Pediatric Pharmacokinetics - Duke Pediatrics Intranet

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Interactions• Given varying metabolic & clearancerates, interactions may be hard topredict• Some drugs affect metabolism by CYPsystem– Recently discovered ritonavir increasesFlonase (fluticasone) levels – increasedsteroid side effects

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Summary• The catchphrase is, “Children are notSmall Adults”• The catchphrase is true….

Page 1 and 2: Pediatric Pharmacokinetics:Why Chil
Page 3 and 4: Problems• Absorption may be more
Page 5 and 6: Absorption - 2• Villous formation
Page 7 and 8: 1 Yr5 Yr10 Yr20 Yr40 Yr9 Mo6 Mo3 Mo
Page 9 and 10: CYP Enzymes• CYP isoforms vary wi
Page 11 and 12: Glomerular Filtration Rate (GFR) by
Page 13 and 14: Targets - non-Host• Antibiotics t
Page 15: Formulations• Not all meds can be

Pediatric Pharmacokinetics - Duke Pediatrics Intranet

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