Curriculum Vitae von Prof. Dr. med. Adrian Schmassmann

Luzerner Kantonsspital, 6210 Sursee
Studium
Luzerner Kantonsspital
Postfach
6210 Sursee
Funktion: Chefarzt Medizin
Tel.: 041 926 41 23
Fax: 041 926 47 76
E-Mail: adrian.schmassmann@ksl.ch
• 1973 - 1979 Medizinstudium Universität Basel
Staatsexamen
• 1979 Universität Basel
www.ksl.ch

Dissertation & Thema
• „Integrated spermiometrics“, Institut für Pathologie, Universität Basel
Habilitation
• 1995 Universität Bern
• 1999 Honorarprofessor Universität Bern
Beruflicher Werdegang
• 1980 Diploma in Tropical Medicine and Hygiene, University of Liverpool
• 1981 Institut für Pathologie, Universität Basel
• 1982 Chirurgische Klinik, Universität Basel
• 1983 - 1984, Innere Medizin, Bruderholzspital
• 1985 - 1986, Innere Medizin, Universitätsspital Basel
• 1987 Oberarzt Innere Medizin (Intensivpflegestation)
• 1989 - 1990 Ausbildung in Gastroenterologie im Kantonsspital Aarau
• 1991 -1999 Inselspital Bern, ab 1995 Leitender Arzt
• Ab 1999 Chefarzt, Medizinische Klinik, Luzerner Kantonsspital Sursee
Auslandaufenthalte
• 1980: University of Liverpool (UK)
• 1988: University of San Diego, California (USA)
• 1993: University of Irvine, California (USA)
• 1999: Harvard University, Boston (USA)
Mitgliedschaften und Funktionen in wissenschaftlichen Gesellschaften
• Luzerner Ärztegesellschaft (inklusive Sektion Gäu)
• Organisation der Leitenden Spitalärzte des Kantons Luzern
• Schweizerische Gesellschaft für Chefärzte
• Schweizerische Gesellschaft für Innere Medizin
• Schweizerische Gesellschaft für Gastroenterologie
• Amerikanische Gesellschaft für Gastroenterologie
• Universitätsverein Luzern
• Dozentenvereinigung der Medizinischen Fakultät der Universität Bern
• Alumni Universität Basel
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Auszeichnungen und Ehrungen
• 1992 Scientific Award of the II. United European Gastroenterology Week
• 1993 Forschungsförderungspreis der Schweizerischen Gesellschaft für Gastroenterologie
Spezialinteressen
• Politik: Gemeindepräsident Eich und Kantonsrat Luzern
• Aus- und Weiterbildung der Assistenzärzte
• SNF Forschungsprojekte (Tumore und Wundheilung im oberen Gastrointestinaltrakt)
Publikationen (Buchbeiträge)
Gebbers J-O, Schmassmann A. Ösophagus: Klinische Pathologie.
Gastroösophageale Refluxkrankheit, infektiöse Ösophagitiden, eosinophile
Ösophagitis. Verdauungskrankheiten, Dustri-Verlag Dr. Karl Feistle. Jahrgang 23,
2005; 235-243.
Schmassmann A, Hirschi C, Stettler C, Poulsom R, Halter F. Recent work with
hepatocyte growth / scatter factor. In: The gut as a model in cell and molecular
biology. Eds. Halter F, Winton D, Wright NA. Kluwer Academic Publishers. Dordrecht.
1997; 180-193.
Hofmann AF, Lillienau J, Schteingart CD, Ton-Nu H-T, Rossi SS, Peng Y, Longmire-
Cook S, Fehr H, Schmassmann A. Cholylsarcosine as a replacement bile acid for bile
acid deficiency in the small intestine: physiochemical and biological properties. In: bile
acids as therapeutic agents. Eds. Paumgartner G, Stiehl A, Gerok W. Kluwer
Academic Publishers. Dordrecht. 1991; 167-176.
Halter F, Scheurer U, Schmassmann A, Renner EL. Krankheiten der
Verdauungsorgange. In: Hadorn, Lehrbuch der Therapie. Ed. T. Hess. Hans Huber
Verlag, Bern, 1993; 413-450.
Halter F, Schmassmann A, Tarnawski A. Das Ulkus – mehr als Säure und
Helicobacter? In: Perspektiven der Gastroenterologie. Eds. K.-H. Meyer zum
Büschenfelde, Paumgartner G, Schölmerich J. Urban & Schwarzenberg. München,
Wien, Baltimore. 1994: 35-41.
Halter F, Schmassmann A. Trophic effects of gastrin: therapeutic and
pathophysiologic implications: in The stomach. Eds. Domscke and Konturek.
Macmillan India Ltd. Bangalore. 1993: 59-67.
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Morscher E, Graf R, Kohler O, Schmassmann. Vergleiche der Resultate zementierter
und nicht-zementierter Hüftgelenkpfannen. Primär- und Revisionsalloarthroplastik.
Endo-Klinik, Hamburg, Springer-Verlag. Berlin, Heidelberg. 1987; 117-126.
Wissenschaftliche Zeitschriften
A. ORIGINALARBEITEN
Gelistet nach Kategorien und Ranking
A1. Gastroenterology & Hepatology
1. Schmassmann A, Waser B, Flogerzi B, Reubi JC. Expression of functional
neurokinin-1 receptors in regenerative glands during gastric wound healing in
rodents. Gastroenterology 2004; 126: 784-95. Ranking 1/46,
2. Schmassmann A, Stettler C, Poulsom R, Tarasova N, Hirschi C, Flogerzi B,
Matsumoto K, Nakamura T, Halter F. Roles of hepatocyte growth factor and its
receptor Met during gastric ulcer healing in rats. Gastroenterology 1997; 113: 1858-
72. Ranking 1/46
3. Reubi JC, Waser B, Laderach U, Stettler C, Friess H, Halter F, Schmassmann A.
Localization of cholecystokinin A and cholecystokinin B-gastrin receptors in the
human stomach. Gastroenterology 1997; 112: 1197-205. Ranking 1/46
4. Reubi JC, Waser B, Schmassmann A, Halter F. Persistent lack of somatostatin
receptors in gastric mucosa of healing ulcers in rats. Gastroenterology 1994; 107:
339-46. Ranking 1/46
5. Schmassmann A, Fehr HF, Locher J, Lillienau J, Schteingart CD, Rossi SS, Hofmann
AF. Cholylsarcosine, a new bile acid analogue: metabolism and effect on biliary
secretion in humans. Gastroenterology 1993; 104:1171-81. Ranking 1/46
6. Marcus SN, Schteingart CD, Marquez ML, Hofmann AF, Xia Y, Steinbach JH, Ton-Nu
HT, Lillienau J, Angellotti MA, Schmassmann A. Active absorption of conjugated bile
acids in vivo. Kinetic parameters and molecular specificity of the ileal transport
system in the rat. Gastroenterology 1991; 100: 212-21. Ranking 1/46
7. Schmassmann A, Angellotti MA, Clerici C, Hofmann AF, Ton-Nu HT, Schteingart CD,
Marcus SN, Hagey LR, Rossi SS, Aigner A. Transport, metabolism, and effect of
chronic feeding of lagodeoxycholic acid. A new, natural bile acid. Gastroenterology
1990; 99: 1092-104. Ranking 1/46
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8. Schmassmann A, Angellotti MA, Ton-Nu HT, Schteingart CD, Marcus SN, Rossi SS,
Hofmann AF. Transport, metabolism, and effect of chronic feeding of
cholylsarcosine, a conjugated bile acid resistant to deconjugation and
dehydroxylation. Gastroenterology 1990; 98: 163-74. Ranking 1/46
9. Schmassmann A, Hofmann AF, Angellotti MA, Ton-Nu HT, Schteingart CD, Clerici C,
Rossi SS, Rothschild MA, Cohen BI, Stenger RJ, Mosbach EH. Prevention of
ursodeoxycholate hepatotoxicity in the rabbit by conjugation with N-methyl amino
acids. Hepatology 1990; 11: 989-96. Ranking 2/46
10. Netzer P, Forster C, Biral R, Ruchti C, Neuweiler J, Stauffer E, Schonegg R, Maurer
C, Husler J, Halter F, Schmassmann A. Risk factor assessment of endoscopically
removed malignant colorectal polyps. Gut 1998; 43: 669-74. Ranking 3/46
10
11. Schmassmann A, Tarnawski A, Gerber HA, Flogerzi B, Sanner M, Varga L, Halter F.
Antacid provides better restoration of glandular structures within the gastric ulcer scar
than omeprazole. Gut 1994; 35: 896-904. Ranking 3/46
12. Schmassmann A, Garner A, Flogerzi B, Hasan MY, Sanner M, Varga L, Halter F.
Cholecystokinin type B receptor antagonist PD-136,450 is a partial secretory agonist
in the stomach and a full agonist in the pancreas of the rat. Gut 1994; 35: 270-4.
Ranking 3/46
13. Schmassmann A, Meyenberger C, Knuchel J, Binek J, Lammer F, Kleiner B,
Hurlimann S, Inauen W, Hammer B, Scheurer U, Halter F. Self-expanding metal
stents in malignant esophageal obstruction: a comparison between two stent types.
Am J Gastroenterol 1997; 92: 400-6. Ranking 4/46, IF: 5.116
14. Schmassmann A, von Gunten E, Knuchel J, Scheurer U, Fehr HF, Halter F.
Wallstents versus plastic stents in malignant biliary obstruction: effects of stent
patency of the first and second stent on patient compliance and survival. Am J
Gastroenterol 1996; 91: 654-9. Ranking 4/46, IF: 5.116
15. Schmassmann A, Zoidl G, Peskar BM, Waser B, Schmassmann-Suhijar D, Gebbers
JO, Reubi JC. Role of the different isoforms of cyclooxygenase and nitric oxide
synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice. Am
J Physiol Gastrointest Liver Physiol 2006; 290: G747-56. Ranking 10/46, IF:
3.472
16. Schmassmann A, Tarnawski A, Peskar BM, Varga L, Flogerzi B, Halter F. Influence
of acid and angiogenesis on kinetics of gastric ulcer healing in rats: interaction with
indomethacin. Am J Physiol Gastrointest Liver Physiol 268: G276-85. Ranking
10/46, IF: 3.472
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17. Stoffel MH, Friess AE, Burnens A, Schmassmann A, Neiger R. Distinction of gastric
Helicobacter spp. in humans and domestic pets by scanning electron microscopy.
Helicobacter 2000; 5:232-9. Ranking 13/46, IF: 2.584
18. Netzer P, Buttiker U, Pfister M, Halter F, Schmassmann A. Frequency of advanced
neoplasia in the proximal colon without an index polyp in the rectosigmoid. Dis Colon
Rectum 1999; 42: 661-7. Ranking 18/46, IF: 2.264
19. Fujiwara Y, Schmassmann A, Arakawa T, Halter F, Tarnawski A. Indomethacin
interferes with epidermal growth factor binding and proliferative response of gastric
KATO III cells. Digestion 1995; 56: 364-9. Ranking 22/46, IF: 1.826
20. Netzer P, Binek J, Hammer B, Lange J, Schmassmann A. Significance of histologic
criteria for the management of patients with malignant colorectal polyps and
polypectomy. Scand J Gastroenterol 1997; 32: 910-16. Ranking 22/46, IF: 1.790
21. Schmassmann A, Fehr HF, Locher J, Klotz J. Pharmacokinetics and toxicity of highdose
topical colonic 5-aminosalicylic acid therapy in patients with severe active total
ulcerative colitis. Eur J Gastroenterol Hepatol 1993; 5: 927-934. Ranking 29/46, IF:
1.690
22. Schmassmann A, Tarnawski A, Flogerzi B, Sanner M, Varga L, Halter F. Antacids in
experimental gastric ulcer healing: pharmacokinetics of aluminium and quality of
healing. Eur J Gastroenterol Hepatol 1993, 5: S111-S116. Ranking 29/46
23. Heidemann J, Schilling MK, Schmassmann A, Maurer CA, Buchler MW. Accuracy of
endoscopic ultrasonography in preoperative staging of esophageal carcinoma. Dig
Surg 2000; 17: 219-24. Ranking 37/46
24. Loertzer H, Hinze R, Knolle J, Rath FW, Schmassmann A. Significance of
proliferative activity and DNA ploidy in pancreatic cancer and chronic pancreatitis. Int
J Pancreatol 1999; 26: 77-83
A2. Medicine, Research & Experimental
25. Schmassmann A, Reubi JC. Cholecystokinin-B/gastrin receptors enhance wound
healing in the rat gastric mucosa. J Clin Invest 2000; 106: 1021-9. Ranking 2/72
A3. Pharmacology & Pharmacy
26. Schmassmann A, Peskar BM, Stettler C, Netzer P, Stroff T, Flogerzi B, Halter F.
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastrointestinal
ulcer models in rats. Br J Pharmacol 1998; 123: 795-804. Ranking 42/193
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A4. Oncology
27. Reubi JC, Waser B, Schmassmann A, Laissue JA. Receptor autoradiographic
evaluation of cholecystokinin, neurotensin, somatostatin and vasoactive intestinal
peptide receptors in gastro-intestinal adenocarcinoma samples: where are they really
located? Int J Cancer 1999; 81: 376-86. Ranking 22/123
A5. Microbiology
28. Neiger R, Dieterich C, Burnens A, Waldvogel A, Corthesy-Theulaz I, Halter F,
Lauterburg B, Schmassmann A. Detection and prevalence of Helicobacter infection in
pet cats. J Clin Microbiol 1998; 36: 634-7. Ranking 20/86
A6. Diverses
29. Schmassmann A, Mikuz G, Bartsch G, Rohr H. Spermiometrics: objective and
reproducible methods for evaluating sperm morphology. Eur Urol 1982; 8: 274-279.
Ranking 8/51
30. Schmassmann A, Zuber M, Livers M, Jäger K, Jenzer HR, Fehr HF. Recurrent
bleeding after variceal hemorrhage: predictive value of portal venous duplex
sonography Am J Roentgenol 1993; 160: 41-7. Ranking 5/84
31. Bastaki SM, Hasan MY, Chandranath SI, Schmassmann A, Garner A. PD-136,450: a
CCK2 (gastrin) receptor antagonist with antisecretory, anxiolytic and antiulcer activity.
Mol Cell Biochem 2003; 252: 83-90
32. Schmassmann A, Mikuz G, Bartsch G, Gysin C, Rohr HP. Deoxyribonucleic acid
(DNA) content of morphologically different sperm types from normal and subfertile
human males. Andrologia 1981; 13: 33-41. Ranking 4/5
12
33. Neiger R, Seiler G, Schmassmann A. Use of a urea breath test to evaluate short-term
treatments for cats naturally infected with Helicobacter heilmannii. Am J Vet Res
1999; 60:880-3. Ranking 5/129
34. Morscher E, Schmassmann A. Failures of total hip arthroplasty and probable
incidence of revision surgery in the future. Calculations according to a mathematical
model based on a ten years' experience in total hip arthroplasty. Arch Orthop
Trauma Surg 1983; 101: 137-43.
35. Netzer P, Binek J, Hammer B, Schmassmann A. Utility of abdominal sonography in
patients with idiopathic deep vein thrombosis. J Clin Ultrasound 1999; 27: 177-81.
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36. Schmassmann A, Mihatsch MJ. Prostatic carcinoma. Incidence and significance of
stage I - preclinical carcinoma. Urologe A 1983; 22 Suppl: 388-92.
37. Neiger R, Tschudi ME, Burnens A, Göke B, Schmassmann A. Diagnosis and
identification of gastric helicobacter species by polymerase chain reaction in dogs.
Microb Ecol Health Dis 1999; 11: 234-240.
38. Kleiner B, Schmassmann A, Scheurer U, Buchler MW, Halter F. 15 years of
endoscopic therapy in choledocholithiasis. Schweiz Med Wochenschr 1996; 126:
1680-7.
39. Gysi B, Schmassmann A, Scheurer U, Halter F. 12 years of endoscopic stone
removal. Schweiz Med Wochenschr 1993; 123: 1115-7.
40. Mihatsch MJ, Rist M, Ohnacker H, Oberholzer M, Spichtin HP, Schmassmann A,
Perret A, Torhorst J, Rutishauser G. Prostatic cancer. Reliability of clinical staging
and the prognostic significance of age, clinical stage and tumor morphology. Z Urol
Nephrol 1983; 76: 281-97.
41. Schmassmann A, Mikuz G, Bartsch G, Rohr H. Quantification of human sperm
morphology and motility by means of semi-automatic image analysis systems.
Microsc Acta 1979; 82: 163-78.
B. ÜBERSICHTSARBEITEN
1. Schmassmann A, Gebbers JO. Barrett's esophagus: diagnosis and therapy. Schweiz
Rundsch Med Prax 2005; 94: 861-8.
2. Halter F, Tarnawski AS, Schmassmann A, Peskar BM. Cyclooxygenase 2-
implications on maintenance of gastric mucosal integrity and ulcer healing:
controversial issues and perspectives. Gut 2001; 49: 443-53.
3. Peskar BM, Maricic N, Gretzera B, Schuligoi R, Schmassmann A. Role of
cyclooxygenase-2 in gastric mucosal defense. Life Sci 2001; 69: 2993-3003.
4. Schmassmann A, Di Nicola A. Prophylaxe und Therapie der Ösophagusvarizen.
Swiss Med Forum 2001; 12: 313-319.
5. Schmassmann A. Nonsurgical therapies for hepatocellular and cholangiocellular
carcinoma. Swiss Surg 1999; 5: 95-100.
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6. Schmassmann A. Esophageal carcinoma: accurate staging thanks to modern
diagnostic methods open up new therapeutic strategies. Schweiz Med Wochenschr
1999; 129: 1207-10.
7. Schmassmann A. Staging of esophagus carcinoma. Ther Umsch 1998; 55: 432-4.
8. Schmassmann A. Mechanisms of ulcer healing and effects of nonsteroidal antiinflammatory
drugs. Am J Med 1998; 104(3A): 43S-51S.
9. Burchert A, Schmassmann A. Evaluation of various screening and surveillance
methods in colorectal carcinoma. Schweiz Med Wochenschr 1998; 128: 999-1011..
10. Loertzer H, Schmassmann A. Interventionelle endoskopische Therapie des malignen
Verschlussikterus beim Pankreaskarzinom. Chir Gastroenterol 1998; 14: 32-36.
11. Halter F, Rainsford KD, Sirko SP, Schmassmann A. NSAID-induced mucosal injury:
Analysis of gastric toxicity of new generation NSAIDs: Ulcerogenicity compared with
ulcer healing. Yale J Biol Med 1997; 70: 33-43.
12. Schmassmann A. Possibilities and limitations in endosonography of the
gastrointestinal tract. Ther Umsch 1997; 54: 31-6.
13. Schmassmann A. Pancreatic carcinoma: conservative and adjuvant therapy. Ther
Umsch 1996; 53: 387-93.
14. Halter F, Schmassmann A, Tarnawski A. Healing of experimental gastric ulcers.
Interference by gastric acid. Dig Dis Sci 1995; 40: 2481-86.
15. Schmassmann A, Tarnawski A, Halter F. Growth factors in benign gastrointestinal
diseases. Dig Surg 1994; 11: 133-137
16. Schmassmann A, Halter F. Cancer of the pancreas. Diagnosis and staging in
pancreatic cancer: Endoscopic retrograde cholangiopancreatography and endoscopic
ultrasound. Dig Surg 1994; 11: 346-350.
17. Schmassmann A, Halter F. Local or systemic therapies of inflammatory bowel
diseases? Ther Umsch 1993; 50: 94-9.
14
18. Schmassmann A, Zuber M, Ritz R. MTBE litholysis and extracorporeal shock wave
lithotripsy of gallstones. Schweiz Med Wochenschr 1988; 118: 1297-300.
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BRIEFE, KOMMENTARE, FALLBEISPIELE, BUCHBEITRÄGE
(nach Publikationsjahr aufgelistet)
BRIEFE (LETTERS)
1. Schmassmann A, Zehnder P, Gebbers JO, Wildisen A. Severe self limiting sclerosing
cholangitis after pancreaticoduodenectomy due to autoimmune pancreatitis. Gut
2006; 55: 1361-2.
2. Yoon S, Schmassmann-Suhijar D, Zuber M, Konietzny P, Schmassmann A.
Chemotherapy with bevacizumab, irinotecan, 5-fluorouracil and leucovorin (IFL)
associated with a large, embolizing thrombus in the thoracic aorta. Ann Oncol 2006
Jun 15
KOMMENTARE (COMMENTARIES)
3. Schmassmann A. Aspirin injury and H pylori. Gut 2002; 50: 589-90.
FALLBEISPIELE (CASE REPORTS)
4. Schmassmann-Suhijar D, Schmassmann A. Aphthous esophagitis as an atypical
manifestation of a primary HIV-infection. Dtsch Med Wochenschr 2001; 126:1136-8.
5. Schmassmann A. A patient with choledocholithiasis--no therapy without risk. Ther
Umsch 1998; 55: 589-91.
6. Triller J, Schmassmann A, Schweizer W, Czerniak A. Combined interventional
radiological and endoscopical approach for the treatment of a postoperative biliary
stricture and fistula. HPB Surgery 1995; 8: 257-262.
7. Moch H, Spondlin M, Schmassmann A, Mihatsch MJ. Systemic karyomegaly with
chronic interstitial nephritis. Discussion of the disease picture based on an autopsy
case. Pathologe 1994; 15: 44-8.
8. Schmassmann A, Tarnawski A, Flogerzi A, Sanner M, Varga L, Halter F. Dynamics of
drug interference with healing of experimental gastric ulcers. Eur J Gastroenterol
Hepatol 1993; S13-S20.
9. Tarnawski A, Halter F, Schmassmann A, Vatier J, Garner A. Experimental models for
the assessment of antacid action on gastrointestinal mucosa and ulcer healing. Eur J
Gastroenterol Hepatol 1992; 4: 12, 966-976.
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10. Marks IN, Schmassmann A, Halter F, Lam SK, Weberg R, Porro GB, Parente F,
Tarnawski A. Antacid therapy today. Eur J Gastroenterol Hepatol 1992; 4: 12, 977-
983.
15
11. Schaffner A, Torhorst J, Schwendener R, Moll C, Schmassmann A. Lupus
erythematosus (SLE), pneumopathy and fever. Schweiz Rundsch Med Prax. 1988;
77: 114-22.
12. Schmassmann A. The case from practice (67). Patient: Mr. S.H., born 1 February
1962, a farmer. Schweiz Rundsch Med Prax 1986; 75: 1432-3.
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