Visit the DOM Annual Report 2012 for a Feature Story (PDF page 7)

Research Highlights continuedPartner 2This trial is to determine the safety and effectiveness of theEdwards SAPIEN XT device and delivery systems: NovaFlex(transfemoral access) and Ascendra2 (transapical access) inpatients with symptomatic, calcific, severe aortic stenosis.PIs: S. Chiu Wong, MD; Geoffrey Bergman, MBBSFunding: Edwards LifesciencesPartner 1The purpose of this trial is to determine the safety andeffectiveness of the device and delivery systems (transfemoraland transapical) in high risk, symptomatic subjects with severeaortic stenosis.PIs: S. Chiu Wong, MD; Geoffrey Bergman, MBBSFunding: Edwards LifesciencesRenal Denervation in Patients With Uncontrolled Hypertension(SYMPLICITY HTN-3)The purpose of this multicenter, prospective, single-blind,randomized, controlled study is to assess the safety andeffectiveness of renal denervation in subjects with uncontrolledhypertension.PI: S. Chiu Wong, MD (MPI with Samuel Mann, MD)Funding: Medtronic, Inc.Somatic Mutation in Idiopathic Ventricular TachycardiaThe purpose of this study is to test in a mouse model thehypothesis that somatic cardiac mutations in G s α duringembryogenesis, and downstream effects on cAMP, cause rightventricular outflow tract tachycardia.PI: Bruce Lerman, MDFunding: Raymond and Beverly Sackler FoundationClinical Epidemiology and Evaluative SciencesResearchCenter of Excellence in Disparities Research and CommunityEngagement (P60)Dr. Carla Boutin-Foster, as principal investigator, and Dr. MaryCharlson, as co-principal investigator, developed the Centerfor Excellence in Health Disparities Research and CommunityEngagement (CEDREC) which has over $8 million in funding.The center involves Weill Cornell Medical College, HunterCollege School of Nursing, Lincoln Medical Center/RenaissanceHealth System and New York University – Center for HealthfulBehavior Change. The specific aims of CEDREC are: create aninterdisciplinary academic and community research enterprisethat expands capacity for conducting cutting-edge andtransdisciplinary research and contribute to improving minorityhealth and reducing health disparities in cardiovascular diseaseand cancer in Central Harlem and the South Bronx; train newminority investigators to conduct original minority health andhealth disparities research while fostering their ability to obtainindependent NIH funding; and build upon existing communityacademicpartnerships and forge new collaborations that willaccelerate the dissemination of research findings to communitystakeholders, inform novel community-based programs, andbuild their capacity for research.PI: Carla Boutin-Foster, MD, MS; Co- PI: Mary E. Charlson, MDFunding: NIH/ NIMHDSCALE: Small Changes and Lasting Effects (U01)This multimillion dollar grant focuses on developing individual,family and faith-based mindful eating interventions targetedat reducing obesity in minority communities. The project isdesigned to develop and test different multilevel interventionsin proof of concept trials to lay the basis for evaluating theeffectiveness in large-scale clinical trials.PI: Mary E. Charlson, MDFunding: NIH/NHLBIEnvironmental Health Disparities Research CoreThe Environmental Health Disparities Research Core (EHCore) is nested into the existing CEDREC (see above). TheEH Core will facilitate dialogue between community-basedorganizations, local residents, and elected officials; and informresearchers, community members and policymakers throughlectures, community forums, webinars, and didactic education.PI: Carla Boutin-Foster, MD, MSFunding: NIH/NIMHDIncreasing Capacity and Public Trust: A Strategy for BuildingEffective Sustainable Community-Academic Partnerships throughMentoring, Education, Training and Workforce DevelopmentA community-academic environmental health researchcollaborative with Good Old Lower East Side (GOLES), acommunity-based housing and economic justice organizationseeking to expand its mission to include environmental justiceand public health. The collaborative creates both formaland informal linkages between the local community andacademic institutions through the employment and training oflocal residents as environmental health community organizers.PI: Beverly Watkins, MA, PhD; Co-PI: Damaris Reyes (Director,GOLES)Funding: NIEHSGOLES Healthy Aging Program (GHAP)The GHAP follows an innovative strategy of actively engagingdisadvantaged Lower East Side seniors in the planning andimplementation of health promotion and disease preventionprogramming to help community elders maintain well-beingand cognitive reserves throughout the life course.PI: Beverly Watkins, MA, PhDFunding: The Fan Fox and Leslie R. Samuels Foundation, Inc.Minority Investigator Research SupplementDr. Winston is engaged in primary data collection in the SmallChanges and Lasting Effects (SCALE) trial to examine therelationship between body image dissatisfaction and weightloss; the relationship between knowledge of health risks ofobesity and weight loss; and the relationship between socialnetwork support and weight loss.PI: Ginger Watson, MDFunding: NHLBI (Funded Under SCALE: Small Changes andLasting Effects (U01)Pain as a Mediator of Behavior ChangeThe focus of this research will be to examine the role of painas a mediator of physical activity over 12 months in a cohortof older patients with chronic cardiovascular disease.PI: Janey Peterson, EdDFunding: NIA (Funded Under Roybal P30 Center Grant“Improving the Management of Pain in Later Life”)Trial Using Motivational Interviewing and Positive Affect andSelf-Affirmation in Hypertension (TRIUMPH)TRIUMPH is a randomized controlled trial which builds on thefindings of previous studies by testing a novel and multifacetedbehavioral intervention framed on social cognitive theory,positive affect theory, and self-affirmation theory amongAfrican American patients with uncontrolled hypertension.PI: Carla Boutin-Foster, MD, MSFunding: NIH/NIMHDOASIS: Osteoarthritis Self-Improvement StudyThis study tests an intervention framed upon the HealthPromotion Model among African-Americans with a diagnosisof osteoarthritis to determine its impact on intention toundergo arthroscopic evaluation.PI: Michael Parks, MD (HSS); Co-PI: Carla Boutin-Foster, MD, MSFunding: Zimmer CorporationClinical PharmacologyA New Drug to Activate Peripheral Histamine 3 ReceptorsActivating the histamine 3 receptor lowers the epinephrine inthe ischemic heart and should reduce arrhythmias. A series ofnovel compounds was made and screened to find a drug thatwill reduce arrhythmias in ischemic hearts.PI: Marcus M. Reidenberg, MDFunding: NIHEmergency MedicineNeurological Emergencies Treatment Trials (NETT)The NETT trials is a five-year grant to create a network oftertiary care emergency departments capable of conductingresearch in neurological emergency care. Recruitment isongoing for the Platelet-Oriented Inhibition in New TIA Trial(POINT) whereas the Rapid Anticonvulsant Medication Prior toArrival Trial (RAMPART) was completed.PIs (WC Site): Neal Flomenbaum, MD; Matthew Fink, MD(Weill Cornell Neurology)Funding: NIH/NINDSEndocrinology, Diabetes and MetabolismAmerican Recovery and Reinvestment Act AdministrativeSupplements for Comparative Effectiveness Research (CER)Workforce DevelopmentThis supplement has two objectives: to strengthen currentformal educational opportunities in CER by increasing thescope and offerings in the track in outcomes and healthservices research; to offer an additional year of training in CERas a KL2 scholar to students who are enrolled in, or who haveobtained, either a Master’s degree or certificate in clinical andtranslational research.PI: Julianne L. Imperato-McGinley, MD; Co-PI: Alvin Mushlin, MDFunding: NIHNIH T32 Training GrantThe Endocrine Research Training Program at Weill Cornell isa Tri-Institutional endeavor with participation from MemorialSloan-Kettering Cancer Center and The Rockefeller University.PI: Julianne L. Imperato-McGinley, MDFunding: NIHEpidemiology of Diabetes Intervention and Complications(EDIC) TrialThe EDIC trial is a continuation study involving the DiabetesControl and Complications Trial (DCCT) cohort. The EDIC studyhas now followed nearly 1,400 individuals with type 1 diabetesfor over 30 years.PI: David Brillon, MDFunding: NIH/NIDDKAction to Control Cardiovascular Risk in Diabetes (ACCORD) StudyThe ACCORD trial compares intensive blood glucose, lipid andblood pressure control in over 10,000 persons with type 2 diabetes.PI: David Brillon, MDFunding: NIH/NHLBI74 75