BIOGRAPHICAL SKETCH Wendy M. Mars Associate Professor of ...
BIOGRAPHICAL SKETCH Wendy M. Mars Associate Professor of ...
BIOGRAPHICAL SKETCH Wendy M. Mars Associate Professor of ...
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Regenerative Medicine, Pittsburgh, Pennsylvania2006-present The University <strong>of</strong> Pittsburgh Department <strong>of</strong> Pathology <strong>Associate</strong> <strong>Pr<strong>of</strong>essor</strong>Pittsburgh, Pennsylvania.2006-present The University <strong>of</strong> Pittsburgh Department <strong>of</strong> Pathology Director, Cell. & Mol. Path.Pittsburgh, PennsylvaniaGraduate ProgramHonors:2010-2011 Awarded University <strong>of</strong> Pittsburgh School <strong>of</strong> Medicine Distinguished Mentor AwardC. Selected Peer-reviewed PublicationsMost relevant to the described projects:1. <strong>Mars</strong>, W.M., vanTuinen, P., Drabkin, H.A., White, J.W., and Saunders. G.F.: A myeloid-relatedsequence that localizes to human chromosome 8q21.1-22. Blood 71, 1713-1719 (1988). PMID:33703152. <strong>Mars</strong>, W.M., Zarnegar, R., and Michalopoulos, G.: Activation <strong>of</strong> hepatocyte growth factor by theplasminogen activators uPA and tPA. Amer J Path 143, 949-958 (1993). PMID: 8362987,PMC18872223. Liu, M.-L., <strong>Mars</strong>, W.M., Zarnegar, R., and Michalopoulos, G.K.: The uptake and distribution <strong>of</strong> hepatocytegrowth factor in normal and regenerating adult rat liver. Amer J Path 144, 129-139 (1994).PMID: 8291602, PMC18871164. <strong>Mars</strong>, W.M., Liu, M.-L., Kitson, R.P., Goldfarb, R., Gabauer, M., and Michalopoulos, G.K.: Immediateearly detection <strong>of</strong> urokinase receptor after partial hepatectomy and its implications for initiation <strong>of</strong> liverregeneration. Hepatology 21, 1695-1701 (1995). PMID: 77685155. <strong>Mars</strong>, W.M., Patmasiriwat, P., Maity, T., Huff, V., Siciliano, M., Weil, M., and Saunders, G.F.:Inheritance <strong>of</strong> unequal numbers <strong>of</strong> the genes encoding the human neutrophil defensins HP-1 and HP-3.J Biol Chem 270, 30371-30376 (1995). PMID: 85304626. <strong>Mars</strong>, W.M., Kim, T.-H., Stolz, D. B., Liu, M.-L., and Michalopoulos, G.K.: The presence <strong>of</strong> urokinase inserum-free, primary rat hepatocyte cultures and its role in activating hepatocyte growth factor. CancerRes. 56, 2837-2843 (1996). PMID: 86655237. Yang, Y., Shultz, R.W., <strong>Mars</strong>, W.M., Wegner, R.E., Dai, C., Nejak, K., and Liu, Y.: Disruption <strong>of</strong> tissuetypeplasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy byselective blockade <strong>of</strong> epithelial to my<strong>of</strong>ibroblast transition. J Clin Invest. 110, 1525-1538, (2002).PMID: 12438450, PMC1518178. Michalopoulos, G.K., Bowen, W.C., Mule, K., Lopez-Talavera, J.C., and <strong>Mars</strong>, W.M.: Hepatocytesundergo phenotypic transformation to biliary epithelium in organoid cultures. Hepatology 36, 278-283,(2002). PMID: 12143035, PMC17693349. Ma, Z., Thomas, K.S., Webb, D.J., Moravec, R., Salicioni, A.M., <strong>Mars</strong>, W.M., and Gonias, S.L.:Regulation <strong>of</strong> Rac1 activation by the low density lipoprotein receptor-related protein J Cell Biol 159,1061-1070, (2002). PMID: 12499359, PMC217398910. Schoedel, K.E., Michalopoulos, G.K., Tyner, V.Z., Kim, T-H., and <strong>Mars</strong>, W.M.: Discernable differencesin MET/HGF and matrix-related proteases in hepatocellular carcinoma, fibrolamellar variant, cirrhoticand normal liver. Modern Pathol 16, 14-21, (2003). PMID: 1252770811. Lagoa, C.E., Vodovotz, Y., Stolz, D.B. Lluillier, F., McCloskey, C., Gallo, D., Yang, R., Ustinova, E.,Fink, M., Billiar, T.R. and <strong>Mars</strong>, W.M. Contribution <strong>of</strong> type 1 plasminogen activator inhibitor (PAI-1) tohepatic injury during hemorrhagic shock. Hepatology 42, 390-399 (2005). PMID: 1602551012. Hu, K., Yang, J., Tanaka, S., Gonias, S.L., <strong>Mars</strong>, W.M., and Liu, Y. Tissue-type plasminogen activatoracts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9gene expression. J Biol Chem 281, 2120-2127 (2006). PMID: 1630377113. Hu, K., Wu, C., <strong>Mars</strong>, W.M. and Liu, Y. tPA promotes my<strong>of</strong>ibroblast activation through LRP-1-mediatedrecruitment <strong>of</strong> integrin signaling. J Clin Invest. 117, 3821-3832 (2007). PMID: 18037995, PMC208214314. Lin, L., Bu, G., <strong>Mars</strong>, W.M., Reeves, W.B., Tanaka, S., and Hu, K. tPA promotes renal interstitialfibroblast proliferation through LDL receptor-related protein 1-mediated p90RSK and GSK3betasignaling. Am. J. Path. 177, 1687-1696 (2010). PMID: 20724593, PMC2947266.15. Coudriet, G.M., He, J., Trucco, M., <strong>Mars</strong>, W.M. and Piganelli, J.D. Hepatocyte Growth FactorModulates Interleukin-6 Production in Bone Marrow Derived Macrophages: Implications For
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