Integrated Physiology/Obesity124-LBA Metabolically Healthy Obese Phenotype in Hispanic Participantsin <strong>the</strong> IRAS Family StudyXANTHIA F. SAMAROPOULOS, KRISTEN G. HAIRSTON, ANDREA ANDERSON,STEVEN M. HAFFNER, CARLOS LORENZO, MARIA MONTEZ, JILL M. NORRIS,ANN L. SCHERZINGER, YII-DER I. CHEN, LYNNE WAGENKNECHT, Winston-Salem, NC, San Antonio, TX, Denver, CO, Aurora, CO, Los Angeles, CASome obese individuals appear to be protected from developing type 2diabetes mellitus and cardiovascular disease. This has led to characterizingdifferent body size phenotypes based on standard cardiometabolic riskfactors. The aim <strong>of</strong> this study was to measure <strong>the</strong> prevalence and describefat distribution across <strong>the</strong>se different phenotypes in a minority population.Hispanic participants (N=1054) in <strong>the</strong> IRAS Family Study were categorizedas obese or overweight, and as metabolically healthy (MH) or metabolicallyabnormal (MA) based upon a previously published algorithm (Wildman, etal. Arch Intern Med 2009). Computed tomography scans were evaluatedfor measures <strong>of</strong> non-alcoholic fatty liver disease (NAFLD) and abdominalfat distribution. Statistical models adjusting familial relationships wereestimated. Seventy percent <strong>of</strong> <strong>the</strong> Hispanic cohort was overweight (32%) orobese (38%). Forty-one percent (n=138) <strong>of</strong> overweight participants and 19%(n=74) <strong>of</strong> obese participants met criteria for MH. In addition to expecteddifferences in metabolic factors used to define <strong>the</strong>se groups, MH individualswere, on average, younger than MA groups, more physically active, less likelyto be on medications, had smaller waist circumference, and had higher levels<strong>of</strong> circulating adiponectin. Adjusted analyses showed <strong>the</strong> MH phenotype wasassociated with lower visceral adipose tissue (VAT) and liver density in obeseparticipants (p=0.0004 and p=0.0002), and lower VAT but not liver densityin overweight participants (p=0.0069 and p=0.15) compared to <strong>the</strong>ir MAcounterparts. Odds <strong>of</strong> NAFLD were reduced in MH obese (OR=0.34, p=0.0007)compared to MA obese. VAT and liver density did not differ between MHoverweight (or obese) and normal weight groups. These findings suggestthat lower levels <strong>of</strong> visceral and liver fat, despite overall increased total bodyfat, may be a defining feature <strong>of</strong> MH obesity in Hispanic Americans. Fur<strong>the</strong>r,obesity as defined by BMI may not have <strong>the</strong> same physiologic significance forevery individual.125-LBLong-Term Effects <strong>of</strong> Lifestyle Intervention on Weight andCardiovascular Risk Factors in Individuals with Type 2 Diabetes inReal World Clinical Practice: 4-Year Longitudinal ResultsOSAMA HAMDY, AMR MORSI, ADHAM ABDEL MOTTALIB, NUHA EL SAYED,ANN GOEBEL-FABBRI, GILLIAN ARATHUZIK, JACQUELINE SHAHAR, JOANBEATON, PAMELA NEEDLE, AMANDA KIRPITCH, JOHN ZREBIEC, MICHAEL SEE,CATHERINE CARVER, JO-ANNE RIZZOTTO, MARTIN J. ABRAHAMSON, Boston,MAClinical studies showed that obese patients with type 2 DM (T2DM) wholose weight through intensive lifestyle interventions (ILI) frequently regainmost <strong>of</strong> that weight within a year. However, no study evaluated <strong>the</strong> impact<strong>of</strong> long-term weight maintenance versus weight regain on cardiovascularrisk factors. We longitudinally evaluated 119 patients with T2DM (meanage 54.5+10.1 yrs) who enrolled in <strong>the</strong> Weight Achievement and IntensiveTreatment (Why WAIT) program, a 12-wk <strong>of</strong> ILI in real-world clinical practice.After 1 yr, we divided <strong>the</strong>m into Group A, who maintained >7% <strong>of</strong> weight lossand group B who regained weight. We followed <strong>the</strong>m for 4 yrs. Group A (55patients, mean weight 249.8 lbs) lost an average <strong>of</strong> -29.8+ 8.9 lbs (-11.9%) at12 wks and maintained -31.6+14.8 lbs (-12.6%) at 1 yr. Group B included (64patients, mean weight 241.5 lbs) lost an average <strong>of</strong> -19.4+8.4 lbs (-8.0%) butwas down to -6.2+9.0 lbs (-2.6%) at 1 yr. At 2, 3 & 4 yrs, group A maintaineda weight loss <strong>of</strong> -24.4, -23.8 & -24.4 lbs respectively. Group B maintained-7.1, -6.5 & -8.2 lbs respectively. In group A, HbA1c dropped from 7.2+1.1%to 6.2+0.9% at 12 wks (p
Islet Biology/Insulin Secretion128-LBAssociations between Common Variants in CYP24A1 and Risk <strong>of</strong>Obesity in Chinese HansLING LU, WEI GAN, JINGWEN ZHU, HAIYING TANG, HUAIXING LI, XU LIN,Shang hai, ChinaThe 24-hydroxylase (encoded by CYP24A1) is a key enzyme involved indegradation <strong>of</strong> vitamin D metabolites, and gene variants in CYP24A1 maymodify vitamin D metabolism. Recently, emerging evidence suggested arole <strong>of</strong> vitamin D in <strong>the</strong> development <strong>of</strong> obesity. Therefore, <strong>the</strong> objective <strong>of</strong><strong>the</strong> present study was to investigate whe<strong>the</strong>r variants in CYP24A1 wereassociated with obesity and its related phenotypes in Chinese Hans. Eight tagsingle-nucleotide polymorphisms (SNPs) in CYP24A1 (rs2245153, rs927651,rs3787554, rs2181874, rs2762941, rs3886163, rs2248461 and rs2296241)were genotyped by using ABI Prism 7900 HT Sequence Detection Systemin a population-based sample including 474 obese (BMI ≥28kg/m2), 1221overweight (24 ≤BMI
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