Early Development of Poorly Water-Soluble NCEs - American ...

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Early Development of Poorly Water-Soluble NCEs - American ...

Early Development of Poorly Water-Soluble NCEs - American ...

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Nanoparticle FormationCommon Techniques9– Wet milling– High pressure homognization– Supercritical fluid technologies• Solvent• Anti-solvent– Liquid precipitation– Nano-emulsion or suspension• Lipid-surfactant systems• Solid dispersion system

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Nanoparticle FormationCommon Techniques9– Wet milling– High pressure homognization– Supercritical fluid technologies• Solvent• Anti-solvent– Liquid precipitation– Nano-emulsion or suspension• Lipid-surfactant systems• Solid dispersion system

Page 1: Early Development of Poorly Water-S
Page 4 and 5: Development Strategies vsOutsourcin
Page 6 and 7: How Does Salt Formation IncreaseDis
Page 10 and 11: 10High-energy Solid
Page 12 and 13: Heat content(enthalpy, H)Advantage
Page 14 and 15: Preparation of Solid Dispersion -So
Page 16 and 17: Preparation of Solid Dispersion -Me
Page 18 and 19: Solid Dispersion by Melt ExtrusionT
Page 20 and 21: Nanoemulsion/Solid NanoemulsionPrec
Page 22 and 23: Limitation of Lipid-based DrugDeliv
Page 24: Outsourcing of Early Development of