Toxicity Assessment of F-T Jet Fuel (JP-8/SPK) - E2S2

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Naval Health Research CenterBackground‣ Jet fuel toxicity risks traditionally associated with aromatichydrocarbons‣ JP-4‣ Conventional petroleum-based military aviation fuels contain ~20%‣ Aromatics and 1-3% naphthalene.‣ toxicity studies have reported skin irritation, defatting, neurotoxicitynephrotoxicity and, in male rats, renal carcinogenicity.‣ In humans, symptoms of neurasthenia, psychasthenia, polyneuropathy andsexual dysfunction has been reported in military and civilian workers.Erica BecvarAFCEE/TDVEnvironmental Health Effects Laboratory
Naval Health Research CenterBackground‣ JP-8 Toxicity‣ Considered slightly toxic‣ Oral Lethal Dose (LD 50 ) > 5.0g/kg (highest tested)‣ Dermal – non-irritating to slightly irritating‣ Repeated and continuous exposure does cause irritation in animals and humans‣ Acute Vapor Inhalation Lethal Concentration (LC 50 ) >3.43 mg/L (highesttested)‣ Acute Aerosol LC 50 >4.39 mg/L (highest tested)‣ Subchronic Inhalation- decreased body weight and renal hydrocarbonnephrothopy in male rats‣ Chronic Inhalation – male rat nephrothapyErica BecvarAFCEE/TDVEnvironmental Health Effects Laboratory
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Toxicity Assessment of F-T Jet Fuel (JP-8/SPK) - E2S2

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