Early Development of Poorly Water-Soluble NCEs - American ...
Early Development of Poorly Water-Soluble NCEs - American ...
Early Development of Poorly Water-Soluble NCEs - American ...
- No tags were found...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Challenges with Melt ExtrusionFeed portHeated barrel withtemperature zonesMotor19Conveying zoneMixingzoneDie• Relatively short dwell time in the heated barrel• Temperature must be higher than the melting temperature (~15-20°C) for complete conversion to amorphous form and ease<strong>of</strong> processing (reduced viscosity)• Risk associated with chemical stability – thermo-labilecompounds• High Tg <strong>of</strong> commonly used polymers (150-160 °C) – needsuitable plasticizers; temperature must be > Tg• Lack <strong>of</strong> miscibility between drug and polymer
Change language