Sepsis and Septic Shock in Pregnancy - Children's Memorial ...

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Probability of SurvivalFluid ResuscitationSevere SepsisRinger’sacetateHES 130 / 0.4Death rateat 90 days43% Ringer’s51% HES 130Days since randomizationPerner, et alNEJM 2012
"Except on few occasions,the patient appears to die fromthe body's response to infection rather thanfrom it."Circa 1904Sir William Oslerin“The Evolution of Modern Medicine”-1904
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Sepsis and Septic Shockin Pregnancy
Page 3 and 4:
Cases / 100,000Deaths/YearCompariso
Page 5 and 6:
Maternal mortality, 1842“It is no
Page 7 and 8: The Intervention:Hand scrub with ch
Page 9 and 10: Definitions• Sepsis- SIRS due to
Page 11 and 12: Case History• 31 wks, sore throat
Page 13 and 14: Group A StreptococcusThe Etiology,
Page 17 and 18: MicroabscessFascia
Page 19 and 20: Early Goal Directed Therapy• Earl
Page 21 and 22: Mortality (%)The Importance of Earl
Page 23 and 24: Algorithm for Septic Shock in Pregn
Page 25 and 26: Antimicrobial Therapy• Infection
Page 27 and 28: Post-op C/SMultilocularabscessDispl
Page 29 and 30: Postpartumnecrotizingfasciitis
Page 31 and 32: Empiric Antimicrobial Therapy• Ge
Page 33 and 34: Vasoactive Therapy• Indication- H
Page 35 and 36: Corticosteroids• Treat patients w
Page 37 and 38: Presentation: Temp 103.5, severe fl
Page 39 and 40: Maintenance PhaseAnticipation of co
Page 41 and 42: H1N1 influenza-associated ARDS: Bil
Page 43 and 44: Indications for surgical interventi
Page 46 and 47: Obesity Trends*Among U.S. AdultsDon
Page 48 and 49: Outcome
Page 50 and 51: References• Mabie WC, Barton JR,
Page 52 and 53: References• Walsh C, Scaife C, Ho
Page 54 and 55: References• Kitter ND, McMullen K
Page 56 and 57: Historical Guidelines for Sepsis Th
Page 60 and 61: Drotrecogin Alfa (Xigris)• Decrea
Page 62 and 63: VentricularFunctionGroup INormalGro
Page 64 and 65: Varicella-Zosterin Pregnancy
Page 66: BACKGROUNDGlobal• Puerperal sepsi
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