Applying quality by design to vaccine development - BioProcess ...

Influenza Virus Types‣ Influenza Type A• Infects humans, birds, pigs, horses• Most prevalent, occurs in several Sub‐Types• Most likely to demonstrate Antigenic Drift Shift• Major Antigenic Shift may lead to pandemic‣ InfluenzaType B• Infects humans, seals• Less volatile, no sub‐types• Antigenic drift, slower than Type A‣ Influenza Type C• Infects humans• Comparatively rare –not included in standard vaccinesFrom Clone to Clinic®