CHEM 732 Fall 2011: Advances in Macromolecular Structure Two ...

CHEM 732 Syllabus, page 4Hellinga HW. 2008. In the wake of two retractions, a request forinvestigation. Nature 454: 397A Successful DesignRöthlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, BetkerJ, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN,Tawfik DS, Baker D. 2008. Kemp elimination catalysts by computationalenzyme design. Nature 453: 190Or Was It?Holfelder F, Kirby AJ, Tawfik DS. 1996. Off-the-shelf proteins that rivaltailor-made antibodies as catalysts. Nature 383: 60Lassila JK, Baker D, Herschlag D. 2010. Origins of catalysis bycomputationally designed retroaldolase enzymes. Proceedings of theNational Academy of Sciences 107: 4937Is there a simpler way to get an enzyme this good?Korendovych IV, Kulp DW, Wu Y, Cheng H, Roder H, DeGrado W F. 2011. Designof a switchable eliminase. Proceedings of the National Academy of Sciences108: 6823.Maybe the best was done years agoAbrahmsen L, Tom J, Burnier J, Butcher KA, Kossiakoff A, Wells JA. 1991.Engineering subtilisin and its substrates for efficient ligation ofpeptide bonds in aqueous solution. Biochemistry 30: 4151What makes a good drug? Lipinski rules of fiveLipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental andcomputational approaches to estimate solubility and permeability in drugdiscovery and development settings. Advanced Drug Delivery Reviews 1997;23: 3-25.