Pediatric Pharmacokinetics - Duke Pediatrics Intranet

ePAPER READ

DOWNLOAD ePAPER

pediatrics.duke.edu

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

START NOW

Host Targets• Some host targets change with age– ?serotonin receptors– Intestinal motilin receptors (erythromycin GIeffects)– Responses to sympatheticomimetic drugsin bronchospasm

2009 Pediatric Hematology/Oncology Fellowship Brochure

Infective Endocarditis - Duke Pediatrics Intranet

Ocular and Periorbital Infections - Duke Pediatrics Intranet

Case presentation #3 - Duke Pediatrics Intranet

Dwight Yin, MD - Duke Department of Pediatrics

Clinical Case Presentation - Duke Pediatrics Intranet

Dialogues in Neonatal- Perinatal Medicine - Duke Pediatrics Intranet

DUKE BIOCHEMICAL GENETICS LAB Version: 09/22/2010 Page 1 ...

Acute Infectious Diarrhea - Duke Pediatrics Intranet

Clinical Case Presentation #3 - Maria G. Lopez-Marti, MD - Duke ...

The Alexander Spock Symposium brochure - Duke Pediatrics Intranet

Clinical Case Presentation #1 - Dorothy Dow, MD - Duke ...

DNA Test Request form 04122011 - Duke Pediatrics Intranet

Urinary Tract Infections Update - Duke Department of Pediatrics

Host Targets• Some host targets change with age– ?serotonin receptors– Intestinal motilin receptors (erythromycin GIeffects)– Responses to sympatheticomimetic drugsin bronchospasm

Formulations• Not all meds can be made into liquids• Some liquid meds taste terrible• Bioavailability problems– Efavirenz as an example• Some vehicles may be toxic

Page 1 and 2: Pediatric Pharmacokinetics:Why Chil
Page 3 and 4: Problems• Absorption may be more
Page 5 and 6: Absorption - 2• Villous formation
Page 7 and 8: 1 Yr5 Yr10 Yr20 Yr40 Yr9 Mo6 Mo3 Mo
Page 9 and 10: CYP Enzymes• CYP isoforms vary wi
Page 11 and 12: Glomerular Filtration Rate (GFR) by
Page 13: Targets - non-Host• Antibiotics t
Page 17: Summary• The catchphrase is, “C

Pediatric Pharmacokinetics - Duke Pediatrics Intranet

Create successful ePaper yourself

Delete template?

Save as template?