CURRICULUM VITAE - Vanderbilt-Ingram Cancer Center

CURRICULUM VITAEAyumi Kamina Shintani, Ph.D., M.P.H.PERSONAL:Business Address: 6007 Medical Center East, Nashville, TN 37232-8300Business Phone: (615) 936 - 1954Business Fax: (615) 936 - 1269Business e-mail:ayumi.shintani@mcmail.vanderbilt.eduEDUCATION:March 1991May 1996May 1999May 2000Bachelor of Science in MathematicsNara Women’s University, Nara, JapanMaster of Public Health in BiostatisticsYale University, New Haven, CTMaster of Philosophy in BiostatisticsYale University, New Haven, CTDoctor of Philosophy in BiostatisticsYale University, New Haven, CTTRAINING:1995 Internship , Cooperative Studies Program Coordinating Center(CSPCC), Veterans Affairs (VA) Medical Center, West Haven, CT1995 Researcher in Yale-Sponsored Consulting Team, New HavenNeedle Exchange Program, Department of Internal Medicine, YaleUniversity School of Medicine & New Haven Health Department,New Haven, CT1995 – 1996 Project Manager, CSPCC, VA Medical Center, West Haven, CT1996 – 1999 Biostatistician / Project Manager, CSPCC, VA Medical Center, WestHaven, CT2000 Post-doctoral Fellow, CSPCC, VA Medical Center, West Haven, CTACADEMIC APPOINTMENTS:

2001 – Present Assistant Professor, Division of General Internal Medicine,Department of Medicine, Vanderbilt University Medical Center2001 – Present Director, Biostatistics Core, Center for Health Services Research,Vanderbilt University Medical Center2002 – Present Adjunct Assistant Professor, Vanderbilt Ingram Cancer CenterBiostatistics Resource, Vanderbilt University Medical Center2003 – Present Visiting Assistant Professor, School of Medicine, TokaiUniversity, Kanagawa, JapanHONORS AND AWARDS:1987 – 1990 Nara Women’s University Tuition Scholarship1987 – 1991 Ikuei-kai Scholarship1996 Master of Public Health awarded with distinction1996 – 1999 Tuition Scholarship, Yale University1999 One-Year Advanced Standing, Yale UniversityPROFESSIONAL ORGANIZATIONS:International Biometric SocietyTEACHING:Spring 2000November, 2001December, 2001September, 2002November, 2002February, 2003February, 2003September, 2003September, 2003Instructor, Advanced Statistics in Nursing ResearchYale University School of Nursing, New Haven, CTObservational Studies, VICC Biostatistics Resource, VanderbiltObservational Studies, GCRC Weekly SeminarSurvival Analysis (2 series), GCRC Weekly SeminarMultivariate ANOVA (3 series), GCRC Weekly SeminarGeneralized Estimating Equations, MSCI course, Biostatistics IIGeneralized Estimating Equations, GCRC Weekly SeminarAssessment of Confounders and Interactions using SubgroupAnalyses and Logistic Regressions, MSCI course, Biostatistics ISurvival Analysis , MSCI course, BiostatisticsGRANT AWARDS: (Co-Investigator)CURRENTNIH 1RO1 AI 50884-01A1 (Hartert)Dietary Antioxidants and Incidence of Adult-onset AsthmaU01 HL072471 (Sheller)Asthma Disparities in Cohorts at Risk for MorbidityK23 AG01023 (Ely)

Cognitive impairment in the ICU: Evaluation and OutcomesBEESON (Ely)Risk factors & prognosis of delirium in intensive care unit patientsKO8 AI01582 (Hartert)Medication Use in Assessing and Improving Asthma ControlRO1 HL65082 (Stein)Vascular Damage in SLEP60 DK20593(Granner)Diabetes Research and Training CenterRO1 CA92653 (Dittus)Simulation Modeling of Colorectal CancerRO1 CA97386 (Zheng)Tumor Markers and Recurrent Adenomas – a Follow-Up StudyR01 HL60906 (Brown)Renin-Angiotensin and Fibrinolysis Interaction in HumansRO1 HL65193 (Brown)Genes and Fibrinolytic Capacity of Human EndotheliumRO1 HL67308 (Brown)PAI-1 and the Vascular Toxicity of Aldosterone1P30 AI 54999-01 (D’Aquila)Vanderbilt Meharry Developmental CFARR18 DK62258 (Elasy)Glycemic Relapse Prevention: Maintenance Dose Assessment1P50CA95103-01 (Coffey)SPORE in GI CancerMulti-center Prospective Cohort Outcome Assessment for patients with ACL Injury(Spindler)PASTRO3 CA89842 (Fowke)Isothiocyanates, Brassica, and Breast Cancer

RO1 CA72784 (Zheng)Evaluation of predictors for recurrent adenomaINVITED LECTURES:2000 Modeling the Emergence of Drug-Resistant Mutants: Implication forTreatment Strategies for HIV-1 Infection. Presented to Middle TennesseeChapter, American Statistical Association, Nashville, TN.2002 Practical Issues for Conducting and Reporting Clinical Trials, TokaiUniversity, Kanazawa, Japan (12/16/2002)PUBLICATIONS:Journal Articles: (Some use Kamina, A. for Ayumi Shintani )1. Peduzzi, P., Kamina, A. and Detre, K. (1998). The 22-Year Follow-up in the VACooperative Study of Coronary Artery Bypass Surgery for Stable Angina,American Journal of Cardiology 81:1393-1399.2. Peduzzi, P., Kamina, A., Detre, K. (1999). The Veterans Affairs CooperativeStudy of Coronary Artery Bypass Surgery for Stable Angina: a continuing debateafter 22 Years. American Journal of Cardiology 83 (2): 303-304.3. Federman, D., Goyal, S., Kamina, A., Peduzzi, P., Concato, J. (1999). Patients’Knowledge of and Attitudes Towards Prostate-Specific Antigen Testing. EffectiveClinical Practice 2: 152-157.4. Anderson, D. R., Patil, S., Kamina, A., Penson, D.F., Peduzzi, P., Concato, J.,Validation of a staging system for evaluating prognosis in prostate cancer.Connecticut Medicine. 64(8):459-464, 2000 August.5. Kamina, A., Makuch, R. and Zhao, H. (2001), A Stochastic Modeling of EarlyHIV-1 Population Dynamics, Mathematical Biosciences Apr;170 (2):187-98.6. Concato, J., Peduzzi, P., Kamina, A. and Horwitz, R., A Nested Case-ControlStudy of the Effectiveness of Screening for Prostate Cancer: Research Design,Journal of Clinical Epidemiology. 54(6):558-64, 2001 Jun.7. James Jackson, Sharon Robert Hart Gordon, Ayumi Shintani, Brenda Truman,Lisa May, Wesley Ely. Six Month Neuropsychological Outcomes of MedicalICU Patients. Critical Care Medicine Vol 31, No 4:1226-1234, 20038. Elasy TA, Graber AL, Wolff K, Brown A, Shintani A.. Glycemic relapse after anintensive outpatient intervention for type 2 diabetes, Diabetes Care 2003May;26(5):1645-6.

9. Wesley Ely, Brenda Truman, Ayumi Shintani, Jason W.W. Thomason, Arthur P.Wheeler, Sharon Gordon, Joseph Francis, Theodore Speroff, Shiva Gautam,Richard Margolin, Robert Dittus, Gordon R. Bernard. The Reliability Testing andValidation of the Richmond Asitation Sedation Scale (RASS): A Two PartInvestigation of 324 ICU Patients, JAMA 2003, Vol 289, No. 22: 2983-299110. Javier Martinez-Picado, Eugènia Negredo, Lidia Ruiz, Ayumi Shintani, CarminaR. Fumaz, Carlos Zala, Pere Domingo, Josep Vilaró, Josep M. Llibre, PompeyoViciana, Kurt Hertogs, Charles Boucher, Richard T. D’Aquila, BonaventuraClotet and the SWATCH Study Team. Alternation of Antiretroviral DrugRegimens for HIV Infection: A Randomized Controlled Trial. Annals of InternalMedicine (2003) 15; 139(2):81-9.11. Tina Hartert, Lathleen Neuzil, Ayumi Shintani, Edward Mitchel Jr., MarySnowden, Lisa Wood, Robert Dittus, Marie Griffin. Maternal Morbidity andPerinatal Outcomes among Pregnant Women with Respiratory Hospitalizationsduring Influenza Season (2003) American Journal of Obstetrics and Gynecology(In press)12. Yu Asanuma, Annette Oeser, Ayumi Shintani, Elizabeth Turner, Nancy Olsen,Sergio Fazio, MacRae F. Linton, Paolo Raggi, C. Michael Stein. PrematureCoronary Artery Atherosclerosis in Systemic Lupus Erythematosus. New EnglandJournal of Medicine (In press)13. Jay H. Fowke, Fung-Lung Chung, Xiao-Ou Shu, Dai Qi, Ayumi Shintani, QiuyinCai, Yu-Tang Gao, Wei Zheng , Urinary Isothiocyanate Excretion, BrassicaConsumption, and Gene Polymorphisms among Women Living in Shanghai,China, Cancer epidemiology, biomarkers & prevention (In press)14. E. Wesley Ely, Brenda Truman, Ayumi Shintani, Theodore Speroff, SharonGordon, Sharon K. Inouye, Shiva Gautam, Gordon R. Bernard, Robert S. Dittus,Development of Delirium in Mechanically Ventilated Patients and AssociatedClinical Outcomes, JAMA (Under revision)15. Eric B. Milbrandt, Stephen Deppen, Patricia L. Harrison, Ayumi K. Shintani,Theodore Speroff, Renée A. Stiles, Brenda Truman, Gordon R. Bernard, RobertS. Dittus, and E. Wesley Ely. ICU Delirium: A Costly Complication in CriticallyIll Patients, Critical Care Medicine (Under revision)16. Julia G. Prado, Ayumi Shintani, Margarida Bofill, Bonaventura Clotet, LidiaRuiz, Javier Martinez-Picado. Lack of Longitudinal Intrapatient Correlationbetween p24 Antigenemia and HIV-1 RNA in Chronic HIV-Infection duringStructured Treatment Interruptions (Under revision)

5. Kathleen Figaro, Ayumi Shintani. Effect of CRP in physical functionabilityamong patients with diabetes.6. Ayumi Shintani. Methodological Issues Analyzing Acute Cognitive Dysfunctionin ICU7. Ayumi Shintani. Application of Sun and Wei model to Minnesota AdenomaStudy “Regression Analysis of Panel Count Data with Covariate-DependentObservation and Censoring Times”8. Paul Moore, Tina Hartert, Ayumi Shintani, Patricia Harrison, Polymorphismand efficacy of treatment for patients with acute athmaAbstracts and Poster Presentations:1. Eicher, A., Eno, R., Greaves, S., Kamina, A., Singh, M., Soni, R. (1995). NeedleExchange Program as A Conduit to Drug Treatment, American Public HealthAssociation Annual Meeting, San Diego, CA. October 19952. Twenty-two Year Follow-up in the Veterans Affairs Cooperative Study ofCoronary Artery Bypass Surgery for Stable Angina, Student Research Day, YaleUniversity, School of Medicine, May 1996.3. Concato, J., Kamina, A., Patil, S., Peduzzi, P. (1998). Misclassification Bias inCase-Control Studies of Cancer Screening. Annual Meeting, Carmel, California,Journal of Clinical Epidemiology 51:1654. Ko, D.T., Kamina, A., Peduzzi, P., Lichtman, J., Brass, L., Krumholz,H.M.,Ezekowitz,M.D. (2001) Anticoagulation for Stroke Prevention in Survivors ofAcute Myocardial Infarction with Ventricular Dysfunction. Annual Meeting,Journal of American College of Cardiology5. TV Hartert, A Shintani, KM Neuzil, LB Wood, EF Mitchel, MS Snowden, MRGriffin, Hospitalizations for respiratory illness during influenza season amongpregnant women with and without asthma, Annual Meeting, American ThoracicSociety 20016. EW Ely, Shintani A, Bernard G, Jackson J, Gordon S, May L, Truman B,Gautam S, Inouye S, Dittus B, Speroff T. Delirium in the ICU is associated withprolonged length of stay in the hospital and higher mortality, Annual Meeting,American Thoracic Society 20017. E.W. Ely, Jackson J, Gordon S, Shintani A, May L, Truman B, Dittus B, GautamS, Bernard G, Speroff T, Hart R. Long-term neuropsychological deficits

following delirium in mechanically ventilated ICU patients, Annual Meeting,American Thoracic Society20018. EW Ely, Shintani A, Bernard G, Jackson J, Gordon S, May L, Truman B,Gautam S, Inouye S, Dittus B, Speroff T. Delirium in the ICU is Associated withHigher Mortality and Prolonged Length Of Stay, Annual Meeting, AmericanGeriatric Society 20019. Coller, Z., Shintani, A., Truman, B., Thomason, J, Milbrandt, E., Bernard, G.R.,Dittus, R., Ely, E.W. The impact of delirium in the ICU on outcomes ofmechanical ventilation. Am. J. Respir. Crit. Care Med. 2002.10. Hartert, T.V., Shintani, A.K., Griffin, M.R., Mitchel, E.F. Jr., Snowden, M.S.,Wood, L.B., Dittus, R.S., Neuzil, K.M. Perinatal outcomes among pregnantwomen following respiratory hospitalization during influenza season. Am. J.Respir. Crit. Care Med. 2002.11. Milbrandt, E.B., Deppen, S., Harrison, P., Shintani, A., Speroff, T., Stiles, R.,Elasy, T., Truman, B., Bernard, G., Dittus, R.S., Ely, E.W. ICU delirium: a costlycomplication in critically ill patients. Am. J. Respir. Crit. Care Med. 2002.12. Peterson, J.F., Thomason, J.W., Shintani, A., Truman, B., Jackson, J., Ely, E.W.The prevalence of hypoactive, hyperactive, and mixed type delirium in medicalICU patients. Am. J. Respir. Crit. Care Med. 2002.13. Thomason, J.W.W., Peterson, J., Shintani, A., Truman, B., Jackson, J., Ely, E.W.Delirium is associated with increased length of stay and mortality in nonventilatedICU patients. Am. J. Respir. Crit. Care Med. 2002.14. Truman, B., Shintani, A., Ely, E.W. Large-scale implementation of delirium andsedation monitoring in the ICU. Am. J. Respir. Crit. Care Med. 2002.15. Truman, B., Shintani, A., Jackson, J., Peterson, J.F., Thomason, J., Ely, E.W.Implementation of the SCCM guidelines for sedation and delirium monitoring inthe ICU. Am. J. Respir. Crit. Care Med. 2002.16. S. Henry; R.M. Ness; P. Harrison; A. Shitani; R. Stiles; R.S. Dittus. The true costof colonoscopy: A micro-costing analysis. The Society for General InternalMedicine. 2002.17. Dhiren S. Dave, Richard L. Roberts, Sandra J. Olson, Sabrina E. Hannah, TomCase, Frances Shook, Ayumi K. Shintani, Jason D. Morrow, Robert J. Matusik,Scott B. Shappell. Chemopreventive effects of selective cyclooxygenase-2 (COX-2) inhibition on prostatic intraepithelial neoplasia in a transgenic mouse model ofprostate carcinoma. (PCA). American Urological Association 2003

18. Matthew D. Shuford,* Sam S. Chang, Michael S. Cookson, Ayumi K. Shintani,Athanasios Tsiatis, Joseph A. Smith, Jr., and Scott B. Shappell. Adverseprognostic significance of capsular incision after radical retropubic prostatectomy.American Urological Association 200319. Yu Asanuma, A. Oeser, A. Shintani, Paolo Raggi, C. M. Stein. Relationshipbetween corticosteriod therapy and atherosclerosis in patients with systemic lupuserythematosus (Abstract). 2003 Annual Meeting of the American Society forClinical Pharmacology and Therapeutics. (Clin Pharm Ther.2003;73 (2): P91.)20. Elizabeth Turner, Annette Oeser, Yu Asanuma, Ayumi Shintani, Nancy Olsen,Paolo Raggi, C. Michael Stein. Premature Coronary Artery Atherosclerosis inSystemic Lupus Erythematosus is not related to Disease Activity or CorticosteroidTherapy (Abstract). 2002 Annual Scientific Meeting of American College ofRheumatology. (Arthritis Rheum. 2002; 46 (9) Suppl.)21. Yu Asanuma, Annette Oeser, Ayumi Shintani, C Michael Stein. MonocyteChemoattractant Protein-1, a Proatherogenic Chemokine, is Increased in SystemicLupus Erythematosus (Abstract). 2002 Annual Scientific Meeting of AmericanCollege of Rheumatology. (Arthritis Rheum. 2002; 46 (9) Suppl.)22. Martha J. Shrubsole, Roberd Bostick, John Potter, John Allen, Kristin Anderson,Cynthia Lais, Lisa Fosdick, Ayumi Shintani, James Wood, Wei Zheng.Pathology of baseline adenomas as predictors of adenoma recurrence: Acolonoscopy-based follow-up study American Association for Cancer Research200323. James C Jackson, Sharon M Gordon, Ayumi Shintani, Robert P Hart, BrendaTruman, Candace Burger, Wesley Ely, Age as a risk factor for long-termcognitive impairment among intensive care unit (ICU) survivors, InternationalPsychogeriatric Association, 200324. Anne Brown, Kathleen Wolff, Colin Armstrong, Jay Groves, Patricia Harrison,Ayumi Shintani, David Schlundt, Connie Root, Elsie Nason, Sheila Misra,Rachel Ribble, Alan Graber, Tom Elasy. A Randomized Controlled Trial toIncrease Daily Activity in Outpatients with Type 2 Diabetes, American DiabetesAssociation, 200325. Yu Asanuma, Annette Oeser, Ayumi Shintani, Elizabeth Turner, Nancy Olsen,Paolo Raggi, Charles M. Stein Accelerated Coronary Artery Atherosclerosis inSystemic Lupus Erythematosus: A controlled study. 2003 Annual ScientificMeeting of American College of Rheumatology.26. Yu Asanuma, Annette Oeser, Tuulikki Sokka, Elizabeth Simpson, AyumiShintani, Paolo Raggi, Theodore Pincus, Charles M. Stein.Coronary Artery

Atherosclerosis is Common in Both Early and Long-Standing RA. 2003 AnnualScientific Meeting of American College of Rheumatology.27. Yu Asanuma, Annette Oeser, Ayumi Shintani, Paolo Raggi, Charles M. Stein.Increased Interleukin-6 in Systemic Lupus Erythematosus: Relationship to OtherCoronary Heart Disease Risk Factors. 2003 Annual Scientific Meeting ofAmerican College of Rheumatology.28. Yu Asanuma, Annette Oeser, Ayumi Shintani, Paolo Raggi, Charles M. Stein.Framingham Risk Score as a Predictor of Coronary Artery Atherosclerosis inSystemic Lupus Erythematosus. 2003 Annual Scientific Meeting of AmericanCollege of Rheumatology.