Therapeutic Handbook - GGC Prescribing

Table 1 – Alert AntibioticsInfectionsAlert AntibioticPermitted IndicationsAmikacin IV 1. Gentamicin resistant Gram-negative infections.2. In combination therapy for mycobacterial infection when oral therapy isnot possible or drug resistance is suspected.3. Severe neutropenic sepsis in accordance with haematology or oncologyunit's sepsis protocol.Ceftaroline IVOnly on the advice of a microbiologist or infectious diseases physician.Ceftazidime IV 1. Febrile neutropenia, in accordance with haematology or oncology unit'ssepsis protocol.2. Empiric therapy for CAPD associated peritonitis.3. Exacerbation of bronchiectasis / cystic fibrosis if evidence of colonisationwith Pseudomonas or resistant Gram-negative organism.Ceftriaxone IV 1. Bacterial meningitis2. Enteric fever (typhoid or paratyphoid)3. Brain abscess4. Acute severe pelvic inflammatory disease.5. Outpatient parenteral antibiotic therapy as per agreement with infectionspecialist.Ciprofloxacin IV 1. If oral route is compromised and ciprofloxacin prescribed in line with theInfection Management Guideline.2. Treatment of spontaneous bacterial peritonitis for 2 days only then oralfor 5 days (in line with Infection Management Guidelines, page 238).3. Neutropenic patient with fever and true penicillin allergy (in line withInfection Management Guidelines, page 214).Clindamycin IV 1. Suspected necrotising fasciitis or severe or rapidly progressive soft tissueinfection2. Suspected severe streptococcal or staphylococcal sepsis / toxic shocksyndrome3. Second-line therapy for PCP e.g. in HIV infection4. Severe pharyngitis5. Surgical prophylaxis for caesarian section in a patient with true penicillinallergyColistin IVOnly on the advice of a microbiologist or infectious diseases physician.Table continues on next pagePage 208