IonWorks Barracuda Automated Patch Clamp System

PatchXpress 7000A SystemAn automated parallel patch clamp system> conventional patchclampquality data> tight giga-ohm seals> fast solution exchange> assays voltage- andligand-gated ionchannels> dataxpress softwarefor data managementand analysisThe PatchXpress ® 7000A Automated ParallelPatch Clamp System directly records ion channelactivity in a true whole-cell patch-clamp screeningassay, dramatically improving throughput incomparison to manual methods. When used atfull capacity as a screening tool, the PatchXpress7000A System can test over 500 compounds inan eight-hour day—an increase in patch-clampthroughput more than two orders of magnitude!A Fully Featured, Research-CapablePatch-Clamp WorkstationThe PatchXpress ® 7000A System is both ascreening system and a fully-fledged, flexible,basic research electrophysiology workstation.For ion channel screening, there is simply nocomparison. The system’s capabilities includeoptional multi-drug or multi-concentrationapplications on a single cell, with sophisticatedstimulation and recording protocols. The highperformancefluidics system automaticallyapplies compounds with exchange rates on theorder of 10–15 ms.The software running the instrument monitorsthe success of each washout—and optionallysupports application of a new compound only ifthe baseline current returns to a user-set threshold.Test compounds are only applied to successfullypatch-clamped cells, thereby eliminating compoundwastage. With the PatchXpress system, you candecide whether to apply many compounds to asingle cell or to apply only one compound and usea sequence of detailed voltage protocols.Seriously Tap into Ion Channel Targetsfor the First TimeThe PatchXpress ® 7000A System opens up a hugepool of highly “druggable” ion channel targets to thedrug discovery industry. The exclusive SealChip 16planar electrodes from AVIVA BioSciences, at theheart of the PatchXpress system, give the systemits edge. These are backed up by robust, accurate,and highly configurable amplification and fluidicssystems.Whether you need a screening or researchtool, high-quality data is absolutely essential.Otherwise, costly false positives and/or negativeswill still be a problem. The PatchXpress 7000ASystem provides high-quality patch-clamp data—backed by over two decades of experience as theworld-leader in electrophysiology hardware andsoftware.