- Page 1 and 2: BioinformaticsGenomics& Medicinehtt
- Page 3: Computational Goals of Bioinformati
- Page 9 and 10: Soybean Leghemoglobin andSperm Whal
- Page 11 and 12: Challenges Understanding Genetic In
- Page 13 and 14: Dayhoff’s PAM 250Amino Acid Repla
- Page 15 and 16: Discovering Function from Protein S
- Page 17 and 18: A Typical Motif:Zinc Finger DNA Bin
- Page 19 and 20: Discovering Function from Protein S
- Page 21 and 22: Position-Specifc Scoring Matrix for
- Page 23 and 24: Blocks or Finger Prints fromMultipl
- Page 25 and 26: Hidden Markov Models fromMultiple S
- Page 27 and 28: Data Mining:The Seach for Buried Tr
- Page 29 and 30: PROSITE Patternshttp://expasy.org/p
- Page 31 and 32: Expasy Bioinformatics Resource Port
- Page 33 and 34: UniProt Knowledge Basehttp://www.un
- Page 35 and 36: UniProt Human Opsin Advanced Search
- Page 37 and 38: UniProt Human Opsin OPN1MW Entryhtt
- Page 39 and 40: Blast UniProt Human OPN1MW Resultsh
- Page 41 and 42: NCBI BLAST Home Pagehttp://blast.nc
- Page 43 and 44: Discovering Function from Protein S
- Page 45 and 46: Entrez Gene search for Colorblindne
- Page 47 and 48: Entrez Gene search for Opsins
- Page 49 and 50: BLAST Similarity Searchhttp://www.n
- Page 51 and 52: Paste Sequence, Choose SwissProt Da
- Page 53 and 54: BLAST Conserved Domain Output
- Page 55 and 56:
Most Signifcant Similarity Hits
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Bovine Blue Opsin Similarity
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Evaluation of ProflesNegative Prote
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MyHits Local Motifs Searchhttp://my
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MyHits Local Motifs Searchhttp://my
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MyHits Local Motif Hitshttp://myhit
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MyHits Local Motifs Hist (Cont.)
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InterProhttp://www.ebi.ac.uk/interp
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InterPro Scanhttp://www.ebi.ac.uk/T
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InterPro Scan Resultshttp://www.ebi
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GO: Gene Ontology Databasehttp://ww
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GO: Gene Ontology for Opsin OPN1MWh
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GO: Annotations for OPN1MWhttp://ww
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GO: Gene Ontology Terms for OPN1MWh
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GO: Gene Ontology GCPR Termhttp://w
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Bioinformatics Homeworkhttp://bioch
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Statistical vs. Biological Signifca
- Page 89 and 90:
Hidden Markov Models fromMultiple S
- Page 91 and 92:
Structure of 5’ CAP© Michael W.
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Intron Splicing Mechanism© Michael
- Page 95 and 96:
GENSCAN Gene Modelhttp://genes.mit.
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ESTs, Full Length cDNAUniGene & Ref
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HiddenMarkov modelsof genestructure
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Genomics, Bioinformatics &Computati
- Page 103 and 104:
Genomics, Bioinformatics &Computati
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Hidden Markov Models (after Haussle
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pFAM at Sanger Center (UK)http://pf
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pFAM at Sanger Center (UK)http://pf
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pFAM at Sanger Center (UK)http://pf