-10In vitro exposure of human intestinal cells to iron phosphate nanoparticles indicate nodirect cytotoxicityvon Moos, Lea; Trantakis, Ioannis; Rast, Peter; Hilty-Vancura, Florentine; Zimmermann, Michael;Pratsinis, Sotiris; Sturla, ShanaP24-11Influence of nano-polystyrene particles in inducing cytotoxicity in mice co-injectedwith carbon tetrachloride, cisplatin, or paraquatIsoda, Katsuhiro; Yoshimi, Shimizu; Nishimura, Tetsuji; Tezuka, Masakatsu; Ishida, IsaoP24-12Long-term biodistribution, metabolism and toxicity of carbon nanotubes in vivoDeng, Xiaoyong; Luo, Man; Shao, Erlei; Zhao, Hui; Yang, Xing; Ni, Qingshun; Jiao, ZhengP24-13Metabolic response of human keratinocytes to silver nanoparticles: a metabolomicsstudyJoana Carrola, Ana M. Gil, Ana L. D. Silva, Verónica Bastos, Helena Oliveira, José M. P. F. Oliveira,Conceição Santos and Iola F. DuarteP24-14Metal nanoparticles caused death of metastatic MDA-MB-231 breast cancer cellsAdeyemi, Oluyomi; Edkins, Adrienne; Whiteley, ChristopherP24-15Neurotoxicity Assessment of Zinc Oxide Nanoparticles: Cytotoxic and GenotoxicEffectsGözde Kiliç, Carla Costa, João Paulo Teixeira, Eduardo Pásaro, Vanessa Valdiglesias, Blanca LaffonP24-16Particle and Fiber toxicity database - PaFtoxSchröder K., Pohlenz-Michel C., Voss J.-U., Simetska N., Escher S., Mangelsdorf I.P24-17Plasma Kinetics and Biodistribution of CdTe Quantum Dots in Mice:A Comparison between Cadmium and TelluriumPeili Huang, Jialing Zhang, Xiaoyan Du, Dong Chang, Zhiwei Sun,Ying Han, Na Liu, Hui Wang

P24-18Study of cyto-genotoxic effects and inflammatory response induced by nano-sizedtitanium dioxide particles on human bronchial cellsCavallo, Delia; Ursini, Cinzia L.; Fresegna, Anna Maria; Ciervo, Aureliano; Maiello, Raffaele;Tassone, Paola; Iavicoli, SergioP24-19The effect of silver nanoparticles in intestinal Caco-2 cellsBöhmert, Linda; Horzowski, Sabine; Lichtenstein, Dajana; Girod, Matthias; Hansen, Ulf; Niemann,Birgit; Thünemann, Andreas; Lampen, AlfonsoP24-20The Th2-biased immune adjuvant effect of silver nanoparticlesYingying Xu, Huan Tang, Jia-hui Liu, Yuanfang Liu, HaifangWangP24-21The ToxTracker assay provides mechanistic insight into the (geno)toxic properties ofmetal oxide nanoparticles.Giel Hendriks, Anda Gliga, Harry Vrieling and Hanna KarlssonP24-22Toxic effects of carbon-based nanomaterials on acetylcholynesterase: an experimentaland computational investigationTina Mesarič, Lokesh Baweja, Damjana Drobne, Darko Makovec, Alok Dhawan, Kristina SepčićP24-23Toxicity mechanisms of coated and uncoated silver nanoparticles to yeastSaccharomyces cerevisiae BY4741Suppi, Sandra; Kasemets, Kaja; Kahru, AnneP24-24Toxicity of Nanomaterials: Availability and Suitability of Data for the Developmentof In Silico ModelsRicharz, Andrea-Nicole; Cronin, Mark; Madden, Judith; Lubinski, Lukasz; Mokshina, Elena;Urbaszek, Piotr; Puzyn, Tomasz; Kuz'min, VictorP24-25Toxicokinetics of zinc oxide nanoparticles in rats treated by two different routes, by asingle intravenous injection and a single oral administrationKwangsik Park, Jonghe Choi, Heyjin Kim, Pilje Kim, Hyun-Mi Kim and Kyunghee ChoiP24-26Transfer of Engineered Nanoparticles across the Human PlacentaStefanie Grafmüller, Ursula von Mandach, Pius Manser, Liliane Diener, Pierre-André Diener,Wolfram Jochum, Harald F. Krug, Peter WickP24-27ZnO nanoparticles and dissolved zinc affect transcripts of pro-inflammatory cytokinesin zebrafish embryosN. Brunab, V. Christena, B. Wehrlib, K. Fentab

P25: OtherP25-01Aluminum hydroxide in preclinical vaccine safety testingHarmke H. van Vugt, Ph.D., Miranda H.M. van Tuyl, M.Sc., Harry H. Emmen, M.Sc.P25-02Antiulcer activity of mirtazapine, escitalopram and venalfaxine on oxidant andantioxidant parameters in stomach tissue of depressed ratsSally A. El-Awdana, Hala F. Zaki, Sanaa A. KenawyP25-03Assessment of chromium and nickel levels in maternal blood, placenta and cord bloodby Graphite Furnace Atomic Absorption SpectrometryArica, Enes; Kayaalti, Zeliha; Kaya Akyuzlu, Dilek; Soylemezoglu, TulinP25-04Etiological and demographic characteristics of poisoning cases admitted to alldepartments of university hospital in Diyarbakir, Turkey.Arica, Enes; Uysal, Cem; Tokgoz, Orhan; Goren, SuleymanP25-05Beneficial impact of polyphenolic compounds from Aronia melanocarpa berries onthe biomechanical properties of the lumbar spine vertebral body in cadmium-exposedratsRoszczenko, Alicja; Brzóska, Malgorzata M.; Rogalska, JoannaP25-06Biochemical and haematological parameters are different for rats of the same strainobtained from different breeders.Schleh C, Allingham P, Rudragowda S, Ceccatelli R, Takawale P, Schropp P, Schmid S, LuetkenhausK, Neuenhahn P, Leoni ALP25-07Brine shrimp toxicity of total extracts of four cruciferous plantsEbadollahinatanzi, Alireza; Maleki, Zohreh; Ahadi-Mikaeildarsi, Monir; Alavi, Seyed MohammadP25-08Measurement of antioxidant capacities in two plant extracts from cruciferae familyEbadollahinatanzi, Alireza; Shoara, Saghar; Farzi, SoheillaP25-09Chlorpyrifos neurotoxicity – a scientometric analysisSchulze, Michaela, Schrumpf, Laura and Schulze, JohannesP25-10Diosmin protects against TCE (trichloroethylene) induced renal injury in Wistar rats:Plausible role of p53, Bax and caspasesMuneeb U Rehman, Mir Tahir, Abdul Quaiyoom Khan, Rehan Khan, Abdul Lateef, Oday-O-Hamiza,Farrah Ali and Sarwat Sultana

P25-11Evaluation of Arsenic Levels in Biological Samples of Smelter Workers in TurkeyBayram Yüksel, Zeliha Kayaalti, Vugar Ali Türksoy, Engin Tutkun, Tülin SöylemezoğluP25-12Evaluation of the Pb, Cd, Fe, Zn and Cu levels in the blood samples of metallurgyworkers exposed to Pb and control groupsOdabasi, Miyase; Kayaalti, Zeliha; Türksoy, Vugar Ali; Yilmaz, Hinç; Söylemezoglu, TülinP25-13Exposure to PM 2,5-bound PAHs in Rome: the contribution of transportationmicroenvironmentsM. Gherardi, M.P. Gatto, A. Gordiani, C. GariazzoP25-14Urban Air Pollution in Rome: Children and Elderly Exposure to Polycyclic AromaticHydrocarbons in Fine Particulate Matter (PM 2.5 )M. Gherardi, M.P. Gatto, C. Gariazzo, A. GordianiP25-15Impact of hexabromocyclododecane on lipid and glucose metabolism in high-fat dietinducedobese miceRie Yanagisawa, Tin-Tin Win-Shwe, Eiko Koike, Hirohisa TakanoP25-16(Cancelled)P25-17Involvement of Heme Oxygenase-1 in attenuation of the Cardioprotective effect ofIschemic Preconditioning in Diabetic Rat HeartGoyal, Shubham; Verma, Nitin; Jinddal, VaneetaP25-18To evaluate the Protective effect of Vitis vinifera & Solanum lycopersicum in dietinduced obesity in RatsGoyal, Shubham; Verma, Nitin; Jinddal, VaneetaP25-19New medicine approach in pollution's hospitalizationsPolichetti, Giuliano; De Sio, AlessandraP25-20Patterns of self-poisoning in Sikasso, MaliHami Hinde, Diallo Tidiane, Maïga Ababacar, Mokhtari Abdelrhani, Soulaymani-Bencheikh Rachida,Soulaymani AbdelmajidP25-21Poisoning of domestic animals: 2012 data from Poison Control Centre of MilanFrancesca Caloni, Cristina Cortinovis, Fabiola Pizzo, Marina Rivolta, Franca Davanzo

P25-22Preclinical Toxicology of Mesima, an Anti-cancer Immunological Activator; Resultsof Oral Subchronic Toxicity in RatsJung-Ho Noh, Jae-Woo Cho, Eun Ju Jeong, Kyoung-Sik MoonP25-23Respiratory consequences of treatments developed to counteract severe somaninducedrefractory status epilepticus in miceSébastien Graziani, Didier Christin, Philippe Desforges, Gilles Guillot, Noel Perrier, Annie Foquin,Frederic Dorandeu et Laurent Taysse.P25-24Subacute toxicity study of CKD-501, a novel thiazolidinedione, after 4-week repeatedoral administration in miceKyoung-Sik Moon, Jung-Ho Noh, Yong-Bum Kim, Eun Ju Jeong, In-Chang Hwang, Dal-Hyun Kim,Ho-Sung Yu, Hyo-In YunP25-25The Apoptotic Effect and Mechanism of Arsenic Compounds in MA-10 MouseLeydig Tumor CellsHuang, Bu-MiinP25-26The Maternal-Infant Research on Environmental Chemicals Study - Overview of theBiomonitoring Component of a Canadian Pregnancy CohortD’Amour M, Arbuckle TE, Fisher M, and Fraser W.P25-27Toxicology Evaluation of Impurities during Small Molecule Drug DevelopmentElizabeth Martin, Charles Humfrey and Andrew TeasdaleP25-28Forensic toxicological Cases in the Pharmacology Curriculum in Undergraduated 3rdyear Medical StudentsPavlina Gateva, MD, PhDClub CasinoP19: Reproductive ToxicologyP19-01Bidirectional placental transfer of BPA and its metabolite in the perfused humanplacental cotyledon modelCorbel T, Gayrard V, Berrebi A, Gil S, Lacroix M, Puel S, Viguié C, Toutain PL, Picard-Hagen NP19-02Effect of Zearalenone gestational exposure: modulation of placenta cell differentiationand transport functionCaroline Prouillac, Farah Koraichi, Bernadette Videmann, Michelle Mazallon, Frédéric Rodriguez,Michel Baltas, Mohamed Benahmed, Sylvaine Lecoeur

P19-03High-throughput compatible EST assaySimon Stroebel, Jan Lichtenberg, Wolfgang Moritz and Jens M. KelmP19-04Human exposure to chlorinated and brominated compounds is associated withincreased risk for subfertility.Elly Den Hond, Willy Baeyens, Bianca Cox, Petra De Sutter, Tim Nawrot, Willem Ombelet, HermanTournaye, Nik Van Larebeke, Thomas D’HoogheP19-05No longitudinal transmission of AAV5-PBGD vector DNA in mice.Ana Gloria Gil Royo, Gloria González-Aseguinolaza, Ismael Aizpun, Astrid Pañeda Rodríguez, MaríaEugenia Cornet, María del Mar Municio, Tracy Freeman, Harald Petry, Marc Sonnemans, LisaSpronck, Florence SalmonP19-06Premature reproductive aging in female rats after developmental exposure to mixturesof endocrine disruptersJacobsen, PR., Axelstad, M., Christiansen, S., Boberg, J., Hass U.P19-07Role of Alcohol-Mediated Rat Testes CYP2E1 Induction in Changes ofSpermatogenesis Indices and Type I CollagenShayakhmetova, Ganna; Voronina, Alla; Bondarenko, Larysa; Kovalenko, ValentinaP19-08Skeletal examination of Cynomolgus monkey fetuses: control morphology andThalidomide-induced malformationsFoulon, Olivier; Spezia, François; Dauzat, Caroline; Da Silva, Marie; Barrow, Paul; Palate, Bernard;Forster, RoyP19-09Subchronic Reproductive Toxicity in Prepubertal Male Rats Exposed to FoodContaminant AcroleinElif Karacaoğlu, Güldeniz Selmanoğglu, Gökçen Mülayimçelik ÖzgünP19-10Teratogenic effects of mixtures of azole fungicides assessed in rodents by using invitro and in vivo methods.Angelo Moretto, Francesca Di Renzo, Francesca Metruccio, Elena MenegolaP19-11The reproductive toxicity of atrazine, an endocrine disruptorSunny O. Abarikwu, Ebenezer O. Farombi, Aditya B. PantP19-12Use of rodent and human cell culture systems for the investigation of testiculartoxicityYannick Brunner, Laura Suter, Stefan Kustermann, Nicole Clemann; Catherine M. Pastore, PaolaAntinori, Alexandre Scherl, Thomas Weiser, Thomas Singer, Denis Hochstrasser; Serge Nef and LucStoppini,

P19-13Using Adverse Outcome Pathway Genes to Assess Developmental Toxicity ofCompounds in a Mouse Stem Cell SystemMarc A.T. Teunis, Danielle Fiechter, Paulina Mika, Peter T. Theunissen, Giel Hendriks, Cyrille A.M.Krul, Aldert H. PiersmaP19-14Validation of the Yeast Estrogen and Yeast Androgen Screens for Endocrine ActiveSubstances: Inter-laboratory ring trialRamirez, Tzutzuy; Woitkowiak, Claudia; Hüner, Hans-Albrecht; Schönlau, Christine; Hollert, Henner;Broschk, Susanne; Zierau, Oliver; Vollmer, Günter; Jäger, Martina; Poth, Albrecht; Higley, Eric;Hecker, Markus; van Ravenzwaay, Ben; Landsiedel, RobertP19-15Double staining technique for minipig fetal skeletons at gestation day 60Pique, Céline; Marsden, Edward; Quesada, Paul; Jocteur-Monrozier, Audrey; Briffaux, Jean-PaulP19-16Histology of selected organs from the Göttingen Minipig fetus from days 60 (midterm) and 110 (term) of gestationThuilliez, Céline; Perron Lepage, Marie-France; Marsden, Edward; Leroy, Mariline; Briffaux, Jean-PaulP19-17Nigella sativa oil protects against reproductive toxicity of acetamiprid insecticide inmale rats.Mosbah, Rachid; Yousef, Mokhtar Ibrahim; Chettoum, AziezP19-18Chronic Exposure to Ethephon Induces Reproductive Stress in Albino RatMayurakshi Deka and Uma DuttaP22: Safety PharmacologyP22-01Cellular Impedance Assay for prediction of QT Prolongation Induced by hERG andnon-hERG Channel Modulators Using Human Stem Cell Derived CardiomyocytesZhang, Xiaoyu; Abassi, YamaP22-02Factors Determining the Emergence of Negative Medicine Outcomes (NMOs) inEmergenciesMerino Alonso J, Rubio Armendariz C, Núñez Díaz S, Martín Conde JA, Callejón Callejón GP22-03Identification of enantiospecific interactions between clinically used chiral drugs andAHR using in vitro stable transfected luciferase reporter gene cell line AZ-AHRNovotna A., Kamenickova A., Dvorak Z.

P22-04Predictivity of non-clinical Repolarization Assay Data for clinical TQT Data in FDADatabaseValentin, Jean-Pierre; Koerner, John; Willard, James; Park, Eun Jung; Bi, Daoqin; Link, William;Fiszman, Monica; Kozeli, Devi; Skinner, Matt; Cantilena, Louis; Gintant, Gary; Wisialowski, Todd;Pettit, Syril; Vargas, HugoP22-05Telemetric data recordings in conscious, freely moving monkeys using the DSI digitalPhysioTel systemM Niehoff, J. Sternberg, B Niggemann