Toxicity Assessment of F-T Jet Fuel (JP-8/SPK) - E2S2

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Naval Health Research CenterEnvironmental Health Effects LaboratoryAlpha 2 MicroglobulinGroup Exposure Level α 2μ - globulin Concentration (µg/mg)MalesFemalesControl 0.02 ± 0.10 49.43 ± 20.87 0.16 ± 0.05Low 200.1 ± 5.0 49.72 ± 20.57 N/AIntermediate 698.6 ± 16.8 50.90 ± 13.72 N/AHigh 1988.4 ± 48.1 35.65 ± 8.49 0.15 ± 0.01
Naval Health Research CenterEnvironmental Health Effects LaboratoryF-T Jet Fuel ToxicityAssessmentConclusions:‣Dermal - animal protocol approved, start date TBD‣Genotox - No genetic mutations observed in vitro‣Inhalation‣Acute - No clinical symptoms observed‣2-week - Histological findings in:‣lung: Inflammatory foci evident in highest doses‣Olfactory epithelia: degeneration in highest doses‣Kidney: hyaline droplet accumulation in all males exposed‣Liver: Panlobular hepatocyte changes in all males exposedand females exposed to the highest concentration‣90-day- Started 28 Apr 08
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Toxicity Assessment of F-T Jet Fuel (JP-8/SPK) - E2S2

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