Crohn's Disease - Thorne Research

ReviewCrohn’s DiseaseConclusionCrohn’s disease results in significant morbiditywith potential life-threatening sequelae.Conventional treatments have been only partiallysuccessful in curbing acute flare-ups and extendingremission. When these drugs fail, surgical interventionis often employed. Surgery removeslocalized inflammation but does nothing to addressthe causes of CD, including abnormal gut immunity,increased intestinal permeability, systemicinflammation, and deranged colonic milieu, or thenutrient deficiencies associated with the disease.Natural therapeutics in the form of dietary modification,nutrient repletion, probiotics, omega-3fatty acids, antioxidants, anti-inflammatory botanicals,and other nutrients can provide benefit inbringing balance to a severely imbalanced system.References1. Crohn’s and Colitis Foundation of America,Inc. 2004. http://www.ccfa.org/research/info/aboutcd2. Motil KJ, Grand RJ. Nutritional managementof inflammatory bowel disease. Pediatr ClinNorth Am 1985;32:447-469.3. Sonnenberg A, McCarty DJ, Jacobsen SJ.Geographic variation of inflammatory boweldisease within the United States. Gastroenterology1991;100:143-149.4. Somerville KW, Logan RF, Edmond M,Langman MJ. Smoking and Crohn’s disease.Br Med J (Clin Res Ed) 1984;289:954-956.5. Cottone M, Rosselli M, Orlando A, et al.Smoking habits and recurrence in Crohn’sdisease. Gastroenterology 1994;106:643-648.6. Lindberg E, Jarnerot G, Huitfeldt B. Smokingin Crohn’s disease: effect on localisation andclinical course. Gut 1992;33:779-782.7. Lashner BA, Shaheen NJ, Hanauer SB,Kirschner BS. Passive smoking is associatedwith an increased risk of developing inflammatorybowel disease in children. Am JGastroenterol 1993;88:356-359.8. Persson PG, Ahlbom A, Hellers G. Inflammatorybowel disease and tobacco smoke – acase-control study. Gut 1990;31:1377-1381.9. Gilat T, Hacohen D, Lilos P, Langman MJ.Childhood factors in ulcerative colitis andCrohn’s disease. An international cooperativestudy. Scand J Gastroenterol 1987;22:1009-1024.10. Wurzelmann JI, Lyles CM, Sandler RS.Childhood infections and the risk of inflammatorybowel disease. Dig Dis Sci 1994;39:555-560.11. Card T, Logan RF, Rodrigues LC, Wheeler JG.Antibiotic use and the development of Crohn’sdisease. Gut 2004;53:246-250.12. Godet PG, May GR, Sutherland LR. Metaanalysisof the role of oral contraceptive agentsin inflammatory bowel disease. Gut1995;37:668-673.13. Alstead EM. The pill: safe sex and Crohn’sdisease? Gut 1999;45:165-166.14. Bielecki JW, Filippini L. Side effects of nonsteroidalantirheumatic agents in the lowerintestinal tract. Schweiz Med Wochenschr1993;123:1419-1428. [Article in German]15. Banerjee AK, Peters TJ. Crohn’s disease andNSAID enteropathy – a unifying model.Gastroenterology 1990;99:1190-1192.16. Felder JB, Korelitz BI, Rajapakse R, et al.Effects of nonsteroidal antiinflammatory drugson inflammatory bowel disease: a case-controlstudy. Am J Gastroenterol 2000;95:1949-1954.17. Kurina LM, Goldacre MJ, Yeates D, SeagroattV. Appendicectomy, tonsillectomy, andinflammatory bowel disease: a case-controlrecord linkage study. J Epidemiol CommunityHealth 2002;56:551-554.18. Frisch M, Gridley G. Appendectomy inadulthood and the risk of inflammatory boweldiseases. Scand J Gastroenterol 2002;37:1175-1177.19. Morris DL, Montgomery SM, Galloway ML,et al. Inflammatory bowel disease and laterality:is left handedness a risk? Gut2001;49:199-202.20. Persson PG, Ahlbom A. Relative risk is arelevant measure of association of lefthandednesswith inflammatory bowel disease.Neuropsychologia 1988;26:737-740.21. Lashner BA. The Cleveland Clinic DiseaseManagement Project: Inflammatory BowelDisease. June 17, 2004. http://www.clevelandclinicmeded.com/diseasemanagement/gastro/inflammatorybowel/inflammatory bowel1.htmAlternative Medicine Review ◆ Volume 9, Number 4 ◆ 2004 Page 389Copyright©2004 Thorne Research, Inc. All Rights Reserved. No Reprint Without Written Permission