Prof. Dr. Ulrich Walter

Prof. Dr. Ulrich Walter
Chairman of Clinical Biochemistry, Institute of Clinical Biochemistry and Pathobiochemistry,
University of Würzburg, Josef-Schneider-Str. 2, D-97080 Würzburg, Germany
Curriculum vitae
Born: 17.09.1949 in Uelzen, Germany
1968 - 1975 Education in Medicine (University of Göttingen, Germany) and Biochemistry
(Brandeis University, Waltham/Boston)
1975 Dissertation (MD thesis), Clinical Biochemistry (Prof.H.D. Söling), Göttingen
1975 - 1980 Research Associate, Pharmacology (Yale University New Haven/ USA;
laboratory of Prof. Paul Greengard, Nobel laureate of the year 2000)
1980 - 1985 Research Career Development Award (DFG Heisenberg-Fellowship),
University of Würzburg / Texas University at Houston (USA)
1985 Habilitation (faculty member), Clinical Biochemistry, Würzburg
1985 - 1999 Founding member and group leader in the SFB 176 (Centre grant)
1989 - 1995 Director (C3/C4-Professorship) of a DFG Clinical Research Group
“Cardiovascular Signal Transduction”, University of Würzburg
1989 / 2000 Board Certification in Internal Medicine / Laboratory Medicine
1995 / 1996 Acting Director, Forschungsinstitut f. Molekulare Pharmakologie (Berlin)
1995 – 1997 C4-Professor (chair),Clinical Biochem. & Pathobiochem, Univ. of Würzburg
1998 - Co-founder, vasopharm biotech GmbH (Würzburg)
2001 - Director, Central Laboratory / Clinical Chemistry, Univ. Hospital Würzburg
2004 - Elected member of the board of directors, Univ. Hospital Würzburg
2006 Coordinator of the SFB 688 “Cardiovascular Cell Cell interactions”
Research Topics:
Signaling by cAMP-/cGMP-dependent protein kinases and their substrates
Physiological / Pathological Biochemistry & Cross-talk of NO/cGMPmediated
signaling in cardiovascular cells
Structure / Function / Cell biology of the Ena/VASP-protein family
Biochemistry and Pharmacology of platelet receptors and signaling
Vascular Biology and Pathobiochemistry
Selected Awards
1971 Fulbright / Wien Fellowship
1980 Heisenberg-Fellowship
1989 Clinical Research Professorship of the DFG
1995 Clinical Research Award, Smith Kline Beecham Foundation
2004 Elected member of the DFG-study section “medicine”
2004 Elected member of the Deutsche Akademie der Naturforscher Leopoldina
Editorial work:
Thrombosis Haemostasis (Editorial Board / section editor since 2002),
J Biol Chem (Editorial Board since 2003)
Protein Modules Consortium (http://www.proteinmodules.org) since 2004
Referee work for EMBO Journal, Nature, Blood and others
Reviewer for Funding (granting) agencies
DFG, BMBF, MPG, NIH, NSF, Academies and Foundations
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Membership in Advisory boards
1996 – 2002 Interdisciplinary Centre for Clinical Research (IZKF), University of Cologne
1996 – present Deutsches Diabetes Forschungsinstitut (DFI), University of Düsseldorf
2000 – present BMBF-committee for Clinical Research of the new federal states of Germany
2003 – present Vasopharm biotech GmbH
2005 - present Elected member of the referee panel for the Helmholtz Graduate Schools
Membership in multiple professional societies, i.e Ges.f. Biochemie und. Molekularbiologie
(GBM); Dt. Ges.f. Thrombose und Hämostase (GTH); American Heart Association (AHA);
International Society of Thrombosis & Haemostasis (ISTH); Dt. Ges. f Innere Medizin; Dt.
Ges. f. Kardiologie (DGK); Dt. Ges. f. Klinische Chemie und Laboratoriumsmedizin (DGKL);
American Society of Biochemistry and Molecular Biology (ASBMB)
Project Management
1985-1999 SFB 176, project leader
1989-1995 DFG Clinical Research Unit, project leader
1993-2004 SFB 355, founding member, project leader, coordinator/vice-coordinator
1996-2003 IZKF, founding member/vice-coordinator, project leader
1997-2004 MDPhD program, Coordinator Medical Faculty
2006 Coordinator SFB 688 “Cardiovascular Cell Cell interactions”
10 Selected Publications
1. Schmidt HHHW, Walter U (1994) NO at work. Cell 78, 919-925 (review)
2. Jarchau T, Häusler C, Markert T, Pöhler D, Vandekerckhove J, De Jonge H R,
Lohmann S M, Walter U (1994) Cloning, expression, and in situ localization of rat
intestinal cGMP dependent protein kinase II. Proc. Natl. Acad. Sci. USA, 91, 9426-
9430
3. Haffner C, Jarchau T, Reinhard M, Hoppe J, Lohmann SM, Walter U (1995)
Molecular cloning and expression of the proline-rich focal adhesion and microfilament
associated protein VASP. EMBO J. 14, 19–27
4. Geiger J, Brich J, Hönig-Liedl P, Eigenthaler M, Schanzenbächer P, Herbert JM and
Walter U (1999) Specific Impairment Of Human Platelet P2YAC ADP Receptor-
Mediated Signaling By The Antiplatelet Drug Clopidogrel. Arterioscler Thromb Vasc
Biol 19, 2007-2011
5. Ball L J, Kühne R, Hoffmann B, Häfner A, Schmieder P, Volkmer-Engert R, Hof M,
Wahl M, Schneider-Mergener J, Walter U, Oschkinat H, Jarchau T (2000) Dual
epitope recognition by the VASP EVH1 domain modulates polyproline ligand
specificity and binding affinity. EMBO J 19, 4903-4914
6. Ball, L J, Jarchau, T, Oschkinat, H and Walter, U. (2002) EVH1 domains: structure,
function and interactions. FEBS Lett, 513, 45-52. (review)
7. Massberg S, Gruner S, Konrad I, Garcia Arguinzonis MI, Eigenthaler M, Hemler K,
Kersting J, Schulz C, Muller I, Besta F, Nieswandt B, Heinzmann U, Walter U, Gawaz
M (2004). Enhanced in vivo platelet adhesion in vasodilator-stimulated
phosphoprotein (VASP)-deficient mice. Blood 103, 136 - 142.
8. Kuhnel K, Jarchau T, Wolf E, Schlichting I, Walter U, Wittinghofer A and Strelkov S.
(2004) The VASP tetramerization domain is a right-handed coiled coil based on a 15residue
repeat. Proc Natl Acad Sci U S A, 101, 17027 - 17032
9. Begonja, A.J., Gambaryan, S., Geiger, J., Aktas, B., Pozgajova, M., Nieswandt, B.
and Walter, U. (2005) Platelet NAD(P)H oxidase-generated ROS production
regulates {alpha}IIb{beta}3 integrin activation independent of the NO/cGMP pathway.
Blood, 106, 2757 – 2760
10. Lohmann SM and Walter U. (2005) Tracking functions of cGMP-dependent protein
kinases (cGK) Front Biosci , 10, 1313-1328. (review)
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Other Original Publications (2001 - 2005)
1. Fischer, T.A., Palmetshofer, A., Gambaryan, S., Butt, E., Jassoy, C., Walter, U.,
Sopper, S. and Lohmann, S.M. (2001) Activation of cGMP-dependent protein kinase
Ibeta inhibits interleukin 2 release and proliferation of T cell receptor-stimulated
human peripheral T cells. J Biol Chem, 276, 5967-5974.
2. Maier, S., Lange, V., Simm, A., Walter, U. and Kirstein, M. (2001) Insulin fails to
modulate the cardiac L-type Ca2+ current in Type II diabetes patients--a possible link
to cardiac dysfunction in diabetes mellitus. Diabetologia, 44, 269.
3. Marienfeld, U., Walter, U. and Simm, A. (2001) Inhibition of rat cardiac fibroblast
growth by cAMP--but not by cGMP- dependent protein kinase. Basic Res Cardiol,
96, 184-191.
4. Mulsch, A., Oelze, M., Kloss, S., Mollnau, H., Topfer, A., Smolenski, A., Walter, U.,
Stasch, J.P., Warnholtz, A., Hink, U., Meinertz, T. and Munzel, T. (2001) Effects of in
vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and
cGMP-dependent protein kinase and their downstream target vasodilator-stimulated
phosphoprotein in aorta. Circulation, 103, 2188-2194.
5. Bader, B., Butt, E., Palmetshofer, A., Walter, U., Jarchau, T. and Drueckes, P. (2001)
A cGMP-dependent protein kinase assay for high throughput screening based on
time-resolved fluorescence resonance energy transfer. J Biomol Screen, 6, 255-264.
6. Gambaryan, S., Hauser, W., Kobsar, A., Glazova, M. and Walter, U. (2001)
Distribution, cellular localization, and postnatal development of VASP and Mena
expression in mouse tissues. Histochem Cell Biol, 116, 535-543.
7. Grossmann, R., Geisen, U. and Walter, U. (2001) In vivo haemostatic effects of
activated prothrombin complex concentrate and recombinant factor VIIa in a
haemophilia A patient with inhibitors. Haemophilia, 7, 589-591.
8. Zimmermann, J., Labudde, D., Jarchau, T., Walter, U., Oschkinat, H. and Ball, L.J.
(2002) Relaxation, equilibrium oligomerization, and molecular symmetry of the VASP
(336-380) EVH2 tetramer. Biochemistry, 41, 11143-11151.
9. Zabel, U., Kleinschnitz, C., Oh, P., Nedvetsky, P., Smolenski, A., Muller, H., Kronich,
P., Kugler, P., Walter, U., Schnitzer, J.E. and Schmidt, H.H. (2002) Calciumdependent
membrane association sensitizes soluble guanylyl cyclase to nitric oxide.
Nat Cell Biol, 4, 307-311.
10. Warnholtz, A., Mollnau, H., Heitzer, T., Kontush, A., Moller-Bertram, T., Lavall, D.,
Giaid, A., Beisiegel, U., Marklund, S.L., Walter, U., Meinertz, T. and Munzel, T.
(2002) Adverse effects of nitroglycerin treatment on endothelial function, vascular
nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic
Watanabe rabbits. J Am Coll Cardiol, 40, 1356-1363.
11. Schulz, E., Tsilimingas, N., Rinze, R., Reiter, B., Wendt, M., Oelze, M., Woelken-
Weckmuller, S., Walter, U., Reichenspurner, H., Meinertz, T. and Munzel, T. (2002)
Functional and biochemical analysis of endothelial (dys)function and NO/cGMP
signaling in human blood vessels with and without nitroglycerin pretreatment.
Circulation, 105, 1170-1175.
12. Renne, T., Sugiyama, A., Gailani, D., Jahnen-Dechent, W., Walter, U. and Muller-
Esterl, W. (2002) Fine mapping of the H-kininogen binding site in plasma prekallikrein
apple domain 2. Int Immunopharmacol, 2, 1867-1873.
13. Mollnau, H., Wendt, M., Szocs, K., Lassegue, B., Schulz, E., Oelze, M., Li, H.,
Bodenschatz, M., August, M., Kleschyov, A.L., Tsilimingas, N., Walter, U.,
Forstermann, U., Meinertz, T., Griendling, K. and Munzel, T. (2002) Effects of
angiotensin II infusion on the expression and function of NAD(P)H oxidase and
components of nitric oxide/cGMP signaling. Circ Res, 90, E58-65.
14. Aktas, B., Honig-Liedl, P., Walter, U. and Geiger, J. (2002) Inhibition of platelet
P2Y12 and alpha2A receptor signaling by cGMP- dependent protein kinase.
Biochem Pharmacol, 64, 433-439.
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15. Garcia Arguinzonis, M.I., Galler, A.B., Walter, U., Reinhard, M. and Simm, A. (2002)
Increased spreading, Rac/p21-activated kinase (PAK) activity, and compromised cell
motility in cells deficient in vasodilator-stimulated phosphoprotein (VASP). J Biol
Chem, 277, 45604-45610.
16. Grossmann, R., Geisen, U., Merati, G., Mullges, W., Schambeck, C.M., Walter, U.
and Schwender, S. (2002a) Genetic risk factors in young adults with 'cryptogenic'
ischemic cerebrovascular disease. Blood Coagul Fibrinolysis, 13, 583-590.
17. Grossmann, R., Schwender, S., Geisen, U., Schambeck, C., Merati, G. and Walter,
U. (2002b) CBS 844ins68, MTHFR TT677 and EPCR 4031ins23 genotypes in
patients with deep-vein thrombosis. Thromb Res, 107, 13-15.
18. Schafer, A., Burkhardt, M., Vollkommer, T., Bauersachs, J., Munzel, T., Walter, U.
and Smolenski, A. (2003a) Endothelium-dependent and -independent relaxation and
VASP serines 157/239 phosphorylation by cyclic nucleotide-elevating vasodilators in
rat aorta. Biochem Pharmacol, 65, 397-405.
19. Mollnau, H., Schulz, E., Daiber, A., Baldus, S., Oelze, M., August, M., Wendt, M.,
Walter, U., Geiger, C., Agrawal, R., Kleschyov, A.L., Meinertz, T. and Munzel, T.
(2003) Nebivolol Prevents Vascular NOS III Uncoupling in Experimental
Hyperlipidemia and Inhibits NADPH Oxidase Activity in Inflammatory Cells.
Arterioscler Thromb Vasc Biol, 23, 615-621.
20. Schick, B., Praetorius, M., Eigenthaler, M., Mack, A., Plinkert, P., Walter, U., Dazert,
S. and Knipper, M. (2003) Expression of VASP and zyxin in cochlear pillar cells:
indication for actin-based dynamics? Cell Tissue Res, 311, 315-323.
21. Deuse, T., Lange, V., Schrepfer, S., Eigenthaler, M., Reichart, B., Walter, U. and
Elert, O. (2003) Correlation between Mononuclear Infiltration and Changes in VASP
Phosphorylation Patterns after Heterotopic Cardiac Transplantation in the Rat. Eur
Surg Res, 35, 6-13.
22. Aktas, B., Utz, A., Hoenig-Liedl, P., Walter, U. and Geiger, J. (2003) Dipyridamole
enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein
phosphorylation and signaling in human platelets: in vitro and in vivo/ex vivo studies.
Stroke, 34, 764-769.
23. Barragan, P., Bouvier, J.L., Roquebert, P.O., Macaluso, G., Commeau, P., Comet, B.,
Lafont, A., Camoin, L., Walter, U. and Eigenthaler, M. (2003) Resistance to
thienopyridines: Clinical detection of coronary stent thrombosis by monitoring of
vasodilator-stimulated phosphoprotein phosphorylation. Catheter Cardiovasc Interv,
59, 295-302.
24. Schafer, A., Fraccarollo, D., Hildemann, S., Christ, M., Eigenthaler, M., Kobsar, A.,
Walter, U. and Bauersachs, J. (2003b) Inhibition of platelet activation in congestive
heart failure by aldosterone receptor antagonism and ACE inhibition. Thromb
Haemost, 89, 1024-1030.
25. Zimmermann, J., Kuhne, R., Volkmer-Engert, R., Jarchau, T., Walter, U., Oschkinat,
H. and Ball, L.J. (2003) Design of N-substituted peptomer ligands for EVH1 domains.
J Biol Chem, 278, 36810-36818.
26. Schroder, F., Klein, G., Fiedler, B., Bastein, M., Schnasse, N., Hillmer, A., Ames, S.,
Gambaryan, S., Drexler, H., Walter, U., Lohmann, S.M. and Wollert, K.C. (2003)
Single L-type Ca(2+) channel regulation by cGMP-dependent protein kinase type I in
adult cardiomyocytes from PKG I transgenic mice. Cardiovasc Res, 60, 268-277.
27. Wollert, K.C., Yurukova, S., Kilic, A., Begrow, F., Fiedler, B., Gambaryan, S., Walter,
U., Lohmann, S.M. and Kuhn, M. (2003) Increased effects of C-type natriuretic
peptide on contractility and calcium regulation in murine hearts overexpressing cyclic
GMP-dependent protein kinase I. Br J Pharmacol, 140, 1227-1236.
28. Eigenthaler, M., Engelhardt, S., Schinke, B., Kobsar, A., Schmitteckert, E.,
Gambaryan, S., Engelhardt, C.M., Krenn, V., Eliava, M., Jarchau, T., Lohse, M.J.,
Walter, U. and Hein, L. (2003) Disruption of cardiac Ena-VASP protein localization in
intercalated disks causes dilated cardiomyopathy. Am J Physiol Heart Circ Physiol,
285, H2471-2481.
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29. Hink, U., Oelze, M., Kolb, P., Bachschmid, M., Zou, M.H., Daiber, A., Mollnau, H.,
August, M., Baldus, S., Tsilimingas, N., Walter, U., Ullrich, V. and Munzel, T. (2003)
Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance. J
Am Coll Cardiol, 42, 1826-1834.
30. Massberg, S., Gruner, S., Konrad, I., Garcia Arguinzonis, M.I., Eigenthaler, M.,
Hemler, K., Kersting, J., Schulz, C., Muller, I., Besta, F., Nieswandt, B., Heinzmann,
U., Walter, U. and Gawaz, M. (2004) Enhanced in vivo platelet adhesion in
vasodilator-stimulated phosphoprotein (VASP)-deficient mice. Blood, 103, 136-142.
31. Schafer, A., Schulz, C., Eigenthaler, M., Fraccarollo, D., Kobsar, A., Gawaz, M., Ertl,
G., Walter, U. and Bauersachs, J. (2004) Novel role of the membrane-bound
chemokine fractalkine in platelet activation and adhesion. Blood, 103, 407-412.
32. Chitaley, K., Chen, L., Galler, A., Walter, U., Daum, G. and Clowes, A.W. (2004)
Vasodilator-stimulated phosphoprotein is a substrate for protein kinase C. FEBS Lett,
556, 211-215.
33. Zhuang, S., Nguyen, G.T., Chen, Y., Gudi, T., Eigenthaler, M., Jarchau, T., Walter,
U., Boss, G.R. and Pilz, R.B. (2004) Vasodilator-stimulated Phosphoprotein Activation
of Serum-response Element-dependent Transcription Occurs Downstream of RhoA
and Is Inhibited by cGMP-dependent Protein Kinase Phosphorylation. J Biol Chem,
279, 10397-10407.
34. Gambaryan, S., Geiger, J., Schwarz, U.R., Butt, E., Begonja, A., Obergfell, A. and
Walter, U. (2004) Potent inhibition of human platelets by cGMP analogs independent
of cGMP-dependent protein kinase. Blood, 103, 2593-2600.
35. Smolenski, A., Schultess, J., Danielewski, O., Garcia Arguinzonis, M.I., Thalheimer,
P., Kneitz, S., Walter, U. and Lohmann, S.M. (2004) Quantitative analysis of the
cardiac fibroblast transcriptome-implications for NO/cGMP signaling. Genomics, 83,
577-587.
36. Chen, L., Daum, G., Chitaley, K., Coats, S.A., Bowen-Pope, D.F., Eigenthaler, M.,
Thumati, N.R., Walter, U. and Clowes, A.W. (2004) Vasodilator-Stimulated
Phosphoprotein Regulates Proliferation and Growth Inhibition by Nitric Oxide in
Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol, 24, 1-6.
37. Schambeck, C.M., Grossmann, R., Zonnur, S., Berger, M., Teuchert, K., Spahn, A.
and Walter, U. (2004) High factor VIII (FVIII) levels in venous thromboembolism: role
of unbound FVIII. Thromb Haemost, 92, 42-46.
38. Zimmermann, J., Jarchau, T., Walter, U., Oschkinat, H. and Ball, L.J. (2004) 1H,
(13)C and (15)N Resonance Assignment of the Human Spred2 EVH1 Domain. J
Biomol NMR, 29, 435-436.
39. Walter U. and Gambaryan S. (2004) Roles of cGMP/cGMP-dependent protein kinase
in platelet activation. Blood, 104, 2609. Letter to the editor
40. Berger M, Zschemisch S, Hocher B, Mönks D, Slowinski T, Halle H, Wanner C,
Walter, U. and Lindner T. (2004) An alternative approach für rapid and reliable SNP
typing with double restriction mutagenesis primer PCR. Clinical Chemistry, 50,
2376-2378. Technical Brief
41. Grossmann, R., Sokolova, O., Schnurr, A., Porsche, C., Obergfell, A., Lengenfelder,
B., Walter, U. and Eigenthaler, M. (2004) Variable extent of clopidogrel
responsiveness in patients after coronary stenting. Thromb Haemost, 92, 1201-6.
42. Obergfell, A., Strotmann, J., Bonz, A., Bauersachs, J., Ertl, G., Walter, U. and
Grossmann, R. (2004) Impaired platelet responses to clopidogrel and ticlopidine in a
patient with recurrent coronary stent stenosis. Thromb Haemost, 92, 1446-7.
43. Schick, B., Praetorius, M., Eigenthaler, M., Jung, V., Müller, M., Walter, U. and
Knipper, M. (2004) Increased noise sensitivity and altered inner ear MENA
distribution in VASP-/- mice. Cell and Tissue Res , 318, 493-502.
44. Engelhardt, C.M., Bundschu, K., Messerschmitt, M., Renne, T., Walter, U., Reinhard,
M. and Schuh, K. (2004) Expression and subcellular localization of Spred proteins in
mouse and human tissues. Histochem Cell Biol, 122, 527-538.
5

45. Kuhnel K, Jarchau T, Wolf E, Schlichting I, Walter U, Wittinghofer A and Strelkov S.
(2004) The VASP tetramerization domain is a right-handed coiled coil based on a 15residue
repeat. Proc Natl Acad Sci U S A, 101, 17027-32.
46. Nikolaev, V.O., Gambaryan, S., Engelhardt, S., Walter, U. and Lohse, M.J. (2005)
Real-time monitoring of live cell's PDE2 activity: Hormone-stimulated cAMP
hydrolysis is faster than hormone-stimulated cAMP synthesis. J Biol Chem. 280,
1716-1719.
47. Berger, M., Mattheisen, M., Kulle, B., Schmidt, H., Oldenburg, J., Bickeböller, H.,
Walter, U., Lindner, T., Strauch, K. and Schambeck, C.M. (2005) High Factor VIII
levels in venous thromboembolism show linkage to imprinted loci on chromosomes 5
and 11. Blood, 150, 638-644.
48. Wang HG, Lu FM, Jin I, Udo H, Kandel ER, de Vente J, Walter U, Lohmann SM,
Hawkins RD and Antonova I. (2005) Presynaptic and post synaptic roles of NO, cGK
and RhoA in long-lasting potentiation and aggregation of synaptic proteins. Neuron ,
45, 389-403.
49. Hohenstein, B., Kasperek, L., Kobelt, DJ., Daniel, C., Gambaryan, S., Renné, T.,
Walter, U., Amann, K. and Hugo, C. (2005) VASP-deficient mice demonstrate
increased platelet activation, but improved renal endothelial preservation and
regeneration in passive nephrotoxic nephritis. JASN, 16, 986-96.
50. Berger M, Monks D, Schmidt H, Krane V, Wanner C, Walter U, Lindner TH. (2005)
Are glucokinase mutations associated with low triglycerides?
Clin Chem. 2005 Apr;51(4):791-3. (Letter to the Editor)
51. Bundschu, K., Knobeloch, K.P., Ullrich, M., Schinke, T., Amling, M., Engelhardt, C.M.,
Renne, T., Walter, U. and Schuh, K. (2005) Gene disruption of spred-2 causes
dwarfism. J Biol Chem. 280, 28572-80.
52. Wendt, M.C., Daiber, A., Kleschyov, A.L., Mulsch, A., Sydow, K., Schulz, E., Chen,
K., Keaney, J.F., Jr., Lassegue, B., Walter, U., Griendling, K.K. and Munzel, T. (2005)
Differential effects of diabetes on the expression of the gp91(phox) homologues nox1
and nox4. Free Radic Biol Med, 39, 381-391.
53. Geiger, J., Teichmann, L., Grossmann, R., Aktas, B., Steigerwald, U., Walter, U. and
Schinzel, R. (2005) Monitoring of clopidogrel action: comparison of methods. Clin
Chem, 51, 957-965.
54. Begonja, A.J., Gambaryan, S., Geiger, J., Aktas, B., Pozgajova, M., Nieswandt, B.
and Walter, U. (2005) Platelet NAD(P)H oxidase-generated ROS production
regulates {alpha}IIb{beta}3 integrin activation independent of the NO/cGMP pathway.
Blood, 106:2757-2760.
55. Moebius, J., Zahedi, R.P., Lewandrowski, U., Walter, U. and Sickmann, A. (2005)
The human platelet membrane proteome reveals several new potential membrane
proteins. Molecular & Cellular Proteomics, 4, 1754-1761.
56. Sitaru AG, Holzhauer S, Speer CP, Singer D, Obergfell A, Walter U, Grossmann R.
(2005) Neonatal platelets from cord blood and peripheral blood. Platelets, 16 (3-
4):203-10.
57. Gambaryan S, Butt E, Tas P, Smolenski A, Allolio B and Walter U. (2005) Regulation
of aldosterone production from zona glomerulosa cells by Ang II and cAMP: Evidence
for PKA independent activation of caMK by cAMP. Am J Physiol Endocrinol Metab
(Oct 2005) e-pub ahead of print.
58. Lewandrowski U, Moebius J, Walter U and Sickmann, A. (2005) Elucidation of Nglycosylation
sites on human platelet proteins - a glycoproteomic approach. Mol Cell
Proteomics, in press
59. Bundschu, K., Gattenlöhner, S., Knobeloch, K.-P., Walter, U. and Schuh, K. Tissuespecific
Spred-2 promoter activity characterized by a gene trap approach. Gene Expr
Patterns, in press (available on-line 22 Dec 2005)
60. Reif, A., Herterich, S., Strobel, A., Ehlis, A-C., Saur, D., Jacob, C-P., Wienker, T.,
Töpner, T., Fritzen, S., Walter, U., Schmitt, A., Fallgatter, AJ. and Lesch, K-P. (2006)
A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia
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modifies prefrontal cortex function. Mol Psychiatry, in press (advance online
publication 3 Jan 2006)
61.
Reviews (since 2001)
1. Reinhard, M., Jarchau, T. and Walter, U. (2001) Actin-based motility: stop and go
with Ena/VASP proteins. Trends Biochem Sci, 26, 243-249.
2. Schwarz, U.R., Walter, U. and Eigenthaler, M. (2001) Taming platelets with cyclic
nucleotides. Biochem Pharmacol, 62, 1153-1161.
3. Schambeck, C.M. and Walter, U. (2002) Analysis of platelet function and dysfunction
- from pathobiochemistry to diagnostics. J of Laboratory Medicine, 26, 555-556.
4. Ball, L.J., Jarchau, T., Oschkinat, H. and Walter, U. (2002) EVH1 domains: structure,
function and interactions. FEBS Lett, 513, 45-52.
5. Aasland, R., Abrams, C., Ampe, C., Ball, L.J., Bedford, M.T., Cesareni, G., Gimona,
M., Hurley, J.H., Jarchau, T., Lehto, V.P., Lemmon, M.A., Linding, R., Mayer, B.J.,
Nagai, M., Sudol, M., Walter, U. and Winder, S.J. (2002) Normalization of
nomenclature for peptide motifs as ligands of modular protein domains. FEBS Lett,
513, 141-144.
6. Feil, R., Lohmann, S.M., De Jonge, H., Walter, U. and Hofmann, F. (2003) Cyclic
GMP-Dependent Protein Kinases and the Cardiovascular System: Insights From
Genetically Modified Mice. Circ Res, 93, 907-916.
7. Munzel, T., Feil, R., Mulsch, A., Lohmann, S.M., Hofmann, F. and Walter, U. (2003)
Physiology and pathophysiology of vascular signaling controlled by cyclic guanosine
3',5'-cyclic monophosphate-dependent protein kinase. Circulation, 108, 2172-2183.
8. Birschmann, I. and Walter, U. (2004) Physiology and pathophysiology of vascular
signaling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein
kinase. Acta Biochim Pol, 51, 397-404.
9. Lohmann SM and Walter U. (2005) Tracking functions of cGMP-dependent protein
kinases (cGK) Front Biosci , 10, 1313-1328.
10. Dittrich M, Birschmann I, Stuhlfelder C, Sickmann A, Herterich S, Nieswandt B,
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