INSIDE: - Medical Device Daily

I do believe Jennifer gets the AY-ward for being the most surprised at getting her JCI Senatorship--you be the judge below.VP Terry has been busy working to fill out his board for the 2012-13 year, so check out his nominees.Also check out the huge goal that Peggy Lewis has set for our upcoming fund raiser in late July.Travel Plans…..On Feb. 4, I visited South Carolina’s JCI Senate for its winter meeting. PresidentRoger Graham welcomed me, and I mentioned Bobby Saunders’ efforts to grow the Jim OllisMemorial Golf Tournament to 60 players on April 14 during the Region IV Calabash Beach Bash inMyrtle Beach. The SC JCI Senate inducted two new senators.After this, I plan a visit to the Madison/Mayodan chapter.Finally, March 1 is our biggest deadline for renewals, so I’m issuing two challenges to you all:Between now and the end of the fiscal year, 1) recruit a new Jaycee for any chapter, and 2) call asenator you haven’t heard from in a long time, and urge that person to renew. And if he or shedoesn’t have the time for a stamp and an envelope, he/she can use the on-line payment feature onour web site. As US JCI Senate Prez Steve said several times now, there is no substitute for a goodold fashioned phone call. So please do it now!And remember, it’s not just a good day to be a Jaycee, it’s a great day. We’re the NC JCI Senate,and we are, Excellence In Action!Wishing you safe travels.Jeff Williams #65414Left to Right: Jeff, Anna, Carter, Roger, President Jennifer, C.O.B. Troy, Steve and Larry Bohn

MONDAY, OCTOBER 3, 2005 BIOWORLD ® FINANCIAL WATCH PAGE 5of 10Company Acquired By Date Date Value Terms/DetailsAcquired* Or Merged With* Announced Completed (M)**(Country; Symbol) (Country; Symbol)Certain assets of Evolva SA* 9/2/05 9/2/05 ND Evolva acquired the pharmaceutical assetsPoalis A/S* (Switzerland) of Poalis; Poalis’ assets in food and flavor(Denmark)chemicals and agriculture were not includedin the dealPyramid Life 7/6/05 9/22/05 $13 Life Therapeutics paid $13M, and assumedBiological Therapeutics $7M in debt; another $5M could be paid ifCorp.* (ASX:LFE) milestones are reachedQuadrant ML Laboratories 6/16/05 7/14/05 £46.7 Combined company name is Innovata plc;Technologies plc (UK; LSE:MLB) (US$85) ML paid £19.5M cash and the rest inLtd.* (UK)shares as part of the 50-50 merger; ML alsopaid £1.85M cash and shares to acquirethe 18.75% interest in Innovata that Biomeddid not already ownScientific Agilent 5/25/05 7/1 1/05 ND Agilent acquired SSI, a provider of scientificSoftware Inc.* Technologies information management solutionsInc. (NYSE:A)Stressgen Assasy 7/12/05 7/12/05 ND Stressgen Bioreagents was spun out ofBioreagents Designs Inc. Stressgen Biotechnologies Corp. in May;Corp.*Ampersand Ventures funded both dealsBioanylitical Qiagen NV 8/1/05 8/8/05 $0.8 Qiagen paid $0.8M up front and could paybusiness of (the Netherlands; another $0.8M if certain milestones areSuNyx GmbH* QGEN) reached for SuNyx, which has nanotechno-(Germany)logy-based sample preparation technologyTranskaryotic Shire 4/21/05 7/27/05 $1.6B Shire paid $37 in cash for each TKT share,Therapies Inc. Pharmaceuticals a premium of 44% to the four-week average(TKTX) Group plc (UK) before the deal was announcedVicuron Pfizer Inc. 6/16/05 9/14/05 $1.9B Pfizer paid $29.10 per share in cash, orPharmaceuticals$1.9B, a 74% premium to the 90-day priceInc. (MICU)before the deal was disclosedXenova Group Celtic Pharma 6/24/05 9/1/05 £26.1 Celtic, a private equity firm, is paying upplc (UK; XNVA) Group (US$48) to £26.1 in notes, cash or a blend of each for(Bermuda)Xenova; separately, Celtic licensed technologyand provided a $20M loan facilityII. PENDING MERGERS AND ACQUISITIONSCompany Acquiring Date Expected Value Terms/DetailsTo Be Acquired* Company* Announced Completion (M)**(Country; Symbol) (Country; Symbol)Aerogen Inc. Nektar 8/15/05 4Q:05 $32 Nektar to pay $8M cash and $24M in stock,(OTC BB:AEGN) Therapeutics but later said it would exercise option to(NKTR)make an all-cash deal, at $0.75 per share.To subscribe, please call BIOWORLD ® Customer Service at (800) 688-2421; outside the U.S. and Canada, call (404) 262-5476.Copyright © 2005 Thomson BioWorld ® . Reproduction is strictly prohibited.

MONDAY, OCTOBER 3, 2005 BIOWORLD ® FINANCIAL WATCH PAGE 6of 10Company Acquiring Date Expected Value Terms/DetailsTo Be Acquired* Company* Announced Completion (M)**(Country; Symbol) (Country; Symbol)Afmedica Inc.* Angiotech 9/13/05 4Q:05 ND Afmedica is developing perivascular tech-Pharmaceuticalsnology using the drug rapamycin to treatInc. (Canada; ANPI)various diseasesArtesian Cardiome 8/29/05 4Q:05 N/A Artesian shareholders can earn $32M inTherapeutics Pharma Corp. payments for development milestonesInc.* (Canada; CRME) related to each of two drug candidatesAsterand Pharmagene 9/19/05 4Q:05 £13 Asterand shareholders would get aboutInc.* plc (UK; LSE:PGN) (US$23.5) 54.2M shares in the deal, or 50% of themerged company; they also would be entitledto deferred payments in stock and cashBioCheck Inc.* OXIS 9/21/05 ND $6 The all-cash deal is contingent on OXIS’Internationalability to raise enough money to purchaseInc. (OTC BB:OXIS)at least 51% of BioCheck; the purchase pricecould increase for any remaining sharesBioFocus plc Galapagos NV 9/21/05 4Q:05 £20.2 Galapagos offered to pay 124 pence in(UK; AIM:BIO) (Belgium; (US$35.6) stock for each BioFocus share, a premiumEuronext:GLPG)of 121% to the Sept. 20 closing price; Bio-Focus would own about 30% of the combinedcompanyBioSource Invitrogen 7/26/05 4Q:05 $130 Invitrogen intends to strengthen its posi-International Corp. (IVGN) tion in proteomics through the all-cashInc. (BIOI)acquisitionCertain assets Maxim 4/21/05 4Q:05 ND As part of a restructuring, Calypte enteredof Calypte Biomedical a nonbinding letter of intent to sell itsBiomedical Corp. Inc.* urine EIA, serum Western Blot and urine(AMEX:HIV)Western Blot HIV in vitro diagnostics businessCardioGenics Medeorex Inc. 5/1 1/05 3Q:05 ND CardioGenics shareholders would getInc.* (OTC BB:MRXI) Medeorex stock representing 75% of themerged companyCellective MedImmune 9/14/05 4Q:05 ND MedImmune intends to pay cash andTherapeutics Inc. (MEDI) potential milestone payments to acquireInc.*Cellective, which is developing monoclonalantibodies that target B-cell antigensCengent Inncardio Inc. 4/1/05 2H:05 ND They signed a definitive agreement underTherapeutics (OTC BB:INDO) which Inncardio would acquire CengentInc.*Chiron Corp. Novartis AG 9/1/05 N/A $4.5B Novartis offered to pay $40 per share, or(CHIR) (Switzerland) $4.5 billion, for the 58% of Chiron it doesn’town; Chiron directors on Sept. 5 termedthe unsolicited offer “inadequate”To subscribe, please call BIOWORLD ® Customer Service at (800) 688-2421; outside the U.S. and Canada, call (404) 262-5476.Copyright © 2005 Thomson BioWorld ® . Reproduction is strictly prohibited.

MONDAY, OCTOBER 3, 2005 BIOWORLD ® FINANCIAL WATCH PAGE 8of 10Company Acquiring Date Expected Value Terms/DetailsTo Be Acquired* Company* Announced Completion (M)**(Country; Symbol) (Country; Symbol)ParAllele Affymetrix 5/31/05 4Q:05 $120 Definitive agreement calls for Affymetrix toBioScience Inc.* Inc. (AFFX) pay $120M in stock for ParAllele, which hasassay technology and with which it hasbeen partnered for two yearsSahajanand MIV 3/1 1/05 4Q:05 ND The merger would bring together productsMedical Therapeutics and drug-eluting technologies in coronaryTechnologies* Inc. (Canada; stents; Sahajanand’s stents are sold in more(India) OTC BB:MIVT) than 33 countriesShenzhen PG Qiagen NV 9/26/05 4Q:05 $14.5 Qiagen intends to pay $14.5M in cash toBiotech Co Ltd.* (the Netherlands; acquire Shenzhen, a supplier of PCR-based(China) QGEN) molecular diagnostic kits in ChinaTargeted Chromos 5/25/05 4Q:05 C$5 Chromos intends to issue about 20.1MMolecules Molecular (US$4) shares in the deal; TMC is developing twoCorp.* Systems Inc. antibody product candidates(Canada; TSE:CHR)Xtrana Inc. Alpha Innotech 12/14/04 4Q:05 ND Xtrana shareholders would own 17% of the(OTC BB:XTRN) Corp.* combined company following the reversemerger; they would keep the AlphaInnotech nameNotes:# This chart is intended to include not only mergers and acquisitions of entire businesses, but also of divisions or subsidiariesof those businesses, where appropriate. In general, it does not include acquisitions of single products or of manufacturingfacilities.For those deals that are pending, and for which the acquiring company is issuing stock, the value of the transaction wascalculated based on the closing price prior to the first announcement. For stock-based deals that have been completed,the final value was calculated based on the closing price before the merger’s completion was announced.* Private companies are indicated with an asterisk.** Conversions of non-U.S. currencies are calculated using the rate on the date the transaction closed, or for pendingdeals, on the date it was announced.@ The deal occurred before the time frame of this chart but was not included in the previous chart.ND = Not disclosed; N/A = Not applicable.Unless otherwise indicated, shares are traded on the Nasdaq exchange.AIM = Alternative Investment Market; AMEX = American Stock Exchange; ASX = Australian Stock Exchange; LSE = LondonStock Exchange; NYSE = New York Stock Exchange; OTC BB = Over-the-Counter Bulletin Board; PK = Pink Sheets; TSE =Toronto Stock Exchange.To subscribe, please call BIOWORLD ® Customer Service at (800) 688-2421; outside the U.S. and Canada, call (404) 262-5476.Copyright © 2005 Thomson BioWorld ® . Reproduction is strictly prohibited.

MONDAY, OCTOBER 3, 2005 BIOWORLD ® FINANCIAL WATCH PAGE 9of 10BioWorld Stock Report For Public Biotechnology CompaniesCompany Symbol Close Close %Change Vol9/23 9/30 WK YTD (000)Aastrom Biosci ASTM 2.35 2.35 0.00 65.49 4883Abgenix ABGX 11.48 12.68 10.45 22.63 8807Acadia ACAD 10.87 11.37 4.60 67.95 403Accelrys Inc ACCL 6.16 6.76 9.74 -13.33 471Access Pharma AKC 0.98 0.88 -10.20 -75.14 300Acusphere ACUS 5.49 5.44 -0.91 -11.26 154Adolor ADLR 9.64 10.68 10.79 7.66 2014Advancis AVNC 1.67 1.41 -15.57 -63.09 1766Aeolus AOLS 1.22 1.12 -8.20 -10.40 113AEterna AEZS 4.9 4.8 -2.04 -23.32 182Affymetrix AFFX 43.19 46.23 7.04 26.48 10607Albany Molecular AMRI 12.44 12.18 -2.09 9.34 1231Alexion Pharma ALXN 27.6 27.65 0.18 9.72 1504Alkermes ALKS 16.79 16.8 0.06 19.23 3710Alliance ALLP 0.15 0.11 -26.67 -42.11 1229Allos ALTH 2.44 2.44 0.00 1.67 264Alnylam ALNY 11.55 11.3 -2.16 51.27 1270Alteon ALT 0.33 0.3 -9.09 -77.10 1037Amgen AMGN 83.29 79.67 -4.35 24.19 47720Amylin AMLN 30.39 34.79 14.48 48.93 15434Anadys ANDS 11.51 10.67 -7.30 42.46 439Antigenics AGEN 5.35 5.42 1.31 -46.44 692Aphton APHT 0.61 0.63 3.28 -79.74 644Aradigm ARDM 1.11 1.07 -3.60 -38.15 435Arena ARNA 8.94 9.9 10.74 47.76 2028Ariad Pharma ARIA 7.44 7.43 -0.13 0.00 1785ArQule ARQL 8.22 7.83 -4.74 35.23 1028Array ARRY 6.99 7.18 2.72 -24.58 464Aspreva ASPV 14.9 14.26 -4.30 29.64 246Atherogenics AGIX 16.54 16.03 -3.08 -31.96 2035AutoImmune AIMM 0.9 0.91 1.11 3.41 26Auxilium AUXL 5.32 4.98 -6.39 -43.73 348Avanir AVN 3.16 3.09 -2.22 -9.38 1371Avant Immuno AVAN 1.39 1.3 -6.47 -35.32 517Avax Technol AVXT 0.29 0.31 6.90 0.00 59AVI BioPharma AVII 2.25 2.64 17.33 12.34 2251Avigen AVGN 2.75 2.78 1.09 -14.72 136Axonyx AXYX 1.16 1.15 -0.86 -81.45 1503BioCryst BCRX 9.67 9.78 1.14 69.20 1793Biogen IDEC BIIB 38.56 39.48 2.39 -40.73 17068BioMarin BMRN 8.96 8.73 -2.57 36.62 1290Biomira BIOM 1.42 1.38 -2.82 -42.74 2188Biopure BPUR 1.21 1.11 -8.26 88.14 468Biotime BTIM 0.42 0.43 2.38 -71.52 900Boston Life BLSI 2.1 2.11 0.48 -25.96 31Bruker BioSciences BRKR 4.41 4.38 -0.68 8.68 567CancerVax CNVX 3.05 3.44 12.79 -68.29 292Cardiovas. Biother CVBT 9.1 8.8 -3.30 -12.00 413Carrington CARN 3.5 4.21 20.29 -31.32 186Celera CRA 11.55 12.13 5.02 -11.78 1183Celgene CELG 53 54.32 2.49 104.83 17237Cell Genesys CEGE 5.6 5.48 -2.14 -32.35 1481Cell Therapeu CTIC 1.99 2.86 43.72 -64.86 44615Cellegy Pharma CLGY 1.49 1.43 -4.03 -50.17 192Cel-Sci CVM 0.48 0.47 -2.08 -21.67 523Cephalon CEPH 45.25 46.42 2.59 -8.77 4362Cepheid CPHD 7.36 7.39 0.41 -25.65 749Cerus Corp. CERS 8.8 8.86 0.68 200.34 661Chiron CHIR 43.47 43.65 0.41 30.96 6728Cholestech CTEC 10.37 10.08 -2.80 22.93 164Ciphergen CIPH 1.81 1.85 2.21 -56.98 211CollaGenex CGPI 9.83 9.92 0.92 35.15 273Columbia Labs CBRX 3.25 3.76 15.69 41.89 1609CombiMatrix CBMX 1.63 1.66 1.84 -58.19 1468Compugen CGEN 3.25 3.31 1.85 -35.73 154Connetics Corp. CNCT 17.99 16.91 -6.00 -30.38 1930Corautus Genetics VEGF 4.29 4.45 3.73 -17.29 1930Corcept CORT 5.7 5 -12.28 -20.00 195Corgentech CGTK 2.66 2.36 -11.28 -71.50 1611Cortex COR 2.37 2.37 0.00 -12.55 689CoTherix CTRX 13.52 13.95 3.18 17.03 704Critical Thera CRTX 6.2 9.42 51.94 17.75 2298Crucell CRXL 24.13 26.81 11.11 94.70 1362Cubist Pharma CBST 19.55 21.54 10.18 82.08 4566CuraGen CRGN 4.51 4.95 9.76 -30.87 775Curis CRIS 4.51 4.59 1.77 -12.07 780CV Therapeutics CVTX 25.99 26.75 2.92 16.30 2338Cyanotech CYAN 0.94 0.96 2.13 -33.33 95Cygnus CYGN 0.13 0.13 0.00 8.33 234Cypress CYPB 12.97 5.41 -58.29 -61.52 34711Cytogen CYTO 3.94 4.04 2.54 -64.93 564Cytokinetics CYTK 8.33 8.14 -2.28 -20.59 571CytRx CYTR 0.88 0.97 10.23 -30.71 5113DeCode DCGN 8.81 8.39 -4.77 7.43 1303Deltagen DGENQ 0.25 0.24 -4.00 242.86 478Dendreon DNDN 6.47 6.71 3.71 -37.76 3586Company Symbol Close Close %Change Vol9/23 9/30 WK YTD (000)DepoMed DEPO 5.91 6.48 9.64 20.00 4409Digene DIGE 27.22 28.5 4.70 8.99 848Discovery Labs DSCO 6.42 6.45 0.47 -18.66 1729Discovery Partners DPII 3.45 3.22 -6.67 -31.63 302Diversa DVSA 5.12 5.79 13.09 -33.75 408DOR BioPharma DOR 0.35 0.33 -5.71 -48.44 872DOV Pharma DOVP 16.51 16.98 2.85 -5.93 881Draxis Health DRAX 4.71 4.62 -1.91 -6.85 217Durect DRRX 6.65 6.85 3.01 108.84 1104DUSA Pharma DUSA 9.48 10.6 11.81 -25.87 625Dyax DYAX 5.43 5.59 2.95 -22.58 778Dynavax DVAX 6.74 6.7 -0.59 -16.25 56Embrex EMBX 12 11.25 -6.25 -15.16 46Emisphere EMIS 3.77 4.5 19.36 11.94 694Encysive Pharma ENCY 12.32 11.78 -4.38 18.63 4016EntreMed ENMD 2.35 2.39 1.70 -26.23 769Enzo Biochem ENZ 15.81 15.36 -2.85 -21.11 577Enzon ENZN 6.61 6.6 -0.15 -51.90 1589Epix Pharma EPIX 7.82 7.7 -1.53 -57.01 1258Ergo Science ERGO 1.25 1.29 3.20 -47.13 61Exact Sciences EXAS 2.2 1.82 -17.27 -52.48 731eXegenics EXEG 0.4 0.4 0.00 17.65 18Exelixis EXEL 7.36 7.65 3.94 -19.47 1107Eyetech EYET 17.8 17.96 0.90 -60.53 15095Favrille FVRL 4.62 4.55 -1.52 -35.00 69Flamel Tech FLML 16.79 18.7 11.38 -4.05 651Genaera GENR 1.9 1.92 1.05 -43.86 4325Genaissance GNSC 1.35 1.39 2.96 -34.74 255Gene Logic GLGC 4.62 4.89 5.84 32.88 1871Genelabs GNLB 0.52 0.64 23.08 -46.67 8659Genentech DNA 85.83 84.21 -1.89 54.68 35365Generex Biotech GNBT 0.73 0.67 -8.22 -10.67 3485Genitope GTOP 6.99 6.94 -0.72 -59.27 873Gen-Probe GPRO 48.61 49.45 1.73 9.38 1562Genta GNTA 1.61 1.5 -6.83 -14.77 18166GenVec GNVC 2.04 2.05 0.49 25.77 2031Genzyme GENZ 69.52 71.64 3.05 23.37 8764Geron GERN 10.32 10.27 -0.48 28.86 3781Gilead Sciences GILD 46.03 48.76 5.93 39.35 16367GPC Biotech GPCB 12.35 12.64 2.35 -11.05 5GTC Biothera GTCB 1.55 1.39 -10.32 -8.55 1650GTx GTXI 9.5 9.31 -2.00 -30.99 256Guilford Pharma GLFD 3.67 3.65 -0.54 -26.26 3299Hana Bio HNAB 5.1 5.1 0.00 -13.56 974Helix Biomed HXBM 1.2 1.03 -14.17 -41.14 101Hemispherx HEB 1.55 1.7 9.68 -10.53 1058Human Genome HGSI 13.5 13.59 0.67 13.06 9442Icagen ICGN 7.18 6.75 -5.99 -15.63 115Icoria ICOR 0.26 0.25 -3.85 -61.54 2021ICOS ICOS 25.12 27.62 9.95 -2.33 7765Idenix IDIX 25.94 25.1 -3.24 46.36 1310Idexx Labs IDXX 66 66.88 1.33 22.51 580ImClone Sys IMCL 30.12 31.45 4.42 -31.75 6976Immtech IMM 11.8 11.66 -1.19 -2.75 124Immucell ICCC 5.03 5.01 -0.40 -30.03 19Immucor BLUD 25.32 28.07 10.86 19.40 0Immune Resp IMNR 0.45 0.46 2.22 -71.43 3041Immunicon IMMC 3.68 3.93 6.79 -43.70 668ImmunoGen IMGN 7.01 7.34 4.71 -16.97 581Immunomedics IMMU 2.17 2.05 -5.53 -32.57 730Incyte Genomics INCY 7.25 4.7 -35.17 -52.95 36673Indevus IDEV 2.96 2.88 -2.70 -51.68 1487Inhibitex INHX 9.85 10.18 3.35 26.62 978InKine Pharma INKP 3.61 3.65 1.11 -32.78 1381Inovio INO 2.75 2.72 -1.09 -30.96 71InSite Vision ISV 0.67 0.64 -4.48 -27.27 1266Insmed INSM 1.18 1.34 13.56 -39.09 17389Inspire Pharma ISPH 7.87 7.6 -3.43 -54.68 1553Integra LifeSci IART 36.16 38.26 5.81 3.60 1022Interleukin ILGN 3.42 3.75 9.65 5.63 91InterMune ITMN 16.32 16.55 1.41 24.81 1434IntraBiotics IBPI 3.75 3.66 -2.40 -10.29 49Introgen INGN 5.04 5.22 3.57 -38.15 487Invitrogen IVGN 76.3 75.23 -1.40 12.07 4204Isis Pharma ISIS 5.2 5.05 -2.88 -14.41 1355Ista Pharma ISTA 6.43 6.64 3.27 -34.39 1270Keryx KERX 15.9 15.76 -0.88 36.21 1055Kosan KOSN 6.9 7.27 5.36 4.91 450La Jolla Pharma LJPC 0.79 0.76 -3.80 -54.49 1439Large Scale LSBC 0.8 0.83 3.75 -34.13 246Lexicon LEXG 4.34 3.97 -8.53 -48.84 1347LifeCell LIFC 24.13 21.63 -10.36 111.64 4247Lifecore Bio LCBM 12.21 12.09 -0.98 7.37 331Ligand LGND 7 7 0.00 -39.86 0MacroChem MCHM 0.06 0.05 -16.67 -93.15 1805Manhattan Pharma. MHTT 1.38 1.3 -5.80 34.02 131To subscribe, please call BIOWORLD ® Customer Service at (800) 688-2421; outside the U.S. and Canada, call (404) 262-5476.Copyright © 2005 Thomson BioWorld ® . Reproduction is strictly prohibited.

MONDAY, OCTOBER 3, 2005 BIOWORLD ® FINANCIAL WATCH PAGE 10 of 10Company Symbol Close Close %Change Vol9/23 9/30 WK YTD (000)MannKind MNKD 11.28 13.69 21.37 -13.08 1370Martek Bio MATK 35.92 35.13 -2.20 -31.39 3549Matritech MZT 0.62 0.63 1.61 -40.57 709Maxim Pharma MAXM 1.36 1.34 -1.47 -55.63 82Maxygen MAXY 8.43 8.29 -1.66 -35.18 216Medarex MEDX 9.07 9.52 4.96 -11.69 2979MedImmune MEDI 31.99 33.65 5.19 24.12 21653Memory MEMY 1.82 2.71 48.90 -49.06 13094Metabasis MBRX 5.99 5.83 -2.67 -19.59 61MGI Pharma MOGN 23.47 23.24 -0.98 -17.03 9959Millennium MLNM 9.18 9.33 1.63 -23.15 2681Miravant MRVT 0.44 0.39 -11.36 -61.39 584Momenta MNTA 28.16 27.25 -3.23 285.98 4968Myogen MYOG 24.11 23.5 -2.53 191.20 4044Myriad Genetics MYGN 19.91 21.86 9.79 -2.89 1507NABI NABI 13.5 13.1 -2.96 -10.58 5907Nanogen NGEN 2.98 3.21 7.72 -56.39 2578Nastech NSTK 13.47 14.15 5.05 16.94 560Nektar Thera NKTR 16.33 16.95 3.80 -16.25 11605NeoPharm NEOL 11.75 12.4 5.53 -0.88 1470NeoRx Corp. NERX 1.06 0.92 -13.21 -55.98 392Neose Technol NTEC 2.17 2.35 8.29 -65.03 280Neurobio Tech NTII 3.79 3.81 0.53 -13.80 119Neurochem NRMX 11.58 12.67 9.41 -27.72 571Neurocrine Biosci NBIX 45.92 49.19 7.12 -0.22 1384Neurogen NRGN 6.86 6.88 0.29 -26.50 102New River NRPH 46.25 47.94 3.65 220.45 304NitroMed NTMD 17.65 18 1.98 -32.46 3375North Amer Scien NASI 3 2.62 -12.67 -51.39 1937Northfield Labs NFLD 12.87 12.9 0.23 -42.79 766Northwest BioThera NWBT 0.17 0.17 0.00 325.00 225Novavax NVAX 1.63 1.75 7.36 -46.32 10748NPS Pharma NPSP 9.66 10.11 4.66 -44.69 3667Nuvelo NUVO 9.55 9.6 0.52 -2.54 871Onyx Pharma ONXX 24.07 24.97 3.74 -22.91 3557OraSure Tech OSUR 9.11 9.45 3.73 40.63 1207Orchid ORCH 8.88 8.5 -4.28 -26.09 622Ortec Int'l ORTN 0.35 0.35 0.00 -63.92 27Oscient Pharma OSCI 2.02 2.12 4.95 -41.92 5970OSI Pharma OSIP 29.35 29.24 -0.37 -60.94 13751Osteotech OSTE 6 5.73 -4.50 4.18 211OXiGENE OXGN 5.34 5.27 -1.31 -4.18 647Oxis Int'l OXIS 0.44 0.37 -15.91 -32.73 496Pain Therapeu PTIE 6.5 6.29 -3.23 -12.76 632Palatin Tech PTN 2.12 2.3 8.49 -13.53 2119Peregrine Pharma PPHM 1.02 1 -1.96 -14.53 2928Pharma Prod Devlp PPDI 58.57 57.51 -1.81 39.28 855Pharmacopeia PCOP 3.57 3.57 0.00 -40.20 124Pharmacyclics PCYC 9.02 9.02 0.00 -13.85 423Pharmion PHRM 22.93 21.81 -4.88 -48.33 1703Pharmos PARS 2.21 2.14 -3.17 50.70 310Pharsight PHST 1.65 1.74 5.45 83.16 59Praecis PRCS 0.56 0.47 -16.07 -75.26 8398Progenics Pharma PGNX 23.68 23.71 0.13 38.17 743Protein Design PDLI 27.99 28 0.04 35.53 5551QLT PhotoTher QLTI 6.96 7.67 10.20 -52.30 7505Questcor Pharma QSC 0.49 0.54 10.20 1.89 400Regeneration RTIX 8.5 8.17 -3.88 -22.04 553Regeneron REGN 8.26 9.49 14.89 3.04 2227Renovis RNVS 13.93 13.53 -2.87 -5.91 1239Repligen RGEN 3.29 3.12 -5.17 8.33 1059Rigel RIGL 23.05 23.77 3.12 -2.66 917Sangamo SGMO 4.73 4.39 -7.19 -26.83 190Santarus SNTS 6.11 6.21 1.64 -31.31 536Savient Pharma SVNTE 3.41 3.77 10.56 39.11 1552SciClone SCLN 5.1 5.64 10.59 52.43 1729Seattle Genetics SGEN 5.12 5.25 2.54 -19.60 501Senomyx SNMX 17.8 17.03 -4.33 105.68 884Sepracor SEPR 57.04 58.99 3.42 -0.64 9109Sequenom SQNM 0.76 0.96 26.32 -33.33 1286Serono SRA 16.13 16.45 1.98 0.80 348Siga Technol SIGA 0.81 1.06 30.86 -36.14 3884Simulations Plus SLP 3.43 3.71 8.16 -33.27 12Sirna Thera RNAI 4.28 4.4 2.80 38.80 6600Solexa SLXA 5.55 5.85 5.41 -23.43 174Sonus Pharma SNUS 4.22 4.25 0.71 20.40 1231Spectrum SPPI 5.01 4.96 -1.00 -25.53 472StemCells STEM 5.21 5.52 5.95 30.50 11158Stratagene STGN 8.79 9.01 2.50 16.26 168SuperGen SUPG 5.85 6.3 7.69 -10.64 2276Tanox TNOX 14.08 14.65 4.05 -3.62 #REF!Tapestry Pharma TPPH 0.38 0.37 -2.63 -61.86 571Targeted Genetics TGEN 0.65 0.68 4.62 -56.13 398Telik TELK 17.15 16.36 -4.61 -14.52 3581Tercica TRCA 11.02 11.28 2.36 12.80 3581Theravance THRX 20.71 21.04 1.59 17.54 311Third Wave Tech TWTI 5.06 4.95 -2.17 -42.44 311Threshold Pharma THLD 13.36 13.65 2.17 95.00 554Titan Pharma TTP 1.85 1.77 -4.32 -45.03 554Transgene TRGNY 2.78 2.65 -4.68 -5.36 757Company Symbol Close Close %Change Vol9/23 9/30 WK YTD (000)Transgenomic TBIO 0.99 1 1.01 -13.04 445Trimeris TRMS 14.95 15.34 2.61 8.26 445Trinity Bio TRIB 7.43 7.4 -0.40 150.00 2254Tripos TRPS 4.33 4.2 -3.00 -21.20 139Unigene UGNE 2.76 2.91 5.43 29.33 93United Thera UTHR 69.64 69.8 0.23 54.60 2289Valentis VLTS 2.31 2.38 3.03 -4.80 270VaxGen VXGN 14.6 14.5 -0.68 -14.71 1348Vernalis VNLS 2.23 2.43 8.97 -24.06 #REF!Vertex Pharma VRTX 18.96 22.35 17.88 111.45 580ViaCell VIAC 5.38 5.8 7.81 -17.14 8956Vical VICL 4.98 4.92 -1.20 4.68 888Vion Pharma VION 2.37 2.17 -8.44 -53.73 343Viragen VRA 0.55 0.5 -9.09 -50.00 343ViroPharma VPHM 18.04 20.8 15.30 540.00 826VioQuest VQPH 1.2 1.05 -12.50 31.25 1588Xcyte Therapies XCYT 0.51 0.48 -5.88 -82.61 11111Xenogen XGEN 3.14 3.07 -2.23 -56.14 16XenoPort XNPT 16.89 16.5 -2.31 57.14 381Xenova Group XNVA 0.52 0.52 0.00 -60.00 201XOMA XOMA 1.7 1.76 3.53 -32.05 310Zonagen ZONA 5.75 5.75 0.00 32.79 0ZymoGenetics ZGEN 15.9 16.5 3.77 -28.26 1574LONDON STOCK EXCHANGECompany Symbol 9/23 9/30 %WK %YTD VolumeAcambis ACM 241 251 4.15 -0.20 2585Ark Therapeutics AKT 102.25 85 -16.87 0.00 1108Antisoma ASM 21.78 16.25 -25.39 0.00 1361Cambridge AntibodyCAT 750 721 -3.87 0.00 139Oxford Biomedica OXB 43 17.5 -59.30 0.00 10041Pharmagene PGN 24 31 29.17 0.00 4Phytopharm PYM 72.5 235 224.14 0.00 872Protherics PTI 53.5 65 21.50 -1.14 2481Provalis PRO 5.7775 8.75 51.45 1.51 1431SkyePharma SKP 53.5 65 21.50 0.00 78118Vernalis Group plc VER 65.5 88.5 35.11 0.00 798Note: Prices are denoted in pence.TORONTO STOCK EXCHANGECompany Symbol 9/23 9/30 %WK %YTD VolumeAdherex AHX 1.45 1.29 -11.03 207.14 90Angiotech Pharma ANP 15.74 16.19 2.86 -27.14 1117Anormed AOM 4.56 4.14 -9.21 -26.73 301Bioniche BNC 1.05 1 -4.76 -39.76 129Chromos Molec CHR 0.17 0.2 17.65 -67.74 25ConjuChem CJC 1.6 0.78 -51.25 -81.43 17073Cangene CNJ 8.49 8.1 -4.59 -27.35 247Cardiome COM 8.78 10.24 16.63 12.65 1969Ecopia EIA 0.5 0.49 -2.00 -53.33 594Hemosol HML 1.05 0.9 -14.29 -10.89 389IBEX IBT 0.21 0.23 9.52 -47.73 50ID Biomed IDB 34.93 34.84 -0.26 94.53 1149Inex IEX 0.18 0.12 -33.33 -86.36 1047Inflazyme IZP 0.14 0.13 -7.14 -40.91 701Lorus LOR 0.67 0.74 10.45 4.23 1200Medicure MPH 1.24 1.16 -6.45 28.89 1265BioMS MS 2.81 2.84 1.07 -15.22 114Neurochem NRM 13.3 14.65 10.15 -30.99 299Oncolytics ONC 3.24 4.48 38.27 -19.28 664Resverlogix RSV 7.9 7.55 -4.43 64.13 184Stressgen Biotech SSB 0.35 0.35 0.00 -16.67 574Theratechnologies TH 1.21 1.24 2.48 -40.95 137YM Bioscience YM 3.49 3.49 0.00 -1.97 610Note: Prices are denoted in Canadian dollars.NOTES:Trading volumes for Nasdaq, Amex and NYSE are recorded as the totalnumber of shares traded (in thousands) on a weekly basis (cumulativeMonday through Friday); the weekly and YTD % changes are from IPOcompletion, where applicable.Average Percent Change Week: +1.18%Range: -58.29% to +51.94%; Number Of Companies: 285(does not include LSE or TSE; not market weighted)Average Percent Change YTD: -2.95%Range: -93.15% to +540.00%; Number Of Companies: 285(does not include LSE or TSE; not market weighted)To subscribe, please call BIOWORLD ® Customer Service at (800) 688-2421; outside the U.S. and Canada, call (404) 262-5476.Copyright © 2005 Thomson BioWorld ® . 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