Pediatric Pharmacokinetics - Duke Pediatrics Intranet

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Renal Clearance• GFR increases until around 8-12 monthsof life• Tubular secretion reaches adult capacityduring first year of life• Illustrations would includeaminoglycosides and beta-lactam drugs

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Glomerular Filtration Rate (GFR) by Age700600ml/min/1.73 m250040030020010001-2 D 2-4 Wk 2 Mo 6 Mo 1 Yr 2 Yr 6 Yr 12 Yr

Page 1 and 2: Pediatric Pharmacokinetics:Why Chil
Page 3 and 4: Problems• Absorption may be more
Page 5 and 6: Absorption - 2• Villous formation
Page 7 and 8: 1 Yr5 Yr10 Yr20 Yr40 Yr9 Mo6 Mo3 Mo
Page 9: CYP Enzymes• CYP isoforms vary wi
Page 13 and 14: Targets - non-Host• Antibiotics t
Page 15 and 16: Formulations• Not all meds can be
Page 17: Summary• The catchphrase is, “C

Pediatric Pharmacokinetics - Duke Pediatrics Intranet

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