Roche Diagnostics Leading and creating new markets
Roche Diagnostics Leading and creating new markets
Roche Diagnostics Leading and creating new markets
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4. Pharmacogenetics: study of genetic variation<br />
underlying differential individual responses to drugs<br />
Source: Kirchheiner et al., Acta Psychiatr. Sc<strong>and</strong> 2001: 104: 173-192<br />
4 Distinct phenotypes exist:<br />
• Ultrarapid Metabolizers (UM)<br />
• Efficient Metabolizers (EM)<br />
• Intermediate Metabolizers (IM)<br />
• Poor Metabolizers (PM)<br />
r<br />
<strong>Roche</strong> AmpliChip CYP450<br />
Genetic analysis of of CYP2D6 <strong>and</strong> CYP2C19 may give insights on dosing in in the future<br />
Drug<br />
Velafaxin<br />
Desipramine<br />
Fluoxamine<br />
Mianserin<br />
Percent of normal dose<br />
UM EM IM PM<br />
- 130 % 80 % 20 %<br />
260 % 130 % 80 % 20 %<br />
- 120 % - 60 %<br />
300 % 110 % - 70 %<br />
<strong>Diagnostics</strong><br />
48
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