Introduction to Organic Synthesis: Design

CHE 686 Spring 2007Introduction to Organic Synthesis: DesignInstructor: Professor Nancy Totah office: 3-004 CSTphone: 443-2657email: ntotah@syr.eduOffice Hours:Web Page:CourseDescription:Text Book:Grading:Exams:Problem Sets:Drop in (please do!) or by appointmenthttp://syllabus.syr.edu/CHE/ntotah/CHE686/This course will build upon the material discussed in CHE 676, with a focus onthe preparation of complex molecules. Principles of synthetic strategy and designwill be discussed in the context of various natural product syntheses, as will theapplication of various synthetic methodologies.There are no required texts for this course. Rather, references will be providedfrom the primary literature for supplementary reading. Further, a number ofexcellent reference texts are listed on the reverse. Most of these texts are onreserve in the Sci/Tech Library and/or on the reference shelves.Final grades will be based equally on the following items:Problem Sets 20%Exams (2) 40%Research Proposal 40%There will be two regular exams this semester, with dates and times indicatedbelow. Times and locations will be announced. Emphasis for each regular examwill be placed on material covered since the preceding exam. However, as thestudy of organic chemistry builds upon itself, you should consider all exams to becomprehensive. Be prepared to apply previously learned concepts to materialencountered later in the semester.Exam I Thursday , March 8, 2007 time TBAExam II Friday, May 4, 2007 time TBAProblem sets will be distributed regularly throughout the semester, and will bedue in class on the date indicated. Late assignments will not be accepted. Somediscussion of strategies, etc. with your fellow students may be helpful when tryingto solve problems. However, as these are graded assignments, you are required todo your own work. Failure to do so will result in a reduction of your grade.Research Proposal: Each student in CHE 686 will be assigned a target molecule, for which they willbe expected to design a viable synthetic route over the course of the semester.This work will culminate in a class presentation and the submission of a researchproposal at the end of the semester. Further instructions and a schedule of duedates for preliminary and final assignments will be forthcoming.

CHE 686 Spring 2007Some Organic Chemistry ReferencesGeneral References on Synthetic Methods: Sci Tech Library reserve (2 hour check out)"Modern Methods of Organic Synthesis" (4th ed), W. Carruthers, Cambridge University Press, 2004."Organic Synthesis: the Disconnection Approach" S. G. Warren, Wiley, 1982."Advanced Organic Chemistry" - Parts A and B (4th ed.), F.A. Carey and R. J. Sundberg, Wiley, 2000"Organic Synthesis" (2nd ed.), M. B. Smith. McGraw Hill, 2002."Modern Synthetic Reactions" H. O. House, W. A. Benjamin, 1972."The Logic of Chemical Synthesis", E. J. Corey, X.-M. Cheng, Wiley, 1989."Classics in Total Synthesis" K. C. Nicolaou, E. J. Sorensen, VCH, 1996"Classics in Total Synthesis II" K. C. Nicolaou, S. A. Snyder, Wiley-VCH, 2003"Comprehensive Organic Transformations" R. J. Larock, VCH, 1999 (reference room)"Advanced Organic Chemistry" (5th ed.), M. Smith and J. March, Wiley, 2001."Protective Groups in Organic Synthesis" (4th ed.) by T.W. Greene, P.G.M.Wuts, Wiley, 2007."Protecting Groups" by P. J. Kocienski, Thieme, 2000."Comprehensive Organic Transformations" R. J. Larock, VCH, 1999. (reference room)"Strategic Applications of Named Reactions in Organic Synthesis" L. Kürti, B. Czako ElsevierAcademic Press, 2005. (reference room)Encyclopedias & Dictionaries: found in Sci Tech Library, reference room 103 (non circulating)"Encyclopedia of Reagents for Organic Synthesis", " (8 volumes), Wiley, 1995."Reagents for Organic Synthesis" (22 volumes), Fieser & Fieser, Wiley, 1967 – present."Organic Reactions" (65 volumes), Wiley, 1942 - present."Comprehensive Organic Chemistry" Oxford, Pergamon, 1979."Comprehensive Organic Functional Group Transformations" Pergamon, 2005."Compendium of Organic Synthetic Methods" (11+ volumes), Wiley.On-Line Resources: see http://libwww.syr.edu/research/internet/chemistry/index.htmlSci-Finder ScholarWeb of KnowledgeElectronic Journals