DONOR SELECTION FOR ALLOGENEIC STEM CELL ... - CBMTG

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SCT DONOR SELECTIONDonor HLA CompatibilityAnasetti,1990: risk of aGVHD in M/M familydonors increased with # of M/M loci→Survival of one-locus M/M recipients equivalentto matched sibsSzydlo,1997: risk of BMT treatment failure with“alternative donors”→In advanced disease, 1-Ag M/M family betterthan matched VUD (which was better than 1-AgM/M VUD)
SCT DONOR SELECTIONDONOR HLA COMPATIBILITYFlomenberg (2004) and Lee (2007)NMDP Data on outcome with VUD-BMTsCollectively showed:- HLA-DQ M/M (isolated) do not affect OAS- Single M/M at A,B,C or DRB1 ⁭ TRM- Each M/M is associated with ~10% OAS- High resolution = Low resolution M/M(except at C-locus)- B & C M/M better tolerated than A & DRB1
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DONOR SELECTION FOR ALLOGENEIC STEM CELL ... - CBMTG

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