Sepsis and Septic Shock in Pregnancy - Children's Memorial ...

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Disclosure of RelevantFinancial RelationshipsResearch support• Alere, San Diego (BIOSITE)• Beckman Coulter(Biomarkers for preeclampsia)Consultation• GTC Biotherapeutics
Cases / 100,000Deaths/YearComparison of Sepsis WithOther Major DiseasesIncidence of Severe SepsisMortality of Severe Sepsis300250,000250200,000200150100500AIDS* Colon Breast CHF † SevereCancer § Sepsis ‡150,000100,00050,0000AIDS*BreastCancer §AMI †SevereSepsis ‡†National Center for Health Statistics, 2001. § American Cancer Society, 2001. *American Heart Association.2000. ‡Angus DC et al. Crit Care Med. 2001;29(7):1303-1310.
Page 1: Sepsis and Septic Shockin Pregnancy
Page 5 and 6: Maternal mortality, 1842“It is no
Page 7 and 8: The Intervention:Hand scrub with ch
Page 9 and 10: Definitions• Sepsis- SIRS due to
Page 11 and 12: Case History• 31 wks, sore throat
Page 13 and 14: Group A StreptococcusThe Etiology,
Page 17 and 18: MicroabscessFascia
Page 19 and 20: Early Goal Directed Therapy• Earl
Page 21 and 22: Mortality (%)The Importance of Earl
Page 23 and 24: Algorithm for Septic Shock in Pregn
Page 25 and 26: Antimicrobial Therapy• Infection
Page 27 and 28: Post-op C/SMultilocularabscessDispl
Page 29 and 30: Postpartumnecrotizingfasciitis
Page 31 and 32: Empiric Antimicrobial Therapy• Ge
Page 33 and 34: Vasoactive Therapy• Indication- H
Page 35 and 36: Corticosteroids• Treat patients w
Page 37 and 38: Presentation: Temp 103.5, severe fl
Page 39 and 40: Maintenance PhaseAnticipation of co
Page 41 and 42: H1N1 influenza-associated ARDS: Bil
Page 43 and 44: Indications for surgical interventi
Page 46 and 47: Obesity Trends*Among U.S. AdultsDon
Page 48 and 49: Outcome
Page 50 and 51: References• Mabie WC, Barton JR,
Page 52 and 53:
References• Walsh C, Scaife C, Ho
Page 54 and 55:
References• Kitter ND, McMullen K
Page 56 and 57:
Historical Guidelines for Sepsis Th
Page 58 and 59:
Probability of SurvivalFluid Resusc
Page 60 and 61:
Drotrecogin Alfa (Xigris)• Decrea
Page 62 and 63:
VentricularFunctionGroup INormalGro
Page 64 and 65:
Varicella-Zosterin Pregnancy
Page 66:
BACKGROUNDGlobal• Puerperal sepsi
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