Regis Chiral Stationary Phases

CHIRAL STATIONARY PHASESChiral ChromatographyChirality has becomevitally important in thepharmaceutical, chemicaland agricultural industries.The differences which makecompounds chiral canproduce critically differentpharmacological effectsin biological systems.As a result, demand forstereoselective separationtechniques and analyticalassays to evaluate theenantiomeric purityof chiral compoundshas increased.Chiral chromatographyhas become a necessarytool—not only for theanalytical determinationof enantiomeric purity,but also for the isolationof pure enantiomers.Regis Technologies is proud to be a leader in chiral separations andserve both the analytical and preparative needs of chromatographersand researchers worldwide. Regis offers three different classesof Chiral Stationary Phases (CSPs):•Pirkle-Concept•Davankov Ligand Exchange•Protein-basedRegis manufactures a complete line of PirkleChiral Stationary Phases and DavankovLigand Exchange columns at its pharmaceuticalmanufacturing facility. Columns range fromanalytical to preparative in size. A line ofprotein-based chiral stationary phases is alsoavailable. All products meet rigorous manufacturingand quality control specifications before release.Pirkle Stationary PhasesIn 1980, Regis Technologies, along with Professor William Pirkle,of the University of Illinois, introduced the Pirkle Chiral StationaryPhases. These Chiral Stationary Phases offer many advantages:•Enantiomer separation on a wide variety of compound groups•Column durability resulting from covalent phase bonding•Ability to invert elution order•Availability of analytical- to preparative-sized columnsand bulk packing material•Universal solvent compatibilityEnantiomer SeparationRegis manufactures ten Pirkle CSPs. These can separate a wide varietyof enantiomers in numerous compound groups. Examples include:•Aryl Propionic Acid Non-Sterodial Anti-Inflammatory Drugs (NSAIDs)•Agricultural Compounds•Natural Products• β--Blockers•Many Pharmaceuticals16