They work toge<strong>the</strong>r in a series of activities designed to encourage,and systematically support, <strong>the</strong> development of new researchinitiatives within, and outside, <strong>the</strong> Division.Dr. Charlson withtrainees.Clinical Epidemiology and EvaluativeSciences ResearchThe Division of Clinical Epidemiology and Evaluative Sciences Research draws upon <strong>the</strong> talentsand experience of a multidisciplinary group of faculty based at Weill Cornell Medical College, CornellUniversity-Ithaca, and o<strong>the</strong>r institutions. Faculty members are experts in qualitative and quantitativeresearch methodology, health services research, clinical epidemiology, medical in<strong>for</strong>matics, decisionsciences, health disparities research, community-based participatory research, clinimetrics, outcomesresearch, behavioral science, and health education. They work toge<strong>the</strong>r in a series of activities designedto encourage, and systematically support, <strong>the</strong> development of new research initiatives within, andoutside, <strong>the</strong> Division.Several related areas of investigation include: studies to improve clinical outcomes; behavioralscience research; health disparities research (under <strong>the</strong> leadership of Dr. Carla Boutin-Foster); researchon complex patients with a significant burden of comorbidity; and comparative effectiveness. In orderto stimulate and support new clinical, health services, and outcomes research within and outside <strong>the</strong>Department of Medicine, <strong>the</strong> division houses consultative services to investigators; e.g., in<strong>for</strong>matics anddata management support and training programs in clinical epidemiology and research methodology.Under <strong>the</strong> auspices of <strong>the</strong> CEDREC and SCALE grants, expansion continues in <strong>the</strong> area of healthdisparities and community-based research. CEDREC established a new environmental justice corewith Drs. Carla Boutin-Foster and Beverly Watkins, PhD, continuing to build on partnerships betweenWeill Cornell Medical College, Lincoln Hospital and Mental Health Center, Hunter College Schoolof Nursing-City University of New York, and The Center <strong>for</strong> Healthful Behavior Change at New YorkUniversity School of Medicine.SCALE partners with <strong>the</strong> Nor<strong>the</strong>rn Manhattan Perinatal Partnership (NMPP), an organizationthat focuses on improving health conditions, such as diabetes and obesity, in families who reside inNor<strong>the</strong>rn Manhattan. In addition to NMPP, several faith-based and community-based organizationsin Harlem and <strong>the</strong> South Bronx have become critical partners in <strong>the</strong> division’s research initiatives onhealth disparities. Drs. Carla Boutin-Foster and Erica Phillips-Caesar had an article, based on <strong>the</strong>irresearch through CEDREC and SCALE, published in The Journal of Immigrant and Minority Healthin October <strong>2012</strong>. Dr. Boutin-Foster had a second article published in The Journal of Immigrant andMinority Health in December <strong>2012</strong>. Dr. Ginger Winston received a NHLBI Minority Investigator ResearchSupplement under <strong>the</strong> mentorship of Dr. Mary Charlson, Division Chief, and CEDREC. Dr. Winston isengaged in primary data collection in <strong>the</strong> SCALE trial to examine relationships between body imagedissatisfaction and weight loss; knowledge of <strong>the</strong> health risks of obesity and weight loss; and socialnetwork support and weight loss.Mary E. Charlson, MDChief, Division of ClinicalEpidemiology and EvaluativeSciences ResearchExecutive Director, Center<strong>for</strong> Complementary andIntegrative MedicineWilliam T. FoleyDistinguished Professorof MedicineProfessor of MedicineWeill Cornell Medical CollegeAttending PhysicianNewYork-PresbyterianHospital3233
Emergency MedicineDr. Charlson, (Executive Director of <strong>the</strong> Center <strong>for</strong> Integrative Medicine at Weill Cornell MedicalCollege and William T. Foley Distinguished Professor of Medicine) and Drs. Janey Peterson and CarlaBoutin-Foster had three articles published in JAMA Internal Medicine (<strong>for</strong>merly Archives of InternalMedicine) in February <strong>2012</strong>. Funded by a $9.5 million grant, <strong>the</strong> papers detail three, randomized trialsrevealing that people can use positive affect and self-affirmation to help <strong>the</strong>m make and sustainbehavior change. The same intervention was used in all three studies. Patients were encouraged tothink of small things in <strong>the</strong>ir lives that make <strong>the</strong>m feel good, when <strong>the</strong>y get up in <strong>the</strong> morning andthroughout <strong>the</strong>ir day. Patients were asked to use self affirmation to help <strong>the</strong>m overcome obstacles to<strong>the</strong>ir plan by recalling moments in <strong>the</strong>ir lives <strong>the</strong>y are proud of.The three-pronged designed study, which simultaneously tested <strong>the</strong> same intervention <strong>for</strong> differentpopulations, was a first <strong>for</strong> National Institutes of Health (NIH) funded research, and began with anaward to Weill Cornell Medical College in 2002. This intervention development approach is now morebroadly used in <strong>the</strong> obesity-related behavioral intervention trial (ORBIT) sponsored by <strong>the</strong> NIH. Thefindings of <strong>the</strong> three trials is <strong>the</strong> basis <strong>for</strong> SCALE <strong>for</strong> overweight or obese patients. Dr. Charlson andfaculty had two articles which fur<strong>the</strong>r illuminated <strong>the</strong> findings of this study, one in <strong>the</strong> Journal ofConsulting and Clinical Psychologyin September <strong>2012</strong> and ano<strong>the</strong>r inBMC Medical Research Methodology inNovember <strong>2012</strong>.Dr. Boutin-Foster atSPARC, where shereceived a SPARCMentoring ExcellenceAward.Clinical PharmacologyMarcus M. Reidenberg, MDChief, Division of ClinicalPharmacologyProfessor of PharmacologyProfessor of MedicineProfessor of Public HealthWeill Cornell Medical CollegeThe Division of Clinical Pharmacology remains actively involved in <strong>the</strong> World Health Organization(WHO) Essential Medicines program. This important global ef<strong>for</strong>t evaluates, updates and publishesa list of about 300 medicines that address <strong>the</strong> world’s major medical problems. The program isdesigned to advise countries on which drugs should be considered priority purchases when health careresources are limited. Since 1975, <strong>the</strong> concept of prioritizing <strong>the</strong> purchase of essential medicines hasbeen accepted in principle by 156 WHO member states. With student help, Dr. Reidenberg submitted,in <strong>2012</strong>, a review of statins <strong>for</strong> children to be discussed at <strong>the</strong> Expert Committee meeting in 2013.Dr. Reidenberg is an inventor of a drug to treat some cancers; trials are ongoing. He continuesto advise <strong>the</strong> present sponsor on fur<strong>the</strong>r development of this drug. He is also an investigator of astudy to discover a new drug to reduce fatal arrhythmias in patients with heart attacks. “Notes onTherapeutics” on <strong>the</strong> Weill Cornell Medical College website continues to receive hundreds of visits at:http://www.med.cornell.edu/cert/patients/notes_on_<strong>the</strong>rapeutics.htmlDr. Flomenbaum (second fromleft) with <strong>the</strong> Toxicology team.34
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