Chemistry PDF - Chemistry Department

Organic ChemistryProf. Dr. Aurangzeb HasanDepartment of Chemistry,Faculty of Science, University ofMalaya,Tel: 03-7967 5165,Fax: 03-7967 4193,E-mail: aurangzeb@um.edu.myResearch InterestsSynthesis of Heterocyclic Compounds: Heterocyclic compounds serve as a central role in thedevelopment of numerous important therapeutic agents and have played an important role inmedicinal chemistry. For small organic molecules simple nitrogen or oxygen containingheterocycles have received a large amount of attention. We are interested in the synthesis ofheterocycles such as pyrazolines, oxadiazoles, triazoles and pyrimidine derivatives having potentialpharmaceutical and other industrial propertiesChemistry of Flavonoids: Flavonoids constitute one of the most characteristic classes ofcompounds in higher plants. Flavonoids, are polyphenol antioxidants. They are secondarymetabolites, meaning they are organic compounds. These natural products are plant nutrients thatwhen consumed in the form of fruits and vegetables are non-toxic and potentially beneficial to thehuman body. Flavonoids give the flowers and fruits of many plants their vibrant colors. Moreimportantly, the consumption of foods containing flavonoids has been linked to numerous healthbenefits. Recent research indicates that flavonoids can be nutritionally helpful by triggeringenzymes that reduce the risk of certain cancers, heart disease, and age-related degenerativediseases. We are interested in the isolation, characterization and biological screening of flavonoidsand related compounds from medicinal plants species.Research Areas Synthetic Organic Chemistry Natural product Chemistry Computational ChemistryResearch Findings Synthesis of heterocyclic compounds exhibiting fluorescent, biological and UV filtrationproperties Isolation of flavonoid and related compounds having antifungal, antibacterial and otherbiological properties. Synthesis of various classes of flavonoids having potential biological activities.NNROHHPyrazolineNNOFlavanoneNH 2PyrimidineOOFlavoneOChalcone1,3-Diphenyl-2-propene-1-onePhenyl steryl ketoneOAuroneOOOEmission Spectra of 1,3,5-triaryl-2-pyrazolinesIsoflavoneHeterocyclic CompoundsFlavonoids48 Faculty of Science, University of Malaya