MATERIAL SAFETY DATA SHEET Page 1 of 5 Product Reorder No ...

MATERIAL SAFETY DATA SHEET Page 1 of 5Product Reorder No. 762125, 769999CHEMICAL PRODUCT AND COMPANY IDENTIFICATION - SECTION 1MSDS Number: VS60341-02Issue Date: August 3, 2001Supersedes: February 22, 2001ERCO No.: 104389Company Identification:Becton Dickinson VACUTAINER® SystemsA Division of Becton Dickinson and CompanyBelliver Industrial EstatePlymouth, PL6 7BPEnglandFOR CHEMICAL EMERGENCY, SPILL LEAK, FIRE, EXPOSURE, OR ACCIDENT:In the continental U.S., call Chemtrec: 1-800-424-9300For additional non-emergency information, call: 1-201-847-4688Product Name: PAXgene Blood RNA TubeReorder Number 762125, 769999Synonym(s): N/AChemical Formula: N/AChemical Family: N/ACOMPOSITION/ INFORMATION ON INGREDIENTS - SECTION 2Chemical CAS Number Exposure Limits Weight of CompoundLiquid (Proprietary Compound Mixture) N/A N/A 2.5-10%HEALTH EFFECTS SUMMARY - SECTION 3The following information summarizes human experience and results of scientific investigations reviewed by healthprofessionals for hazard evaluation of and development of Precautionary Measures and Occupational ControlProcedures recommended in this document.Primary Route of Entry: Dermal contact, eye contact, or inhalation.Medical Conditions Which Might be Aggravated: None identified.Acute Exposure Effects:1. Skin: May cause slight irritation.2. Eyes: May cause slight irritation.3. Inhalation: May cause drying of respiratory tract, which results in irritation, and coughing.4. Ingestion: Large quantities may cause nausea and vomiting.Repeated Exposure Effects:

MATERIAL SAFETY DATA SHEET Page 2 of 5Product Reorder No. 762125, 7699991. Skin: Unknown at this time. Similar compounds have been observed to cause localized pain andcyanosis in fingers (arteris) with repeated exposure.2. Inhalation: Unknown at this time.3. Ingestion: Unknown at this time. Similar compounds have been observed to cause changes in thyroidweights, weight loss, musculoskeletal changes.EMERGENCY AND FIRST AID PROCEDURES - SECTION 4Skin: Immediately wash skin with soap and copious amounts of water.Eyes: Immediately flush eyes with copious amounts of water for at least 15 minutes. Assure adequate flushing ofthe eyes by separating the eyelids with fingers.Inhalation: Remove to fresh air. Give artificial respiration if victim is not breathing. If breathing is difficult, giveoxygen.Ingestion: Give copious amounts of water to dilute. Seek medical attention.FIRE PROTECTION INFORMATION - SECTION 5Flash Point: N/A Method: N/AAutoignition Temperature: N/A Method: N/ACombustibility: N/A Method: N/AExtinguishing Media: Use Carbon dioxide, dry chemical powder or appropriate form. Fight larger fires with waterspray or alcohol resistant foam.Special Fire Fighting Procedures: Wear self-contaminated breathing apparatus and protective clothing to preventcontact with skin and eyes. Emits toxic fumes.ACCIDENTAL RELEASE MEASURES - SECTION 6For Person-related safety precautions ensure adequate ventilation and wear protective equipment and for measuresfor environmental protection do not allow to enter users/surface or ground water and wipe up with damp sponge ormop. For measures for cleaning/collecting, absorb with liquid-binding material (sand, diatomite, acid binders,universal binders, sawdust).HANDLING AND STORAGE PROCEDURES - SECTION 7For safe handling, ensure good ventilation/exhaustion at the workplace and for protection against explosions andfires, no special measures are required. Store in cool, dry conditions in well sealed receptacles.OCCUPATIONAL CONTROL PROCEDURES - SECTION 8Eye Protection: Use safety glasses.Skin Protection: Use lab coat, apron and proper gloves.Respiratory Protection: None required where adequate ventilation conditions exist.

MATERIAL SAFETY DATA SHEET Page 3 of 5Product Reorder No. 762125, 769999Ventilation:Use a chemical fume hood or a NIOSH/MSHA-approved respirator.Airborne Exposure Limits: None identifiedOther Protective Equipment: Eye bath, safety shower, aprons. The usual precautionary measures are to beadhered to when handling chemicals.PHYSICAL PROPERTIES - SECTION 9Appearance: fluid Odor: aracteristicVapor Pressure (@20 C): 23 hPa Viscosity @ 40 C (centistokes): N/ASpecific Gravity @ 25/25 C: N/A Solubility in Water (wt. %): Fully miscibleSolubility in Other Solvents: N/ANote:These physical data are typical values based on material tested but may vary from sample to sample.Typical values should not be construed as a guaranteed analysis of any specific lot or as specifications forthe product.REACTIVITY DATA - SECTION 10Reactivity: Reacts with acids, alkalis and oxidizing agentsIncompatibility: None identified.Hazardous Decomposition Products: No decomposition if used according to specificationsHazardous Polymerization: Not establishedTOXICOLOGY INFORMATION - SECTION 11Acute Eye Effects: May cause irritation. Acute Skin Effects: May cause irritation to skin and mucous membraneInhalation Toxicity: Not establishedIngestion Toxicity: Not establishedExposure Limits: Not established.Teratogenicity: Not established.Reproductive Toxicity: Not established.Mutagenicity: Not established.Synergistic Products: Not established. Sensitization to Product: No sensitizing effects knownCarcinogenicity: Not establishedOther Chronic Effects: None identified.Signs and Symptoms of Overexposure: None identified.Medical Conditions Generally Aggravated by Overexposure: None identified.ECOLOGICAL INFORMATION - SECTION 12Water hazard class 1 (Self assessment); slightly hazardous for water. Do not allow undiluted product or large

MATERIAL SAFETY DATA SHEET Page 4 of 5Product Reorder No. 762125, 769999quantities of it to reach ground water, water course or sewage system.DISPOSAL CONSIDERATIONS - SECTION 13Disposal should be done in accordance with local, state and federal regulations.TRANSPORTATION INFORMATION - SECTION 14D.O.T.Proper Shipping Name:N/AHazard Class/I.D. No./Packing Group: N/A.Label: N/A.I.M.O.Proper Shipping Name:N/AHazard Class/I.D. No./Packing Group: N/A.Label: N/A.I.C.A.O./I.A.T.A.Proper Shipping Name:N/AHazard Class/I.D. No./Packing Group: N/A.Label: N/A.

MATERIAL SAFETY DATA SHEET Page 5 of 5Product Reorder No. 762125, 769999REGULATORY INFORMATION - SECTION 15TSCA Inventory: NoneReportable Quantity (RQ) Under US EPA CERCLA Regulations: This Product does not contain chemicalshaving a Reportable Quantity (RQ)SARA Hazard Notification Hazard Categories Under Criteria of SARA Title III Rules(40 CFR Part 370): 311/312: may be subject to reporting313: Not subject to reportingSection 313 Toxic Chemical(s): This product is exempt under TCSAHazardous Chemical(s) Under OSHA Hazard Communication Standard: NoneOTHER INFORMATION - SECTION 16Label Information:WARNINGKeep container tightly closed when not in use. May cause irritation. Avoid contact with eyes, skin and clothing.Store away from incompatible materials. Wash thoroughly after handling.Hazard Ratings:NFPAFire -- 0Health -- 1Reactivity -- 0Specific Hazard -- 0Information Contact:Becton Dickinson VACUTAINER® SystemsA Division of Becton Dickinson and CompanyBelliver Industrial EstatePlymouth, PL6 7BPEnglandTo the best of our knowledge, the information contained herein is accurate. However, neither Becton Dickinson andCompany nor any of its subsidiaries assumes any liability whatsoever for the accuracy or completeness of theinformation contained herein. Final determination of suitability of any material is the sole responsibility of the user.All materials may present unknown hazards and should be used with caution. Although certain hazards aredescribed herein, we cannot guarantee that these are the only hazards that exist.