Les Statines sont-elles efficaces chez la personne âgée
Les Statines sont-elles efficaces chez la personne âgée
Les Statines sont-elles efficaces chez la personne âgée
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PROSPER: Study designDouble-blind, randomized p<strong>la</strong>cebo-controlled trialin:5804 elderly men and women patients (70-82 years)• Total cholesterol 155–350 mg/dL (4-9.0mmol/l)• Good cognitive function• ~ 44% with vascu<strong>la</strong>r disease• ~ 56% at high risk of vascu<strong>la</strong>r diseasePravastatin 40 mg qd(N=2891)P<strong>la</strong>cebo(N=2913)Average Follow-up:3.2 yearsPrimary Combined Endpoint:CHD Death, Nonfatal MI, Fatal plus Nonfatal StrokeAm J Cardiol 1999;84:1192
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