FORMULATION OF AN ULTIMATE NUTRITIONAL SUPPLEMENT ...

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24B. The Packaging1. DescriptionMEGADERM is packed in a 250 ml PET bottle. Thanks to the physical properties ofPET? This bottle has a glass clear appearance. A colour UV-filter has be added to protectthe formula from UV action.MEGADERM is delivered thanks to an automatic 5ML dosing system.2. Advantages of the PET materialPET (the full name is PolyEthyleneTerephalate) is a thermoplastic polyester used firstly asa textile fibre and nowadays in food, water, cosmetics and pharmaceuticals packaging.The inherent leakproofness, light weight and resistance to physical damage of this materialmake it the “natural” material in Veterinary products.PET has a very good resistance against many chemicals.PET does not interact with the products that are packed in it, nor will it gave a taste, smellor flavour.PET has been registered as a safe material by FDA and other health institutions.PET can be easily recycled.3. Advantages of this automatic dosing system
25III. KEYPOINTS OF THE BENEFITS OF MEGADERM IN ANIMALSAFFECTED WITH SKIN DISEASES(refer to figure 2B)MEGADERM offers a large quantity of all the necessary EFAs among the sole ω6 andω3 families (the amount of detrimental FA is considerably reduced) according to theoptimal ratio (5:1) and in addition to their cofactors and antioxidants, within a galenicalinnovation.ω6 - Supplementation in LA is of direct structural benefit to the quality of the superficiallipid film and of the intercellular cement in the epidermis.In addition to improving skin integrity and epidermal barrier function, LA and GLAsupplements may also favour the production of anti-inflammatory mediators.ω3 - ω3 supplementation (EPA and DHA) engenders stock of EPA in cell membraneswhich ameliorates their fluidity and stability, and therefore reinforces skin integrity.Moreover, this supplement favours the production of anti-inflammatory mediators to thedetriment of pro-inflammatory mediators.Cofactors (VitA, VitB 6 , VitE, VitH, Zn) – The presence of cofactors enhances theeffects of these FA (refer to figure 2A). They are also beneficial in nourishing the skin andhaircoat.Antioxidants - The presence of antioxidants, as vitamin E, guarantee an optimalpreservation of the FA from the manufacture till their metabolic use.A liquid form - The liquid form is the most adequate form for delivering the desireddaily amount. This is explained by the fact that EFAs are present in liquid oils that cannotbe compressed or dehydrated. Therefore, for a certain amount of given EFAs, the liquidform is the one that fills the less volume. The administration is facilitated by the presenceof EFAs in a bottle with a delivery system since the administered dose may be spread overthe food.An innovative galenic - Galenical research has leaded to a drinkable emulsion, whichallows excellent stability of the product and improves the digestive biodisponibility of thesolubilised ingredients.MEGADERM is, amongst the EFA diet supplements, the most adequate formulaaccording to current knowledge and in respect of the goals coveted : improve skin and coatcondition, reinforce skin integrity, maintain efficient epidermal barrier function anddiminish clinical signs due to allergic conditions or keratinisation disorders.Furthermore, thanks to it’s richness as far as quality and quantity, for each of both families,the new MEGADERM formula is hardly influenced by any diet variation of FA. Thisformula preserves and grants all of its qualities even when added to the most deficient or“rich” diets.
Page 5: 21A diet supplement must be rich en
Page 10 and 11: 26Because EFAs are uncommonly toler
Page 12 and 13: 2819. VAUGHN D.M., REINHART G.A., S
Page 14 and 15: 3012. JOEL M. KREMER, M.D., WILLIAM
Page 16 and 17: 3240. JEAN A. HALL, DVM, PhD - 1995

FORMULATION OF AN ULTIMATE NUTRITIONAL SUPPLEMENT ...

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