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Multiparticle Dosage Forms - TTC Technology Training Center

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Program<br />

Tuesday, 5 July 2011<br />

MULTIPARTICULATE DOSAGE FORM<br />

08.30 Transfer from hotel to <strong>TTC</strong><br />

08.45 LogIn<br />

09.00 Introduction Klaus Eichler<br />

09.10 Pellets as oral multiparticulate Mike Newton<br />

dosage forms<br />

10.00 Pelletizing by prilling Denis Poncelet<br />

10.45 Coffee break<br />

11.15 Innovative technologies for Norbert Pöllinger<br />

the development and production<br />

of controlled release pellets<br />

12.00 Lunch and optional factory tour<br />

PELLET TECHNOLOGY<br />

13.15 Preparation of pellets by Mike Newton<br />

extrusion / spheronization<br />

14.00 Pelletizing by solution, suspension Atul Mehta<br />

and dry powder layering<br />

14.45 Rotor pelletizing techniques Pascale Gauthier<br />

15.30 Coffee break<br />

16.00 Continuous fluid bed pelletization Sebastian Pfütze<br />

16.45 Case study: Solid state Anke Stroyer<br />

interactions between proton pump<br />

inhibitor omeprazole and enteric<br />

coating polymers<br />

17.30 Transfer to hotel<br />

19.30 Workshop dinner<br />

Wednesday, 6 July 2011<br />

08.15 Transfer from hotel to <strong>TTC</strong><br />

08.30 The main excipients for Jörg Brunemann<br />

pelletizing and pellet coating<br />

09.30 Functional filmcoating of pellets Atul Mehta<br />

10.15 Coffee break<br />

10.45 Adjusting desired drug Bruno Leclercq<br />

release kinetics from<br />

ethylcellulose-coated pellets<br />

CAPSULE TECHNOLOGY<br />

11.30 Capsule filling techniques Karlheinz Seyfang<br />

12.15 Lunch<br />

12.45 Excursion to Capsugel in Colmar (France)<br />

to look at innovative capsule technology<br />

13.45 Welcome and Introduction Thilo Schmierer<br />

14.00 Capsules in multiparticulate Thilo Schmierer<br />

drug delivery<br />

14.45 Defining the capsule design Claire Tardy<br />

space in hard capsule product<br />

development<br />

15.30 Visit to the hard capsule manufacturing plant<br />

17.45 Guided old city tour with subsequent dinner<br />

Thursday, 7 July 2011<br />

08.45 Check-out from hotel and transfer to <strong>TTC</strong><br />

09.00 The PATability of coating Frank Thielmann<br />

processes - illusion or opportunity?<br />

10.00 Coffee break<br />

10.30 Process demonstrations:<br />

- direct pelletizing<br />

- suspension layering<br />

- capsule filling<br />

13.30 Snack buffet and LogOut<br />

14.00 Transfer to Badischer Bahnhof Basel / Airport<br />

Workshop no. 167<br />

<strong>Multiparticle</strong><br />

<strong>Dosage</strong><br />

<strong>Forms</strong><br />

Background<br />

Who should attend<br />

Binzen, 5 - 7 July 2011<br />

More and more pharmaceutical products are reaching the<br />

market as multiparticulate dosage forms, mainly as pellets.<br />

The healthcare sector also frequently selects pellets as an<br />

optimal marketable form of functional food.<br />

As there is quite a number of existent techniques relating<br />

to the production of pellets, it is often very difficult for a<br />

formulator or marketing manager to make a choice, since<br />

every technique claims to be optimal.<br />

This workshop is aimed at elaborating the advantages and<br />

drawbacks of the individual techniques, focusing on the<br />

optimal spectrum of each one but also considering the<br />

economical and ergonomical aspects of manufacturing<br />

processes. On special request of various participants this<br />

workshop has been extended to include lectures on the<br />

main excipients for pelletizing and pellet coating, on<br />

functional pellet coating, compression of pellets into tablets,<br />

capsule filling and the most suitable capsule materials.<br />

All speakers are specialized, experienced and renowned<br />

experts from science and industry.<br />

Researchers, product developers and product<br />

managers from all industrial fields which market<br />

products in pellet form.


Speakers<br />

Dr. Jörg Brunemann<br />

HARKE Pharma, Germany<br />

Dr. Pascale Gauthier<br />

University of Clermont-Ferrand, France<br />

Dr. Bruno Leclercq<br />

FMC, Belgium<br />

Dr. Atul Mehta<br />

Mehta Consulting, USA<br />

Prof. Dr. Mike Newton<br />

University of London, UK<br />

Sebastian Pfütze<br />

Glatt Weimar, Germany<br />

Dr. Norbert Pöllinger<br />

Glatt Pharmaceutical Services, Germany<br />

Prof. Dr. Denis Poncelet<br />

Capsulae, France<br />

Dr. Thilo Schmierer<br />

Pfizer, Belgium<br />

Dr. Karlheinz Seyfang<br />

Harro Höfliger, Germany<br />

Dr. Anke Stroyer<br />

Bayer Healthcare, Germany<br />

Dr. Claire Tardy<br />

Pfizer, France<br />

Dr. Frank Thielmann<br />

Novartis, UK<br />

Moderation<br />

Dr. Mike Newton, Prof. Emeritus<br />

The School of Pharmacy, University of London, UK<br />

Details<br />

l The participation fee is € 1.640,- (exclusive of VAT).<br />

This fee includes participation, accompanying course<br />

notes, daytime catering and dinner.<br />

Any other expenses are to be borne by the attendee.<br />

l Free attendance granted to a limited number<br />

of students.<br />

l Participation is limited. Registrations will be<br />

confirmed on a first come first serve basis.<br />

l Courses taking place in Germany are subject<br />

to Value Added Tax (VAT).<br />

l Each participant will receive a certificate<br />

of attendance at the end of the course.<br />

Organisation<br />

<strong>TTC</strong> (<strong>Technology</strong> <strong>Training</strong> <strong>Center</strong>)<br />

Klaus Eichler / Bianca Nowak / Saskia Nitsche<br />

Werner-Glatt-Straße 1, 79589 Binzen, Germany<br />

Ph.: + 49 (0) 76 21 / 664 - 308<br />

Fax: + 49 (0) 76 21 / 16 799 200<br />

eMail: ttc@ttc-binzen.de<br />

For further information or online-registration please visit<br />

www.ttc-binzen.de<br />

Place of venue<br />

<strong>Technology</strong> <strong>Training</strong> <strong>Center</strong><br />

Binzen, Germany<br />

Registration <strong>TTC</strong> 167<br />

<strong>Multiparticle</strong> <strong>Dosage</strong> <strong>Forms</strong><br />

5 - 7 July 2011<br />

First name<br />

Last name<br />

Company<br />

Dept.<br />

Function<br />

Street<br />

City<br />

Zip Code<br />

Country<br />

Phone<br />

Fax<br />

Email<br />

o Accommodation required -<br />

we will reserve the hotel for you.<br />

Check-in-day<br />

Check-out-day = Nights<br />

Approx. Euro 95,00 / Night incl. breakfast<br />

s<br />

Click here to register online

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