2007 Winter Meeting - London - The Pathological Society of Great ...

P41Outcome of Screen Detected Breast Lesions with False PositivePre-operative Core Biopsy or FNAC{P} Y F Baber, J Dove, D RavichandranLuton NHS Foundation Trust, Luton, United KingdomThe objective was to study the outcome of patients with screen detected breastlesions in whom pre-operative core biopsy and/or FNAC were reported assuspicious or definitely malignant but the final histology of the excised lesionwas benign.Between April 1998 and March 2004 40 patients were identified from theBedfordshire and Hertfordshire Breast Screening Centre database. The meanage was 56 years(50-78). Mammographic abnormalities were microcalcificationin 17, soft tissue lesion in 19 and both in 4. Thirty-five patients had both FNACand CB and 5 had FNAC only.All cytology, core biopsies and final excisions, where available, were reviewedon 33 patients.The median follow up period following surgery was 36 months. No patient hadbeen diagnosed with breast cancer in this period.In conclusion, "false positive" core biopsy or FNAC is uncommon in screendetected lesions and this data suggests that these patients are not at a higher riskof being diagnosed with a malignancy following this episode and may bereturned to routine screening.P42Glycan Profiles of Breast Cancer: Distinguishing Invasivefrom In-Situ{P} A Leathem 1 , H Lacey 1 , MDwek 21 University College London, London, United Kingdom, 2 University ofWestminster, London, United KingdomGlycans, or complex-sugar chains on the surface of cells, provide importantsignals for cell-cell interaction, such as fertilization, cell adhesion and immunerecognition. Changes in the glycans of normal cells have been described inmany cancers, some probably related to invasive and metastatic behaviour. Weare developing methods to compare the glycans of healthy and cancer tissuesand discovered differences between glycans of In-Situ and Invasive breastcancer tissues.Intact glycans were released from tissues using anhydrous hydrazine and and,after labelling with a fluorescent tag, were separated on a range of HighPerformance Liquid Chromatography matrices.The profiles of Invasive and In-Situ cancers were mapped and show severaldifferences, particularly in the diversity of sialylated and neutraloligosaccharides and the number of sialylated structures. We are trying toseparate and characterize these structures. This may help us follow in-situ toinvasive behaviour and provide a simple biomarker to aid in diagnosis.P43Hidden Danger: Carcinoma Arising in Accessory BreastTissue in a BRCA2 Germline Mutation Carrier.{P} H G Shenoy, M B Peter, S A Lane, K Horgan, A M HanbyLeeds General Infirmary, Leeds,West Yorkshire, United KingdomA 43-year-old lady with a family history of breast cancer presented with a rightaxillary lump. Excision revealed two lymph nodes infiltrated withundifferentiated carcinoma (ERα positive). Investigation failed to identify theprimary tumour but an occult primary breast cancer was assumed and treatmentwith adjuvant chemotherapy followed. Subsequent genetic assessment showedshe had a germline BRCA2 mutation. She opted for bilateral prophylacticmastectomies, a right axillary node clearance and bilateral oophoretomies- all ofwhich showed benign histology.20 months later, she noted a small superficial lump in the skin of thecleared axilla. A clinical diagnosis of a benign skin adnexal lesion was made.Excision showed a 10mm Invasive Ductal Carcinoma (ERα+ve, PR-ve, Her-2+ve) with extensive high grade DCIS within accessory breast tissue. Furtherexcision of remaining axillary tissue revealed residual high grade DCIS andfive negative lymph nodes. A retrospective history revealed that she had a rightaxillary swelling during breast-feeding and regression on cessation.This case underlines the possibility that even after risk-reducing surgery,affected kindred with a risk of heritable breast cancer may develop breastcancer in any accessory breast tissue found along the milk-line; which extendsfrom the axilla to the vulva.P44Adenoid Cystic Carcinoma (ACC) of the Breast – A Report ofa Case with Long Follow-up{P} MB Peter, HG Shenoy, K Horgan, AM ShaabanLeeds General Infirmary, Leeds, West Yorkshire, United KingdomACC is a rare mammary neoplasm representing