Annual Review 2004 - Wellcome Trust

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TRANSLATION20Promoting patient-oriented and health services research.Advancing the dissemination and exploitation of theresults of Trust-funded research.‘Translation’ is all about making apractical difference – generating andusing new knowledge to provide healthbenefits to people. There are manyways in which those benefits maybe realised:• Page 22: Genetic analysis of cancersis revealing new drug targets;• Page 22: A ‘dipstick’ diagnostic toolfor Chlamydia is being taken up andused, and adapted for otherinfections;• Page 23: Field tests of malariadiagnostic kits confirm theirpractical value;• Page 23: Studies of deadly avian fluare helping us prepare for furtheroutbreaks.Malaria continues to exact adevastating toll, particularly amongyoung children in Africa. Around 3000children in Africa die every day. Clinicalresearch is tackling several aspectsof the disease:• Page 24: Artemisinin combinationtherapy – drug treatment pioneeredin South-east Asia – could have amajor impact if widely used in Africa;• Page 24: Unravelling the compleximmune response to themalaria parasite;• Page 25: How the parasite becomesresistant to the antimalarialdrug mefloquine;• Page 25: Why cerebral malaria isn’talways what it seems.The most direct benefits, of course,come from studies on patients.Wellcome-funded clinical researchis continuing to suggest and testnew therapies, in the UK and indeveloping countries:• Page 26: In Vietnam, steroids havebeen shown to enhance survival aftertuberculous meningitis infection;• Page 26: In the UK, the WellcomeTrust’s Clinical Research Facilitieshave begun to deliver a streamof important findings and are havinga significant local impact;• Page 27: The ‘Myskin’ smartdressing was launched duringthe year for burns patients.
TRANSLATION21TRANSLATION
Page 1 and 2: ANNUAL REVIEW2004
Page 3 and 4: CONTENTS120 TranslationAdvancing th
Page 5: DIRECTOR’S STATEMENT3• A bioche
Page 8 and 9: KNOWLEDGE6VANISHING GENESThe ‘gol
Page 10 and 11: KNOWLEDGE8STUCK IN A RUTLIVING BRAI
Page 12 and 13: KNOWLEDGE10HEATEDDISCUSSIONGlobal w
Page 14 and 15: KNOWLEDGE12CROSS-CHANNELTHERAPYThan
Page 16 and 17: RESOURCES14RESOURCES
Page 18 and 19: RESOURCES16HUNTINGTON’S HOPEWork
Page 20 and 21: RESOURCES18OPENING TIMETOBACCO ARCH
Page 24 and 25: TRANSLATION22GENE TARGETSThe identi
Page 26 and 27: TRANSLATION24ACT NOWFIGHTING BACKAn
Page 28 and 29: TRANSLATION26STEROIDSUCCESSSteroids
Page 30 and 31: PUBLIC ENGAGEMENT28Stimulating an i
Page 32 and 33: PUBLIC ENGAGEMENT30PLEASURE AND PAI
Page 34 and 35: PUBLIC ENGAGEMENT32MEDICALINNOVATIO
Page 36 and 37: A YEAR AT THE WELLCOME TRUST34A YEA
Page 38 and 39: FINANCIAL SUMMARY36FINANCIAL SUMMAR
Page 40 and 41: IMMUNOLOGY AND INFECTIOUS DISEASE38
Page 42 and 43: MOLECULES, GENES AND CELLS40MOLECUL
Page 44 and 45: NEUROSCIENCE AND MENTAL HEALTH42NEU
Page 46 and 47: POPULATIONS AND PUBLIC HEALTH44POPU
Page 48 and 49: TECHNOLOGY TRANSFER46TECHNOLOGY TRA
Page 50 and 51: PUBLIC ENGAGEMENT48PUBLIC ENGAGEMEN
Page 52 and 53: FUNDING COMMITTEES50FUNDINGCOMMITTE
Page 54 and 55: FUNDING COMMITTEES52FUNDINGCOMMITTE
Page 56: The Wellcome Trust is an independen

Annual Review 2004 - Wellcome Trust

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