Therapeutic Handbook - GGC Prescribing

InfectionsDosage regimens for antibiotics with narrowtherapeutic rangesHeight and weight conversion and maximum body weight for creatinine clearance estimation (MBW)Maximum body weight tableHeight(feet/inches)Height(cm)MBW (kg)(male)MBW (kg)(female)4’8” 142 49 434’ 9” 145 52 474’ 10” 147 54 494’ 11” 150 58 525’ 0” 152 60 555’ 1” 155 62 585’ 2” 158 66 605’ 3” 160 68 625’ 4” 163 71 665’ 5” 165 74 685’ 6” 168 77 715’ 7” 170 79 745’ 8” 173 82 775’ 9” 175 85 795’ 10” 178 88 825’ 11” 180 90 856’ 0” 183 94 886’ 1” 185 96 906’ 2” 188 98 946’ 3” 191 101 976’ 4” 193 104 996’ 5” 195 107 1016’ 6” 198 109 1056’ 7” 201 113 1086’ 8” 203 115 110Estimation of creatinine clearanceThe following ‘Cockcroft Gault’ equation can be used to estimate creatinine clearance (CrCl).Cautions!• Use actual body weight (ABW) or maximum body weight (MBW), whichever is lower.• Use 60 micromol/L if the creatinine concentration is < 60 micromol/L.• This equation may overestimate CrCl in elderly or malnourished patients.• DO NOT USE eGFR.Page 260CrCl =(ml/minute)[140 – age (years)] x weight (kg)serum creatinine (micromol/L)Weight conversion tableStones lb kg5 0 325 7 356 0 386 7 417 0 457 7 488 0 518 7 549 0 579 7 6010 0 6410 7 6711 0 7011 7 7312 0 7612 7 8013 0 8313 7 8614 0 8914 7 9215 0 9515 7 9916 0 10216 7 10517 0 10818 0 11519 0 121x 1.23 (male) OR x 1.04 (female)