Download PDF - jifsan

More documents

Recommendations

Info

Gaps In Science Related to Susceptibility Biomarkers• Large variation ingenetic associations• Studies oftenunderpowered• May require more thanSNPS, i.e.• transcriptomics,proteomics,metabolomics• Confounders notadequately evaluated
% Reduction in LDL Cholesterol as an•Jenkins et al., JAMA 290:502-510, 2003•4 weeks• Statins vs. NCEPStep 2 diet vs. a Portfolioeating plan: plant sterols (1g/1000 kcal) almonds (14 g/1000 kcal) viscous fiber (9.8 g/1000 kcal) soy protein (21.4 g/1000 kcal)Effect Biomarker0-5-10-15-20-25-30-35-8-31-29NCEP Statins Portfolio(20 mg) dietDietary can lower cholesterol as much as cholesterol-lowering drugs
Page 2: Unprecedented opportunities exist f
Page 5 and 6: Surrogate markerIs a response varia
Page 7 and 8: SYSYTEMS BIOLOGY APPROACH TOBIOMARK
Page 9 and 10: Pathway of DiseaseNatural History o
Page 11 and 12: Biomarkers and Other IntermediateId
Page 13 and 14: Three Types Biomakers NeededExposur
Page 15 and 16: Epidemiologic Studies of Soy Compon
Page 17 and 18: Tissue and Leukocyte IQ-DNA Adducts
Page 19 and 20: Bronchodilator Response to Albutero
Page 21 and 22: The “Omics” of Nutrition and Ef
Page 23 and 24: Influence of Caffeine on Bone Mass
Page 25: Nutrigenomics today!• Commercial
Page 30 and 31: MULTIPLE PATHWAYSEBDMOne Pathway: A
Page 32 and 33: • Tomatoes• Spinach• Broccoli
Page 34 and 35: Components are “complexmixtures
Page 36 and 37: Similar to Drugs One Size Does Not
Page 38 and 39: Life Style Issues• What are appro
Page 40 and 41: Nutritional Preemption(A Strategy f
Page 42: Success Will Rest With the ability

Download PDF - jifsan

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?