Applying quality by design to vaccine development - BioProcess ...
Applying quality by design to vaccine development - BioProcess ...
Applying quality by design to vaccine development - BioProcess ...
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Recombinant Influenza VaccineIdentifyTarget StrainObtain sequence of antigeniccomponents (HA +/‐NA)GeneraterecombinantexpressionconstructGenerally requires no more than two weeksProduceRecombinantprotein or VLP onLarge ScaleHarvest, purify(protein or VLP)Fill/finish similar <strong>to</strong> standardbiopharmaceuticalsFrom Clone <strong>to</strong> Clinic®