Prof. Dr. Ulrich Walter

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Membership in Advisory boards 1996 – 2002 Interdisciplinary Centre for Clinical Research (IZKF), University of Cologne 1996 – present Deutsches Diabetes Forschungsinstitut (DFI), University of Düsseldorf 2000 – present BMBF-committee for Clinical Research of the new federal states of Germany 2003 – present Vasopharm biotech GmbH 2005 - present Elected member of the referee panel for the Helmholtz Graduate Schools Membership in multiple professional societies, i.e Ges.f. Biochemie und. Molekularbiologie (GBM); Dt. Ges.f. Thrombose und Hämostase (GTH); American Heart Association (AHA); International Society of Thrombosis & Haemostasis (ISTH); Dt. Ges. f Innere Medizin; Dt. Ges. f. Kardiologie (DGK); Dt. Ges. f. Klinische Chemie und Laboratoriumsmedizin (DGKL); American Society of Biochemistry and Molecular Biology (ASBMB) Project Management 1985-1999 SFB 176, project leader 1989-1995 DFG Clinical Research Unit, project leader 1993-2004 SFB 355, founding member, project leader, coordinator/vice-coordinator 1996-2003 IZKF, founding member/vice-coordinator, project leader 1997-2004 MDPhD program, Coordinator Medical Faculty 2006 Coordinator SFB 688 “Cardiovascular Cell Cell interactions” 10 Selected Publications 1. Schmidt HHHW, Walter U (1994) NO at work. Cell 78, 919-925 (review) 2. Jarchau T, Häusler C, Markert T, Pöhler D, Vandekerckhove J, De Jonge H R, Lohmann S M, Walter U (1994) Cloning, expression, and in situ localization of rat intestinal cGMP dependent protein kinase II. Proc. Natl. Acad. Sci. USA, 91, 9426- 9430 3. Haffner C, Jarchau T, Reinhard M, Hoppe J, Lohmann SM, Walter U (1995) Molecular cloning and expression of the proline-rich focal adhesion and microfilament associated protein VASP. EMBO J. 14, 19–27 4. Geiger J, Brich J, Hönig-Liedl P, Eigenthaler M, Schanzenbächer P, Herbert JM and Walter U (1999) Specific Impairment Of Human Platelet P2YAC ADP Receptor- Mediated Signaling By The Antiplatelet Drug Clopidogrel. Arterioscler Thromb Vasc Biol 19, 2007-2011 5. Ball L J, Kühne R, Hoffmann B, Häfner A, Schmieder P, Volkmer-Engert R, Hof M, Wahl M, Schneider-Mergener J, Walter U, Oschkinat H, Jarchau T (2000) Dual epitope recognition by the VASP EVH1 domain modulates polyproline ligand specificity and binding affinity. EMBO J 19, 4903-4914 6. Ball, L J, Jarchau, T, Oschkinat, H and Walter, U. (2002) EVH1 domains: structure, function and interactions. FEBS Lett, 513, 45-52. (review) 7. Massberg S, Gruner S, Konrad I, Garcia Arguinzonis MI, Eigenthaler M, Hemler K, Kersting J, Schulz C, Muller I, Besta F, Nieswandt B, Heinzmann U, Walter U, Gawaz M (2004). Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)-deficient mice. Blood 103, 136 - 142. 8. Kuhnel K, Jarchau T, Wolf E, Schlichting I, Walter U, Wittinghofer A and Strelkov S. (2004) The VASP tetramerization domain is a right-handed coiled coil based on a 15residue repeat. Proc Natl Acad Sci U S A, 101, 17027 - 17032 9. Begonja, A.J., Gambaryan, S., Geiger, J., Aktas, B., Pozgajova, M., Nieswandt, B. and Walter, U. (2005) Platelet NAD(P)H oxidase-generated ROS production regulates {alpha}IIb{beta}3 integrin activation independent of the NO/cGMP pathway. Blood, 106, 2757 – 2760 10. Lohmann SM and Walter U. (2005) Tracking functions of cGMP-dependent protein kinases (cGK) Front Biosci , 10, 1313-1328. (review) 2
Other Original Publications (2001 - 2005) 1. Fischer, T.A., Palmetshofer, A., Gambaryan, S., Butt, E., Jassoy, C., Walter, U., Sopper, S. and Lohmann, S.M. (2001) Activation of cGMP-dependent protein kinase Ibeta inhibits interleukin 2 release and proliferation of T cell receptor-stimulated human peripheral T cells. J Biol Chem, 276, 5967-5974. 2. Maier, S., Lange, V., Simm, A., Walter, U. and Kirstein, M. (2001) Insulin fails to modulate the cardiac L-type Ca2+ current in Type II diabetes patients--a possible link to cardiac dysfunction in diabetes mellitus. Diabetologia, 44, 269. 3. Marienfeld, U., Walter, U. and Simm, A. (2001) Inhibition of rat cardiac fibroblast growth by cAMP--but not by cGMP- dependent protein kinase. Basic Res Cardiol, 96, 184-191. 4. Mulsch, A., Oelze, M., Kloss, S., Mollnau, H., Topfer, A., Smolenski, A., Walter, U., Stasch, J.P., Warnholtz, A., Hink, U., Meinertz, T. and Munzel, T. (2001) Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta. Circulation, 103, 2188-2194. 5. Bader, B., Butt, E., Palmetshofer, A., Walter, U., Jarchau, T. and Drueckes, P. (2001) A cGMP-dependent protein kinase assay for high throughput screening based on time-resolved fluorescence resonance energy transfer. J Biomol Screen, 6, 255-264. 6. Gambaryan, S., Hauser, W., Kobsar, A., Glazova, M. and Walter, U. (2001) Distribution, cellular localization, and postnatal development of VASP and Mena expression in mouse tissues. Histochem Cell Biol, 116, 535-543. 7. Grossmann, R., Geisen, U. and Walter, U. (2001) In vivo haemostatic effects of activated prothrombin complex concentrate and recombinant factor VIIa in a haemophilia A patient with inhibitors. Haemophilia, 7, 589-591. 8. Zimmermann, J., Labudde, D., Jarchau, T., Walter, U., Oschkinat, H. and Ball, L.J. (2002) Relaxation, equilibrium oligomerization, and molecular symmetry of the VASP (336-380) EVH2 tetramer. Biochemistry, 41, 11143-11151. 9. Zabel, U., Kleinschnitz, C., Oh, P., Nedvetsky, P., Smolenski, A., Muller, H., Kronich, P., Kugler, P., Walter, U., Schnitzer, J.E. and Schmidt, H.H. (2002) Calciumdependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide. Nat Cell Biol, 4, 307-311. 10. Warnholtz, A., Mollnau, H., Heitzer, T., Kontush, A., Moller-Bertram, T., Lavall, D., Giaid, A., Beisiegel, U., Marklund, S.L., Walter, U., Meinertz, T. and Munzel, T. (2002) Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits. J Am Coll Cardiol, 40, 1356-1363. 11. Schulz, E., Tsilimingas, N., Rinze, R., Reiter, B., Wendt, M., Oelze, M., Woelken- Weckmuller, S., Walter, U., Reichenspurner, H., Meinertz, T. and Munzel, T. (2002) Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment. Circulation, 105, 1170-1175. 12. Renne, T., Sugiyama, A., Gailani, D., Jahnen-Dechent, W., Walter, U. and Muller- Esterl, W. (2002) Fine mapping of the H-kininogen binding site in plasma prekallikrein apple domain 2. Int Immunopharmacol, 2, 1867-1873. 13. Mollnau, H., Wendt, M., Szocs, K., Lassegue, B., Schulz, E., Oelze, M., Li, H., Bodenschatz, M., August, M., Kleschyov, A.L., Tsilimingas, N., Walter, U., Forstermann, U., Meinertz, T., Griendling, K. and Munzel, T. (2002) Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling. Circ Res, 90, E58-65. 14. Aktas, B., Honig-Liedl, P., Walter, U. and Geiger, J. (2002) Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP- dependent protein kinase. Biochem Pharmacol, 64, 433-439. 3
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Prof. Dr. Ulrich Walter

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