Screening for hepatocellular carcinoma - IAGH

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• Imaging studies• Ultrasound*HCC: Screening Tests• Computed tomography• No significant differences between spiral CT andMRI Stoker J, Gut 2002• Blood tests• Alpha-fetoprotein*• Des-gamma-carboxy prothrombin• Hepatoma-specific isoforms of alpha-fetoprotein
Changes in sensitivity and specificity of AFPfor diagnosis of HCC using various cut-offsSensitivity SpecificityDiagnostic criteria (%) (%)AFP > 615 ng/mL 56.4 96.4AFP > 530 ng/mL 56.4 94.5AFP > 445 ng/mL 56.4 94.5AFP > 100 ng/mL 72.6 70.9AFP > 20 ng/mL 87.1 30.9Johnson, Clin Liver Disease 2001
Page 5 and 6: Population-based Cancer Registry Da
Page 7: Rising Incidence of HCC(Last 2 deca
Page 10 and 11: Number of casesOverall trend in the
Page 12 and 13: Why is HCC Incidence Rising?Increas
Page 14 and 15: 1. HBVRisk factor of HCC in Iran•
Page 16 and 17: Low incidence of HCC In Iran??• M
Page 18 and 19: Multiple logistic regression analys
Page 20 and 21: HBV In PregnancyContinue the case:
Page 22 and 23: Perinatal Transmission riskMother:
Page 24 and 25: Risk with High Maternal HBV DNA- 31
Page 26 and 27: Teatment During PregnancyOutcomes:-
Page 28 and 29: Treatment Option for Chronic HBVInt
Page 30 and 31: AFP In PregnancyAFP produced byYolk
Page 32 and 33: Screening for chronic diseaseMust b
Page 36 and 37: ScreeningUS Sensitivity and Specifi
Page 38 and 39: HCC Screening: clinical studiesStud
Page 40 and 41: Zhang BH et al, J Cancer Res Clin O
Page 42 and 43: Zhang BH et al, J Cancer Res Clin O
Page 44 and 45: AASLD Recommendation for HCC survei

Screening for hepatocellular carcinoma - IAGH

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