Integration in Chromatography - BEBAC ⢠Consultancy Services for ...
Integration in Chromatography - BEBAC ⢠Consultancy Services for ...
Integration in Chromatography - BEBAC ⢠Consultancy Services for ...
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<strong>Integration</strong> <strong>in</strong> <strong>Chromatography</strong><strong>Integration</strong>•Automatic vs. manual•Example: LC/MS-MS, risperidone, prote<strong>in</strong> precipitation,dilution factor 8, API 4000, software Analyst1.4.1; 1 ng/mL and 0.1 ng/mL (at LLOQ)<strong>Integration</strong> methodautomated (smooth<strong>in</strong>g 1, bunch<strong>in</strong>g 2)1 ng/mL 0.1 ng/mLCV (n=10)6.5%15.1%manual correction (one analyst)manual correction (ten analysts)6.3%5.2%(3.8% – 6.8%)11.1%12.8%(6.9% – 16.0%)H Kirchherr, Data Evaluation <strong>in</strong> LC-MSIn: H-J Kuss and S Kromidas (eds.), Quantification <strong>in</strong> LC and GC, Wiley, p243-259 (2009)Workshop | Bucarest, 19 March 201326 • 32
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