Formulation and Evaluation of Herbal Antidandruff Shampoo ...
Formulation and Evaluation of Herbal Antidandruff Shampoo ...
Formulation and Evaluation of Herbal Antidandruff Shampoo ...
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International Journal <strong>of</strong> Pharma Research & Review, Oct 2013; 2(10):12-24Figure 9: In-Vitro Release <strong>of</strong> the Drug <strong>Herbal</strong> Antid<strong>and</strong>ruff <strong>Shampoo</strong> <strong>of</strong> <strong>Formulation</strong> 7, 8,9CONCLUSIONAllicin (which is extracted from garlic)contain antifungal activity <strong>and</strong> it isgenerally used in a home-made preparation.While using the garlic for long term use itinhibited the fungal infection/d<strong>and</strong>ruff.Here the formulation <strong>of</strong> antid<strong>and</strong>ruffshampoo, firstly prepared the allicin loadedsolid lipid nanoparticles. SLNs wereprepared by using hot homogenizationmethod for better control release over thekinetics, very long term stability <strong>and</strong> actualamount <strong>of</strong> drug to be encapsulated. Herethe formulation <strong>of</strong> allicin loaded SLNsprepared by using the soy lecithin, tween80, drug <strong>and</strong> some organic solvent. Soylecithin is used as a phospholipids, Tween80 as a surfactant. Surfactant can act as awetting agent <strong>and</strong> lowering the surfacetension <strong>of</strong> solution. Then it was evaluatedby using zeta potential, particle size, SEM<strong>and</strong> drug loaded capacity to achieve desiredSLNs. Now, Antid<strong>and</strong>ruff shampoo wereprepared by homogenization method, byusing the drug, EDTA, CMC, saturatedsolution <strong>of</strong> Nacl solution, sodium laurylsulphate, peppermint oil, lemon oil etc.sodium lauryl sulphate is used as a nanionic surfactant. Lemon oil is also act as aanti- d<strong>and</strong>ruff agent <strong>and</strong> also act as aperfume. At different concentration <strong>of</strong> SLSwere used for the evaluation parameter thebatches were concluded <strong>and</strong> optimized.Allicin loaded SLNs herbal Antid<strong>and</strong>ruffshampoo was prepared successfully.ACKNOWLEDGEMENTAuthors wish to express their thanks to allfaculty members <strong>and</strong> my friends <strong>of</strong> thecollege for their help <strong>and</strong> co‐operationwhile carrying out this research work.REFERENCES1. Saint D L., The history <strong>of</strong> d<strong>and</strong>ruff <strong>and</strong>d<strong>and</strong>ruff in history, A HOMAGE TORAYMOND SABOURAUD ANN DERMATOLVENEREOL, 1990; 117: 23- 27.2. Gupta A K, Batra R, Bluhm R, Boekhout T,Dawson TL Jr. Skin disease associated withMalassezia species .JOURNAL AM ACADDERMATOL 2004;51:785-98.3. Pitard C F, Xhauflaire E U, PitardG.E,Revisiting d<strong>and</strong>ruff, INTERNATIONALJOURNAL OF COSMETIC SCIENCE 2006;28:311-318.4. Pitard C F, Pitard G E, Klingman A, Seasonalmodulation <strong>of</strong> the sebum excreation,DERMATOLIGICA 1990;181:21-225. Vijayanthi G, Kulkarni C, Abraham A,Kolhapure SA. <strong>Evaluation</strong> <strong>of</strong> antid<strong>and</strong>ruffactivity <strong>and</strong> safety <strong>of</strong> polyherbal hair oil, ANOPEN PILOT CLINICAL TRIAL, THEANTISEPTIC 2004;101(9):368-372.6. Amdt K A, Hsu J T. MANNUAL OFDERMATOLOGICTHERAPEUTICS.LIPPINCOTT WILLIAMS AND WILKINSPHILADELPHIA PA, 2007,7;180-184.7. Saint DL, Klingman AM, Stoudemeyer T J, TheRole <strong>of</strong> resident micro flora in thepathogenesis <strong>of</strong> d<strong>and</strong>ruff, JOURNAL OF SOC.COSMETIC CHEMI. 1988; 40:109-117.8. The medicinal uses <strong>of</strong> garlic/natural holistichealth blog.”NATURAL- HOLISTIC- HEALTH.COM. 2009;06-02.Neeta Rai et.al, IJPRR 2013; 2(10) 23
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