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Weill Cornell Medical CollegeNewYork-Presbyterian HospitalNewYork-Presbyterian Hospital/Weill Cornell Medical CollegeDepartment of Medicine525 East 68th Street, Box 130New York, NY 10065www.cornellmedicine.comDepartment of Medicine Annual Report 2012 Weill Cornell Medical College NewYork-Presbyterian HospitalDepartment of MedicineTranslating DiscoveriesAR2012

Dear Colleagues and Friends:Our Annual Report of the Department of Medicine of Weill Cornell Medical College andNew York-Presbyterian Hospital/Weill Cornell Medical Center highlights the department’saccomplishments during the Calendar Year 2012. It provides but a glimpse of the extraordinarybreadth and depth of contributions generated by our gifted, tireless and dedicated group offaculty, trainees and staff.By remaining adaptable in the way we do things, while at the same time asserting anuncompromising commitment to our core values, we have sustained an indomitable spirit in theface of adversities that are the inevitable consequence of a rapidly changing, often unpredictableenvironment in academic medicine today. We have maintained a steadfast, unwavering focus onthe patients we serve: they are at the very center of and reason for everything we do, includingleadership in medical research and producing a next generation of physicians who we want tobe, like our own children, even better than we are.As I write this in my seventh year as Chairman of this great Department of Medicine, I feel moreconfident than ever that this department is well-prepared to meet the formidable challengesahead and will, under Dr. Augustine Choi’s vigorous new leadership, rise to new heights ofexcellence for many years to come.Table of Contents1 Welcome from the Chairman2 A New Generation is Gaining on Cancer…The Melnick Laboratory4 Diversity Defines the CTSC6 A New Hub of Scientific DiscoveryLocated on E9: The Glimcher Laboratory8 New Technologies for Patients with Disorders of theBiliary System and Pancreas10 Suthanthiran Laboratory: A Model of Progressin Precision MedicineAndrew I. Schafer, M.D.The E. Hugh Luckey Distinguished Professor of MedicineChair, Department of MedicineWeill Cornell Medical CollegePhysician-in-ChiefNewYork-Presbyterian Hospital/Weill Cornell Medical Center13 Elder Abuse Cannot be Treated in a Silo:Financial Abuse on the Rise14 DOM Strategic Plan Successfully AdvancesQuality Improvement in Patient Care15 New Leadership Appointments17 Honors & Awards29 Division Profiles61 Faculty Members69 Research Highlights91 Medical Education112 Alumni113 Financial Report & Donors128 Contacts The cover shows the Belfer Research Building.1

A New Generationis Gaining on Cancer…The Melnick Laboratorysystems that he investigates control production of proteins thatproduce cancer. These systems are governed by epigeneticmechanisms. Using sophisticated gene mapping, Dr. Melnickand his team have been unearthing various cancer-causingmechanisms (at the molecular level) that they are able to locatethroughout the human genome.Leukemias have surprisingly few mutations comparedto other cancers, but they are some of the most intractablecancers to treat. Children who have ALL (acute lymphoblasticleukemia) are usually cured, but unfortunately, adults haveexperienced the worst outcomes. During 2012, Dr. Melnickled a team that included national and international scientistsin a first of its kind study using integrative epigenomics toinvestigate B-ALL in adults. Their results, entitled, “IntegrativeEpigenomic Analysis Identifies Biomarkers and TherapeuticTargets in Adult B-Acute Lymphoblastic Leukemia,” werepublished in Cancer Discovery.In sum, the group decoded the key “software” instructionsthat drive three of the most virulent forms of ALL. Specifically,they uncovered that ALL’s “software” is encoded with certainepigenetic marks, or chemical modifications of DNA andsurrounding proteins, and identified a novel biomarker inB-ALL called IL2RA(CD25). The new biomarker, IL2RA(CD25),is a master regulatory protein that causes aberrant growth andthe survival of lymphoma cells by assembling a multiproteingene repressor complex. After reporting this initial finding, hewent on to publish a paper in Nature Medicine (2004) showing thatthe actions of BCL6 in gene regulation could be blocked, therebyinducing growth arrest and death of lymphoma cells. These twoadvances proved that transcription factors (such as the BCL6oncogene) are indeed feasible drug targets for the treatment ofcancer – an idea, previously held by many, to be unlikely at best.From Dr. Melnick’s perspective, the year 2010 brought one ofthose watershed moments for the team. He and his colleaguespublished a paper in Cancer Cell, entitled, “Leukemic IDH1 andIDH2 mutations result in a hypermethylation phenotype, disruptTET2 function, and impair hematopoietic differentiation.”Translation: a new class of leukemia was discovered that iscaused by mutations in metabolic enzymes that generate akind of chemical poison which disrupts production of a newlydiscovered class of epigenetic marker called 5-hmC. Whenthese mutations occur in bone marrow cells the consequenceis altered growth properties and development of leukemia.“This was a monumental advance for us,” explainsDr. Melnick, “as it showed for the first time an entirely new andunsuspected disease mechanism could lead to developmentdecodingDr. Melnick (center) with some of his postdocs (l-r): Drs. Lorena Fontan Gabas; Francine Garrett-Bakelman; Karen Bunting; Yanwen Jianglatter enables cancer clinical investigators to target a particulartumor more precisely with effectively tailored drugs.As researchers seek to better understand the chemicallayers of epigenetic programming that can regulate ourDNA, they will be able to produce more effective drugs totreat a tumor, understanding exactly how one tumor can bevery different from another. Dr. Andrew Schafer, Chairman,Department of Medicine, notes, “When we recruited Dr. Melnickfive years ago, we knew he was the ideal candidate to lead NYP/WC’s Epigenomics Program in Cancer. The breakthroughshe and his team have achieved have included some predictedadvancements, as well as some welcome surprises. Thesebreakthroughs have created a path towards personalizedmedicine that will effectively target a particular tumor.”Dr. Schafer continues, “Just as importantly, beyond his ownscientific accomplishments, we knew that Ari would bring withhim a remarkable ‘halo effect’ in stimulating better sciencearound him.”Since Dr. Ari Melnick joined the Department of Medicinein 2008, his group has produced a steady stream of researchbreakthroughs. Dr. Melnick has been instrumental in movingthe nascent field of epigenomics into the translational arena forhematologic malignancies. His laboratory has created a virtualarsenal of sophisticated methodologies, including computermapping, transcriptional analysis, and therapeutic targeting.At the same time, Dr. Melnick has also been effectivelymentoring a remarkable number of young scientists who aredrawn to his laboratory from around the world. To date, he hastrained more than 60 residents, fellows, and medical students,many of whom have published in the leading peer-reviewedjournals, presented their work at national meetings, and haveearned research funding of their own. They are a newly trainedgeneration of scientists, and they are gaining on cancer. Theyare also ready for the duration in a challenging field, where, asDr. Melnick explains, “the diversity among the various strainsof cancer is mind boggling.”Dr. Melnick believes that there are two main avenues ofattack on hematological malignancies: one, finding specificbiomarkers to determine how tumors work in individualpatients as well as identifying those with highest risk forresistant forms of the disease; and two, discovering whatbasic mechanisms encode instructions that program thespecific biological features of these disease processes. TheDecoding Cancer Leads to Destroying CancerWhen conditions are right, master regulatory factors inthe body can reprogram normal cells into cancerous cells.Just as bacteria can divide quickly, every 20 minutes, so cancancerous cells multiply at a staggering pace – combinationsinto the billions, says Dr. Melnick. The master regulatorywas determined to hold actionable potential for clinical use,an advance that could translate into better therapeutic targetsand improved treatments for adults with B-cell ALL. Currently,therapeutic antibodies to the CD25 protein exist, and theMelnick laboratory seized the opportunity to use these CD25antibodies, proving that they could successfully kill one of thethree forms of leukemia investigated in their study.“Our study is the first to integrate the decoding of manylayers simultaneously, which has enabled us to unlock some ofthe mysteries explaining the malignant and aggressive behaviorof three leukemias,” says Dr. Melnick. “One could potentiallyconceive of a human clinical trial where those antibodies areused to attack these cancerous cells.”This type of advancement is one of many followingDr. Melnick’s first major discovery in which he described themechanism of action of BCL6, a crucial lymphoma oncogenein the field of cancer research. Dr. Melnick found that BCL6“Our study is thefirst to integratethe decodingof many layerssimultaneously,which has enabledus to unlock someof the mysteriesexplaining themalignant andaggressivebehavior of threeleukemias.”of cancer. This discovery opened a window for developmentof specific targeted therapies to reverse this metabolicabnormality, which are expected to be in clinical trials inthe near future. Hence the cycle of discovery of new diseasemechanism to specific therapy was greatly accelerated.”A month after the Department of Medicine prepared itsreport on year 2012, yet another major breakthrough occurredin the Melnick Lab. The team has shown, published in NatureImmunology, that it is possible to shut down BCL6 in the cancerknown as diffuse large B-cell lymphoma (DLBCL) and withoutnegatively affecting its vital function in T cells and macrophageswhich is needed to support a healthy immune system.“This means that drugs we have developed against BCL6 aremore likely to be significantly less toxic and safer for patientswith this cancer than we realized. The finding comes as a verywelcome surprise,” says Dr. Melnick, and one which is sure togenerate many more.2 3

In 2009, Dr. Lachs was named Director of the first elderabuse center in the New York area, the NYC Elder Abuse Center(NYCEAC), which was the result of a longtime collaborationbetween several colleagues at Weill Cornell, Cornell University(Ithaca), and many NYC government organizations andcommunity agencies.In his recent testimony, Dr. Lachs listed six recommendationsto the Elder Justice Coordinating Council which he believes willempower a dedicated, multidisciplinary group of individualsworking to protect a vulnerable population:n Convene an expert panel of ethicists, clinicians, and othercommunity clinicians to explore and address HIPPA and IRBissues surrounding elder abuse; this instead of placing elderabuse under a general rubric of “domestic violence.”n Encourage hospital and physician education about currentHIPAA provisions regarding Domestic Violence disclosure, asthe law is often interpreted and invoked erroneously to thedetriment of victims.n Encourage research in several areas with a focus on decisionmakingby protective service workers, while developingmethods and techniques for accessing victims and protectingthem to the greatest extent possible while permitting theirparticipation in elder abuse research.n Encourage IRBs be composed of members with research andclinical experience in domestic violence generally and elderabuse specifically.n Provide guidance to the growing number of elder abuseteams multidisciplinary teams on how they may (a) Servevictims in an interdisciplinary fashion while maintainingHIPAA compliance; (b) Participate in elder abuse interventionresearch (and refer clients to such research).n Advocate for a national voice and national leadership in thefield at the federal level, so that these and other priorities beeffectively implemented. The absence of a unified front in thisregard is, ironically, an ageist state of affairs.“Elder justice is fundamentally ahuman rights issue as freedom fromfear and personal safety is at its core.With this funding, we can help restorehealth and security to victimizedolder adults and prevent abuse fromhappening to others.”DOM StrategicPlan SuccessfullyAdvancesQuality Improvementin Patient CareDuring 2012, Dr. Naina Sinha Gregory spearheadedone of many successful quality improvement projectsproposed within the DOM Strategic Plan. Her particularproject addressed diabetes. It is estimated that onethirdof hospitalized patients have diabetes, or elevatedblood glucose. Unfortunately, poor glucose controlincreases the risk for complications, including infection,in this group of patients. Optimizing glucose control,therefore, has become a priority. The question thatDr. Gregory’s project posed was: Can a computerorder set improve control of diabetes for hospitalizedpatients? Her project found an answer, as she explains:“We were able to show that using a computer-basedinsulin order set significantly decreased the rate of lowblood sugar (or hypoglycemia). This is an importantpatient safety issue as hypoglycemia is associated withnegative outcomes including seizure, stroke or death.”Naina Sinha Gregory, MD is an Assistant Professorof Clinical Medicine in the Division of Endocrinology,Diabetes, and Metabolism.It is estimated that one-thirdof hospitalized patients havediabetes, or elevated bloodglucose.New LeadershipAppointmentsJoseph T. Cooke, MDChief of the Division of Pulmonaryand Critical Care MedicineDavid J. Christini, PhDVice Chair for Basic ResearchDr. David J. Christini has been appointed to Vice Chair for Basic Research, a role in which heis advancing the department’s mission in basic research, as well as the parent institutions ofWeill Cornell Medical College and NewYork-Presbyterian Hospital. Dr. Christini received his PhDin Biomedical Engineering from Boston University, and joined our faculty after completing apostdoctoral fellowship in cardiac electrophysiology. He was promoted to Professor of Medicine(with tenure) in 2010, with secondary appointments in Physiology and Biophysics, ComputationalBiomedicine, and Biomedical Engineering at the University. Since 2009, he has served as Directorof Basic Cardiovascular Research in the Greenberg Division of Cardiology. His research group,funded by the NIH, has been a leader in our understanding of cardiac electrophysiological dynamicsfrom the cellular to the organ level, using experimental and computational approaches to study themechanisms of arrhythmia initiation and in developing new arrhythmia therapies.Dr. Joseph T. Cooke has been appointed to Chief of the Division of Pulmonary and Critical CareMedicine. He is also the Chief Quality and Patient Safety Officer of the Weill Cornell PhysicianOrganization at Weill Cornell Medical College, and an Associate Professor of Clinical Medicineand Public Health. A graduate of the State University of New York Downstate, he completedresidency and fellowship training at NYP-Weill Cornell, where he was also a Chief MedicalResident in 1990. He has been a full time faculty member of the Physician Organization sincethen. Throughout his career he has served as the MICU (Medical Intensive Care Unit) Director;Medical Director of Respiratory Therapy; and Director of the Remote ICU trial. He served asChairman of the GNYHA Critical Care Leadership Network, and he continues as a member of theMedical Advisory Board for the New York Organ Donor Network. Annually listed as one of thebest doctors in the Metropolitan area, he is the recipient of numerous teaching and leadershipawards, and was recognized nationally in 2008 with the HRSA/CMS Medal of Honor for beinga regional champion in Organ Donation.14 15

New LeadershipAppointmentsBarbara L. Hempstead, MD, PhDAssociate Dean for Faculty DevelopmentDr. Barbara L. Hempstead has been appointed to Associate Dean for FacultyDevelopment in the newly established Office of Faculty Development atWeill Cornell Medical College. In this role, Dr. Hempstead assists in theorganization of departmental mentorship and leadership programs thatform the cornerstone of successful academic careers through all stages ofa career in medicine. An internationally-recognized physician-scientist andThe O. Wayne Isom Professor of Medicine, Dr. Hempstead has dedicated hercareer to mentorship, while working with more than 30 undergraduate andgraduate students, postdoctoral fellows and junior faculty in her laboratoryover the years. She received her bachelor’s degree from Tufts Universityand her medical degree, as well as a PhD in cellular biology, from Washington University School ofMedicine’s Medical Scientist Training Program. She completed her training at NYP/Weill Cornell ininternal medicine and hematology and medical oncology and served previously as the Co-chief ofthe Division of Hematology and Medical Oncology. She is a member of the American Physicians, apast recipient of the Burroughs Wellcome Clinical Scientist Award in Translational Research, and apast chair of the Gordon Research Conference on Neurotrophic Factors. Over the last two decadesher laboratory has made major advancements in defining the biological actions of growth factors,called neurotrophins. While these factors have been extensively studied in the brain, where theypromote neuronal survival and modulate memory formation, her laboratory identified importantactions in the injured vasculature, where they can induce new blood vessel growth. In addition, herlaboratory has identified unexpected activities of precursor forms of neurotrophins in promoting celldeath and impairing brain function. These studies have clinical implications in acute neuronal injury,neurodegenerative disease, in complex behaviors of anxiety and depression, and in modulating theresponse to vascular injury.John P. Leonard, MDVice Chair for Clinical ResearchDr. John P. Leonard has been appointed to Vice Chair of Clinical Research in the Department of Medicine,a role in which he is advancing the broad mission of the department, as well as the parent institutionsof Weill Cornell Medical College and NewYork-Presbyterian Hospital. He has also been appointed toAssociate Dean of Clinical Research at WCMC. He serves as Chief of the Lymphoma/Myeloma Serviceand as Associate Director for Clinical Research of the Weill Cornell Cancer Center. The Richard T.Silver Distinguished Professor of Hematology and Medical Oncology, Dr. Leonard is an innovative,internationally recognized clinical investigator in the field of hematological malignancies. He is a pioneerof monoclonal antibody based therapies and leads major clinical trials funded by the NIH and conductedthrough the Cancer and Leukemia Group B (CALGB) of the National Cancer Institute. During the past twoyears he has spearheaded innovative initiatives in the Department of Medicine to facilitate cutting edgepatient-oriented research.Honorsand Awards16 17

RESEARCH AWARDSThe Department of Medicine Annual Investigators AwardThe David E. Rogers Memorial Research AwardThis award is presented annually to members of theDepartment of Medicine below the rank of professor whoperform on outstanding levels in the areas of clinical and/or basic biomedical research. Supported by the Michael WolkFoundation.WinnerDr. Himisha BeltranTopic: Understanding Disease Heterogeneity in AdvancedProstate Cancer and Identification of New Drug Targets UsingNext Generation DNA SequencingDivision: Hematology and Medical OncologyRunner-UpDr. Kyu Y. RheeTopic: A Chemically Revised View of Lehmann’s Magic Bullet:Implications for Rational Anti-Infectives DevelopmentDivision: Infectious DiseasesRunner-UpDr. Thangamani MuthukumarTopic: Micro RNA Deep Sequencing of Human Kidney AllograftFibrosisDivision: Nephrology and HypertensionDr. Thangamani MuthukumarThis award was established in 1995 to encourage medicalresidents to continue their investigative research in internalmedicine. Four finalists are chosen to present their research atMedical Grand Rounds.WinnerDr. Aaron VinyTopic: MICA Polymorphism Identified by Whole Genome ArrayAssociated with NKG2D-Mediated Cytotoxicity in T-Cell LargeGranular Lymphocyte LeukemiaSecond PlaceDr. Neha Mehta-ShahTopic: Bexarotene is Active Against Subcutaneous Panniculitis-Like T-Cell Lymphoma in Adult and Pediatric PopulationsRunners UpDr. Daneng LiTopic: Pre-Operative Geriatric Assessment and SurgicalOutcomes in Older Women With Gynecological CancerDr. Eugene LichtTopic: The Role of Lactulose in the Prevention of ClostridiumDifficile DiarrheaThe Department of Medicine Annual Fellows Research AwardInitiated in 2002, this award is presented annually to fellowswithin the Department of Medicine who have presentedoutstanding research.WinnerDr. Selin Somersan-KarakayaTopic: Novel Compounds that Kill Mycobacterium Tuberculosis(Mtb), Identification of rv2466c as a Candidate Gene in the Actionof these CompoundsRunners-UpDr. Konstantinos CharitakisTopic: A Novel Role for Perinatal Myosin in Cardiac DevelopmentDr. Jyoti MathadTopic: Screening for Mycobacterium Tuberculosis Infectionamong Pregnant Women: A Comparison of an Interferon-Gamma Release Assay with Tuberculin Skin Testingin Pune, India2012 TEACHING AWARDSSenior List(voted on by the Weill Cornell medical school’s senior class)This award was established by the WCMC Class of 1994 torecognize 17 faculty members who have made a commitmentto and demonstrated excellence in teaching. Of those 17, thefollowing faculty members were selected from the Departmentof Medicine.Dr. Charles L. BardesDr. Salvatore CilmiDr. Byron P. DemopoulosDr. Ernie EsquivelDr. Erica C. JonesDr. Richard LinDr. B. Robert MeyerDr. Anthony OgedegbeDr. Mark PochapinThe Charles L. Bardes MD, Teaching PrizeThe prize is awarded annually to a member of the faculty who,in the opinion of the prize committee, has been an outstandingteacher at the Weill Cornell Medical College, demonstratingleadership, dedication and concern for the students.Dr. Ernie EsquivelThe Richard A. Herrmann, MD Teaching AwardExcellence in Teaching AwardsCathleen Acres, BS, BS, MAMedicine, Patients & Society IIIDr. Jeffrey Fisher (Voluntary)Medicine, Patients & Society I Office PreceptorDr. Oren FriedmanAdvanced Biomedical ScienceDr. Jason KendlerMedicine, Patients & Society IIDr. Herbert Lempel (Voluntary)Medicine, Patients, & Society I Office PreceptorDr. Shari MidoneckIntroductory ClerkshipDr. Dana SpivakPrimary Care ClerkshipDr. Suzanne WenderothMedicine ClerkshipDr. Cecilia YoonMedicine, Patients & Society I Office PreceptorExcellence in Teaching (Voluntary Faculty Awards)Dr. Richard CohenDr. Jeffrey FisherDr. Paul MiskovitzThe award is given to an outstanding teacher in the thirdyear and is chosen by members of the third-year medicalschool class.Dr. Richard Lin1819

VISITING PROFESSORSThe Richard T. Silver Visiting ProfessorFebruary 14, 2012Jerry Spivak, MDJohns Hopkins University School of MedicineThe Rogosin Institute LectureApril 3, 2012Myles S. Wolf, MD, MMScUniversity of Miami Miller School of MedicineThe Mark S. Pecker, MD Clinical MasterMay 8, 2012John S. Sergent, MD, MACP, MACRVanderbilt University Medical CenterThe 2012 Lila A. Wallis Distinguished VisitingProfessor in Women’s HealthMay 15, 2012Laurie H. Glimcher, MDWeill Cornell Medical CollegeThe SASS Foundation Visiting ProfessorJune 19, 2012Giorgio Trinchieri, MDCenter for Cancer Research, NCI, NIHThe BH Kean-Boxer Family Foundation Lecturein Global HealthOctober 9, 2012Herbert L. DuPont, MD, MACPBaylor College of MedicineThe Aaron Feder Visiting ProfessorOctober 23, 2012Joseph A. Kovacs, MDNIH Clinical Center, National Institutes of HealthThe Ralph L. Nachman, MD Distinguished Visiting ProfessorNovember 13, 2012Jeffrey I. Weitz, MDMcMaster UniversityThe Arthur Ashe Endowment-Christopher L. Barley, MDLectureDecember 11, 2012Myron S. Cohen, MDUniversity of North Carolina at Chapel HillThe Stephen Scheidt, MD Distinguished Visiting ProfessorDecember 18, 2012Sanjiv Narayan, MD, PhDUniversity of California, San DiegoEndowed Professorships & ChairsDr. Ronald D. AdelmanEmilie Roy Corey Professor in Geriatrics and GerontologyDr. Phyllis AugustRalph A. Baer Professor of Medical ResearchDr. Carl Blobel (HSS)Virginia F. and William R. Salomon Chair in MusculoskeletalResearchDr. Lewis C. CantleyMargaret and Herman Sokol Professor in Oncology ResearchDr. Mary E. CharlsonWilliam T. Foley Distinguished Professor in MedicineDr. Mary K. CrowJoseph P. Routh Professor of Rheumatic Diseases in MedicineBenjamin M. Rosen Chair in Immunology and InflammationResearchDr. Ronald G. CrystalThe Bruce Webster Professor of Internal MedicineDr. Andrew J. DannenbergHenry R. Erle, MD-Roberts Family Professor of MedicineDr. Orli R. EtinginLisa and Sanford B. Ehrenkranz Professor in Women’s HealthDr. Joseph J. FinsE. William Davis, MD Professorship of Medical EthicsDr. Richard R. FurmanRichard A. Stratton Assistant Professorship in Hematology andOncologyDr. Laurie H. GlimcherThe Stephen and Suzanne Weiss DeanDr. Yoon KangRichard P. Cohen, MD Associate Professor of Medical EducationDr. Robert J. KimDavid S. Blumenthal Assistant Professor of MedicineDr. Harvey KleinThe William S. Paley Professor of Clinical MedicineDr. Mark S. LachsThe Irene F. & I. Roy Psaty Distinguished Professor of ClinicalMedicineDr. John P. LeonardRichard T. Silver Distinguished Professor of Hematology andMedical OncologyDr. Steven R. GoldringRichard L. Menschel Research ChairDr. Antonio M. Gotto, Jr.Lewis Thomas University ProfessorDr. Barbara L. HempsteadO. Wayne Isom Professor of MedicineDr. Julianne L. Imperato-McGinleyThe Abby Rockefeller Mauzé Distinguished Professorship inEndocrinology in MedicineDr. Lionel B. IvashkivDavid H. Koch Chair for Arthritis and Tissue DegenerationResearchDr. Ira M. JacobsonVincent Astor Distinguished Professor of MedicineDr. Warren D. Johnson, Jr.B. H. Kean Professor of Tropical MedicineDr. Mary CrowDr. Bruce B. LermanHilda Altschul Master Professor of MedicineDr. Lia S. LogioHerbert J. and Ann L. Siegel Distinguished Professor ofMedicineDr. C. Ronald MacKenzieC. Ronald MacKenzie, MD, Chair in Ethics and MedicineDr. Tomer M. MarkMorton Coleman Assistant Professor in Multiple Myeloma20 21

Dr. Bassem M. MasriDaisy and Paul Soros/Recanati-Kaplan Family AssistantProfessor in Preventive CardiologyDr. Shari R. MidoneckEhrenkranz Family/Orli R. Etingin, MD Associate Professor inWomen’s HealthDr. Henry W. MurrayArthur R. Ashe, Jr. Professor of MedicineDr. David M. NanusMark W. Pasmantier Professor of Hematology and Oncology inMedicineDr. Stephen A. PagetStephen A. Paget, MD, Chair in RheumatologyDr. Alessandra B. PernisPeter Jay Sharp Chair in Lupus ResearchDr. R. A. Rees PritchettLouis & Gertrude Feil Professor of Clinical MedicineDr. M. Carry ReidIrving Sherwood Wright Professor in Geriatrics and GerontologyDr. Brendan M. ReillyGladys and Roland Harriman Professor of MedicineDr. Isadore RosenfeldThe Ida and Theo Rossi Distinguished Professor of ClinicalMedicineDr. Jane E. Salmon (HSS)Collette Kean Research ChairDr. Andrew I. SchaferThe E. Hugh Luckey Distinguished Professor of MedicineDr. Ellen J. ScherlJill Roberts Associate Professor of Inflammatory Bowel DiseaseClinical ScholarsThe Clinical Scholar Endowment is designed to provideoutstanding junior faculty members in the Departmentof Medicine with financial support early in their careers.Support is provided specifically to help young physiciansbalance patient care with research and teaching. The awardsallow junior faculty to make a commitment to academicmedicine and, as a result, support promising new talent.Dr. Paul BascianoNan and Stephen Swid Research ScholarDr. Brian P. BosworthAnne and Ken Estabrook Clinical Scholar inGastroenterologyDr. Carla Boutin-FosterNanette Laitman Clinical Scholar in Public Health/Community HealthDr. Leandro CerchiettiRaymond and Beverly Sackler Research ScholarDr. Ben-Gary HarveyJames P. Smith Clinical Scholar Award (through July 2012)Dr. Sergio SchwartzmanFranchellie M. Cadwell ChairDr. Eugenia L. SieglerMason Adams Professor of Geriatric MedicineDr. Kendall A. SmithRochelle Belfer Professor in MedicineDr. Charles SteinbergHoward and Carol Holtzmann Professor in Clinical MedicineDr. Kotha SubbaramaiahJack Fishman Professor of Cancer PreventionDr. Manikkam SuthanthiranStanton Griffis Distinguished Professor of MedicineDr. Alan M. WeinsteinThomas H. Meikle, Jr. Professor of Medical EducationDr. Marc E. WekslerThe Irving Sherwood Wright Professor of GeriatricsDr. James E. IpBruce B. Lerman Clinical ScholarDr. Elizabeth L. JacobsonBonnie Johnson Sacerdote Clinical Scholar in Women’sHealthDr. Robert J. KanerJames P. Smith M.D. ScholarDr. Laura KirkmanWilliam Randolph Hearst Foundation Clinical Scholar inMicrobiology & Infectious DiseasesDr. Fay Yu-Huei LinAbby Joseph Cohen Clinical ScholarDr. Louis AronneDr. Gail RobozDr. Christopher LiuMichael Wolk Heart Foundation Clinical Scholar Award inCardiologyDr. Veronica M. LoFasoRoland Balay Clinical ScholarDr. Bassem M. MasriHelen and Robert Appel Clinical ScholarDr. Allyson J. OceanAnne Moore M.D. Clinical Scholar in Hematology-OncologyDr. M. Cary Reid, Jr.Joachim Silbermann Family Clinical Scholar in GeriatricPalliative CareDr. Kyu Young RheeWilliam Randolph Hearst Foundation Clinical Scholar inMicrobiology & Infectious DiseasesDr. Ellen K. RitchieMadoff Family Clinical Scholar in Hematology-OncologyDr. M. Carry ReidDr. Bryan J. SchneiderMadeline and Stephen Anbinder Clinical Scholar inHematology/OncologyDr. Felice Schnoll-Sussman (through March 31, 2012)Linda Horowitz Cancer Research Foundation Clinical Scholar inGastroenterology2223

New York Magazine (Best Doctors) & Castle ConnollyAllergyDr. Daniel Burton*Dr. Gillian Shepherd**Cardiac ElectrophysiologyDr. Bruce Lerman**Dr. Steven Markowitz*Dr. Miguel Valderrabano (Texas Methodist)*Cardiovascular DiseaseDr. Holly Andersen**Dr. James Blake *Dr. David Blumenthal**Dr. Adam Deutsch*Dr. Richard Devereux*Dr. Richard Fuchs*Dr. Harvey Goldberg*Dr. Antonio Gotto, Jr.*Dr. Evelyn Horn**Dr. Lawrence Inra**Dr. Matteethra C. Jacob (Texas Methodist) *Dr. Mazen Kamen*Dr. Paul Kligfield*Dr. Karla M. Kurrelmeyer (Texas Methodist)*Dr. Eliot Lazar*Dr. John J. Mahmarian (Texas Methodist)*Dr. Bassem Masri*Dr. David Miller*Dr. Richard Mueller *Dr. Sherif F. Nagueh (Texas Methodist)*Dr. Martin Post*Dr. Craig M. Pratt (Texas Methodist)*Dr. Miguel A. Quinones (Texas Methodist)*Dr. Howard S. Rubin (Texas Methodist)*Dr. Richard Steingart (MSKCC)*Dr. Theodore Tyberg*Dr. Michael Wolk*Dr. William A. Zoghbi (Texas Methodist)*Interventional CardiologyDr. Neal Kleiman (Texas Methodist)*Endocrinology, Diabetes, and MetabolismDr. Richard Bockman (HSS)**Dr. David Brillon**Dr. Willa Hseuh (Texas Methodist)*Dr. Barry Klyde*Dr. Richard Robbins (Texas Methodist)*Dr. R. Michael Tuttle (MSKCC)**Dr. Kathleen L. Wyne (Texas Methodist)*GastroenterologyDr. Paul Basuk*Dr. Robert S. Brown, Jr. **Dr. Michael Cantor*Dr. Bradley Connor*Dr. Robert Cooper*Dr. Gulchin Ergun (Texas Methodist)*Dr. Hans Gerdes (MSKCC)**Dr. Howard Goldin*Dr. Ira Jacobson**Dr. Michel Kahaleh*Dr. Robert Kurtz** (MSKCC)Dr. Arnon Lambroza*Dr. Arnold Markowitz (MSKCC)*Dr. Franklin Marsh*Dr. Paul Miskovitz**Dr. Jerry Nagler*Dr. Ian Sachs (Texas Methodist)*Dr. Ellen Scherl**Dr. Moshe Shike*Dr. Michael J. Schmerin *Dr. Meyer N. Solny *Geriatric MedicineDr. Ronald Adelman*Dr. Beatriz Korc-Grodzicki (MSKCC)*Dr. Mark Lachs**Dr. Bharathi Raman*Dr. Eugenia Siegler*Dr. George E. Taffet (Texas Methodist)*HematologyDr. Hugo R. Castro-Malaspina (MSKCC)*Dr. Harvey Dosik*Dr. John Leonard*Dr. Peter Maslak (MSKCC)*Dr. John J. McCarthy (Texas Methodist)*Dr. Gerald Soff (MSKCC)*Dr. Martin Tallman (MSKCC)**Dr. David Wolf*Infectious DiseaseDr. Barry Brause (HSS)**Dr. Arthur Brown (MSKCC)*Dr. Ashley Drews (Texas Methodist)*Dr. Victor Fainstein (Texas Methodist)*Dr. Marshall Glesby*Dr. Barry Hartman**Dr. David Helfgott*Dr. Jonathan Jacobs*Dr. Henry Murray*Dr. Kent Sepkowitz (MSKCC)**Dr. Paul Smith (HSS)*Dr. Rosemary Soave*Internal MedicineDr. Louis Aronne*Dr. Christopher Barley**Dr. Thomas Baxter (Texas Methodist)*Dr. Richard Cohen**Dr. Symra Cohn*Dr. Ward Cunningham-Rundles*Dr. John F. Eichelberger (Texas Methodist)*Dr. Orli Etingin**Dr. Laura Fisher*Dr. Flavia Golden*Dr. Daniel Goldin*Dr. Catherine Hart*Dr. Richard A. Jackson (Texas Methodist)*Dr. Margaret Lewin**Dr. Samuel Mann*Dr. Jennifer Meyer (Texas Methodist)*Dr. Deena Nelson*Dr. Mark Pecker*Dr. Charles R. Steinberg*Medical OncologyDr. Carol A. Aghajanian (MSKCC)*Dr. Dean Bajorin (MSKCC)*Dr. Ellin Berman (MSKCC)*Dr. George Bosl (MSKCC)**Dr. Jenny Chang (Texas Methodist)*Dr. Paul B. Chapman (MSKCC)**Dr. Morton Coleman**Dr. Julian Decter*Dr. Maura N. Dickler (MSKCC)*Dr. Darren Feldman (MSKCC)*Dr. Eric J. Feldman*Dr. Monica N. Fornier (MSKCC)*Dr. Mitchell L. Gaynor (Voluntary)*Dr. Subhash Gulati (Voluntary)*Dr. Hani Hassoun (MSKCC)*Dr. Steven Horwitz (MSKCC)*Dr. Clifford Hudis (MSKCC)**Dr. David Ilson (MSKCC)*Dr. Ann A. Jakubowski (MSKCC)*Dr. Joseph Jurcic (MSKCC)*Dr. David Kelsen (MSKCC)**Dr. Nancy E. Kemeny (MSKCC)**Dr. Mark Kris (MSKCC)**Dr. Lee M. Krug (MSKCC)*Dr. Anne Moore**Dr. Craig H. Moskowitz (MSKCC)*Dr. Robert Motzer (MSKCC)*Dr. David Nanus*Dr. Larry Norton (MSKCC)**Dr. Kenneth Offit (MSKCC)*Dr. Eileen O’Reilly (MSKCC)**Dr. Mark Pasmantier**Dr. David Pfister (MSKCC)**Dr. Carol S. Portlock (MSKCC)*Dr. Naiyer Rizvi (MSKCC)*Dr. Gail Roboz*Dr. Mark Robson (MSKCC)*Dr. Joseph Ruggiero*Dr. Paul J. Sabbatini (MSKCC)**Dr. Leonard Saltz (MSKCC)**Dr. David Scheinberg (MSKCC)*Dr. Howard Scher (MSKCC)**Dr. Nancy Sklarin (MSKCC)*Dr. Susan Slovin (MSKCC)*Dr. David Spriggs (MSKCC)*Dr. David Straus (MSKCC)*Dr. Scott Tagawa*Dr. William Tap (MSKCC)*Dr. Linda Vahdat*Dr. Jedd Wolchok (MSKCC)*Dr. Andrew Zelenetz (MSKCC)**NephrologyDr. Phyllis August**Dr. Jon Blumenfeld (Rogosin)**Dr. Raymond Sherman*Pulmonary DiseaseDr. Joseph Cooke**Dr. Ana C. Krieger *Dr. Daniel Libby**Dr. Thomas Nash**Dr. Abraham Sanders*Dr. Diane Stover-Pepe (MSKCC)**Rheumatology (HSS)Dr. Theodore Fields **Dr. Allan Gibofsky*Dr. Susan Goodman*Dr. Steven Magid**Dr . Joseph Markenson*Dr. Stephen Paget*Dr. Edward Parrish*Dr. Jane Salmon (HSS)**Dr. Sergio Schwartzman**Dr. Sandra L. Sessoms (Texas Methodist)*Dr. Harry Spiera (Mount Sinai)** Castle Connolly ** Castle Connolly and New York MagazineBased on Castle Connolly America’s Top Doctors 12th edition(hard copy edition and on-line); New York Magazine’s Best Doctorsof 2012. This information does not reflect Castle Connolly metrolistings.24 25

Society MembershipsSELECTED INDIVIDUAL HONORSIOM (Institute of Medicine) of the NationalAcademy of Sciences (2012)Dr. Jeremiah A. Barondess (Emeritus)Dr. Joseph J. FinsDr. Laurie H. GlimcherDr. R. Gordon Douglas, Jr. (Emeritus)Dr. Antonio M. Gotto, Jr.Dr. Ralph L. NachmanDr. Carl F. NathanDr. Jean W. PapeDr. Andrew I. SchaferDr. David J. SkortonAssociation of American Physicians (2012)Dr. Jeremiah A. Barondess (Emeritus)Dr. Morton D. Bogdonoff (Emeritus)Dr. Mary E. CharlsonDr. Bayard D. Clarkson (MSKCC Affiliate)Dr. Ronald G. CrystalDr. Andrew J. DannenbergDr. Ralph L. NachmanDr. David M. NanusDr. Carl Nathan (secondary appt)Dr. Eric G. Pamer (MSKCC Affiliate)Dr. Marcus M. ReidenbergDr. Neal Rosen (MSKCC Affiliate)Dr. Jane E. Salmon (HSS Affiliate)Dr. Charles L. Sawyers (MSKCC Affiliate)Dr. Andrew I. SchaferDr. David A. Scheinberg (MSKCC Affiliate)Dr. Manikkam SuthanthiranDr. Marcel R.M. van den Brink (MSKCC Affiliate)Dr. Babette B. WekslerDr. Marc E. WekslerDr. Sidney J. Winawer (MSKCC Affiliate)Dr. Alastair J. J. Wood (Courtesy)The American Society for ClinicalInvestigation (2012)Dr. John D. Baxter (TMH Affiliate)Dr. Alan N. Houghton (MSKCC Affiliate)Dr. James J.-D. Hsieh (MSKCC Affiliate)Dr. Katherine C. Hsu (MSKCC Affiliate)Dr. Lionel B. IvashkivDr. Eric A. Jaffe (Adjunct)Dr. Attallah Kappas (Rockefeller Affiliate – Emeritus)Dr. Richard N. Kolesnick (MSKCC Affiliate)Dr. Ione A. Kourides (Voluntary)Dr. Jeffrey C. LaurenceDr. John P. LeonardDr. Ross L. Levine (MSKCC Affiliate)Dr. Martin Lipkin (Rockefeller Affiliate)Dr. Aaron J. Marcus (VA NY Harbor HealthcareSystem Affiliate)Dr. Paul A. Marks (MSKCC Affiliate)Dr. Ari M. MelnickDr. Henry W. MurrayDr. Ralph L. NachmanDr. David M. NanusDr. Carl F. NathanDr. Holly Andersen: Member, Dartmouth Medical School Boardof OverseersDr. Phyllis August: Member, Task Force on Treatment ofHypertension in Pregnancy; Invited Speaker, American Societyof Hypertension Annual MeetingDr. Brian Bosworth: Fellow, American College ofGastroenterology; Admitted to AGA Academy of EducatorsDr. David Calfee: Elected Fellow, Society for HealthcareEpidemiology of America (SHEA); Elected Fellow, InfectiousDiseases Society of America (IDSA)Dr. Juan Emilio Carillo: Appointed to the Board of Directors,National Hispanic Medical AssociationDr. Leandro Cerchietti: Doris Duke Clinical Scientist AwardDr. Mary K. Crow: Named a Master of the American College ofRheumatologyDr. Joseph J. Fins: Elected Fellow, American Academy ofArts and Sciences; Inducted, Master of the American Collegeof Physicians (MACP); Wesleyan University’s DistinguishedAlumnus Award and also elected as Trustee Emeritus for Life;Laureate Award from the New York Chapter of the AmericanCollege of Physicians (ACP)Dr. Paraskevi Giannakakou: Mary Kalopathakes Award fromthe Hellenic Medical Society of New YorkDr. R. Gordon Douglas, Jr (Emeritus)Dr. James A. Fagin (MSKCC Affiliate)Dr. Laurie H. GlimcherDr. Antonio M. Gotto, Jr.Dr. Roy M. GulickDr. Katherine A. Hajjar (secondary appt)Dr. Barbara L. HempsteadDr. Jules Hirsch (Rockefeller Affiliate)Dr. Alan N. Houghton (MSKCC)Dr. Richard S. Bockman (HSS Affiliate)Dr. Morton D. Bogdonoff (Emeritus)Dr. Ralph Carmel (Brooklyn Methodist Affiliate)Dr. Bayard D. Clarkson (MSKCC Affiliate)Dr. Ronald G. CrystalDr. Andrew DannenbergDr. R. Gordon Douglas, Jr (Emeritus)Dr. James A. Fagin (MSKCC Affiliate)Dr. Edward Paul Gelmann (Columbia Affiliate)Dr. Kenneth Offit (MSKCC Affiliate)Dr. Eric G. Pamer (MSKCC Affiliate)Dr. Alessandra B. Pernis (HSS Affiliate)Dr. David N. PosnettDr. Shahin RafiiDr. Marcus M. ReidenbergDr. Arleen B. RifkindDr. Michel Sadelain (MSKCC Affiliate)Dr. Charles L. Sawyers (MSKCC Affiliate)Dr. Laurie H. Glimcher: 2012 Ernst W. Bertner Memorial Awardfrom The University of Texas MD Anderson Cancer Center;2012 William B. Coley Award for Distinguished Research inBasic Immunology from the Cancer Research Institute; Dr. LuisFederico Leloir Prize of International Cooperation in Science,Technology and Innovation (Argentina)Dr. Roy Gulick: Lifetime Achievement Award for invaluablecontributions in the field of HIV medicine, medical educationand research, 2012 HIV Congress in Mumbai, India; AnnualVisiting Professor, Beth Israel-Deaconess/Harvard; HIV MedicalAssociation (HIVMA) Clinical Educator Award, InfectiousDiseases Society Association (IDSA)Dr. Julianne L. Imperato-McGinleyDr. Warren D. Johnson, Jr.Dr. Attallah Kappas (Rockefeller Affiliate-Emeritus)Dr. Ione Kourides (Voluntary)Dr. Mary Jeanne Kreek (Rockefeller Affiliate)Dr. Aaron J. Marcus (VA NY Harbor Healthcare System Affiliate)Dr. Paul A. Marks (MSKCC Affiliate)Dr. Michael S. Glickman (MSKCC Affiliate)Dr. Laurie H. GlimcherDr. Antonio M. Gotto, Jr.Dr. Roy M. GulickDr. Katharine A. Hajjar (secondary appt)Dr. Barbara L. HempsteadDr. Jules Hirsch (Rockefeller Affiliate)Dr. Andrew I. SchaferDr. David A. Scheinberg (MSKCC Affiliate)Dr. Kendall A. SmithDr. David Solit (MSKCC Affiliate)Dr. Manikkam SuthanthiranDr. Marcel van den Brink (MSKCC Affiliate)Dr. Alan M. WeinsteinDr. Yariv Houvras: Elected to the International Thyroid OncologyGroup’s Board of DirectorsDr. Warren Johnson: Board Member, Foundation Merieux USA;Keynote Speaker, Global Health Day, Yale School of PublicHealthDr. Robert Kim: Emerging Faculty Member, American Collegeof Cardiology FoundationDr. Henry W. MurrayDr. Peter R. Holt (Rockefeller Affiliate)Dr. Babette B. WekslerDr. Marc E. WekslerDr. Alastair J.J. Wood (Courtesy)26 27

Dr. Mark Lachs: Speaker, White House World Elder AbuseAwareness Day (Topic: New York City’s Elder Abuse Center)Dr. Meredith Lash-Dardia: Fellow, American Collegeof PhysiciansDr. Jeffrey C. Laurence: The Red Ribbon Foundation VisionaryAwardDr. John P. Leonard: Co-Director, American Society ofHematology’s Clinical Research Training InstituteDr. Michael Lockshin: Lifetime Achievement Award, LupusFoundation of America (National Leadership Award for LupusMedical Advancement)Dr. Lia Logio: Elected to the Council of the Associationof Program Directors of Internal MedicineDr. Cathleen London: Appointed to the New York State Academyof Family Physicians’ Advocacy CommissionDr. Samuel Mann: Hypertension and You – Old Drugs, New Drugs,and the Right Drugs for Your High Blood Pressure (Published byRowman & Littlefield Publishers, Inc.)Dr. Steven Markowitz: Appointed to the American HeartAssociation: Cardiac Electrophysiology Clinical Peer ReviewStudy GroupDr. Bassem Masri: Fellow, National Lipid AssociationDr. Allyson Ocean: Elected Chairperson, Medical AdvisoryBoard and Board of Directors, Michael’s Mission, Inc.Dr. Ellen Scherl: Woman of Distinction Award in Medicine(19th Annual), Crohn’s and Colitis Foundation of America;Mentor Recognition Program Honoree, American MedicalAssociation Women Physician’s Congress, AMA House ofDelegatesDr. Richard T. Silver: Lifetime Achievement Award,SASS FoundationDr. David Skorton: Exemplary President, GovernmentalRelations Award from the Association of Public and Land-grantUniversities’ (APLU) Council on Governmental AffairsDr. Kendall A. Smith: Editor-in-Chief, Frontiers in Immunology(open access journal)Dr. Manikkam Suthanthiran: Invited Chair, American Societyof Nephrology Program Committee 2012 Annual MeetingDr. Thomas J. Walsh: Keynote Speaker, Australasian Societyfor Infectious Diseases 2012 Meeting, Freemantle, Australia;Editorial Advisory Board, Journal of Infectious Diseases; VisitingProfessor, the National and Kapodistrian University of AthensSchool of Medicine; Opening Address, 30 th Annual Meetingof the European Society of Pediatric Infectious Diseases,Thessaloniki, Greece; Elected President of the MedicalMycology Society of New YorkDr. William A. Zoghbi: President, American Collegeof CardiologyDr. Jean Pape: Co-chair, French HIV/AIDS ConferenceDr. Richard Pasternak: Received the title of “Championsof Heart & Stroke,” American Heart Association,2012 New York City Heart BallDr. Jane E. Salmon: Virginia Kneeland Frantz ’22 Award forDistinguished Women in Medicine, Columbia University Collegeof Physicians and Surgeons Alumni AssociationDr. Andrew I. Schafer: Robert H. Williams DistinguishedProfessor Award from the Association of Professorsof Medicine; Elected to the Institute of Medicine (IOM)DivisionProfiles28

CardiologyBruce B. Lerman, MDChief, Maurice R. andCorinne P. GreenbergDivision of CardiologyHilda Altschul MasterProfessor of MedicineProfessor of MedicineWeill Cornell MedicalCollegeAttending PhysicianNewYork-PresbyterianHospitalThe Maurice R. and Corrine P. Greenberg Division of Cardiology is a leader in cardiovascular research,education and clinical care. The Division’s mission is to remain at the forefront of scientific and technologicaldevelopments that are revolutionizing cardiology and to translate these findings to the clinical bedside.We have assembled internationally renowned programs that investigate the basic mechanisms ofcardiovascular disease, including the genetics of heart disease, the cellular signals and transcriptionfactors responsible for cardiac development, the transformation and homing of stem cells for myocardialregeneration and the delineation of the molecular bases for cardiac arrhythmias. Strategies are continuallyimplemented to enhance physical space, expand comprehensive clinical programs and continue ourhistory of cutting-edge research.Clinically, our priorities are to develop and deliver cutting-edge therapies for heart disease and toadvance clinical investigation. Expert faculty provide mentoring, training and supervision to medicalstudents, internal medicine residents and fellows in cardiology, preparing them as tomorrow’s leaders.The faculty also provide a host of weekly conferences for internal and external colleagues. Our highlysought after fellowship programs now total four. In addition to fellowships for cardiovascular disease,clinical cardiac electrophysiology, and interventional cardiology, we have launched advanced heart failureand transplantation cardiology. Dr. Evelyn Horn will serve as director of this new training program.From basic science, investigating the mechanisms of arrhythmias and large population-based studiesof new diagnostic and therapeutic approaches, to a vast array of cardiovascular conditions and diseases,the focus is on improving patient care. This involves a majority of our faculty and almost all of cardiologyfellows-in-training, as well as postdoctoral trainees and graduate and medical students, thus creatinga rich intellectual milieu in which trainees develop into experienced investigators.Clinical services achieve superior outcomes in all areas, from cutting-edge interventional and imaginglaboratories, to outpatient consultative and ongoing care. Patient care covers all types of heart and vasculardiseases, including, but not limited to, arrhythmias, coronary and peripheral arterial disease, valve disease,the Marfan syndrome and inherited heart diseases, as well as heart failure and transplantation cardiology.To allow immediate treatment of patients presenting in the early stages of a heart attack, there exists24-hour, in-hospital coverage of the Cardiac Intensive Care Unit, Telemetry and Step-Down Unit and theinterventional laboratory.The Electrophysiology Laboratory (Drs. Bruce Lerman, Steven Markowitz, Jim Cheung, Christopher Liuand James Ip) continues expansion of its program in catheter ablation for complex arrhythmias (includingatrial fibrillation, atrial tachycardias, and ventricular tachycardias). There was significant growth in clinicalactivities related to complex rhythm device procedures, such as device lead extraction. In conjunction withthe Cardiac Catheterization Laboratory, the Electrophysiology Laboratory has introduced percutaneousclosure of the left atrial appendage to prevent strokes in atrial fibrillation. Active research projects includeoutcomes of catheter ablation for atrial fibrillation; characterization of complex atrial tachycardias;idiopathic ventricular tachycardia; risk stratification for sudden death; the relationship of heart failure andarrhythmias; and long-term outcomes after pacemaker and defibrillator implantation.Dr. S. Chiu Wong continues his outstanding research, including a multicenter trial begun in 2012 for whichhe serves as principal investigator. The trials involve two centers in the United States and three in Germanyand investigate arterial access site closure following invasive procedures. Dr. Wong is also working onresearch projects for renal artery denervation for the treatment of resistant hypertension, as well as mitralvalve repair for treatment of mitral regurgitation in high risk patients.Additionally, under the direction of Dr. Wong, the Catheterization Laboratory team (with the Departmentof Cardiothoracic Surgery) successfully treated over 100 patients with critical aortic stenosis (patients whowere considered high risk or “not treatable” by our qualifying surgical colleagues). Additionally, thepartnership between the Division of Cardiology and the Department of Cardiothoracic Surgery resultedin the creation of a new Valve Center dedicated to high-impact clinical research and optimization in thedelivery of patient care.Dr. Lerman, Division Chief, continues to serve on the editorial boards of Circulation, Heart Rhythm,The Journal of Cardiac Electrophysiology and The Journal of Innovations in Cardiac Rhythm Management.Dr. Steven Markowitz serves on the Electrophysiology Committee, American College of Cardiology,and on the editorial boards of HeartRhythm and Journal of Interventional Cardiac Electrophysiology.We welcomed several highly skilled new recruits in 2012 who cover a wide swath of expertise incardiology. Dr. Rebecca A. Acunce, who completed her residency training at NYP/WC and a fellowship atNew York University, joins our faculty as a consultative cardiologist. Dr. James M. Horowitz, a graduate ofDr. Lerman (third from left) with new recruits: Harsimran Singh, Henry Tran, Rebecca Ascunce, Luke Kim, Rajesh Swaminathan (l to r)the University of Pennsylvania recently joined our team after his stellar service as Chief Residentwith the Department of Medicine’s residency training program in internal medicine. A new NYPsponsoredaward has been established in his name, which may be given to any chief resident from anydepartment who demonstrates the shared values of “acollaborative patient-centered approach to patient careon the Weill Cornell campus.” Dr. Harsimran Singh,directs our adult congenital heart disease programand is also an interventional cardiologist. He holds anundergraduate degree from Princeton University andan MD from Yale. Dr. Rajesh V. Swaminathan receivedhis MD from Duke University and completed residencytraining at Massachusetts General Hospital, Boston.Clinical services achieve superior outcomes inall areas, from cutting-edge interventional andimaging laboratories, to outpatient consultativeand ongoing care.With a research focus on mechanisms of vascular injury and remodeling, he is working in both theoutpatient clinic and in the cardiac catheterization laboratory. Dr. Henry A. Tran, bringing expertisein cardiovascular diseases and echocardiography, received his MD from Georgetown University andcompleted residency training at New York University. The division also gained new recruits from SoundShore Cardiology Associates, located in New Rochelle and Mamaroneck, thus expanding our patientcare reach to the Westchester area. These new recruits are Drs. Richard Charney, Leonard J. Di Re,Paul Gerardi, and David Messinger.3031

They work together in a series of activities designed to encourage,and systematically support, the development of new researchinitiatives within, and outside, the Division.Dr. Charlson withtrainees.Clinical Epidemiology and EvaluativeSciences ResearchThe Division of Clinical Epidemiology and Evaluative Sciences Research draws upon the talentsand experience of a multidisciplinary group of faculty based at Weill Cornell Medical College, CornellUniversity-Ithaca, and other institutions. Faculty members are experts in qualitative and quantitativeresearch methodology, health services research, clinical epidemiology, medical informatics, decisionsciences, health disparities research, community-based participatory research, clinimetrics, outcomesresearch, behavioral science, and health education. They work together in a series of activities designedto encourage, and systematically support, the development of new research initiatives within, andoutside, the Division.Several related areas of investigation include: studies to improve clinical outcomes; behavioralscience research; health disparities research (under the leadership of Dr. Carla Boutin-Foster); researchon complex patients with a significant burden of comorbidity; and comparative effectiveness. In orderto stimulate and support new clinical, health services, and outcomes research within and outside theDepartment of Medicine, the division houses consultative services to investigators; e.g., informatics anddata management support and training programs in clinical epidemiology and research methodology.Under the auspices of the CEDREC and SCALE grants, expansion continues in the area of healthdisparities and community-based research. CEDREC established a new environmental justice corewith Drs. Carla Boutin-Foster and Beverly Watkins, PhD, continuing to build on partnerships betweenWeill Cornell Medical College, Lincoln Hospital and Mental Health Center, Hunter College Schoolof Nursing-City University of New York, and The Center for Healthful Behavior Change at New YorkUniversity School of Medicine.SCALE partners with the Northern Manhattan Perinatal Partnership (NMPP), an organizationthat focuses on improving health conditions, such as diabetes and obesity, in families who reside inNorthern Manhattan. In addition to NMPP, several faith-based and community-based organizationsin Harlem and the South Bronx have become critical partners in the division’s research initiatives onhealth disparities. Drs. Carla Boutin-Foster and Erica Phillips-Caesar had an article, based on theirresearch through CEDREC and SCALE, published in The Journal of Immigrant and Minority Healthin October 2012. Dr. Boutin-Foster had a second article published in The Journal of Immigrant andMinority Health in December 2012. Dr. Ginger Winston received a NHLBI Minority Investigator ResearchSupplement under the mentorship of Dr. Mary Charlson, Division Chief, and CEDREC. Dr. Winston isengaged in primary data collection in the SCALE trial to examine relationships between body imagedissatisfaction and weight loss; knowledge of the health risks of obesity and weight loss; and socialnetwork support and weight loss.Mary E. Charlson, MDChief, Division of ClinicalEpidemiology and EvaluativeSciences ResearchExecutive Director, Centerfor Complementary andIntegrative MedicineWilliam T. FoleyDistinguished Professorof MedicineProfessor of MedicineWeill Cornell Medical CollegeAttending PhysicianNewYork-PresbyterianHospital3233

Emergency MedicineDr. Charlson, (Executive Director of the Center for Integrative Medicine at Weill Cornell MedicalCollege and William T. Foley Distinguished Professor of Medicine) and Drs. Janey Peterson and CarlaBoutin-Foster had three articles published in JAMA Internal Medicine (formerly Archives of InternalMedicine) in February 2012. Funded by a $9.5 million grant, the papers detail three, randomized trialsrevealing that people can use positive affect and self-affirmation to help them make and sustainbehavior change. The same intervention was used in all three studies. Patients were encouraged tothink of small things in their lives that make them feel good, when they get up in the morning andthroughout their day. Patients were asked to use self affirmation to help them overcome obstacles totheir plan by recalling moments in their lives they are proud of.The three-pronged designed study, which simultaneously tested the same intervention for differentpopulations, was a first for National Institutes of Health (NIH) funded research, and began with anaward to Weill Cornell Medical College in 2002. This intervention development approach is now morebroadly used in the obesity-related behavioral intervention trial (ORBIT) sponsored by the NIH. Thefindings of the three trials is the basis for SCALE for overweight or obese patients. Dr. Charlson andfaculty had two articles which further illuminated the findings of this study, one in the Journal ofConsulting and Clinical Psychologyin September 2012 and another inBMC Medical Research Methodology inNovember 2012.Dr. Boutin-Foster atSPARC, where shereceived a SPARCMentoring ExcellenceAward.Clinical PharmacologyMarcus M. Reidenberg, MDChief, Division of ClinicalPharmacologyProfessor of PharmacologyProfessor of MedicineProfessor of Public HealthWeill Cornell Medical CollegeThe Division of Clinical Pharmacology remains actively involved in the World Health Organization(WHO) Essential Medicines program. This important global effort evaluates, updates and publishesa list of about 300 medicines that address the world’s major medical problems. The program isdesigned to advise countries on which drugs should be considered priority purchases when health careresources are limited. Since 1975, the concept of prioritizing the purchase of essential medicines hasbeen accepted in principle by 156 WHO member states. With student help, Dr. Reidenberg submitted,in 2012, a review of statins for children to be discussed at the Expert Committee meeting in 2013.Dr. Reidenberg is an inventor of a drug to treat some cancers; trials are ongoing. He continuesto advise the present sponsor on further development of this drug. He is also an investigator of astudy to discover a new drug to reduce fatal arrhythmias in patients with heart attacks. “Notes onTherapeutics” on the Weill Cornell Medical College website continues to receive hundreds of visits at:http://www.med.cornell.edu/cert/patients/notes_on_therapeutics.htmlDr. Flomenbaum (second fromleft) with the Toxicology team.34

Neal E. Flomenbaum, MDChief, Division of EmergencyMedicineProfessor of Clinical MedicineWeill Cornell Medical CollegeMedical DirectorEmergency Medical ServicesEmergency Physician-in-ChiefNewYork-PresbyterianHospitalOf the 85,000 patients treated annually in the NewYork-Presbyterian Weill Cornell EmergencyDepartment (ED), approximately 22,000 are subsequently admitted to inpatient services. In addition, theED evaluates and stabilizes patients transferred to Weill Cornell from hospitals all over the world.The Division of Emergency Medicine has been widely acknowledged for starting the first geriatricemergency medicine fellowship training program in 2005, and for opening the first geriatric emergencydepartment in the New York metropolitan area in 2009. We provide state-of-the-art emergency care for allpatients 24-hours a day, while teaching NYP/WC residents from every specialty how to provide that care.The NYP/Weill Cornell ED is officially designated as a 911 receiving hospital, a level I trauma center, astroke center, a spinal cord injury center, and a psychiatric emergency receiving center. We are also theburn center for the City of New York, an accredited chest pain center, and we maintain one of the largesthospital-based ambulance services in the northeast, providing basic, advanced, and critical pediatric andadult prehospital care. NYP*EMS is completely integrated with our emergency department and hospitalcare and medical supervision for all NYP EMTs and paramedics is provided by Weill Cornell EM facultyphysicians. NYP ambulances operate throughout all five boroughs of NYC, north to Albany, east intoNassau County, and south and west to Central New Jersey. Our extensive disaster preparedness activitiesutilize the most advanced techniques in biological, chemical, radiation and “Hazmat” decontamination.Senior Weill Cornell faculty attendings are present in the ED 24/7, working with residents, physicianassistants, nurse practitioners, nurses and patient care facilitators in newly expanded state-of-the-artfacilities. In recent years, we have raised patient satisfaction scores and reduced ED patient lengths ofstay to record levels, despite dramatic increases in the number of annual patient visits and admissions.Since implementation of the EMR in the NYP/WC ED in 2010, we have worked with Hospital IT to monitor,modify and enhance it (as needed) while developing new ways to utilize its potential in furthering patientcare and clinical research.In Geriatric Emergency Medicine, we remain dedicated to anticipating and addressing the specificemergency care issues in this rapidly increasing segment of the population. The Division of EmergencyMedicine created a first-of-its kind (non ACGME) Geriatric Emergency Medicine (GEM) Fellowship in2005, and a state-of-the-art geriatric ED facility (Area C) in 2009. We offer both a one-year clinicalfellowship, and a two-year combination clinical/research fellowship, culminating in a master’sdegree in Clinical Investigation from the WeillCornell Graduate School of Medical Sciences. Acollaborative research effort with colleagues fromthe University of Toronto began in 2008, resulting in a paper co-authored by Dr. Neal Flomenbaum andpublished in the Annals of Emergency Medicine. Dr. Michael Stern, Co-Director of the fellowship, hasauthored several textbook chapters; most recently, on orthogeriatrics. He has also updated his innovativeGEM curriculum for EM residents. Of the five abstracts submitted to national GEM and geriatricorganizations, five were accepted for presentation or publication.Another innovative pioneering practice is the Medical Toxicology Service, which continues to offer WeillCornell physicians’ bedside and telephone consultations throughout the hospital for all patients acutely,or potentially poisoned, and those experiencing the effects of chronic overdoses, withdrawal syndromes,medication errors and adverse drug reactions. Since its inception in 2009, the toxicology service hasprovided over 700 consultations in the adult and pediatric EDs, internal medicine, critical care, neurology,surgery, psychiatry, and pediatric intensive care units and services.The toxicology group consists of six faculty members: Dr. Flomenbaum, a senior co-author and coeditorof the last eight editions of Goldfrank’s Toxicologic Emergencies, and five WC faculty membersboard certified in both emergency medicine and medical toxicology, Drs. Brenna Farmer, Jane Prosser,Joseph Rella, Zhanna Livshits, and Dr. Rama Rao (director of the toxicology service). Nationally, Dr.Farmer serves as chair of the American College of Medical Toxicology Subcommittee on Pharmacyand Therapeutics, and Dr. Rao serves on the Medical Toxicology Sub-board for the American Board ofEmergency Medicine. Regionally, our toxicology attendings work with the teaching faculty at the NewYork City Poison Control Center and collaborate on educational programs and research with the NYCPCCfellows-in-training and other faculty. At Weill Cornell, we also collaborate with the division of criticalcare on research involving presentations on drugs of abuse. Dr. Jane Prosser runs a clinical elective inMedical Toxicology at Weill Cornell. All members of our toxicology faculty have contributed to peer reviewpublications and textbook chapters. In addition to direct patient care, the medical toxicology service ishelping to enhance medication safety throughout the hospital.Our unique Wilderness Medicine (WM) Program began in 2006 as a collaborative effort with CornellOutdoor Education (COE) in Ithaca. It continues to make great strides in medical education, clinicalresearch, and the provision of clinical care under extreme conditions. The WM group creates newcourses and experiences for our residents, attending physicians, Weill Cornell medical students andCornell University undergraduates, and our student electives annually draw participants from all overNorth America and abroad.Working with faculty in our Global Emergency Medicine Program, the WM group is developing atraining program to better equip humanitarian first-responders with the skills they need to be effective indisaster and crisis situations throughout the world. In the past two years collaborations have also beenWe provide state-of-the-art emergency care for all patients24-hours a day, while teaching NYP/WC residents from everyspecialty how to provide that care.initiated with Cornell’s Department of Botany in Ithaca to conduct translational research on botanicalsthat may be useful medically. We have also begun to explore the feasibility of a post-residency fellowshipin wilderness and rural medicine designed, in part, to alleviate the severe physician shortages in ruralNew York State. The current academic year has been a busy one for the Global Emergency MedicineProgram with faculty and residents serving in Tanzania, Iraq and South Sudan.The faculty currently teaches several post-graduate and CME-credit courses, including the GlobalHealth Emergencies Course - a rigorous two-week educational initiative aimed at training doctors, nurses,and mid-level providers engaged in international work.Attended by over 40 participants from around the world, thecourse faculty includes leading experts from internationalNGOs, UN agencies and Cornell, Columbia, Brown, HarvardUniversities and UCLA. Dr. Satchit Balsari, Director of theGlobal EM Program, led a team of over 30 physicians from theUS and India to implement a real-time surveillance system inthe world’s largest gathering of pilgrims – the Kumbh Mela. Supported by Harvard School of Public Health,the team’s field work was covered by international media; The New York Times, Times of India, and severaltelevision channels. The Program continues its commitment to the Global Health Working Curriculum atWCMC, and supports the Global Health Grand Rounds – a monthly seminar series that has invited heads ofstate and global health leaders from around the world to address the Weill Cornell community.The last two months of 2012 became an unprecedented test of our state of preparedness and our surgecapacity, when three of the largest Manhattan hospitals suffered severe damage from Hurricane Sandy onOctober 29 and remained closed beyond the end of the year. In November and December our patient visitsincreased by 19.8% and our admissions by 4.3%, over the same two-month period to the year before. Asthe only remaining East Side Level I trauma center from the Battery to the Bronx, our trauma activationcases doubled. Remarkably, though the number of patients arriving by FDNY 911 dispatched ambulancesincreased by 61%, our ambulance turnaround time increased by less than a minute.In 2012, the Division of Emergency Medicine has once again distinguished itself as an innovator inpatient care, medical education, and clinical research.In recent years, we have raised patient satisfactionscores and reduced ED patient lengths of stayto record levels, despite dramatic increases in thenumber of annual patient visits and admissions.Endocrinology, Diabetes and MetabolismAs part of a world-class academic medical center, the Division of Endocrinology, Diabetes andMetabolism is dedicated to fulfilling our mission of excellence in providing quality care to patientswith endocrine and metabolic disorders; conducting promising research to advance the frontiers ofendocrinology and diabetes; and training of highly motivated and dedicated physicians to becomesuccessful clinicians and physician-scientists. Division Chief, Dr. Imperato-McGinley serves as thePrincipal Investigator of the Weill Cornell NIH-funded Clinical and Translational Science Center (CTSC).Established in 1997, our Diabetes Center provides the highest standard of care for patients withtype 1 and type 2 diabetes mellitus. It offers a multidisciplinary team approach for diabetes care withcomprehensive case management and the development of an individualized treatment plan. An expertteam is composed of diabetologists, certified diabetes educators, and registered dieticians who areexperienced in intensive diabetes management, including insulin pump therapy. The Center also hasextensive experience in the management of gestational diabetes in patients with type 1 and type 2diabetes mellitus. The Diabetes Center receives federal funding to support ongoing clinical research.The division’s areas of expertise in clinical care include: general endocrinology; reproductiveendocrinology, including the treatment of menstrual irregularities, hirsutism, and menopause; thyroiddisease, with particular emphasis on thyroid cancer; disorders of calcium metabolism; and osteoporosisand metabolic bone disease. Should surgery be necessary for the treatment of an endocrine disorder,we also have an endocrine surgeon on-site.The subspecialty program in Endocrinology, Diabetes and Metabolism is designed to provide thetraining and experience necessary to acquire all competencies to become an expert in this field. Thiscomprehensive program fulfills the needs of trainees anticipating a clinical and/or basic endocrineresearch career in academia; those expecting to function as clinician-educators; and those interested inpursuing the clinical practice of endocrinology.The Endocrinology, Diabetes and Metabolism fellowship is a joint program between NewYork-Presbyterian/Weill Cornell and Memorial Sloan-Kettering Cancer Center (MSKCC). A two-year trainingprogram accredited by the Accreditation Council for Graduate Medical Education (ACGME), fellows receivedidactic and clinical instruction from faculty using the inpatient and ambulatory facilities at the hospitals.They also attend Metabolic Bone Clinic and conferences at the Hospital for Special Surgery (HSS). Thefirst year of the fellowship is primarily clinical, while the second year emphasizes clinical investigationJulianne L. Imperato-McGinley, MDChief, Division ofEndocrinology, Diabetes,and MetabolismAssociate Dean forTranslational Research andEducational MedicineDirector, Clinical andTranslational Science Center(CTSC)The Abby Rockefeller MauzéDistinguished Professor ofEndocrinology in MedicineProfessor of MedicineWeill Cornell MedicalCollegeAttending PhysicianNewYork-PresbyterianHospital36 37

Dr. Rekah Kumar withDr. Aaron Shulmanor basic research. Fellows are expected to have at least one paper prepared for publication in a peerreviewedjournal at the completion of their fellowship. An optional third year is devoted to further researchtraining. Based on individual interest and past research experience, fellows may select mentors from arange of disciplines in the tri-institutional community and Rockefeller University, in both basic and clinicalresearch. Additionally, our faculty is active in the training of Internal Medicine Residents and leads theEndocrinology Section of the Basis of Disease Course for Weill Cornell medical students.The division conducts promising state-of-the-art research to generate new knowledge and improveunderstanding with the ultimate goal of applying the latest scientific and medical advances for theprevention, detection, and treatment of patients with endocrine diseases. Major areas of researchinclude: Clinical and Translational Science Center (CTSC), for which Dr. Imperato-McGinley servesas the Principal Investigator of Weill Cornell Medical College’s $49 million NIH-funded Clinical andTranslational Science Award (CTSA); Androgens and Cognitive Function, and NIH-funded projectevaluating the effects of hormones in utero, and postnatally, on cognitive function in normal subjectsand subjects with inherited androgen action defects; Molecular Genetics of Male Sexual Differentiationand Development, a study defining the genetic defects of subjects with inherited conditions affectingmale sexual differentiation, particularly subjects with 5α-reductase-2 deficiency; Molecular Genetics of21 Hydroxlyase Deficiency, a study to identify inherited genetic defects in the 21-hydroxylase enzyme inhumans which result in genital ambiguity (genotype-phenotype relationships of this condition also beingstudied); The Epidemiology of Diabetes Intervention and Complications Trial (EDIC), a continuation of themulticenter Diabetes Control and Complications Trial (DCCT) evaluating the effect of intensive glucosecontrol on both microvascular and macrovascular complications of diabetes; The Action to ControlCardiovascular Risk in Diabetes (ACCORD) trial, a multicenter study of the effects of intensive versusconventional glucose, blood pressure and lipid treatment on cardiovascular disease in 10,000 individualswith type II diabetes mellitus; Molecular Basis of Sex Steroid Hormone Interaction in Prostate Diseases,a study focusing on androgen-estrogen interaction in the prostate and the development of specificestrogen analogs with fewer side effects for the hormonal therapy of prostate cancer; The Effectsand Mechanisms of Dietary Fat in Prostate Development and Pathogenesis to facilitate developmentof strategies for prostate cancer prevention; and Chinese Herbal Medicine and Phytochemicals inProstate Cancer studies to determine their effects in the treatment of prostate cancer in animal models,elucidating mechanisms of action, with the ultimate goal of proceeding to clinical trials in patients withadvanced prostate cancer. In addition to a specific Chinese herbal formula, phytochemicals derived fromChinese herbs, such as genistein and camptothecin analogs, are also being evaluated.New recruits during 2012 included Louis J. Aronne, MD, Professor of Clinical Medicine and MedicalDirector of the Center for Weight Management and Metabolic Clinical Research; David A. Cohen, MD,Assistant Professor of Medicine; and Rekah B. Kumar, MD, who, after completing her fellowship in thedivision, was appointed to Assistant Professor of Medicine.38Ira M. Jacobson, MDChief, Division ofGastroenterology andHepatologyVincent Astor DistinguishedProfessor of MedicineProfessor of MedicineWeill Cornell Medical CollegeAttending PhysicianNewYork-PresbyterianHospitalGastroenterology and HepatologyThe Division of Gastroenterology and Hepatology, providing outstanding and compassionate patientcare, offers first-rate clinical services in a wide range of subspecialty areas, including hepatology,inflammatory bowel disease, gastrointestinal reflux disease, advanced endoscopic diagnostic andtherapeutic procedures, functional bowel disorders, gastrointestinal infections and gastrointestinalcancer prevention and treatment. During 2012, established a pancreas program, the first ever at NYP/WC. Faculty are active in education and research. Numerous research projects and clinical trialsare underway for the prevention and treatment of viral hepatitis, gastrointestinal cancers, Barrett’sesophagus, inflammatory bowel disease, pancreatic lesions, and other gastrointestinal diseases. TheDivision houses the Jay Monahan Center for Gastrointestinal Health; the Center for the Study of HepatitisC; and The Jill Roberts Center for Inflammatory Bowel Disease.Dr. Ira Jacobson, Division Chief, is directing an active clinical trials program aimed at developingnew, more effective, and better tolerated treatments for chronic hepatitis C (HCV). The current standardof care for genotype 1 HCV infection, the most prevalent viral genotype in the U.S., is a combination ofpegylated interferon, ribavirin, and one of two protease inhibitors, telaprevir and boceprevir. During 2012two phase 3 programs involving newer protease inhibitors, simeprevir and faldaprevir, were substantiallycompleted, along with a phase 3 trial evaluating peginterferon, ribavirin, and sofosbuvir, a nucleotidepolymerase inhibitor. At the Annual Meeting of the American Association for the Study of Liver Diseases,Dr. Jacobson presented the results in patients with advanced liver fibrosis from a trial of a quadrupleregimen consisting of peginterferon, ribavirin, the protease inhibitor danoprevir, and the nucleotidepolymerase inhibitor mericitabine. He also presented the findings of a study of an interferon-freeregimen of telaprevir, the non-nucleoside inhibitor VX-22 and ribavirin.The development of interferon-free therapies is the most sought after goal in the field of hepatitis C.Trials of interferon-free therapy performed in 2012 included two phase 3 studies of sofosbuvir combinedwith ribavirin in the treatment of patients with genotypes 2 and 3, and a phase 2 study of daclatasvir, anNS5A replication complex inhibitor combined with sofosbuvir with or without ribavirin.Dr. Michel Kahaleh, Chief of Endoscopy and Medical Director of NYP/Weill Cornell’s first pancreasprogram, led an outstanding year for advanced endoscopy. The volume of interventional proceduresincreased by 175%. New procedures performed included: endoscopic suturing, confocal endomicroscopyfor early detection of GI cancers, photodynamic therapy and radiofrequency ablation for pancreaticobiliarycancers, endoscopic drainage of pseudocysts, and endoscopic necrosectomy and EUS-guidedERCP. The advanced group has launched international registries related to these novel procedures andparticipated in multicenter trials, validating probe-based confocal endomicroscopy in bile duct lesionsand a novel metal stent for drainage of pancreatic pseudocysts. Their research produced 16 articles inpeer-reviewed journals; 8 abstract presentations atinternational meetings; and they secured an ASGEplanning grant and several unrestricted grantsfrom industry. They also launched an annual, liveconference related to innovations in gastroenterologywhich featured an international faculty and includedlive demonstrations of advanced endoscopicprocedures performed by the faculty at NewYork-Presbyterian Hospital.Dr. Andrew Dannenberg’s laboratory is activelyworking on several projects, including NIH-sponsored studies, continuing to focus on strategies toreduce the cancer burden. Their research scope is wide-ranging, from mechanistic studies to elucidatethe relationship between obesity, inflammation and cancer, to the development of a novel metabolomicsbasedstrategy for the early detection of experimental colorectal neoplasia.Dr. Steven Lipkin’s laboratory made major new contributions and published in leading journals:the CCR9/CCL25 axis is an important prognostic mechanism for colorectal cancer as a mechanismpreventing metastasis lost in late stage tumors (Journal of Clinical Investigation); microRNAs 23 and 27determined as prognostic markers for colon cancer (Cancer Discovery); and a new methodology devisedusing protein-interactome networks to classify genetic variants as causative mutations or benignpolymorphism (Nature Biotechnology). Dr. Lipkin was appointed to the American Society of ClinicalOncology Cancer Prevention Committee and the Cancer Genetics Subcommittee and is writing an ASCOFamily Cancer History intake form to be used by general community oncologists as a template. It willlikely be utilized by physicians worldwide, setting the standard for clinical care.Dr. Andrew Talal continued to study fine needle aspiration (FNA) of the liver as a method forintrahepatic sampling. FNA is a technique with decreased morbidity compared to conventional liverbiopsy (CNB) and that allows for serial liver sampling. For the first time in humans, liver sampling wasused to address differences in HCV RNA decline, pharmacokinetics, appearance of resistant variants, andNumerous research projects and clinical trials areunderway for the prevention and treatment of viralhepatitis, gastrointestinal cancers, Barrett’s esophagus,inflammatory bowel disease, pancreatic lesions, andother gastrointestinal diseases.39

Dr. Lipkin iswriting an ASCOFamily CancerHistory intakeform to beused by generalcommunityoncologists asa template ...setting thestandard forclinical care.host genes between the liver and blood in patients under antiviraltherapy with the protease inhibitor telaprevir (in a study performedin collaboration with Vertex Pharmaceuticals Inc.). Results werepresented at the Presidential Plenary Session of the AmericanAssociation for the Study of Liver Disease (AASLD) 2012 meeting.The Jill Roberts Center for Inflammatory Bowel Disease(Dr. Ellen Scherl, Director; Dr. Brian P. Bosworth and Dr. VinitaJacob, principal or co-investigators) activated five new studiesincluding research on moderate to severely active Crohn’s Disease,eating patterns and disease activity in patients with InflammatoryBowel Disease ((IBD), health care maintenance in patients withIBD, and safety and tolerability of Budesonide Foam in subjectswith active ulcerative proctitis or proctosigmoiditis. Collaborationsremain with institutions across the globe to establish internationalbiobanks; explore the relationship between vitamin D and IBDhealth; and explore IBD genotypes. They include ColumbiaUniversity, NYU, Yale University, Albert Einstein Hospital, JohnsHopkins Hospital, Rockefeller University, and a MicrobiomeConsortium headed by Dr. Kenneth Simpson at Cornell University,Ithaca, with facilities and institutions in New Mexico, NorthCarolina, Texas and Switzerland. In addition, collaborationscontinue with Dr. Andrew Dannenberg, Director of the WCMC-NYPCancer Center, on two mediators in gastrointestinal inflammationstudies; Dr. Simpson, on mucosa associated bacterial flora; andresearchers at Weill Cornell Medical College on NOD 2 genotyping,hemangiogenesis and animal models of colon cancer and IBD.Dr. Scherl continues her work with the University of Leiden,Netherlands utilizing the IBD patient database to study the roleof inflammatory markers in predicting the clinical course of IBD,and with the New York-Moscow IBD Journal Club via Skype.Dr. Scherl was recognized by the American Medical AssociationWomen Physician’s Congress as a Mentor Recognition Programhonoree and by the CCFA as a Woman of Distinction in Medicine.Dr. Bosworth co-authored an article on multiphoton tomographicimaging as an optical tool for the diagnosis of gastrointesintalinflammation and neoplasia, and participated in and publishedthe findings of an ad hoc committee of the American Society forGastrointestinal Endoscopy in September 2012 on the use ofendoscopy simulators for training and assessing skill. Dr. Bosworth,the Anne and Ken Estabrook Clinical Scholar in Gastroenterology,continues as Program Director of the Gastroenterology andHepatology Fellowship, and was named Vice President of the NewYork Society of Gastrointestinal Endoscopy.The Jay Monahan Center (JMC) for GastrointestinalHealth has been working with the Center for Advanced DigestiveCare (CADC) at Weill Cornell Medical Center to significantly growprogrammatic efforts while serving as the ‘clinical home’ for theCADC’s adjunctive patient care services. Through this collaboration,the hereditary cancer program has expanded to include an additional genetic counselor. Dr. StevenLipkin has also joined the clinical team, providing consultative genetic services. The nutritionalprogram has gained a full-time registered dietitian with inpatient/outpatient expertise. Social workerservices added a full-time hire with expertise in both navigating inpatient referrals for social servicesand therapeutic counseling.During 2012, the JMC geared up for its official opening of an Esophageal Function Laboratoryfor the evaluation of esophageal disorders and diseases including GERD, non-cardiac chest painand swallowing disorders. The lab is equipped to offer a full range of diagnostic testing including;high-definition manometry with impedance, 24-hour pH analysis with impedance and Wireless48-hour pH analysis. The lab will complement a CADC-sponsored multidisciplinary esophagealprogram co-directed by Dr. Felice Schnoll-Sussman and Dr. Nasser Altorki (Department ofCardiothoracic Surgery).JMC advocacy and outreach covered campaigns for colon cancer and pancreas cancer awareness,and the research program has been actively recruiting patients to several new clinical trials includinga novel proteomic-based serum study for colon cancer screening and a Next-Generation Sequencing toevaluate transcriptomic changes associated with H. pylori infection and gastric cancer carcinogenesis.The division welcomed two new recruits: Reem Z. Sharaiha, MD, MSc, who received her MD at theUniversity of London, completed residency training at NYP/WC, where she also received a Master’s inpatient oriented research. She served a fellowship in gastroenterology at NYP/Columbia and at JohnsHopkins in advanced endoscopy. Her research interests include the pancreas and biliary tract. Dr. SonalKumar obtained her MD from Washington University School of Medicine; served her internal medicineresidency at Barnes-Jewish Hospital at Washington University School of Medicine; and completed afellowship in Gastroenterology at Brigham and Women’s Hospital. She holds a Master’s in Public Healthfrom the Harvard School of Public Health.Dr. Lipkin. At computerscreen, which shows theCircosPlot of Dr. Lipkin’sgenome.40 41

Geriatrics and Palliative CareRonald D. Adelman, MDCo-Chief, Division ofGeriatrics and Palliative CareMedical Director, IrvingSherwood Wright Centeron AgingThe Emilie Roy CoreyProfessor in Geriatrics andGerontologyProfessor of Clinical MedicineWeill Cornell Medical CollegeAttending PhysicianNewYork-PresbyterianHospitalThe mission of the Division of Geriatrics and Palliative Medicine is to improve the quality of lifefor older people through the integration of high-quality clinical care; teaching of geriatric medicine;and advancing knowledge through scientific research. We seek to alleviate symptoms and othercauses of human suffering through palliative care programs. The Division holds a number of federaland foundation grants and continues extensive clinical operations with a steady increase in patientvolumes on the inpatient and outpatient services. U.S. News & World Report ranked NewYork-Presbyterian Hospital 11th in the nation in geriatric medicine.A notable development during 2012 was a name change to the Division of Geriatrics and PalliativeMedicine. This represents an important shift in the division’s activities and a focus on palliativemedicine (since the inception of the Palliative Care Consultation Service in 2005). Care for patientssuffering with chronic illness and chronic pain, as well as other significantissues relating to goals of care at the end of life, have become an intrinsicpart of our role as geriatricians. We are increasingly focused on palliativecare through patient care, teaching activities, and research efforts andcollaborations. Six of our faculty members became board certified inpalliative medicine in 2012, giving us a total of seven board certifiedphysicians in this discipline. We have an active and successful PalliativeCare Champions Training Program for both nurses and social workersat NYP/WC. The NIA-funded Roybal Center, directed by Dr. M. Cary Reid,investigates pain in later life and the role of palliative care in pain andsymptom relief.The Irving Sherwood Wright Center on Aging sees an ever-increasingnumber of geriatric outpatients annually (average age is over 80 with manyMark S. Lachs, MD, MPHCo-Chief, Division ofGeriatrics and Palliative CareDirector, Geriatrics for theNewYork-Presbyterian HealthSystemThe Irene F. and I. Roy PsatyDistinguished Professorof Clinical MedicineWeill Cornell Medical CollegeAttending PhysicianNewYork-PresbyterianHospitalvibrant centenarians). For patient satisfaction scores, the center continuesto excel within the Ambulatory Care Network as one of the highestrankingpractices. Expanding our reach, The House Call Program providescomprehensive services to the most frail, homebound elderly patients,while maintaining a collaborative relationship with the highly regardedsocial services agency, DOROT. Activities in palliative care remain under theleadership of Dr. Ronald Adelman, Division Co-Chief, and Dr. Sonal Mehta,Assistant Director. The division’s dedication to the prevention of elder abuseis exemplified by its NYC Elder Abuse Center which supports elder justicethrough multidisciplinary team activities in Manhattan and Brooklyn.The Liz Claiborne Center for Humanism in Medicine, thanks to generousfunding from the Liz Claiborne/Art Ortenberg Foundation, was launchedin 2011. An educational hub for health care professionals and traineesin multiple disciplines, the mission enhances and integrates awareness,attitudes, knowledge, and skills of palliative care, and promotes the profile and practice of medicalhumanism. Aiming to foster better consciousness and understanding of the human experience of ourpatients, and promoting self-reflection and professional growth among our healthcare professionalsand trainees, the center supports the incorporation of the humanities and creative engagement in thepractice of medicine and medical education. It hosted several relevant speakers in 2012, including apresentation at Geriatric Grand Rounds, given by Victoria Sweet, MD, from the University of Californiaand the author of God’s Hotel – A Doctor, A Hospital and A Pilgrimage to the Heart Of Medicine. Regularnarrative medicine seminars and interdisciplinary meetings for clinical teams provide in-depthdiscussions on challenging clinical issues. A recent Grand Rounds speaker was Russell Hilliard, PhD,LCSW, LCAT, MT-BC, noted music therapist and Vice President of Supportive Care, Research, andEthics at Seasons Hospice in Chicago, Illinois.Medical residents often lack the opportunity to work with older adults who are not acutely ill, or tolearn of the types of community-based services available that keep them well. The division continuesto provide training to each PGY-2 resident assigned to a 4-week geriatric rotation in the following: twoweeks managing a panel of patients on the 10N team; one week covering nights on the 10N team; oneweek in an outpatient module to introduce systems of care that address the medical and psychosocialneeds of community-dwelling older adults. During the systems-based practice (outpatient) module,residents visit a PACE (Program of All-inclusive Care for the Elderly) site; make hospice and geriatricshouse calls; accompany geriatric care managers on client visits, visit a nursing home, an independentliving site, and other levels of senior housing; see an elder abuse shelter; and assist with the division’stransitional care clinic and the Wright Center’s walk-in patients. They present one of their own WCIMApatients in the weekly geriatrics team meeting for discussion and advice. An oral exam/debriefing at theend of the week enables the residents to integrate their experiences within the context of their inpatientand outpatient responsibilities. For medical interns, increased exposure to palliative care is gainedthrough a 12-hour educational series. Co-Chief Resident for Quality, Dr. Brian Eiss, also served in thedivision during 2012 as part of his one-year appointment with the Department of Medicine’s residencytraining program in internal medicine.Dr. Adelman secondfrom right with fellowsDrs. Veerawat Phongtankuel,Sonica Bhatia, Wei Wang(l to r)42 43

David M. Nanus, MDChief, Division of Hematologyand Medical OncologyMedical DirectorGenitourinary OncologyProgramMark W. PasmantierProfessor of Hematology andOncology in MedicineProfessor of MedicineProfessor of UrologyWeill Cornell Medical CollegeAttending PhysicianNewYork-PresbyterianHospitalAt work in theMelnick Lab.Hematology and Medical OncologyThe Division of Hematology and Medical Oncology consists of 40 clinical researchers and 13full-time scientists. There are six clinical services: Solid Tumor Oncology, Leukemia, Lymphoma,Myeloma, Stem Cell Transplant and Nonmalignant Hematology, operating at four sites: NewYork-Presbyterian Hospital Main Campus (third floor), Weill Greenberg Ambulatory Care Building (SolidTumor Oncology), Oxford Building (Myeloma) and at the Woman’s Health Center at 425 East 61stStreet (Breast Cancer). Each service contains disease-site specific programs. The Solid TumorService has active clinical and research programs in Breast Oncology, Gastrointestinal Oncology,Genitourinary Oncology and Thoracic Oncology, with developing programs and expertise in Headand Neck Oncology, Neuro-Oncology, and Endocrine Oncology.Each of the programs works closely with faculty in the corresponding surgical oncologydepartment, division or program. The Hematological Malignancies Program, under the directionof Dr. Eric Feldman, encompasses the Leukemia, Lymphoma, Multiple Myeloma, and StemCell Transplant Services. The Lymphoma and Myeloma Services contains several diseasespecificprograms, including the Chronic Lymphocytic Leukemia (CLL) Research Center and theWaldenstrom’s Macroglobulinemia Program. The Leukemia Service, in addition to acute andchronic leukemias, has developed programs in Myelodysplastic Syndromes and MyeloproliferativeDisorders.The division houses the largest group of clinical investigators in the College. Basic andtranslational research has benefitted from renovated research space and multiple new facultyrecruits over the last six years. A major emphasis is placed on translational (bench-to-bedside)studies. Dr. Lewis Cantley, who has an appointment in the division, was recruited to lead the WeillCornell Cancer Center. The division will play a central role in the Weill Cornell Cancer Centerworking with Dr. Cantley to recruit basic science translational researchers to the Belfer ResearchBuilding (scheduled to open in 2014), as well as partnering with other divisions/departments toexpand the research base through large collaborative grants.Laboratory research faculty of the Belfer Institute of Hematology and Oncology are integrallyinvolved in the translational components of numerous clinical trials, working hand-in-hand withclinical researchers and using cutting-edge technology to address oncologic questions thatimpact patient care and outcomes. A major focus is the understanding of molecular mechanismsunderlying individual patient sensitivity and resistance to chemotherapy or targeted treatment.These studies have the potential, not only to uncover certain aspects of fundamental cancerbiology, but to lead to the development of novel biomarkers that can be used to tailor treatmentto the individual. An example of such a translational team effort is the TAXYNERGY prospective,multi-institution Phase II clinical trial in prostate cancer; with Dr. Scott Tagawa (principalinvestigator clinical side) and Dr. Evi Giannakakou (lead investigator basic science side) in whichpatient-derived circulating tumor cells are used to interrogate mechanisms of taxane resistance.The Cancer Program at NYP/Weill Cornell was ranked number one at an academic medicalcenter in the New York metropolitan area by U.S. News and World Report in 2012. Building agrowing reputation in clinical care and clinical research, the clinical research program enrolledmore than 450 research subjects into 120 different treatment studies, e.g., high-impact protocolsacross the entire spectrum of hematologic malignancies and solid tumors, and projects inareas of non-malignant hematology. The Weill Cornell Leukemia Program offers a wide varietyof novel investigator-initiated, cooperative group, and industry-sponsored clinical trials.Dr. Gail Roboz, recognized internationally for her studies on myelodysplastic syndromes (MDS),is leading NewYork-Presbyterian/Weill Cornell Medical Center as one of six institutions selectedto join the newly-founded MDS Clinical Research Consortium, focused on innovative researchand clinical trials for MDS patients. The bone marrow transplant programcontinues to grow under the leadership of Dr. Koen van Besien with over165 autologous and allogeneic stem cell transplants in 2012. Drs. JohnLeonard and Peter Martin are members of the Lymphoma Committee ofthe Alliance for Clinical Trials in Oncology, helping to direct the portfolioof trials for the NCI-supportive cooperative research group. Both leadongoing national clinical studies through this venue. Dr. Manish Shah hassignificantly increased the number of correlative studies and investigatorinitiated studies in gastrointestinal malignancies.The breast cancer research group (Drs. Ellen Chuang, Tessa Cigler,Anne Moore, Linda Vahdat) continue to work toward unraveling theprocess of metastases in patients with triple negative breast cancer (incollaboration with Dr. Vivek Mittal), with publications in Cancer Cell andAnnals of Oncology.The Breast Program hosted the 3rd Annual Breast Cancer SurvivorshipSymposium reaching over 200 participants. The agenda included topics ofinterest to survivors; the latest research on diet, nutrition, exercise andstrategies for maintaining a healthy heart and bones, as well as the latestbreast cancer research within and outside of Weill Cornell.The Hospital-based oncology and hematology practices and infusioncenter, undergoing major renovations to create a state-of-the-art Centerfor Oncology and Hematological Care, is near completion for 2013. In2012, the division opened a Myeloma Center (Oxford Building) underthe direction of Dr. Ruben Niesvizky for the care of patients with plasmacell neoplasms. A center of patient care and clinical research, it allowspatients to receive some of the newest agents to treat myeloma.The Cancer Research and Treatment Fund, Inc. (“CR&T”) made apledge to Weill Cornell Medical College to create the Richard T. Silver,M.D. Myeloproliferative (MPD) Disease Center to build the leadingtranslational research and patient treatment center in the US forindividuals with MPD. This Center will include a new senior lab-basedclinician, Dr. Silver, and dedicated support staff. Dr. Andrew Schaferchairs the Advisory Board of the national Myeloproliferative Neoplasms(MPN) Research Foundation.New faculty recruits included: Francine Garrett-Bakelman, MD, PhD, appointed Instructor inMedicine and Assistant Attending Physician. As a physician-scientist under the guidance of Dr.Ari Melnick, she is focused on epigenetic gene regulation in myeloid disorders in the elderly, andthe development of novel, more effective therapies. Duane Hassane, PhD, from the Departmentof Pathology and Laboratory Medicine, was appointed Assistant Professor of ComputationalBiomedicine in Medicine, continuing bench research in genomics.Allyson Ocean, MD, was promoted to Associate Professor of Clinical Medicine. Ari Melnick,MD was promoted to Professor of Medicine (with Tenure); Tsiporah Shore, MD, to Professor ofClinical Medicine; and Scott T. Tagawa, MD, to Associate Professor of Clinical Medicine. RichardR. Furman, MD, became the Richard A. Stratton Assistant Professor in Hematology and Oncology,continuing to develop and study novel therapies for patients with chronic lymphocytic leukemia.Maureen Lane, PhD, received a joint appointment as Director of the Hematology/OncologyNewly recruited,Dr. Lewis Cantley4445

Dr. Garrett-Bakelmanreceived an NIH K08award.Translational Core Laboratory, and the Leukemia Biorepository and Personalized Medicine Center.Peter Martin, MD was appointed as Director of the Waterfall Waldenstrom MacroglobulinemiaConsortium. His prospective lymphoma clinical database, a major resource to clinical and basicscience investigators, has nearly reached the 500 patient mark.David M. Nanus, MD was appointed to Chief, Division of Hematology and Medical Oncology;Evi Giannakakou, PhD to Director of Laboratory Research, Division of Hematology and MedicalOncology; John P. Leonard, MD became the Associate Dean for Clinical Research at WCMC; andBarbara L. Hempstead, MD, PhD, became the Associate Dean for Faculty Development. Joseph Ruggiero,MD was selected to be senior editor of the ASCO SEP 3rd Edition, the primary educational resourcedeveloped by the American Society of Clinical Oncology for continuing medical education.It was a banner year in research funding. In an increasingly competitive climate, we are positioned tomake even more remarkable strides and expand our already impressive research portfolio. Comparedto 2011, there was a two-fold increase in research with 28 new grants awarded, including four R21s,six LLS, three industry-sponsored collaborative agreements, and several seed and CTSC (Clinical &Translational Science Center) grants. We saw a dramatic increase in grant submissions, with morethan 80 competitive applications submitted. Dr. Leandro Cerchietti received 3 new grantstotaling over $800,000 in funding, including awards from the prestigious Doris Dukeand ASH foundations. His exploration of markers and novel therapeutic targets in non-Hodgkin’s lymphoma ranges from finding new ways to detect lymphomas before theybecome an incurable aggressive disease, to finding new cures and improving availabletreatment. Dr. Garrett-Bakelman received an NIH K08 and a prestigious ASH (AmericanSociety of Hematology) award. Four of our post-docs currently hold grants from ASH,DOD (Department of Defense), LRF (Lymphoma Research Foundation), and NIH (NationalInstitutes of Health). Dr. Melnick was a lead principal investigator on two collaborativefederal pilot grants, including one from the NIH-sponsored Physical Science OncologyCenter (Cornell-Ithaca), serving to strengthen existing collaborations and layinggroundwork for future multidisciplinary projects (e.g. PPG grants). He was also awardeda program grant from the LLS, three Starr Foundation grants, and a Special Collaborativegrant from Gabrielle’s Angels Foundation. A world-renowned expert in epigenetics, he andhis team reported major research breakthroughs regarding the decoding of the softwarethat drives acute lymphoblastic leukemia (ALL) published in Cancer Discovery. With nearly40 publications as senior author and co-author over the past year, Dr. Melnick’s highlightsinclude articles in Nature, Nature Chemical Biology, and Cancer Cell (all cited by faculty of1000), and senior-author articles in Blood and Cancer Discovery.Dr. Hempstead received a major Pfizer research grant, signifying strong collaborationbetween WCMC and industry. Her studies of Huntington’s Disease were recognized by theCHDI Foundation in their research award of over $250,000. Dr. Monica Guzman expandedtranslational studies on leukemia stem cells and formed new collaborations at WeillCornell and the Methodist Hospital Research Institute. Her studies with Dr. Roboz andDr. Feldman, leaders of the Weill Cornell Leukemia Program, have established an active tumor bank andperfected cell isolation methods to capture and study the stem cells that give rise to human leukemia.She was the recipient of an NIH-R21 and one new LLS grant, and serves as a co-investigator on twoadditional LLS awards (one led by Dr. Niesvizky and the other by Dr. Hassane). She continues efforts toidentify novel therapies to ablate chemotherapy-resistant leukemia stem cells. Dr. Giannakakou received$2.6 million dollars from industry funding to perform functional analyses of circulating tumor cells (inthe context of the TAXYNERGY prospective multi-institutional clinical trial in prostate cancer) withDrs. Nanus and Tagawa as clinical co-principal investigators.Drs. Giannakakou and Vahdat each received a grant from the Manhassat Women’s Coalition AgainstBreast Cancer (MWCBC) foundation for breast cancer research, $100,000 and $50,000 respectively.Dr. Joseph Scandura received a new NIH-R21 to study mechanisms of leukemia survival and relapse.Dr. Rita Shaknovich received an LRF (Leukemia Research Foundation) grant to integrate genomic andepigenetic changes in chronic lymphocytic leukemia. Dr. Shah received a grant from the DeGregorioFoundation, allowing him to use next-generation sequencing to study changes during gastric cancercarcinogenesis, and a $1.8 million award to lead a multicenter phase II study in gastric cancer, workingclosely with Dr. Giannakakou to prospectively examine taxane resistance in clinical patient samples.Dr. Jeffrey Laurence is submitting a T32 training grant in benign hematology, on behalf of the division,and in collaboration with 16 faculty across three institutions (including Rockefeller University andMSKCC) to educate and mentor post docs and fellows in the conduct of translational research related toproblems in benign hematology.Arthur T. Evans, MD, MPHChief, Division of HospitalMedicineVice Chair of FacultyDevelopmentProfessor of MedicineWeill Cornell Medical CollegeAttending PhysicianNewYork-PresbyterianHospitalDr. Rachel Dubroff, “ArtClass” at The MetropolitanMuseum of Art.Hospital MedicineThe Division of Hospital Medicine was founded in the summer of 2009 with the arrival of Dr. ArthurEvans, who assumed the role of Division Chief after 20 years in clinical research, teaching, and bothprimary care and hospital-based medicine at Dartmouth, UNC, Rush, and Cook County Hospital.Dr. Sean Pickering joined the division in 2010 as Assistant Division Chief with a career dedicated toAcademic Hospital Medicine since 1998.With more than 30 faculty and expanding services, the division is focused on providing compassionate,effective, and efficient inpatient medical care and to advancing the profession through innovation,rigorous scientific inquiry, and continuous learning. It is responsible for the daily care of well over 100hospitalized patients and provides general medical consultation year-round. The division’s facultymembers bring a wealth of experience and talent. Many have advanced training and degrees beyondboard certification in internal medicine, including medical ethics, critical care, infectious diseases,emergency medicine, nephrology, medical informatics, pediatrics, geriatrics, molecular biology, andclinical epidemiology.A significant barrier to communication among patient care providers is the geographic dispersion ofinpatients and their care team members. Hospital Medicine continues to lead the effort towards teamsbeing “localized” to dedicated units. Individual Hospital Medicine attending physicians are becomingincreasingly assigned to the same units, working with nurses and other staff on those units to care forthe same number of patients. This system supports “multidisciplinary” rounds, also initiated by HospitalMedicine, whereby input is considered and care plans discussed among all team members includingphysicians, nurses, social workers and care coordinators.Because 60% of medical hospital admissions occur at night, Hospital Medicine initiated a newnocturnist service, with 2 faculty members working nightly. Nocturnists supervise overnight house staffand physician assistants, both in the care of patients and in the sign-out process, and they also teach aformal curriculum. Patients can now see a senior physician much sooner than before, and house staffget more feedback and attention. In a new “swing shift” role, a faculty member sees admissions everyweekday in the evening from 4 pm to 2 am, a key period when there is a high number of admissions.This significantly improved throughput and helpeddecompress the emergency room. Dr. RebeccaFlorsheim, who primarily serves the role of “swingshift” mentioned previously, is also on the Hospital’sDisaster Response Committee.The division continues to supervise the triageprocess for inpatient admissions. This processrequires effective communication among referringphysicians, the emergency department, bedassignment personnel, and physicians on the variousinpatient Medicine teams. Drs. Renuka Gupta, ChinTang and Dan Crossman served as the Unit MedicalDirectors on three inpatient general medicineservices and (along with Dr. Sean Pickering) promoteda multidisciplinary care approach, identifyingopportunities for quality improvement and careefficiencies.Drs. Anna Maw and Saraswati Iobst designed andconducted a mandatory 12-hour course for internson Basic Evidence-Based Medicine skills, focusedon critically appraising the medical literature.Dr. Evans taught an advanced 18-hour course onEvidence Based Medicine for 3 rd year resident. Drs.Anthony Ogedegbe, Anna Maw, Vishal Dodia andSean Pickering serve on the Program LeadershipCommittee, interfacing Hospital Medicine with theResidency Program in joint efforts to improve the education and experience of residents. Drs. AnnaMaw, Ernie Esquivel and Richard Lin successfully developed an inpatient procedure service and offertraining to both house staff and faculty on ultrasound-guided procedures. Dr. Rachel Dubroff combinedher training in medicine and art and continues a unique program for first-year medical students usingpaintings and sculpture at the Metropolitan Museum of Art to enhance the students’ observational skills.46 47

Dr. Ernie Esquivel became the director of the 3 rd year medicine clerkship for the medical school andcontinues to conduct a clinical elective for 4th-year medical students that allows students to work oneon-onewith an experienced senior physician learning the clinical skills of caring for Medicine inpatients.Dr. Amy Chused, with a strong background in Information Technology, is on the hospital Chemistry/IT Committee, Discharge Summary Task Force, IT User Group and various other committees thatboth assist with patient care and the division’s efforts. Dr. Chin Tang, trained in Emergency Medicine,continues to improve the interface between Hospital Medicine through the Medicine and EmergencyMedicine Care Review Committee. He is also on the Diabetes Care Council and the Sepsis Task Force.Dr. Richard Lin is on the NYP bi-campus Inpatient Pain Committee as well as the Department ofMedicine End of Life Cancer Care Communication Committee. Drs. Evans and Pickering both serve onthe Hospital Capacity Management Committee.Dr. Jennifer Lee’s focus is on quality and preventable readmissions. She is leading a CTSC pilot granton A Conceptual Model of Preventable Readmissions using the perceptions of members of the “PatientCare Circle”; the resultant manuscript of this qualitative study is currently being written (with Dr. SeanPickering). She continues to bridge Hospital Medicine and Quality Improvement, Co-Chairs the QualityImprovement and Patient Safety Committee and is on the NYP/WC Cornell Quality and Patient SafetyJoint Executive Committee/Department of Medicine Quality Chair.In the wake of the Superstorm Sandy, and resultant hospital closures in NYC last year, the divisionsuccessfully coped with the enormous increase in patients seen at NYP/WC and also taught the visitinghouse staff from dislocated programs.In addition, the hospitalist group continues to participate in several of the bi-campus HERCULESinitiatives offering their expertise on in-patient care.Roy M. Gulick, MD, MPHChief, Division of InfectiousDiseasesProfessor of MedicineWeill Cornell Medical CollegeAttending PhysicianNewYork-PresbyterianHospitalInfectious DiseasesThe Division of Infectious Diseases provides expertise in research, clinical care, and education.Internationally recognized physician-scientists conduct cutting-edge basic laboratory and patientorientedresearch in infectious diseases, in New York City and abroad, in the Division’s Global Healthprogram with established sites in Brazil, Haiti, India and Tanzania. In New York City, research includesbacteriology (including antibiotic-resistant organisms), bioterrorism, food- and water-borne pathogens,fungi, hepatitis, HIV/AIDS, hospital-acquired infections, human papillomavirus (HPV), influenza,leishmaniasis, malaria, transplant/oncology infectious diseases and tuberculosis. The Division alsoleads research and training programs abroad in HIV/AIDS, HPV, HTLV-1, leishmaniasis, syphilis andtuberculosis.Divisional faculty head the Weill Cornell Medical College/NewYork-Presbyterian Hospital InfectiousDiseases Inpatient Consult Service, the HIV/AIDS Program, and Weill Cornell Infectious DiseaseAssociates, an outpatient practice comprising faculty and fellow consultation services and TravelMedicine. The Travel Medicine Service has weekday, Saturday, and evening sessions and offers valuablecomprehensive pre- and post-travel advice/vaccinations for adults, children, and families.The Infectious Diseases Fellowship Training Program includes individualized training through facultyguidance, clinical rotations, mentored research, and didactic course work, for the next generation ofinfectious diseases specialists and physician-scientists. Our faculty members also teach and trainmedical students, internal medicine residents, and peer physicians in the latest strategies for diagnosis,management, and treatment of infectious diseases.The Golightly Lab (Director: Dr. Linnie Golightly) is working on a novel noninvasive, cell phone-baseddevice to diagnose and determine the severity of malaria (in collaboration with Dr. Alberto Bilenca ofthe Ben-Gurion University, Israel). Ultimate testing of the device is planned in Ghana. The lab alsocollaborates with John C. March, PhD, Cornell University Department of Engineering, to develop aquorum sensing-based cholera prophylactic using genetically engineered commensal bacteria; testingis planned in Port-au-Prince, Haiti (with colleagues from GHESKIO). The Rhee Lab (Director: Dr. KyuRhee) continues its highly innovative work on Mycobacterium tuberculosis (MTb) using novel massspectrometry-based metabolomic approaches.Above: The Golightly Lab (Director:Dr. Linnie Golightly) is working on anovel noninvasive, cell phone-baseddevice to diagnose and determine theseverity of malaria (in collaboration withDr. Alberto Bilenca of the Ben-GurionUniversity, Israel).The Cornell HIV Clinical Trials Unit (CCTU) conducts studies of HIV treatment and prevention andimportant pathogens in both HIV-infected and -uninfected people (e.g., hepatitis C, human papillomavirus(HPV), and influenza). The emergence of the 2009 H1N1 (“swine”) strain of influenza raised awarenessof the need to better characterize the current epidemiology of influenza and to develop novel therapeuticapproaches. The CCTU is participating in four NIH-funded studies of influenza. The Transplant/OncologyInfectious Diseases Program (Director: Dr. Tom Walsh) continues to develop interactive laboratoryresearch, translational/clinical research, and clinical care efforts.GHESKIO (Groupe Haitien d’Etude du Sarcome de Kaposi et des Infections Opportunistes; Director:Dr. Jean Pape) conducts NIH-sponsored research with the AIDS Clinical Trials Group and the HIV VaccineTrials Network. GHESKIO’s extensive free clinics treated over 100,000 patients in 2012, including 40,077patients receiving HIV counseling and testing; 1,666 patients newly diagnosed with tuberculosis; and10,500 patients admitted for cholera. Construction on a new 35-bed TB hospital began in 2012 (withgenerous support from Becton Dickinson) and on a permanent cholera treatment center and MaternalChild Health Center – both of which are scheduled to open in late 2013.The Tanzania Training Program (Mulago) (Director: Dr. Daniel Fitzgerald) trains health professionals inthe design, implementation, and measurement of innovative health interventions; Dr. Jennifer Downs andDr. Robert Peck in Mwanza, Tanzania, provide clinical care and conduct research on-site.Two new recruits joined the division: Samantha Jacobs, MD, a clinician and clinical researcherin transplant-oncology infectious diseases; and Emily Shuman, MD, a new Associate HospitalEpidemiologist.48 49

Our case consultvolume makes usone of the mostactive EthicsConsultationServices in theUnited States.L-R: Dr. Fins,Cathleen Acres, RN,Dr. Ellen MeltzerMedical EthicsA very active year for the Division of Medical Ethics, we pursued our tripartite mission ofmedical education, ethics consultation, scholarship and research. The Division of Medical Ethicsis jointly housed in Weill Cornell’s Departments of Medicine and Public Health and is led byDr. Joseph J. Fins.The Division teaches medical students, house staff, and attending staff. Assisted by over 30faculty members, we offer an eight-week introductory course in Medical Ethics to second-yearWeill Cornell students on the history of medical ethics, methods in ethics consultation, and ethicalissues across the life-span. We also consider ethical and regulatory issues in clinical research,so that students appreciate their responsibilities as clinicians and investigators. In our Third-YearClerkship in Clinical Ethics and Palliative Care, students learn to address the humanistic andclinical challenges of providing compassionate and competent care at life’s end. This two-weekrotation, taken by all Weill Cornell students, is a unique offering in American medical education, asit demonstrates a strong pedagogical commitment to this essential dimension of medical practice.Our educational programs for the house staff in the Department of Medicine have expandedand now include an addiction medicine module offered by Dr. Ellen Meltzer, as well as offerings inclinical ethics. A novel ethics curriculum developed by our Ethics Fellows and designed for medicalresidents will be featured as a peer-reviewed paper in the Journal of General Internal Medicine.With our NewYork-Presbyterian Hospital colleagues in Patient Services Administration, theEthics Consultation Service performed 204 ethics consults in 2012, affording wise counsel topatients, families, and staff regarding the ethical challenges confronted in patient care. Ourcase consult volume makes us one of the most active Ethics Consultation Services in the UnitedStates. Additionally, we have consulted with the Weill Cornell Institutional Review Board to provideexpertise for their deliberations. Cathleen Acres, RN, and Dr. Fins, along with colleagues from theColumbia campus of NewYork-Presbyterian Hospital, published the first institutional standards forcredentialing clinical ethicists in the United States in the Journal of Clinical Ethics.Dr. Fins continues a fruitful collaboration with Dr. Nicholas D. Schiff in the Department ofNeurology as they co-direct the Consortium for the Advanced Study of Brain Injury (CASBI) atWeill Cornell and Rockefeller University. Dr. Fins’s scholarship in neuroethics and disorders ofconsciousness will result in the expected publication of Rights Come to Mind: Brain Injury, Ethicsand The Struggle for Consciousness from Cambridge University Press in 2013. Dr. Meltzer’s focusis on the ongoing consideration of the ethics of advanced life-saving technologies. Cathleen Acres’work on ethics case consultation continues, and of special note, she received a Weill CornellTeaching Award for Medicine Patient Society III, becoming the first nurse-faculty member to be sohonored. Additionally, Dr. Fins is pursuing an intellectual history of the late Senator Daniel PatrickMoynihan’s defense of academic medical centers, drawing upon the Moynihan Papers housed atthe Library of Congress.Collaboration has been a hallmark of the Division of Medical Ethics for many years. We aregratified to have had Dr. Andrew Shuman as an Ethics Fellow, while he also served as a Fellowin the Section of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center. Involving thebroader Medical Center Community, we offered our Annual Seminar Series in Medical Ethics. Thisyear it was thematically devoted to “Perspectives in Bioethics and Humanities.” Notable speakersincluded Daniel Callahan, President Emeritus of the Hastings Center, Art Caplan, PhD, from NewYork University, Nancy Dubler, LLB, from Albert Einstein Medical Center, and Franklin G. Miller,PhD, of the Ethics Center at the NIH.We look forward to expanding the East River Bioethics Club, inaugurated in conjunction withour local neighbors, the Hospital for Special Surgery, Memorial Sloan-Kettering Cancer Centerand NYU-Langone Medical Center. This consortium will share speakers on a regular basis andpromote discourse on medical ethics across New York City.Joseph J. Fins, MD, FACPChief, Division of MedicalEthicsE. William Davis, Jr., M.D.Professor of Medical EthicsProfessor of MedicineProfessor of Public HealthProfessor of Medicine inPsychiatryWeill Cornell Medical CollegeDirector of Medical Ethicsand Chair, Ethics CommitteeAttending PhysicianNewYork-PresbyterianHospital5051

Nephrology and HypertensionOngoing researchhas identified anew and treatablemechanism forkidney injury thatwe hope to translateinto clinicalpractice.Dr. Suthanthiran (r) with Dr. Muthukumar.The Division of Nephrology and Hypertension provides compassionate, comprehensive, state-of-theartcare to every patient afflicted with kidney disease and/or high blood pressure. US News and WorldReport has consistently ranked the NewYork-Presbyterian nephrology program in the top five programsin the country. In 2012, the NewYork-Presbyterian’s kidney disease program was ranked number 3nationally, the highest ranked specialty at the hospital.The nephrology program excels in providing renal consultation services, dialysis therapy (about6,000 dialysis per year at the Hospital) and kidney and pancreas transplantation (more than 200 kidneytransplants per year with superior patient and transplant survival rates). Several innovations have beenintroduced in the transplantation arena: blood type (ABO) incompatible transplant; positive cross-matchtransplant; minimizing the amount of drugs patients need for successful transplantation; developmentof treatment protocols to reduce serious post-transplant complications (i.e., infection and malignancy);and, significantly, the development of noninvasive molecular assays for assessing transplant status andreducing the need for an invasive biopsy procedure.The division’s Hypertension Center is the only center in the greater New York metropolitan areadevoted exclusively to patients with disorders of blood pressure and circulation. The division providesevidence-based clinical care for patients afflicted with acute or chronic kidney disease. We activelyinvestigate factors predisposing individuals with hypertension to develop kidney failure. Hypertensionfaculty pursue research including pregnancy-induced hypertension, the mind-body link in hypertension,and personalized drug therapy for hypertension control. Ongoing research has identified a new andtreatable mechanism for kidney injury that we hope to translate into clinical practice.2012 was a great year for molecular medicine in the field of kidney transplantation. The divisionpioneered the development of noninvasive gene-based assays to ascertain transplant status (publishedin The New England Journal of Medicine); which had previously required an invasive biopsy procedure. Ouroriginal study, first conducted at Weill Cornell, led to an NIH-sponsored multicenter Cooperative ClinicalTrial in Transplantation (about 500 subjects from 5 major transplant centers in the United States).The division’s Gene Expression Monitoring (GEM) Laboratory functioned as the molecular core for thisextensive study. Based on a bench-to-bedside approach, this study should lead to state-of-the-art,individualized care (personalized medicine) of transplant recipients. A major diagnostic company (Quest)has introduced a version of the molecular test as the first of its kind molecular test for kidney transplantrecipients. And the division’s faculty, collaborating with national and international scientists, sequenced– for the first time – human kidney allografts for expression patterns of small RNAs. A milestone in thefield of transplantation, this pioneering study was published in Transplantation (December 15, 2012).The ultimate goal in organ transplantation is transplant tolerance; transplantation of organs without theneed for any drug therapy. The ability to transplant a human organ without drug therapy is of exceptionalsignificance. The division contributed to the first ever report on tolerance of mismatched kidney transplants,published in The New England Journal of Medicine. In recognition of our contribution, NYP/WC has alsobeen selected by the NIH to conduct innovative transplant tolerance trials (Principal Investigator: Dr. CholiHartono). In this regard, we have identified a molecular signature in the urine of patients who are tolerant ofkidney transplants, a seminal finding published in The Journal of Clinical Investigation.Each year, we carry out more than 200 kidney transplants at New-York Presbyterian/Weill Cornell witha total of 4,000 kidney transplants performed as of 2012. Patient and graft survival rates continue to bestellar. The survival rate of kidney graft recipients was 93% following deceased donor transplantation,and the graft survival rate was 86%. Following evaluation of 221 kidney transplant programs in the UnitedStates, NYP/WC was one of only 8 hospitals to receive a HealthGrades Kidney Transplant ExcellenceAward. This recognition was awarded for the 3rd year in a row and was based on one- and three-yearrisk-adjusted patient survival, one-and three-year risk-adjusted graft survival, the rate at which waitlistedpatients received transplants, and waitlist mortality.The Division of Nephrology and Hypertension remains committed to the education and trainingof the next generation of renal and hypertension specialists. Our distinguished faculty members arehighly sought after for their participation and leadership in national and international meetings. Therenal fellowship program is highly competitive with hundreds of applications submitted for the fouravailable positions.New recruit, Darshana Dadhania, MD, MS, previously of the Rogosin Institute, now serves as anAssociate Professor of Medicine in our division. She brings with her a unique immunologic and clinicalexpertise needed for transplants of high risk patients with kidney failure. She will direct the High RiskKidney Transplantation Program in the Division of Nephrology, Department of Medicine, and Departmentof Transplantation Medicine at NYP/WC.Manikkam Suthanthiran, MDChief, Division of Nephrologyand HypertensionChief, Department ofTransplantation Medicine andExtracorporeal TherapyStanton Griffis DistinguishedProfessor of MedicineProfessor of MedicineProfessor of BiochemistryProfessor of Medicine inSurgeryWeill Cornell Medical CollegeAttending PhysicianNewYork-PresbyterianHospital52 53

Joseph T. Cooke, MDChief, Division of PulmonaryChief, Quality & PatientSafety OfficerAssociate Professor ofClinical Medicine & PublicHealthPulmonary and Critical Care MedicineThe Division of Pulmonary and Critical Care Medicine employs expertise that is highly skilled in thediagnosis and treatment of patients with all types of breathing or lung disorders, as well as all disordersrelated to sleep. Physicians of Weill Cornell Pulmonary Associates provide advanced diagnostic andtherapeutic services in a state-of-the-art medical facility. The Division provides 24-hour, in-hospital coverageof the Medical Intensive Care Unit (MICU) by both Pulmonary/Critical Care faculty and fellows. Researchinterests focus on genetic medicine – the development of strategies for understanding and modifying geneexpression in the treatment and/or prevention of human disease. Full-time faculty members teach in anoutstanding, multifaceted educational program training students, residents, and fellows.It was another year of remarkable accomplishments in clinical care, education, and research. TheDivision’s faculty received accolades and awards for their clinical care and dedication to education.With Dr. David Berlin serving as Director of the Medical Intensive Care Unit (MICU), clinical care wasenhanced by an increase in faculty attending services during overnight hours. Under the leadershipof Drs. Oren Friedman and Kapil Rajwani (critical care specialists), world-class care was provided tocritically ill patients throughout the MICU, and the Hospital, via consultation and procedural services.Dr. Friedman has become the division’s expert in Cardiac Resuscitation and Therapeutic Hypothermia.Working with Drs. Kapil Rajwani and Kirana Gudi, simulation programs for providing ACLS (AdvancedCardiovascular Life Support) and insertion of Central Venous Catheters are in process for Department ofMedicine residents. Division Chief, Dr. Joseph Cooke, who also serves as Chief Quality and Patient SafetyOfficer, in collaboration with Drs. Lia Logio, Laura Fanucchi,and Jennifer Lee, developed a Quality and Safety TrainingProgram and a monthly House Staff Quality Conference forthe Department of Medicine.Training our clinical fellows in all aspects of pulmonaryand critical care medicine, including sleep disorders, isa major focus. The teaching faculty maintains intensiveteaching rounds in the MICU, Bronchoscopy Suite,Outpatient Clinic, and Pulmonary Consult Service, whichis supplemented by faculty-led weekly lectures, courseteachings, and hosting of case conferences.The Pulmonary Inpatient Consult Service has developedinto a robust program providing expert clinical care sevendays a week. It is experiencing a significant increase involume, while upgrading continuity of care for patients whoare transitioning from inpatient to outpatient management.This development has led to successful interdisciplinarycollaborations with specialists throughout the institution.Fellowship Director, Dr. Dana Zappetti, has developed anexpertise in pulmonary complications of bone marrowtransplantation. Dr. Thomas King continues to be an integralmember of the Complex Spine Disease Service at Hospitalfor Special Surgery and moderates the William BriscoeLung Club. At the Lung Club, fellows from the trainingprograms throughout the area present their scientificwork. Dr. Abraham Sanders hosts a monthly clinical JointCase Conference where affiliates present complicatedpulmonary cases. Dr. Robert Kaner hosts a multidisciplinaryconference on diagnosis and management of InterstitialLung Disease: radiologists, pathologists, and pulmonologistsmeet to correlate clinical with pathologic diagnoses, makingrecommendations on patient management or possibleenrollment in clinical trials.The Pulmonary Outpatient Service has seen significantgrowth. Strong emphasis has been placed on a patientcenteredcontinuum of care through which patient servicesare coordinated within the division and throughout the largerhealth care system. The Pulmonary Procedure Service,under the direction of Dr. Ben-Gary Harvey, continues toembrace innovations in diagnostic and treatment services,such as “EBUS” (endo-bronchial ultrasound) for the diagnosing and staging of mediastinal masses,lymphadenopathy and lung cancer. This is in addition to traditional bronchoscopy and laryngoscopyservices. The Pulmonary Function Laboratory, led by Dr. Sanders, remains a vital component of thedivision’s continuum of care via expert and timely diagnostic services.Weill Cornell’s newly relocated and renovated Weill Cornell Center for Sleep Medicine (run jointlyby the Department of Medicine/Division of Pulmonary and Critical Care Medicine and Department ofNeurology) is led by Dr. Ana Krieger, Medical Director, and other experts, in evaluating the full range ofsleep problems. The team includes specialists in pulmonary medicine; neurology; internal medicine; ear,nose and throat (ENT); pediatrics; psychiatry; psychology; bariatric surgery; nutrition; and endocrinology.The center provides outpatient visits, at home sleep studies, and overnight studies. Patients are monitoredby the use of advanced sleep-recording equipment in private rooms; there are also sleep study roomsequipped for pediatric and bariatric patients. By increasing the availability of physician services, thecenter has become a provider of choice for patients and referring physicians on a local, national, andinternational level.Research programs, in conjunction with Dr. Ronald Crystal and the Department of Genetic Medicine,include one of only 11 NIH-sponsored Idiopathic Pulmonary Fibrosis Clinical Research Networksites in the country (Dr. Robert Kaner); and studies of the molecular and genetic basis of acceleratedemphysema development in smokers (Drs. Kaner, Ann Tilley, and Ben-Gary Harvey). Dr. Krieger isconducting NIH-funded clinical and translational research on the mechanisms of cardiovasculardiseases and thrombosis in sleep apnea.The division welcomed a new recruit in 2012, Dr. Meredith Turetz, an Assistant Professor of Medicinewho will be working on our Pulmonary Consult Service.The Division provides24-hour, in-hospitalcoverage of theMedical Intensive CareUnit (MICU) by bothPulmonary/Critical Carefaculty and fellows.Research interests focuson genetic medicineDr. Kapil Rajwaniworking in the MICU.54

RheumatologyMary K. Crow, MDChief, Division ofRheumatologyJoseph P. Routh Professorof Rheumatic Diseases inMedicineProfessor of MedicineWeill Cornell Medical CollegeBenjamin M. RosenChair in Immunology andInflammation ResearchAttending PhysicianNewYork-PresbyterianHospitalBased at Hospital for Special Surgery (HSS), the Division of Rheumatology is a well establishednational and international leader in clinical care of patients with autoimmune, inflammatory andmusculoskeletal conditions, including those with some of the most complex of all medical diseases;research that has contributed to identification of novel therapeutic targets and new understandingof disease mechanisms; and innovative approaches to medical education and education research.In addition to its comprehensive approach to patients with rheumatologic disorders, the Division hasresponsibility for all of the pre- and post-surgical medical care of the more than 26,000 patients whoundergo orthopaedic surgery procedures at HSS each year.Clinical care, research and educational programs in rheumatology are dedicated to tapping insightsderived from study and care of complex patients with autoimmune and inflammatory diseases to drivelaboratory studies that result in new understanding, and ultimately novel treatments, for these complexdiseases. The division’s rich academic environment attracts the future leaders in academic rheumatologyto its NIH T32 training grant-supported fellowship program.Achieving optimal outcomes for patients is the goal of our 25 active consultative rheumatologypractitioners, with more than 33,000 office visits in 2012, an increase of 7% over 2011, for disordersranging from osteoarthritis and rheumatoid arthritis to the most complex patients with lupus, vasculitis,progressive systemic sclerosis or diagnostic dilemmas. A Practice Effectiveness Committee, led byDr. Theodore Fields, regularly assesses opportunities for application of best practices across all practicesin order to provide the most cost effective and efficient care. In addition to the patients evaluated in therheumatology practices located at HSS, members of the rheumatology faculty supervise our traineesin providing rheumatology consultations for in-patients at New-York Presbyterian Hospital, as well asthose patients at Memorial Sloan-Kettering Cancer Center. Our rheumatology clinics are also focusedon serving the needs of patients, with more than 3,500 patient visits in 2012, but additionally, arethe centerpiece of our fellowship program, led by Drs. Anne Bass and Jessica Berman. The divisionconducted a re-evaluation of the structure of our clinics with the goals of improving patient accessand the educational experience for our fellows. Recommendations from Drs. Bass and Berman, alongwith those from a task force led by Dr. Sergio Schwartzman, include inauguration of a clinic dedicatedexclusively to new patients, as well as a novel primary care rheumatology clinic directed by Dr. HalWhitman and focused on evaluation of clinical problems typically encountered in the context of primarycare medical practices.In addition to providing timely access to patients referred from general medicine practices at NYPH,this new clinic provides an opportunity for WCMC/NYP residents to experience direct patient contactand one-on-one discussion of management with rheumatology faculty. A rich learning environment isalso provided in the multidisciplinary clinic conferences following Monday Inflammatory Arthritis Clinicand Friday Lupus Clinic. These conferences are an opportunity for discussion of patient management,guided by recent literature and enriched by attendance of representatives from other WCMC specialties,including Dr. Joanna Harp from Dermatology and Dr. John Barnhill from Psychiatry. Both conferencesemphasize consideration of patients who might be candidates for enrollment in clinical research studies(observational and interventional). A new multiinstitutionalresearch initiative led by Dr. KyriakosKirou, in collaboration with Dr. Surya Seshan fromWCMC Surgical Pathology, grew out of discussionsin the Lupus Clinic Conference and will collectretrospective data on patients with microangiopathicnephropathy to understand the clinical course andoptimal management of these patients.The Rheumatology Division is recognized for itsstrong collaborations between bench scientists andclinicians, and HSS rheumatologists are considered leaders in providing research data that supportsdevelopment of new therapeutics. Studies directed by Dr. Lionel Ivashkiv, developed over two decades,have characterized the role of the so-called Jak-STAT molecular pathway in activation of inflammatoryresponses mediated by cytokines. His detailed analysis of the regulation of this important cell systemcontributed to the knowledge base essential for the recent approval of an oral agent for patientswith rheumatoid arthritis. The Mary Kirkland Center for Lupus Research remains a focal point forrheumatology research at HSS. Dr. Alessandra Pernis has discovered the essential role of a cell signalingpathway, dependent on a transcription factor called interferon regulatory factor 4 (IRF4), in productionof inflammatory mediators involved in both lupus and rheumatoid arthritis. She is studying the effect ofcurrently available therapeutic agents on modulation of IRF4-dependent syndromes in murine models.A Practice Effectiveness Committee, led byDr. Theodore Fields, regularly assesses opportunitiesfor application of best practices across all practicesin order to provide the most cost effective andefficient care.Dr. Stephen J. Di Martino (HSS) with patient.Studies by Dr. Mary Crow’s laboratory, based on analysis of a patient cohort developed by Dr. Kirou,have identified a central role for interferon-alpha in the pathogenesis of lupus and have provided strongrationale for several drug development programs that target interferon production or cellular response tointerferon. Dr. Jane Salmon has had a longstanding interest in defining the pathologic mechanisms thataccount for tissue damage in lupus, and has provided important rationale for targeting the complementpathway in lupus patients at high risk for pregnancy complications.Clinical research programs grew in 2012 with the leadership of Dr. Vivian Bykerk, who has embarkedon development of a multicenter observational study of patients with early inflammatory arthritis.Dr. Susan Goodman led development of a collaborative research effort, along with Dr. Lisa Mandl andorthopedic surgeons Drs. Mark Figgie and Michael Alexiades, with the goal of identifying predictorsof outcome of hip and knee arthroplasty in patients with rheumatic disease. Drs. Doruk Erkan andMichael Lockshin continued their development of the APS ACTION international consortium for studiesof antiphospholipid syndrome. These important research projects supplement the diverse academicactivities organized through the division’s Centers of Excellence in SLE and Antiphospholipid Syndrome,directed by Dr. Salmon; Scleroderma, Vasculitis and Myositis, directed by Dr. Robert Spiera; andInflammatory Arthritis, led by Research Director, Dr. Vivian Bykerk, and Clinical Director, Dr. SergioSchwartzman. These academic programs develop initiatives in patient education, quality indicators,public communication, and development of collaborative research projects.5657

Weill Cornell Internal Medicine Associates (WCIMA)The HSS Academy of Rheumatology Medical Educators, co-directed by its founder Dr. Stephen Pagetand Dr. Jessica Berman, completed selection and funding of three pilot education research grants todivision faculty. The projects included further development of the Rheumatology Objective StructuredExamination for Fellowship Trainees, directed by Dr. Berman; development of a curriculum for aRheumatology Epidemiology Journal Club, led by Drs. Berman and Mandl; and a project with the goalof fostering professionalism, led by Dr. C. Ronald MacKenzie in collaboration with WCMC faculty. TheHSS Academy has also sponsored two workshop meetings, bringing together participants fromNew York area medical schools, including NYU, Downstate, Stony Brook, as well as WCMC.The division assures optimal preparation and post-operative management of patients undergoingorthopedic surgery at HSS. Dr. Linda Russell, Director of Perioperative Medicine, has demonstratedstrong leadership in designing a comprehensive structure for efficient preoperative medical evaluationof patients scheduled for in-patient surgery and has developed new guidelines for laboratory, imaging,and consultative assessment of those patients based on current evidence-based literature. Sheoversees 11 internists and hospitalists who, along with 8 rheumatologists with active perioperativemedical practices, collaborate with HSS surgeons to optimize medical status prior to surgery andmonitor patients post-operatively. HSS is gaining nationwide recognition for its systematic approach andacademic programs aimed at achieving optimal medical care for patients undergoing musculoskeletalprocedures, with Dr. Russell presenting a featured state-of-the-art lecture on perioperative medicine atthe Annual Scientific Meeting of the American College of Rheumatology in 2012.Members of the Division of Rheumatology faculty are highly visible among the administrativeleadership of HSS through their dedicated service to the institution. In additional to the essential role ofDr. Russell in Perioperative Medicine, Dr. Susan Goodman co-chairs the hospital’s Multispecialty PeerReview Committee, and Dr. Steven Magid co-chairs the hospital’s Quality Coordinating Committee. In2012, Dr. Magid was named the Chief Medical Information Officer for HSS, an influential role as newinformation technology systems are rolled out inthe hospital and office practices.Members of the division were honored basedon their significant academic and researchachievements. Dr. Vivian Bykerk was promotedto Associate Professor of Medicine andDr. Robert Spiera was promoted to Professor ofClinical Medicine. Dr. Crow was named a Masterof the American College of Rheumatology,Dr. Salmon received the Virginia Kneeland Frantz’22 Distinguished Women in Medicine Award fromthe Columbia P & S Alumni Association, andDr. Russell was the 2012 Women on the Movehonoree from the Arthritis Foundation, NewYork Chapter. Dr. Michael Lockshin received theNational Leadership Award for Lupus MedicalAdvancement from the Lupus Foundation ofAmerica, and Dr. Elana Bernstein, a rheumatologyfellow, received the Distinguished Fellow Awardfrom the American College of Rheumatology.Dr. MacKenzie was honored as the recipient ofthe C. Ronald MacKenzie, MD, Chair in Ethics andMedicine, and Dr. Steven Goldring was named theRichard L. Menschel Research Chair.Judy Tung, MDDirector, Weill CornellInternal Medicine AssociatesActing Chief, GeneralInternal MedicineAssociate Chair ofEducational AffairsAssociate Director, InternalMedicine Residency ProgramAssociate Professor ofClinical MedicineWeill Cornell Medical CollegeAssociate AttendingPhysicianNewYork-PresbyterianHospitalWCIMA achieved Level 3 recognition from the National Committee for Quality Assurance as a PatientCenter Medical Home in 2012. Additionally, the New York State Department of Health awarded NewYork-Presbyterian Hospital $16M, over the next three years, to transform WCIMA and the other primary carepractices into Hospital Medical Homes. The grant is awarded to New York State hospitals to expand thecontinuity training experience for primary care residents, including enhanced training for the residentphysicians in the patient-centered medical home model for healthcare delivery.The goal is to improve the coordination, continuity and quality of care for individuals receiving primarycare services in outpatient primary care settings used by teaching hospitals to train resident physicians.WCIMA’s recent innovations, including our 6+2 rotation schedule, our team-based model for continuityof care, and our structured end-of-year sign out process. The latter was described in a September2012 publication (by Drs. Christina Harris and EricaPhillips-Caesar) in the Journal of General Internal Medicine;“Development of a Structured Year-End Sign-Out Programin an Outpatient Continuity Practice.” These developmentshave positioned WCIMA for optimal growth as a hospitalhome.WCIMA faculty continue to hold leadership positions withinthe organization. Dr. Judy Tung is currently Acting Chief of theDivision of General Internal Medicine. Dr. Nicole Sirotin, whojoined our faculty in 2011, now serves as the Medical Directorfor the Weill Cornell Center for Human Rights (WCCHR).WCCHR, founded in 2010, is the first medical student-runhuman rights clinic dedicated to providing forensicevaluations to survivors of persecution seeking asylum inthe United States. Through a partnership with Physicians forDr. Ginger Watson with a resident in trainingat WCIMA.Human Rights, WCCHR has conducted 98 medical and psychological evaluations for 87 asylum seekersfrom 35 countries with a 100% asylum grant rate for those who have gone to court. WCCHR is a nationalleader in training medical students to evaluate clients for signs of past physical and psychologicaltrauma with over 166 students trained to date. The work of WCCHR furthers WCIMA’s mission of instillinga strong dedication to service learning and care for the underserved and augments Dr. Sirotin’s efforts increating a new Vulnerable Populations curriculum emphasizing Global Health at Home. Also, Dr. Sirotinand peers published an article entitled “Structural Determinants of Food Insecurity and Low DietaryDiversity in Rwandan HIV+ Women” in the Boston Medical Journal.Dr. Sanjai Sinha joined WCIMA in November 2012, recruited from the Department of Veteran Affairs.Dr. Sinha served as Director of the Residency Outpatient Primary Care Clinic at the James J. PetersVA Medical Center in the Bronx until 2010 when he was appointed Chief of Primary Care for the VAHudson Valley Healthcare System. His achievements at the VA included securing NCQA certification forits 9 clinical sites as Patient Centered Medical Homes; leading the Patient Aligned Care Team (PACT)into a systems redesign that improved access to care;and implementing panel management and utilizingteam-based care. Dr. Sinha will serve as the Directorof Care Management for the Weill Cornell Physician’sOrganization, in addition to serving as a clinician educatorat WCIMA at the Irving Wright Center on Aging. WCIMAat the Wright Center is an extension of WCIMA locatedon 1484 First Avenue (between 77 th & 78 th ). Other WCIMAmembers at the Wright Center are Dr. Fran Ganz-Lord,selected as a member of Cornell’s Health LeadershipFellows Program; Dr. Lauren Acinapura, director of theWCIMA curriculum; and Dr. Matthew Press, Department ofPublic Health.Dr. Alessandra B. Pernis58 59Dr. Tung (far left) received the 2012 Cornell ACN Physician of the YearAward. The Department of Nursing gives this award to recognizephysicians who consistently practice with nursing and support staff ina collaborative, collegial, and respectful manner. At the celebration:(L to R) Dr. Judy Tung, Stephen Toppin (Practice Supervisor), PatriciaDeely (Nurse Clinician), Diego Arias (Practice Administrator)

Iris Cantor Women’s Health CenterOrli R. Etingin, MDDirector, Iris Cantor Women’sHealth CenterLisa and Sanford B.Ehrenkranz Professor inWomen’s HealthProfessor of ClinicalMedicineProfessor of ClinicalObstetrics and GynecologyWeill Cornell Medical CollegeAttending PhysicianNewYork-PresbyterianHospitalThe Iris Cantor Women’s Health Center (ICWHC) offers the most comprehensive array of healthcareservices, designed specifically for women, in a single location in New York City. All of the Center’sphysicians are full-time faculty members of Weill Cornell Medical College and attending physicians atNewYork-Presbyterian/Weill Cornell Medical Center. Many of these physicians have set internationalstandards for medical care through their pioneering research. A team of nurses, technicians and otherhealthcare professionals provide superb coordination of care at the Center. With more than 40,000 squarefeet of clinical space occupying four floors under one roof, women can access the finest prevention,screening, and treatment services in one convenient location. A Health Education Resource Center isavailable on-site providing educational materials on physical, psychological and social issues thatimpact health.Physicians at the ICWHC continued to provide comprehensive clinical care to both women and men.The Women’s Health Center also continued to assist in the development of the Iris Cantor Men’s HealthCenter, which opened in the summer of 2012, with Dr. Etingin involved in the planning, fundraising,and implementation phases. The new men’s health practice enhances the primary care network ofWeill Cornell by providing access to seven physicians who deliver patient care to men focused oninternal medicine, cardiology, endocrinology, hematology, and urology. The new center also houses theDepartment of Urology’s Institute for Bladder andProstate Health. Clinical research collaborationsbetween Men’s and Women’s Health are underway.Women’s Health sponsored a number ofcommunity events in 2012. Monthly healtheducation seminars were attended by more than200 community members; topics included Womenand Heart Disease, Dietary Supplements, Sleep,and others.L-R: Drs. Pardes, Etingin, Saltz, (Joan and Sanford I. Weill center),Dr. Laurie Glimcher (Dean, WCMC), Dr. KriegerL-R: Drs. Saltz, Krieger,and PardesThis year’s (the 30th) annualWomen’s Health Symposium,entitled “The S Factor: Sleep,Sex and Stress,” hosted over 300women at the Citicorp Center andincluded Dr. Ana Krieger andDr. Gail Saltz as guest speakers.FacultyMembers60

Department of Medicine FacultyProfessorsRonald D. Adelman, MDLouis J. Aronne, MDPhyllis August, MD, MPHCharles L. Bardes, MDDavid J. Brillon, MDJames B. Bussel, MDLewis C. Cantley, PhDMary E. Charlson, MDPamela Charney, MDDavid J. Christini, PhDRonald G. Crystal, MDAndrew J. Dannenberg, MDRichard B. Devereux, MDLewis M. Drusin, MD, MPHOrli R. Etingin, MDArthur T. Evans, MD, MPHOliver T. Fein, MDEric J. Feldman, MDJoseph J. Fins, MDNeal E. Flomenbaum, MDLinda M. Gerber, PhDPatricia Giardina, MDMarshall Jay Glesby, MD, PhDLaurie H. Glimcher, MDStanley J. Goldsmith, MDAntonio M. Gotto, Jr., MD, DPhilLorraine J. Gudas, PhDRoy M. Gulick, MD, MPHKatherine A. Hajjar, MDBarbara L. Hempstead, MD, PhDEvelyn M. Horn, MDJulianne L. Imperato-McGinley, MDJonathan L. Jacobs, MDIra M. Jacobson, MDStephen G. Jenkins, PhDWarren D. Johnson, Jr., MDMichel Kahaleh, MDRainu Kaushal, MDHarvey Klein, MDPaul D. Kligfield, MDMark S. Lachs, MD, MPHJeffrey C. Laurence, MDJohn P. Leonard, MDBruce B. Lerman, MDMartin Lipkin, MDLia S. Logio, MDSamuel J. Mann, MDAaron J. Marcus, MDSteven M. Markowitz, MDAri M. Melnick, MDB. Robert Meyer, MDAnne Moore, MDHenry W. Murray, MDAlvin I. Mushlin, MDRalph L. Nachman, MDDavid M. Nanus, MDCarl F. Nathan, MDPeter Michael Okin, MDJean W. Pape, MDMark S. Pecker, MDKarl Pillemer, PhD, MADavid N. Posnett, MDR.A. Rees Pritchett, MDShahin A. Rafii, MDMarcus M. Reidenberg, MDBrendan M. Reilly, MDMary J. Roman, MDIsadore Rosenfeld, MDAndrew I. Schafer, MDTsiporah B. Shore, MDEugenia L. Siegler, MDRichard T. Silver, MDDavid J. Skorton, MDKendall A. Smith, MDJames P. Smith, Jr., MDCharles R. Steinberg, MDKotha Subbaramaiah, PhDManikkam Suthanthiran, MDLinda T. Vahdat, MDKoen van Besien, MD, PhDThomas J. Walsh, MDAlan M. Weinstein, MDBabette B. Weksler, MDMarc E. Weksler, MDShing-Chiu Wong, MDAssociate ProfessorsHolly Andersen, MDSusan Clark Ball, MDGeoffrey W. Bergman, MBBSBrian Bosworth, MDCarla Boutin-Foster, MDDavid P. Calfee, MDCarol Capello, PhDJuan Emilio Carrillo, MD, MPHWallace A. Carter, Jr., MDAdam D. Cheriff, MDEllen Chuang, MDCurtis Leland Cole, MDJoseph T. Cooke, MDDarshana M. Dadhania, MDByron Paul Demopoulos, MDMaria T. DeSancho, MDRuchuang Ding, MDEdgar Figueroa, MD, MPHDaniel W. Fitzgerald, MDChristine L. Frissora, MDMaya Gambarin-Gelwan, MDParaskevi Giannakakou, PhDLinnie M. Golightly, MDBen-Gary Harvey, MDJames Paul Hollenberg, MDIngrid Hriljac, MDNathaniel Hupert, MD, MPHErica C. Jones, MDSian Jones, MDRobert Jeffrey Kaner, MDYoon Kang, MDJason S. Kendler, MDLisa M. Kern, MDThomas K.C. King, MDAna C. Krieger, MDKeith A. LaScalea, MDEliot J. Lazar, MDSteven M. Lipkin, MD, PhDVeronica M. LoFaso, MDCharles Maltz, MD, PhDJoseph P. Mele, MDSamuel T. Merrick, MDShari R. Midoneck, MDDavid H. Miller, MDCarlyle H. Miller, MDRobert M. Minutello, MDSusana R. Morales, MDRuben Niesvizky, MDRoger Niles Pearse, MD, PhDAllyson J. Ocean, MDFred N. Pelzman, MDErica G. Phillips, MDBarrie L. Raik, MDSharda D. Ramsaroop, MDM. Cary Reid, Jr., MD, PhDKyu Young Rhee, MD, PhDArleen B. Rifkind, MDGail J. Roboz, MDJoseph T. Ruggiero, MDAbraham Sanders, MDDiana L. Santini, MDRobert A. Schaefer, MDEllen J. Scherl, MDManish A. Shah, MDRosemary Soave, MDCarol L. Storey-Johnson, MDAdam Reed Stracher, MDScott T. Tagawa, MDAndrew H. Talal, MD, MPHJudy Tung, MDMary A. Vogler, MDJonathan W. Weinsaft, MDTimothy Wilkin, MDStephen Wilson, MDHua Yang, MDYuan-Shan Zhu, MD, PhDMichael A. Zull, MDAssistant ProfessorsJosyann Abisaab, MDLauren Acinapura, MDElizabeth L. Alexander, MDAlicia Alonso, PhDMonica Altman, MDRichard L. Altman, MDJohn Arbo, MDElliot J. Arons, MDRebecca R. Ascunce, MDJason Baker, MDJeffrey E. Ball, MDSatchit Balsari, MBBSJohn Thomas Barnard, MDPaul Basciano, MDCindy H. Baskin, MDHimisha Beltran, MDDavid Berlin, MDDoron Betel, PhDTara F. Bishop, MDEllen Blye, MDGary J. Bouchard, PhD, PA-CRisa Breckman, MSWJuliet Caldwell, MD, BALeandro Cerchietti, MDJoseph J. Chang, MD, MPH, FACPMacarthur Charles, MD, PhDRichard Charney, MDJim W. Cheung, MDHarold Chin, MDAmy E. Chused, MDTessa Cigler, MDSunday Clark, MPH, ScDDavid A. Cohen, MDCarl Crawford, MDDaniel J. Crossman, MDYpe P. de Jong, MD, PhDTessa del Carmen, MDRandi R. Diamond, MDJ Leonard DiRe, MDVishal H. Dodia, MDJennifer A. Downs, MDJoan H.F. Drosopoulos, PhDNiels Dua, MDRachel P. Dubroff, MDNell Eisenberg, MDErnie L. Esquivel, MDBrenna Farmer, MDMarc J. Felberbaum, MDDmitriy V. Feldman, MDJose L. Fernandez, MDEmily S. Finkelstein, MDEva K. Flores, MDRebecca L. Florsheim, MDAlyson N. Fox, MDOren A. Friedman, MDRichard R. Furman, MDChristopher Gade, MD, MPHFran A. Ganz-Lord, MDFlavio G. Gaudio, MDElaine Y. Gee, MDJoy Gelbman, MDPaul Gerardi, MDUsama Gergis, MDJohn Travis Gossey, MDPeter W. Greenwald, MDKelly Griffin, MDKirana Gudi, MDRenuka Gupta, MDMonica L. Guzman, PhDSandra M. Hall-Ross, MDAlexis Halpern, MDChristina Elaine Harris, MDDuane C. Hassane, PhDCathy J. Greene Hatcher, PhDCaren Heller, MD, MBAMargaret L. Hoffman, MDJames M. Horowitz, MDYariv Houvras, MD, PhDHanson Hsu, MDJonathan L. Hugo, MDSaraswati Iobst, MDJames E. Ip, MDVinita E. Jacob, MDHelen Hyonji Lee, MD, MPHElizabeth Leef Jacobson, MDSteven Kaplan, MDAnne S. Kastor, MDMelissa Dee Katz, MDAgnes S. Kim, MD, PhDLuke K. Kim, MDRobert J. Kim, MDLaura Kirkman, MDRonald B. Kraft, MDTrine Krogh-Madsen, PhD, MScRekha B. Kumar, MDSonal Kumar, MDCharles O. Kwon, MDMaureen E. Lane, PhDRichard I. Lappin, MD, PhDMeredith F. Lash-Dardia, MDJennifer I. Lee, MDMoshe Lehrer, MDRichard Liebowitz, MDFay Yu-Huei Lin, MDRichard J. Lin, MD, PhDSophia Lin, MDChristopher F. Liu MDCathleen G. London, MDMarcia Lux, MDTomer M. Mark, MDKristen M. Marks, MDPeter Martin, MDJohanna Martinez, MDBassem M. Masri, MDKedar S. Mate, MDUsha Mathur-Wagh, MBBSAnna Myint Maw, MDSebastian Mayer, MDMargaret L. McNairy, MDSonal S. Mehta, MDEllen C. Meltzer, MDDavid B. Messinger, MDRaffaele Milizia, MDRenu Chawla Mital, MDSerena Mulhern, MDThangamani Muthukumar, MDNancy N. Nealon, MDDanielle Nicolo, MD, PhDOksana Ocheretina, PhDAnthony Ogedegbe, MDSonja Olsen, 0MDKarin-Elizabeth Ouchida, MDLucy N. Painter, MDRobert N. Peck, MDJaney C. Peterson, EdDSean P. Pickering, MDElizabeta C. Popa, MDMatthew J. Press, MDJane Prosser, MDPouneh Kermani Rabbany,PhD, MScBharathi Raman, MDCarmen M. Ramis, MDRama B. Rao, MDJospeh G. Rella, MDEllen Ritchie, MDEric A. Rosenberg, MDJia Ruan, MD, PhDMirella Salvatore, MDYaveen K. Santhiraj, MDRobert L. Savillo, MDJoseph M. Scandura, MD, PhDRonald J. Scheff, MDBryan J. Schneider, MDFelice Schnoll-Sussman, MDAudrey Schuetz, MDAaron P. Schulman, MDBrian D. Schwartz, MDMarco Seandel, PhD, MDSam Senturia, MDRita Shaknovich, MD, PhDReem Z. Sharaiha, MBBSShahrokh Shariat, MDLawrence Siegel, MDHarjot K. Singh, MDHarsimaran S. Singh, MDVishwas A. Singh, MDNaina Sinha, MDSanjai Sinha, MDNicole Sirotin, MDDuane M. Smith, MDVivian Sobel, MDIrina Sobol, MDJeremy Sperling, MDCarolyn Robb Steinberg, MDMichael E. Stern, MDHans Stohrer, MDDean Straff, MDJames Stulman, MDRajesh V. Swaminathan, MDMassimiliano Szulc, PhD, MSChin C. Tang, MDGeorge Thomas, MDAnn Tilley, MDHenry A. Tran, MDMeredith L. Turetz, MDBrian G. Turner, MDCarlos M. Vaamonde, MD, MSMichael J. Vortmann, MDJonathan A. Waitman, MDDavid Wenhan Wan, MDBeverly X. Watkins, PhDLuise L. Weinstein, MDJames R. Wilentz, MDGinger J Winston, MDFranklin J. Wong, MDJennifer K. Wright-McCarthy, MDYi-Ming Yang, MDCecilia J. Yoon, MDDana Zappetti, MDChristine Zink, MDInstructorsWilliam J. Ameres, PA-C, BSEdward Amores, MDCaitlin Anderson, MDDavid Anthony, MD, MPHPamela Apolaya, MDRyan Patrick Bayley, MDRana Biary, MDIlana Bragin, MDAmanda S. Carmel, MDDonald Catino, MDBrian Eiss, MDPaul J. Fenyves, MDMichael E. Ford, MDFrancine Garrett-Bakelman, MD,PhDHina Ghory, MDSamantha E. Jacobs, MDMarianna Karounos, DOJennifer Kherani, MDStephen Kuperberg, MDJacqueline Mahal, MDAdrian Mei, MDCMAlia (aka) Maria Menezes, MDMary Mulcare, MDMatthew T. O’Neill, MDAnjali Tripathi Pant, MDKapil K. Rajwani, MDMayra Ramirez, MA, PA-CPaula Roy-Burman, MDMichael J. Satlin, MDChristopher Schultz, MDVivien Shiah, MDMili Shum, MDEmily K. Shuman, MDRachel Smerd, MDPeter A. Steel, MBBSMedea Y. Valdez, PA-C, BSHenry George Wei, MDJessica L. Widmer, DOGerardo L. Zullo, MDNetwork, Affiliate, Voluntary,and Emeritus FacultyOmar I. Abdel-Wahab, MDAhmad Salih Abdulhadi, MBChBMichael L. Abott, MDGhassan Khaled Abou-Alfa, MDSherly Abraham, MDNiraj N. Acharya, MBBS, MDKatafan Achkar, MDAlberto M. Acosta, MD, PhDCarol A. Aghajanian, MDJugal Agrawal, MBBS, MDMohammad Abdul Ahad, MBBSMeena Ahluwalia, MBBSHisham Abdul Aleem AbdulAhmed, MBChBJuliet B. Aizer, MDCorina E. Akerele, MDOlakunle Akinboboye, MBBSDavid P. Akman, MDSafaa Hassan Ali Al Azewei,MBChBSalih Ali A. Hadi Al Marri, MBBChAbdulwahab Al Musleh, MDIbrahim Yousif Mahmood Al Omary,MBChBButhina Ibrahim Al Owainati, MBBSIbrahim Al Shaar, MBBChHussam Al Soub, MBBSJassim Al Suwaidi, MBChBJameela Al-Khowaiter Al-Ajmi, MDAhmed A.R. Muhamad Al-Ani,MBChBSalah Abdul Aziz Al-Azab, MBBChKhalid Al-Badr, MDAlaa K. Al-Badran, MBChBMichael H. Alderman, MDLouis M. Aledort, MDSamar Al-Emadi, MBBSNikolas Alexandrou, MDMushtak Talib Abbas Algherbawe,MBChBAbdulzaiz A. Al-Hashemi, MBBSRana Ali, MBBSWaleed Muhsin Ali, MBChBSawsan H. Al-Izzi, MBChBAbdullatif Mohamed Alkhal,MBChBRobert Allan, PhDMona Hass Al-Langawi, MBBSJohn P. Allegrante, MS, PhDHassan Ali M. Al-Malki, MDMuna A.S. Almaslamani, MBBSAbdelrahman Almasri, MBBChAhmed A.A. Al-Mohammed,MBBChAzza Awad Al-Mujalli, MDNoora Ahmad Al-Mutawa, MBChBAbdulrahman D. Alnabti, MDSaad Abdulfatah A. Al-Nuaimi,MBChBReynaldo H. Alonso, MDMourhege M. Al-Saloum, MDAhmed Subhy H. Alsheikhly,MBChBHashim Mohamed Al-Sayed,MBBChSuryanarayan Anand, MBBSNanarao Anandarao, MBBS62 63

Suzanne Anderson, MDMelina Anwar, MDSouraya aka Thurayya Arayssi, MDFrancis P. Arena, MDCarlos O. Arevalo, MDFarhad Arjomand, MDJodh S Arora, MD, MBBSPablo A. Arteta, MDDavid R. Artz, MD, MBAVijaypal Arya, MBBSNidal Ahmed Asaad, MBBSAmanda Falick Ascher, MDDalit Ashany, MDSamina Ashraf, MBBSMuhammad Asim, MBBSDeborah S. Asnis, MDFrederick Ast, MDMyint Myint Aye, MDSulaiman Azeez, MBBSSaiera Babaeva, MDRajeev Babbar, MDRalph A. Baer, MDDean F. Bajorin, MDWallace Baker, MDNomeda Balcetis, MDJean Balzora, MDDeepa Bangalore, MBBSColin MacLeod Barker, MDJuliet Barker, MBBSDavid Barlas, MDChristopher L. Barley, MDJeremiah A. Barondess, MDPeter R. Barra, MDAlberto O. Barroso, MDBaquar Bashey, MBBS, MDZelaikha Mohsin Bashwar, MBBSRiyad J. Basir, MBChBAnne R. Bass, MDCraig T. Basson, MD, PhDPaul M. Basuk, MDMichael Seth Baum, MDCarol Grossman Baum, MDShrujal Baxi, MDThomas L. Baxter, III MDShamim A. Begum, MBBSGarth A. Beinart, MDRita Bellevue, MDPaul C. Bellman, MDKatherine Bell-McGuinn, PhD, MDEdward Bennett, MDKalman J. Berenyi, MDBarbara J. Berger, MDJack J. Berger, MDIvan Bergstein, MDSamarth Beri, MDIsrael Berkowitz, MDArnold Berlin, MDJessica Berman, MDEllin Berman, MDNathaniel Berman, MDAllan E. Beyda, MDNiyati Bhagwati, MBBSThayyullathil Bharathan, MBBSKiran K. Bhat, MBBSArvind Bhimaraj, MBBSHarry Bienenstock, MDRobert H. Birkhahn, MDRichard B. Birrer, MDRachel D. Bishop, MDAna L. Blackmon, MDLester Blair, MDJames A. Blake, MDCarl P. Blobel, MD, PhDJon David Blumenfeld, MDDavid S. Blumenthal, MDMitchell J. Blutt, MDRichard S. Bockman, MD, PhDMorton D. Bogdonoff, MDRoxana M. Bologa, MDJ. Scott Bomann, DO, BAJoseph Bonanno, DO, BSMarc L. Boom, MD, MBASonal Bordia, MBBSLisa Borg, MDGeorge Joseph Bosl, MDLaura Boucai, MDJoseph Bove, MDCarrie Bowler, DScNorman Brachfeld, MDTerence M. Brady, MDBarry D. Brause, MDRobert Breiman, MDMelvin Breite, MDSorin J. Brener, MDPeter T. Brennan, MDRenier J. Brentjens, MD, PhDWilliam Briner, MDDonald Briscoe, MDNeil M. Brodsky, MDJacqueline Francoise Bromberg,MD, PhDMichelle Brosnan, MDArthur E. Brown, MDRobert S. Brown, Jr., MD, MPHJohn L. Brown, Jr., MDMatthew L. Buchalter, MDAndrew J. Buda, MDJohn Buergler, MDTrang M. Bui, MDAri L. Bunim, MDDaniel Arthur Burton, MDChristopher Busillo, MDAhmar A. Butt, MBBSMohammed Tariq Butt MBBSVivian Bykerk, MDDaniel J. Byrns, MDMagdalena Cadet, MDLisa Rowland Callahan, MDJames J. Calloway, MDAnnamaria Calleo-Cross, BS, DORobert D. Campagna, MDSalvatore J. Cannizzo, MDMichael C. Cantor, MDNina Caplin, MDTimothy Cardina, MDRalph Carmel, MDPhilip Charles Caron, MD, PhDRichard Carvajal, MDEdgar Marcelino Carvalho Filho,MD, PhDDavid B. Case, MDMarina Caskey, MDEphraim S. Casper, MDHugo R. Castro-Malaspina, MDSilvio Ceccarelli, MDAndrea Cercek, MDJamie E. Chaft, MDHakim Chalabi, MDPingkwan Chan, MDSarat Chandarlapaty, MD, PhDPradeep Chandra, MBBSJenny C-N Chang, MBChBMichael L. Chang, MDWoo-Taek Chang, MDSu Min Chang, MDRaymond Yeesung Chang, MDFang Chang, MD, PhDPaul B. Chapman, MDAntoine V. Charles, MDChaim Charytan, MDBansidhar M. Chauhan, MBBSMohit Chawla, MDJhoong S. Cheigh, MD, MSYu Chen, MD, PhDWaina Cheng, MDAbel Cherian, MDJames Chevalier, MDPing Chi, MD, PhDWarren Chin, MDKaris Cho, MDAllen Chodock, MDEdward Won Choi, MDCharles L. Christian, MDJames P. Christodoulou, MDPaul J. Chrzanowski, MDEvelyn Chu, MDSedgundina N. Chua-Gan, MDIsabelle Chughtai-Harvey, MDHelen Chung, MDLouis C.F. Chung, MBBSDavid J. Chung, MD, PhDMiriam Chung, MDBayard D. Clarkson, MDJ. Marietta Clewing, MDBarry A. Cohen, MDRichard P. Cohen, MDSymra A. Cohn, MDMorton Coleman, MDLara M. Colton, MDPaul A. Colombo, MDElizabeth A. Comen, MDRick Conetta, MDBradley A. Connor, MDJohn Cooke, MDRobert B. Cooper, MDHeidi P. Cordi, MDEngracio P. Cortes, MDSteven J. Corwin, MDAnn Costello, MDJohn Costello, MDMary K. Crow, MDWard F. Cunningham-Rundles, MDLisa M. Czanko, MDWafer Amen Kasim Dabdoob, MDAntonio Dajer, MDJane Daly, MDGabriella M. D’Andrea, MDChau T. Dang, MDSandra P. D’Angelo, MDJean Pratt Daniel, MDDaniel C. Danila, MDJames Darling, MDLloyd A. Darlow, DMD, MDSara Mohammed A. Darwish, MDMalay Das, MBBSAnita R. Datta, MDAmish S. Dave, MD, PhDMarco L. Davila, MD, PhDJames Davis, MAYonette Davis, MDBita Deyhimpanah, MDGiovanni de Simone, MDBarbara Ann DeBuono, MD, MPHJulian A. Decter, MDMary L. DelMonte, MDMoutaz Derbala, MBBCh, MDSylvie D. DeSouza, MDAdam Deutsch, MDGerard Devas, MBBSLekshmi Dharmarajan, MBBSMaura N. Dickler, MDMark A. Dickson, MDBruno F. DiCosmo, MDHajir Ely Dilmanian, MDStephen J. DiMartino, MD, PhDVihren Dimitrov, MDJoshua A. Donis, MDAlan Dosik, MDDavid C. Dosik, MDHarvey Dosik, MDR. Gordon Douglas, Jr., MDLorna M. Dove, MD, MPHJames J. Doyle, MDAshley L. Drews, MDJoseph Claude Dreyfus, III, MDNatalie J. Dryden, MDSushil Duddempudi, MDWilliam M. Duke, MDElinor Greenspun Dulit, MDMark Dursztman, MDTimothy C. Dutta, MDMurray Dworetzky, MDAmmar Nasser Eddin, MDBrian R. Edlin, MDWilliam T. Edwards, MDPetros Efthimiou, MDBarbara C. Egan, MDJohn F. Eichelberger, MDCristiano Eirale, MDHoward B. Eison, MDIsam El Bagi, MBChBAbdel Haleem Ahmed El Hiday,MBBSMamoon M. Elbedawi, MBBSGeorge C. Ellis, MDAyman A. El-Menyar, MBBChMarie Eloi-Stiven, MDElhadi Elouzi, MBBChAbdul M.T. El-Qawasameh,MBBChMohamed S. El-Tawil, MBBChRoger Ira Emert, MDAngie M. Eng, MDRonald Englert, DOAndrew S. Epstein, MDGulchin A. Ergun, MDDoruk Erkan, MDHenry R. Erle, MDIrina V. Erlikh, MDMehdi Mohammed Errayes,MBBSAlistair Erskine, MDAtilla Ertan, MDSusan M. Escudier, MDMaria T. Espejo, MDJorge I. Esquivel, MDJerry D. Estep, MDDavid G. Evelyn, MD, MPHMonte Ezratty, MDJames A. Fagin, MDThomas J. Fahey, Jr., MDVictor Fainstein, MDSamya Ahmed Falamerzi, MBBSGeorge A. Falk, MDAlbert Fano, MDAzeez Farooki, MDAndrew Feda, MDThomas A. Feely, MDArthur E. Feinerman, MDLeonard Feingold, MDMarc B. Feinstein, MDDarren Feldman, MDStuart Feldman, MDDavid Feldshuh, MDMichael J. Feltovich, MDJohn Fernandez, MDMauro Ferrari, PhDFrederick J. Feuerbach, III, MDTheodore R. Fields, MDStanley R. Fine, MDWilmore B. Finerman, Jr., MDJeremy Paul Finkelstein, MDChristopher J. Finnila, MDStephanie A. Fish, MDAkinola O. Fisher, MBBSLaura L. Fisher, MDJeffrey D. Fisher, MDEdward Flaschner, MDRobert Fleming, MDGloriande Fleurimont, MDCarlos D. Flombaum, MDJohn T. Flynn, MDArthur L. Forni, MDMonica N. Fornier, MDJordan C. Foster, MDAllison M. Fox, MDSusan C. Fox, MDAndrew Francella, MDJoseph A. Franciosa, MDRichard C. Frank, MDRichard H. Frankel, DPMKenneth W. Franklin, MDJohn E. Franklin, Jr., MDJames Dermot Frengley,MBChB, MSMark S. Friedman, MDSamuel Friedman, MDErika Friedmann, PhDTodd M. Friend, DOAbraham Fruchter, MDRichard M. Fuchs, MDMatthew G. Fury, PhD, MDJacobo Futran, MDTheodore J. Gaeta, DO, MPHMarina Gafanovich, MDDevika Gajria, MDMarilyn Galler, MDBoris Gambarin, MD, PhDMaya Gambarin-Gelwan, MDNeil A. Gandhi, MDSandy B. Ganz, DSc, BSAaron Garber, MDDelfino Garcia, III, MDRajinder K. Garg, MBBSVivek Garg, MDBruce A. Garrison, MDMitchell L. Gaynor, MDCeleste Geertsema, MBChBAbdurrazzak Gehani, MBBChMitchell Geizhals, MDBrian D. Gelbman, MDRobert M. Gelfand, MDJeremiah Gelles, MDEdward P. Gelmann, MDRichard L. Geltman, MDRonnie Alan Gentry, MDLiziamma George, MBBSHans Gerdes, MDJohn Frank Gerecitano, MD, PhDJanet A. Gershengorn, PhDMenard M. Gertler, MDCM, DScAndrew Getzin, MDWisam K. Ghadban, MBBChIssa Mousa Ghanem, MBBChAllan Gibofsky, MDHolly Gilbert, MDTeresa Ann Gilewski, MDSergio A. Giralt, MDFabio F. Giron, MDMonica Girotra, MDEllen Spielman Gitler, MDJoel S. Gitlin, MDPaul A. Glare, MBBS, MDRobert H. Glassman, MDClifford F. Glatzer, MDIlya G. Glezerman, MDMichael S. Glickman, MDJerry Gliklich, MDDavid L. Globus, MDIsaiarasi Gnanasekaran, MBBSDavid H. Goddard, MD, MBBSJoshua M. Gold, MDCM, PhDSeth Goldbarg, MDJenna Dey Goldberg, MDHarvey L. Goldberg, MDRobert S. Goldblatt, MDRonald A. Golden, MDOwen Golden, MDFlavia A. Golden, MDGrigoriy Goldenberg, MD, PhDShari Goldfarb, MDDaniel Goldin, MDHoward Goldin, MDSteven R. Goldring, MDDavid Goldschmitt, MDNatalya Goldshteyn, MDJonas Goldstone, MDTamas Gonda, MDSusan M. Goodman, MDStephanie M. Goodman, DOMarci Goolsby, MDJessica K. Gordon, MDBruce R. Gordon, MDGeorge W. Gorham, MDTabitha Goring, MDRichard S. Gottfried, MDBenjamin V.G. Gozun, MDVenera Grasso, MDStuart A. Green, MDMichele G. Greene, DrPHIrina Gressel, MDWilliam R. Griffo, MD, PhDKevin A. Grimes, MD, MPHRachel N. Grisham, MDJeffrey S. Groeger, MDHarry L. Gruenspan, MD, PhDGregory Grunberg, MDAyca Gucalp, MDMadhav A. Gudi, MBBSRebecca S. Guest, MDKim A. Guishard, MDSubhash C. Gulati, MD, PhDRamesh S. Gulrajani, MBBSShellie Gumbs, MDSandeep Gupta, MBBSSanjey Gupta, MDGregory Miner Gustafson, MDCristina Gutierrez, MDBrian Halpern, MDNeil A. Halpern, MDAhmed F.A.A. Hamdi, MBBChNachida Hamidi-Sitouah, MDBruce Hamilton, MBChBDale J. Hamilton, MDPaul Anthony Hamlin, MDCostas Hanjis, MDGeorge Haralambou, MDRobert B. Harooni, MDMelanie Jane Harrison, MDCatherine C. Hart, MDRev. Curtis Webb Hart, MDivBarry J. Hartman, MDCholi Hartono, MDKristen A. Harvey, MDDebra K. Harvey, MDShaikh Hasan, MBBSElizabeth Haskins, MDAzza Adel Ibrahim Hassan,MBBCh, PhDIbrahim Mohamed Fawzy Hassan,MDHani Hassoun, MDThomas L. Hau, MDJoseph G. Hayes, MDKirsten Healy, MDDavid C. Helfgott, MDArthur D. Heller, MDWilliam F. Heneghan, MDKaren Hennessey, MDMartee L. Hensley, MDLawrence L. Herman, MDEdmund M. Herrold, MD, PhDRobert Hesson, MDEdward William Hillhouse, PhDChristopher D. Hillyer, MDJules Hirsch, MDYashar Hirshaut, MDStuart E. Hisler, MDAlan Loh Ho, MD, PhDMelvin C. Hochman, MDEric R. Hoffer, MDMagdelena Hohn, MDWesley P. Hollomon, MD, MBAPeter R. Holt, MDJohn W. Hon, DOThomas E. Hong, MDJaleh E. Hoorfar-Nathan, DPMSteven M. Horwitz, MDKarlene Hosford, MDAlan N. Houghton, MDJames J.D. Hsieh, MD, PhDKatherine C. Hsu, PhD, MDWilla Hsueh, MDJohn T. Hsueh, BMXiaoyu Hu, BM, PhDAndy Y. Huang, MDZheng-Bo Huang, BMLisa Cooper Hudgins, MDClifford Alan Hudis, MDI-Lo Hung, MD, MSJames R. Hurley, MDBarry N. Hyman, MDDavid Hyman, MDChul Soo Hyun, PhD, MDAbdulsalam Saif Ibrahim, MBBSWanis Hamad Ibrahim, MBBChDavid H. Ilson, PhD, MDDmitry Ilyevsky, MDBarton Inkeles, MDLawrence A. Inra, MDMuhammad Z. Iqbal, MBBSLisandro Irizarry, MD, MPHLionel B. Ivashkiv, MDTranice D. Jackson, MDRichard A. Jackson, MDRobert E. Jackson, MDMatteethra C. Jacob, MDMichael Jacobson, MDAlan H Jaffe, MDEric A. Jaffe, MDAnn A. Jakubowski, MD, PhDMorris L. Jampol, MDRachana Jani, MDYelena Janjigian, MDFernando Jara, MDCharles I. Jarowski, Jr., MDRobert Ray Jenq, MDNeeti Jha, MBBSAnil K. John, MBBSErik Kent Johnson, MD64 65

Michelle N. Johnson, MDThomas C. Jones, MDElaine Josephson, MDVijay Jotwani, MDGeorge J. Juang, MDAlan B. Kadet, MDJohn Kahoun, MDSamuel K. Kajubi, MBChB, MDMarcia F. Kalin, MDJeffrey E. Kalina, MDGeorge Kalliolias,MDAnna Kaltsas, MDMini Kamboj, MBBSMazen Kamen, MDLewis Jay Kampel, MDAladdin Kanbour, MBChBS. Balavenkatesh Kanna, MBBSMarc Kanter, MDRana Kaplan, MDBarry H. Kaplan, MD, PhDMorrie A. Kaplan, MDTushar Kapoor, MDAttallah Kappas, MDHelen Karakelides, MDStephen R. Karbowitz, MDAbdool Salim Karim, MBChB, MSAmin H. Karim, MBBSSimon G. Kassabian, MBChB, MDMoiz M. Kasubhai, MBBSLawrence Alton Katz, MD, MPHSandhya G. Katz (Ganti), MBBSNoah D. Kauff, MDMartin M. Kay, MDSaka A. Kazeem, MDSeth Keller, MDRaymond S. Keller, MDDavid P. Kelsen, MDNancy E. Kemeny, MDRobert Owen Kenet, MD, PhDDavid J. Kerr, MD, PhDTodd Kerwin, MDSrinivas Kesanakurthy, MBBSSandra Kesh, MDGeorge J. Kessler, DOAmsale Ketema, MDIssam Khafaja, MBChBMuayad Kasim Khalid, MBChBAsadullah Khan, MBBSFahmi Yousef Khan, MBBSFaiz Khan, MDFarida Khan, MBBSAbdul-Jabbar Asim Khan, MBBSAzeem Khan, MD, MBBSIzzat Khanjar, MDGalina Kharash, MDSang H. Kim, MDChung Eun Kim, MDSusan Kim, MDBack Kim, MDRobin S. Kim, MDWoo Sup Kim, BMYong Rak Kim, MDBrian J. Kirby, PhDKyriakos A. Kirou, MD, DScNeal S. Kleiman, MDLudwig Klein, MDWilliam A. Klepack, MDHarold N. Klestzick, DOVirginia M. Klimek, MDAdam David Klotz, MDBarry J. Klyde, MDZoulficar A. Kobeissi, MDDrew Koch, DOGuenther Koehne, MD, PhDIosif Kolbovsky, MDRichard N. Kolesnick, MDMary Kollakuzhiyil, MBBSVasantha Kumari Kondamudi,MBBSJason Konner, MDDouglas J. Koo, MD, MPHEdward Koppel, MDBeatriz Korc-Grodzicki, MD, PhDAnthony F. Korosi, MDConstantine E. Kosmas, MD, PhDGamil S. Kostandy, MBChBIone A. Kourides, MDEmanuel L. Kouroupos, MDElizabeth Kozora, PhDLawrence S. Kraftowitz, MDRobert C. J. Krasner, MDDaniel Krauser, MDMary Jeanne Kreek, MDMark G. Kris, MDPadmanabhan Krishnan, MBBSLee M. Krug, MDBernard M. Kruger, MDGeoffrey Y. Ku, MDAnuradha Kumar, MBBSSuresh Kumar, MBBS, MDChhavi B. Kumar, MDSanjay Kunapuli, MDSheng Kuo, MDJulie S. Kuriakose, MDKarla M. Kurrelmeyer, MDRobert C. Kurtz, MDOliver Kurucz, MDKaren LaFace, MDEseng Lai, MD, PhDDiana Lake, MDArnon Lambroza, MDHeather J. Landau, MDThomas K. Landau, MDBrian R. Landzberg, MDEdith J. Langner, MDHonore Lansen, MDStephan C. Lansey, MDJose R. Lapa e Silva, PhD, MDSheron Latcha, MDJanice L. Lau, MDJeffrey Lazar, MD, MPHRoxana Lazarescu, MDAdam Law, MBBS, MDMark J. Leber, MDMarvin A. Leder, MDThomas Lee, MDRobert P. Lee, MDJun Lee, MDYi-An Lee, MDDavid Lefkowitz, MDDaniel E. Lehane, MDMonika J. Leja, MDHerbert S. Lempel, MDNikoletta Lendvai, MDPaul J. Leo, DOMichael Richard Leonard, MDAlfred Ba Tun Leong, MBBSChester W. Lerner, MDAlexander M. Lesokhin, MDWai L. Leung, MDJay M. Levat, MDSeth R. Leven, MDLawrence F. Levin, MDRoss L. Levine, MDSuzanne Marin Levine, DPMMargaret Lewin, MDBenjamin Lewis, MDMinji Li, BMDaniel M. Libby, MDWarren B. Licht, MDAmy Dale Lichtenfeld, MDStuart M. Lichtman, MDRobert Y. Lin, MDLilli B. Link, MDStephen H. Little, MDJack H. Liu, MDJennifer Liu, MDFrank Ming-Shi Liu, MDMichael D. Lockshin, MDBruce D. Logan, MDRaghu S. Loganathan, MBBSGeorge Vincent Lombardi, MDGerard T. Lombardo, MDOlivia A. Lopez, MDJorge A. Lopez-Ovejero, MDDaniel Louis Lorber, MDJonathan Lorch, MDMaeve Lowery, MBZhicheng Lu, DOEmmy Ludwig-Miller, MDPreston Lurie, MDJasminder Luthra, MDJoseph H. Ma, MDLuis R. Maceira-Rodriguez, MDC. Ronald MacKenzie, MDNicholas T. Macris, MDQutaybeh Maghaydah, MDSteven K. Magid, MDNorman M. Magid, MDRichard J. Mahler, MDJohn J. Mahmarian, MDMai A. Mahmoud, MBBSTimothy R. Mainardi, MDVicky Makker, MDMariam Abdul Malik, MBBSCarol A. Mancuso, MDLisa A. Mandl, MD, MPHDebra A. Mangino, DOForrest Manheimer, MDJack M. Mann, MDAnnaRita Marcelli, MDJoseph A. Markenson, MDPaul L. Marino, PhD, MDJunnie Mark-Kobashi, MDArnold Jay Markowitz, MDPaul A. Marks, MDFranklin Marsh, Jr., MDWilliam A. Martimucci, MDGeorge T. Martin, MDAndrew Martorella, MD, MSRobert J. Mascitelli, MDPeter G. Maslak, MDIssa Matar, MBChBMatthew J. Matasar, MDEdward J. Matta, MDJacqueline Mayo-Morris, MDJeffrey Mayer, MDGary Mazer, MDEileen P. McAleer, MDHeather L. McArthur, MDJohn J. McCarthy, MDMoira Kathleen McCarty, MDMichael R. McDevitt, PhDCarl J. McDougall, MDJohn C. McKechnie, MDTerry B. McLendon, MDJohn-Paul Mead, MDPeter A. Mead, MDParag Mehta, MBBS, MDKenneth R. Meisler, DPMDanielle M. Mellace, DOJennifer A. Meller, MDAdrianne H. Mellos, MDEllen M. Mellow, MDLawrence A. Melniker, MDJay Ivan Meltzer, MDLaura Melville, MDRobin Beth Mendelsohn, MDAntonio Mendez, MDCharis Fan-Hui Meng, MDChandra Menon, MBBSFrank V. Meriano, MDJennifer K. Meyer, MDMark L. Meyer, MDSpyros G. E. Mezitis, MD, PhDLiJun Mi, BM, PhDRameen M. Miarrostami, MDOllie S. Miettinen, MD, PhDAndy O. Miller, MDSusan M. Miller, MDNancy E. Mills, MDPaul F. Miskovitz, MDRakeshkumar Mistry, MBBSSubhada Mithilesh, MBBSAbraham M. Mizrahi, MDShanu Modi, MDKhaled M.M. Mohamed, MD,MBBChVinuta Mohan, MDAna Maria Molina, MDThomas G. Molnar, MDAbdul S. Mondul, MDHoward P. Monsour Jr., MDDonald E. Moore, MDAlexei Morozov, MD, PhDMichael J. Morris, MDNatalie Moryl, MDLori J. Mosca, MD, PhDJeffrey W. Moses, MDEliot P. Moshman, MDAlison Moskowitz, MDCraig H. Moskowitz, MDZarina Motorwala, MDRobert J. Motzer, MDEmmanuel N. Moustakakis, MDLawson A. Moyer, III, MDMary Ellen Moynahan, MDEric J. Mueller, MDRichard L.P. Mueller, MDFranco B. Muller, MDJames E. Muntz, MDJohn Munyak, MDSkender Murtezani, MDElizabeth C. Muss, MDAmy T. Mynderse, MDFaisal Nabi, MDJerry Nagler, MDSherif F. Nagueh, MBBChKesav G. Nair, MBBSThomas Naparst, MDParathasarathy Narasimhan, MDThomas W. Nash, MDLaurie Claire Nash, MDGeorge M. Nassar, MDSam N. Natarajan, MDEthan A. Natelson, MDAsha D. Nayak, MBBSKotresha H. Neelakantappa,MBBSDeena J. Nelson, MDFrank Nelson, MDSanjay Nerkar, MBBSChristopher L.B. Nevins, MDBarney D. Newman, MDMarissa D. Newman, MDKenneth K. Ng, MDKaman Ng, MDVincent Waikuen Ng, MDJulie C. Nguyen, MDSusan C. Nicholson, MDJohn P. Nicholson, Jr., MDAryel Nicoleau, MDCarl Andre Nicoleau, MD, PhDTanya Nikolova, MDStephen David Nimer, MDRudolph H. Nisi, MDLarry Norton, MDMichelle K. Nowak-Logozzo, MDAriela Noy, MDParirokh Nozad, MDSteve Esfandiar Nozad, MDMichel Ernest Nussbaum, MDMartin Nydick, MDIrwin Nydick, MDRoisin O’Cearbhaill, MBBChHerbert F. Oettgen, MDKenneth Offit, MD, MPHAdesuwa Okesanya, MDIon Oltean, MDAnas Ahmed Omer, MBChBKenneth Ong, MDEileen M. O’Reilly, MBBChRuth Osowsky, MDAneta Ostrowska, MDLaszlo Osvath, MDJacob Ouseph, MDStephen A. Paget, MDJoseph Thomas Paglia, MDPaul K. Paik, MDShashishekhar Palekar, MBBSJeffrey E. Paley, MDMaria Lia Palomba, MDEric G. Pamer, MDCynthia X. Pan, MDEsperanza B. Papadopoulos, MDGenovefa A. Papanicolaou, MDBenoit Jerry Papon, MDFirjeeth Paramba, MBBSChong H. Park, MDJae Hong Park, MDRichard Park, MDSonal Shah Parr, MDEdward J. Parrish, MDMark W. Pasmantier, MDMina Pastagia, MDRichard C. Pasternak, MDRaymond D. Pastore, MDStephen M. Pastores, MDLeonard T. Pastula, II, DOManisha Patel, MDNaveena Pathmakumar, MBBSDoru Paul, MDGeorge W. Pelebecky, Jr., MDOrlando Perales, MDMiguel-Angel Perales, MDJose A. Perez, Jr., MDAlan S. Perlman, MDAlessandra B. Pernis, MDFrancis S. Perrone, MDLynne V. Perry-Bottinger, MDManana Petrov, MDDavid Gerard Pfister, MDPatricia Phan, MDMaria C. Pietanza, MDAnush S. Pillai, DO, BARiccardo Pini, MDZarina Pino (Motorwala), MDHeidi M. Pinkert, MDIan Pinto, MBBSMartin Poliak, MDDoris M. Ponce, MDJovan M. Popovich, MDCarol S. Portlock, MDJohn A. Posey, Jr., MD, PhDRock Gerard Positano, DPMDavid H. Posner, MDMartin R. Post, MDCraig M. Pratt, MDJacek J. Preibisz, DMSc, MDJoanna M. Preibisz, MDLuminita Pricop, MDFernando Arturo Pujol-Morato, MDPrabhakar Putheti, PhDMiguel A. Quinones, MDSina Y. Rabbany, PhDStephen H. Rabinowitz, MDMichael R. Rabinowitz, MDMichael Stavros Radeos, MD, MPHArthur I. Radin, MDAllen Robert Radin, MDRussell N. Radoff, MDLinda Radomski, MDJames J. Rahal, MDAli Rahil, MBBChRummana Rahman, MBBSShafiqur Rahman, MBBSRitesh Raichoudhury, MDRavindra Rajmane, MDMarwan Ramadan, MBChBRamya Ramakrishnan, MDDharmarajan Ramaswamy, MBBSGumpeni Rammohan, MBBSElizabeth Ramos, MDRaajit K. Rampal, MD, PhDDragos Rancea, MDScott E. Rand, MDJames A. Rand, MDSuhail Raoof, MBBSKakil Ibrahim Rasul, MBChBDana Rathkopf, MDKanwar S. Rauhila, MBBSCarroll A. Rayner, MDTasleem Raza, MBBSRose A. Recco, MDSteven G. Reed, PhDAbdul Rehman, MBBSLilian M. Reich, MDSteven F. Reichert, MDBonnie S. Reichman, MDDiane Reidy-Lagunes, MDDaniel Reingold, JDMarshal Scott Reminick, MDMichael T. Rendel, MDGene D. Resnick, MDLawrence Rice, MDCharles M. Rice, PhDJack Richard, MDJill M. Rieger, MDGregory J. Riely, MD, PhDRobert R. Riggio, MDLee Woodland Riley, MDDeborah L. Rimler, MDNaiyer A. Rizvi, MDKeith W. Roach, MDChristopher P. Robben, MDWilliam C. Robbins, MDLaura Robbins, DSWRichard J. Robbins, MDRichard B. Roberts, MDMark E. Robson, MDArnold M. Rochwarger, MDJohn S. Rodman, MDA. Arturo Rodriguez, MD, MBASteven A. Rogers, MDNancy Roistacher, MDAna E. Roman, MDDavid N. Rose, MDYocheved Rose, MDNeal Rosen, MD, PhDHerman Rosen, MDHoward E. Rosenberg, MDMichael A. Rosenbluth, MDAlbert M. Ross, MDGary E. Rothbart, MDMonisankar Roy, MBBSDebasish Roychoudhury, MBBSMarina Rozenberg, MDHoward S. Rubin, MDDavid Scott Rubin, MDMoshe Rubin, MDAndrea T. Ruskin, MDLinda A. Russell, MDMary T. Ryan, MDJames G. Ryan, MDMabel M. Ryder, MDMona Sabra, MDStuart D. Saal, MDPaul Joseph Sabbatini, MDReza Sabet, MDIan L. Sachs, MDMichel Sadelain, MD, PhDNagham D. Sadik, MBChBMassimiliano Sala, MDR. Benjamin Saldana, DOAnthony Saleh, MDMansoura Fawaz Salem, MBChBJane E. Salmon, MDLeonard B. Saltz, MDLori Beth Saltzman-Gabelman, MDRavinder Saluja, MBMSCori Salvit, MDLisa R. Sammaritano, MDNelson Sanchez, MDDonna Sandidge, MDJean T. Santamauro, MDThomas Santucci, Jr., MDHousam Aldeen Sarakabi, MDBarry I. Saul, MDCraig Sauter, MDCharles L. Sawyers, MDBrian Scanlan, MDWendy Schaffer, MD, PhDLiviu Schapira, MDLawrence L. Scharer, MDMark A. Schattner, MDElaine J. Schattner, MDDavid Schechter, MDDavid A. Scheinberg, MD, PhDHoward I. Scher, MDLawrence Scherr, MDAndrew N. Schiff, MDDavid Ross Schifter, MDRalph E. Schlossman, MDMichael J. Schmerin, MDH. Alan Schnall, MDWilliam J. Schneider, MD, MPHSteven J. Schneider, MDMelissa P. Schori, MDAvraham Schreiber, MDGeorge Schroth, MDChristian M. Schupp, MDEliot Schuster, MDLeonard H. Schuyler, MDErnest Schwartz, MDGary K. Schwartz, MDSimeon Schwartz, MDFred S. Schwartz, MDJoseph S. Schwartz, PhDSergio Schwartzman, MDJohn C. Sciales, MD66 67

Richard F. Scofield, MDStephen M. Scott, MD, MPHJean E. Sealey, DScNeil H. Segal, MD, PhDSorana Segal-Maurer, MDAndrew D. Seidman, MDSusan Seo, MDKent A. Sepkowitz, MDJoshua D. Septimus, MDDavid Serur, MDSandra L. Sessoms, MDAmrita Sethi, MDKenneth K. Sha, MBBSNabeel Shaath, MBBChAdel M. Shabana, MBBChNehad Shabarek, MDRajendra C. Shah, MBBSAlpesh R. Shah, MBBSDipan J. Shah, MDMonika Kanu Shah, MDPari Shah, MDNooruldin F. Shakir, MBBSBenson H. Shalette, MDNeil F. Shallish, MDNedal Shami, MBBChJerome B. Shapiro, MD, PhDNeil H. Shapiro, MDAtul Sharma, MDManik Sharma, MBBSManish Sharma, DOPuneeta Sharma, MBBSVijay Kumar Sharma, PhDRahul Sharma, MDNitya Sharma (Srinivasan), MDGillian M. Shepherd, MDStanley Sherbell, MDBruce E. Sherling, MDEric J. Sherman, MDRaymond L. Sherman, MDPatricia Ann Shi, MDChristopher P. Shields, MDMoshe Shike, MDMaurice E. Shils, MD, DScMorris A. Shorofsky, MDMeenal Shukla, MBBSAbdul Rahim M. Siam, MBBSJonathan Siegal, MDSteven E. Siegel, MDVasilios Sierros, MDSteven H. Silber, DOJonathan Silberlitch, MDJeffrey I. Silberzweig, MDHoward Silcoff, MDTodd L. Simon, MDMonisha Singh, MDAmit Singh, MDDinesh Chandra Sinha, MD, MBBSSteven Jay Siskind, MDDiane M. Sixsmith, MDNancy T. Sklarin, MDMichael Skelly, MDAlexander J. Slotwiner, MDSusan Faith Slovin, MD, PhDAnthony J. Smith, MDPaul T. Smith, MDCharles Smithen, MDAlan G. Snart, MBBS, MDGerarld A. Soff, MDBenny Soffer, MD, MBAWon Sohn, MDDavid B. Solit, MDMeyer N. Solny, MDHenry A. Solomon, MDAnthony A. Somogyi, MDDebbie R. Sonenblick, MDPrabhat Soni, MBBSAnita Soni, MBBSGirish M. Sonpal, MBBSAlan J. Sonsky, MDJulio E. Sotelo, MDAllison Spatz, MDGabriel Spergel, MDRobert J. Spiegel, MDHarry Spiera, MDRobert Forman Spiera, MDBruce S. Spinowitz, MDIrving M. Spitz, MDDana Spivak, MDDavid R. Spriggs, MDEmmanuel L.G. St. Louis, MDStacy Stabler, MD, PhDDora J. Stadler, MDZsofia K. Stadler, MDMartin Stallone, MDLawrence E. Stam, MDIoannis A. Stathopoulos, MD, PhDRandy Stein, MDHerman Steinberg, MDRichard M. Steingart, MDKurt H. Stenzel, MDRichard Stern, MDRadomir Stevanovic, MDMark Y. Stoeckle, MDHans Stohrer, MDDiane E. Stover, MDMitchell S. Strand, MDDavid J. Straus, MDJoan A. Stroud, MDSheena G. Stubbers, MDAlison E. Suarez, MDSteven M. Sugarman, MDChang Ho Suk, MDMohammed Abd El-SattarSuliman, MBChBJohn F. Sullivan, MDSung Wu Sun, BMWei Fun Sung, MDRanjit Suri, MBBSGeorge C. Surla, MDLynn Swisher, MDJohn L. Szalyga, MDM. Javad Tabaee-Zadeh, MDGeorge E. Taffet, MDMichael Tafoya, MDAvraham Tal, MDMartin S. Tallman, MDSteve C. Tam, MDKenneth C. Tam, MDWilliam D. Tap, MDStephen G. Targett, MBChBSilvio Robert Tasso, MDJaime Tavarez, MDYing Taur, MD, MPHWilliam John Tenet, MDJeffrey Tepler, MDMark J. Tessler, MDWilliam Tew, MDMalcolm Thaler, MDMaria Theodoulou, MDGeorge E. Thibault, MDCarolyn H. Thompson, MDJoseph Tibaldi, MDRoma Tickoo, MBBSJitendra Tolia, MBBSAlexander Tomasz, PhDEmily S. Tonorezos, MDFrantz Torchon, MDGuillermo Torre-Amione, MD, PhDJose D. Torres, MDTiffany A. Traina, MDNicholas Triantafillou, MDTheodore J. Trumble II, MDRobert M. Tuttle, MDTheodore I. Tyberg, MD, MScWesley Tzall, MDEva Urtasun-Sotil, MDSudhir P. Vaidya, MBBS, MSMiguel Valderrabano, MDEmmanuel Valery, MDMarcel Rudolf M. van den Brink,MD, PhDRobbart van Linschoten, MDNicholas Jon Vander Els, MDNitza A. Vanga, MDLisa Catherine Vasanth (Varley), MDStephen R. Veach, MDSaimamba Veeramachaneni, MBBSSindhaghatta K. Venkatram, MBBSUsha Venugopal, MD, MBBSMichael Verdirame, DOMohamud Verjee, MBChBElizabeth Verna, MDElvira Villafuerte, MDAdrienne Vincenzino, MDAnnette M. Visconti, MDNicholas G. Vogiatzis, MDKristian Wachtell, MDRachel Waldron, MDLila A. Wallis, MDMary Beth Walsh, MDFrederick A. Walther, MDRimda Wanchoo, MBBSGeorge K. Wang, MD, PhDJohn C.L. Wang, MD, PhDCraig Warschauer, MDCarolyn Wasserheit-Lieblich, MDAdrienne Wasserman, MDJulia Wattacheril, MDMuhammad Wattoo, MBBSJenne Wax, MDPaul Webb, PhDGeoffrey Webber, MDArnold L. Weg, MDWehbeh A. Wehbeh, MDClinton G. Weiman, MDJeremy A. Weingarten, MDHoward Weinstein, MDJessica M. Weiser-McCarthy, MDStephen R. Weiss, MDGil Weitzman, MDDavid Wentzel, DOMary H. White, MDHendricks H. Whitman, III, MDJoseph Wiesel, MDPamela G. Williams-Russo, MD, MPHLucy Willis, MDRobert Wilson, MDSidney J. Winawer, MDWilliam L. Winters, Jr., MDRuth L. Wintz, MDNatasha Withers, DORobert E. Wittes, MDJames F. Wittmer, MDJedd Wolchok, MD, PhDDavid H. Woldenberg, MDDavid J. Wolf, MDSteven Wolinsky, MDMichael J. Wolk, MDGena Won, MDDavid C. Wong, MDJohn Eu-Li Wong, MBBSAlastair J.J. Wood, MBChBAnton Wray, MDSteven Wright, MDDavid Lynn Wuest, MDKathleen L. Wyne, MD, PhDJiaqiong Susan Xu, PhDHooman Yaghoobzadeh, MDHenry Jiann-Cherng Yan, MBBSChristine Yang-Kauh, MDMohamed Abdel Daem M. Yassin,MBBSArthur M.F. Yee, MD, PhDBenson Yeh, MDAnne Yim, MDLinus Yoe, MBBSBernard Yonk, MDSerena Yoon, MDJames W. Young, MDChristine Yu, MDChristine Mei-Yan Yu, MDFlorence Yu, MDKenneth Ho-ming Yu, MDHoward S. Yudin, MDTasneem Zahra, MBBSGeorge Zahrah, MDDavid Zakim, MDAndrew D. Zelenetz, MD, PhDRichard Zelkowitz, MDNejat Zeyneloglu, MDCynthia X. Zhang, MDMing Zhu, MD, MSWendy S. Ziecheck, MDLara M. Zilberstein, MDJanice L. Zimmerman, MDMahmoud A. Zirie, MBBSWilliam A. Zoghbi, MDResearchHighlights6869

Research Highlights 2012CardiologyMechanisms of Cardiac AlternansCardiac alternans is an electrophysiological instability thatcan trigger lethal cardiac arrhythmias. We are using asynergistic computational and experimental (patch clampingand subcellular calcium imaging) approach to determineits mechanism. In the past year we implemented thefirst experimentally viable method to quantify the relativecontributions of ionic currents and subcellular calciumhandling to the instability that triggers cellular alternans.PI: David Christini, PhDFunding: NIH R01Predictive Multiscale Modeling of Atrial Fibrillationfor Therapy DevelopmentWe are using large-scale computational modeling, informedby electrophysiological experiments, to predict the efficacy ofpharmacological agents in controlling paroxysmal, persistent,and chronic atrial fibrillation in the presence of common humanion-channel polymorphisms. In the past year we improvedthe model to incorporate fibrosis, which is a structuraldeterioration that occurs to atrial tissue during prolonged atrialfibrillation.PI: David Christini, PhDFunding: NIH R01Real-Time Development of Cardiac Cell Computer ModelsComputer models of cardiac cells are widely used to predictand test arrhythmia therapies. Unfortunately, the equationsunderlying such models are often incorrect approximations,resulting from a model-development paradigm that is decadesold and does not exploit modern automated search algorithms.We have developed a novel automated technique that mergesdynamic experiment protocols with an automated searchalgorithm to significantly improve the realism of models ofcardiac cells. We are currently working to apply this method tohuman atrial myocytes.PI: David Christini, PhDFunding: NIH R01Transcriptional Regulation of Cardiovascular DevelopmentThis study defines the molecular and cellular requirementsfor cardiovascular development. It is investigating how cells inthe developing myocardium, epicardium and coronary vesselsare established through signals from transcription factors,microRNAs and chromatin-modifying enzymes. Knowledgegained from this study will provide a framework for designingtherapeutic interventions to prevent congenital heart defects.PI: Cathy Hatcher, MDFunding: Raymond & Beverly Sackler Foundation70 71

Research Highlights continuedOptimization of A-V and V-V Delay in CRT with SurfaceElectrocardiogram and Impedance Cardiography Compared toEchocardiography (ECGOPT)The study compares a novel ECG-based A-V and V-Voptimization algorithm with optimal A-V and V-V delaysderived by echocardiography and impedance cardiography.The study will also assess whether the ECG based A-V andV-V optimization algorithm can yield significant clinical data tobetter optimize and increase responder rate. It will compare theresults from the surface 12 lead ECG with that of traditional AVand VV optimization using Echo and ICG.PI: Jim Cheung, MDFunding: New York Cardiac Center; Michael Wolk HeartFoundationLate Sodium Current Blockade in High Risk ICD Patients,Ranolazine ICD Trial (RAID)A multicenter study to determine whether Ranolazine (anovel drug with anti-ischemic and antiarrhythmic properties)administration will decrease the likelihood of having anarrhythmic event as a composite endpoint, consisting ofventricular tachycardia or ventricular fibrillation (VT/VF)requiring anti-tachycardia pacing (ATP) therapy, ICD shocksor death in high risk patients with ICD/CRT-D implanted forprimary or secondary prevention of sudden death.PI: George Thomas, MDFunding: NIH U01 (subaward from University of Rochester);Gilead Sciences, Inc.Genetic Epidemiology of Left Ventricular HypertrophyThis study utilizes data from echocardiograms to identify genescontributing to abnormalities of left ventricular (LV) structureand function.PI: Richard Devereux, MDFunding: NIH R01Genetically-Associated Thoracic Aortic Aneurysm (GENTAC)RegistryThis multicenter registry has enrolled over 2,600 patients withgenetically-associated thoracic aortic aneurysms, with Cornellcontributing the largest number of participants and the largestnumber of de-identified imaging studies. New findings includedocumentation of the long-term implications of emergency vs.elective proximal aortic surgery in Marfan patients, identifiedduplications in chromosome 16p13.1 as a risk factor foraortic dissections, and discovered a susceptibility for aorticaneurysms and dissections in non-Marfan patients spanningthe FBN1 locus at 15q21.1.PI: Richard Devereux, MDFunding: NIH NHLBI (subcontract from RTI International)Randomized Clinical Trial of Beta Blocker Therapy (Atenolol)vs. Angiotensin II Receptor Blocker Therapy (Losartan) inIndividuals with Marfan SyndromeFollow-up of participants has exceeded expectations andthe independent Data and Safety Monitoring Board hasrecommended study continuation after two interim reviews.Detect Fluid Early from IntrA-thoracic Impedance MoniToring(DEFEAT-PE)PI: Mary J. Roman, MDFunding: NIH U01; National Marfan FoundationA multicenter study to evaluate the safety and effectiveness ofa specific feature called the “Impedance Monitoring Feature” inthe CRT-D and ICD devices made by St. Jude Medical that hasshown to be able to detect an increase in the amount of fluid ina person’s body.PI: Steven Markowitz, MDFunding: St. Jude Medical, Inc.CVD In American Indians: Imaging and Cardiovascular Center(formerly “Cardiovascular Evaluation for the Strong Heart StudyPhase V”)This study re-evaluated, by echocardiography, carotidultrasound and computerized ECGs and performed initialpopliteal ultrasound studies in ~3,200 members of 64 multigenerationAmerican Indian families, and is in the planningphase of another examination to use magnetic resonanceimaging to assess hepatic steatosis and abdominal aortic size.PI: Richard Devereux, MDFunding: NIH U01Automated ECG Interval Measurements by Four MajorManufacturers of Computerized ElectrocardiographsThe purpose of this study is to use an FDA ECG database tocompare automated ECG intervals made by algorithms ofwidely-used ECG manufacturers.PI: Paul D. Kligfield, MDFunding: NIH U01; National Marfan FoundationPredictors and Cardiovascular Outcomes Associated with ECG-Evident Left Ventricular Hypertrophy in a Large PopulationThe purpose of this study is to evaluate LVH at baseline in1.6 million adults for cardiovascular outcomes and all-causemortality after adjusting for other known and suspectedpredictors of outcomes in this well-defined population. Thestudy will then examine serial assessment of Cornell voltageLVH on multiple ECGs in over 600,000 patients with multipleECGs over time to determine if changing levels of ECG LVH areindependent predictors of outcome in a general population.PI: Peter Okin, MDFunding: Kaiser PermanenteCoronary Artery Disease and Heart Failure with NormalEjection FractionPatients with HFNEF frequently have CAD, which may be atreatable cause of diastolic dysfunction, but the value of CADscreening in HFNEF is unknown. We propose to evaluateCAD by CCTA in patients with HFNEF and to correlate CADburden with abnormalities by echocardiography and exercisephysiology.PI: Fay Y. Lin, MDFunding: American Heart AssociationDelayed Enhancement MRI for Detection of Sub-ClinicalPapillary Muscle InfarctionThe goal is to elucidate novel structural mechanisms andpredictive indices of post-myocardial infarction mitralregurgitation (MR), with focus on papillary muscle infarctiondetected by DE-MRI tissue characterization as a longitudinalpredictor of mitral regurgitation. Adjunctive research isemploying developmental image segmentation approaches tostudy cardiac remodeling following acute myocardial infarction.PI: Jonathan Weinsaft, MDFunding: NIH K23The Natural History and Outcomes of Scleroderma Patients atHigh Risk or with Early Pulmonary HypertensionThis is an observational study of scleroderma patients todetermine the time of pathologic progression of pulmonaryhypertension from pre-pulmonary hypertension, to diagnosablepulmonary hypertension, to clinical worsening of disease.PI: Evelyn Horn, MDFunding: Gilead Sciences, Inc.; Mackley Award for Sibley Hospital72 73

Research Highlights continuedPartner 2This trial is to determine the safety and effectiveness of theEdwards SAPIEN XT device and delivery systems: NovaFlex(transfemoral access) and Ascendra2 (transapical access) inpatients with symptomatic, calcific, severe aortic stenosis.PIs: S. Chiu Wong, MD; Geoffrey Bergman, MBBSFunding: Edwards LifesciencesPartner 1The purpose of this trial is to determine the safety andeffectiveness of the device and delivery systems (transfemoraland transapical) in high risk, symptomatic subjects with severeaortic stenosis.PIs: S. Chiu Wong, MD; Geoffrey Bergman, MBBSFunding: Edwards LifesciencesRenal Denervation in Patients With Uncontrolled Hypertension(SYMPLICITY HTN-3)The purpose of this multicenter, prospective, single-blind,randomized, controlled study is to assess the safety andeffectiveness of renal denervation in subjects with uncontrolledhypertension.PI: S. Chiu Wong, MD (MPI with Samuel Mann, MD)Funding: Medtronic, Inc.Somatic Mutation in Idiopathic Ventricular TachycardiaThe purpose of this study is to test in a mouse model thehypothesis that somatic cardiac mutations in G s α duringembryogenesis, and downstream effects on cAMP, cause rightventricular outflow tract tachycardia.PI: Bruce Lerman, MDFunding: Raymond and Beverly Sackler FoundationClinical Epidemiology and Evaluative SciencesResearchCenter of Excellence in Disparities Research and CommunityEngagement (P60)Dr. Carla Boutin-Foster, as principal investigator, and Dr. MaryCharlson, as co-principal investigator, developed the Centerfor Excellence in Health Disparities Research and CommunityEngagement (CEDREC) which has over $8 million in funding.The center involves Weill Cornell Medical College, HunterCollege School of Nursing, Lincoln Medical Center/RenaissanceHealth System and New York University – Center for HealthfulBehavior Change. The specific aims of CEDREC are: create aninterdisciplinary academic and community research enterprisethat expands capacity for conducting cutting-edge andtransdisciplinary research and contribute to improving minorityhealth and reducing health disparities in cardiovascular diseaseand cancer in Central Harlem and the South Bronx; train newminority investigators to conduct original minority health andhealth disparities research while fostering their ability to obtainindependent NIH funding; and build upon existing communityacademicpartnerships and forge new collaborations that willaccelerate the dissemination of research findings to communitystakeholders, inform novel community-based programs, andbuild their capacity for research.PI: Carla Boutin-Foster, MD, MS; Co- PI: Mary E. Charlson, MDFunding: NIH/ NIMHDSCALE: Small Changes and Lasting Effects (U01)This multimillion dollar grant focuses on developing individual,family and faith-based mindful eating interventions targetedat reducing obesity in minority communities. The project isdesigned to develop and test different multilevel interventionsin proof of concept trials to lay the basis for evaluating theeffectiveness in large-scale clinical trials.PI: Mary E. Charlson, MDFunding: NIH/NHLBIEnvironmental Health Disparities Research CoreThe Environmental Health Disparities Research Core (EHCore) is nested into the existing CEDREC (see above). TheEH Core will facilitate dialogue between community-basedorganizations, local residents, and elected officials; and informresearchers, community members and policymakers throughlectures, community forums, webinars, and didactic education.PI: Carla Boutin-Foster, MD, MSFunding: NIH/NIMHDIncreasing Capacity and Public Trust: A Strategy for BuildingEffective Sustainable Community-Academic Partnerships throughMentoring, Education, Training and Workforce DevelopmentA community-academic environmental health researchcollaborative with Good Old Lower East Side (GOLES), acommunity-based housing and economic justice organizationseeking to expand its mission to include environmental justiceand public health. The collaborative creates both formaland informal linkages between the local community andacademic institutions through the employment and training oflocal residents as environmental health community organizers.PI: Beverly Watkins, MA, PhD; Co-PI: Damaris Reyes (Director,GOLES)Funding: NIEHSGOLES Healthy Aging Program (GHAP)The GHAP follows an innovative strategy of actively engagingdisadvantaged Lower East Side seniors in the planning andimplementation of health promotion and disease preventionprogramming to help community elders maintain well-beingand cognitive reserves throughout the life course.PI: Beverly Watkins, MA, PhDFunding: The Fan Fox and Leslie R. Samuels Foundation, Inc.Minority Investigator Research SupplementDr. Winston is engaged in primary data collection in the SmallChanges and Lasting Effects (SCALE) trial to examine therelationship between body image dissatisfaction and weightloss; the relationship between knowledge of health risks ofobesity and weight loss; and the relationship between socialnetwork support and weight loss.PI: Ginger Watson, MDFunding: NHLBI (Funded Under SCALE: Small Changes andLasting Effects (U01)Pain as a Mediator of Behavior ChangeThe focus of this research will be to examine the role of painas a mediator of physical activity over 12 months in a cohortof older patients with chronic cardiovascular disease.PI: Janey Peterson, EdDFunding: NIA (Funded Under Roybal P30 Center Grant“Improving the Management of Pain in Later Life”)Trial Using Motivational Interviewing and Positive Affect andSelf-Affirmation in Hypertension (TRIUMPH)TRIUMPH is a randomized controlled trial which builds on thefindings of previous studies by testing a novel and multifacetedbehavioral intervention framed on social cognitive theory,positive affect theory, and self-affirmation theory amongAfrican American patients with uncontrolled hypertension.PI: Carla Boutin-Foster, MD, MSFunding: NIH/NIMHDOASIS: Osteoarthritis Self-Improvement StudyThis study tests an intervention framed upon the HealthPromotion Model among African-Americans with a diagnosisof osteoarthritis to determine its impact on intention toundergo arthroscopic evaluation.PI: Michael Parks, MD (HSS); Co-PI: Carla Boutin-Foster, MD, MSFunding: Zimmer CorporationClinical PharmacologyA New Drug to Activate Peripheral Histamine 3 ReceptorsActivating the histamine 3 receptor lowers the epinephrine inthe ischemic heart and should reduce arrhythmias. A series ofnovel compounds was made and screened to find a drug thatwill reduce arrhythmias in ischemic hearts.PI: Marcus M. Reidenberg, MDFunding: NIHEmergency MedicineNeurological Emergencies Treatment Trials (NETT)The NETT trials is a five-year grant to create a network oftertiary care emergency departments capable of conductingresearch in neurological emergency care. Recruitment isongoing for the Platelet-Oriented Inhibition in New TIA Trial(POINT) whereas the Rapid Anticonvulsant Medication Prior toArrival Trial (RAMPART) was completed.PIs (WC Site): Neal Flomenbaum, MD; Matthew Fink, MD(Weill Cornell Neurology)Funding: NIH/NINDSEndocrinology, Diabetes and MetabolismAmerican Recovery and Reinvestment Act AdministrativeSupplements for Comparative Effectiveness Research (CER)Workforce DevelopmentThis supplement has two objectives: to strengthen currentformal educational opportunities in CER by increasing thescope and offerings in the track in outcomes and healthservices research; to offer an additional year of training in CERas a KL2 scholar to students who are enrolled in, or who haveobtained, either a Master’s degree or certificate in clinical andtranslational research.PI: Julianne L. Imperato-McGinley, MD; Co-PI: Alvin Mushlin, MDFunding: NIHNIH T32 Training GrantThe Endocrine Research Training Program at Weill Cornell isa Tri-Institutional endeavor with participation from MemorialSloan-Kettering Cancer Center and The Rockefeller University.PI: Julianne L. Imperato-McGinley, MDFunding: NIHEpidemiology of Diabetes Intervention and Complications(EDIC) TrialThe EDIC trial is a continuation study involving the DiabetesControl and Complications Trial (DCCT) cohort. The EDIC studyhas now followed nearly 1,400 individuals with type 1 diabetesfor over 30 years.PI: David Brillon, MDFunding: NIH/NIDDKAction to Control Cardiovascular Risk in Diabetes (ACCORD) StudyThe ACCORD trial compares intensive blood glucose, lipid andblood pressure control in over 10,000 persons with type 2 diabetes.PI: David Brillon, MDFunding: NIH/NHLBI74 75

Research Highlights continuedClinical and Translational Science CenterThis is a major center grant to facilitate clinical andtranslational research among multiple partnering institutions.PI: Julianne L. Imperato-McGinley, MDFunding: Astra ZenecaThe study is investigating the efficacy by sustained virologicresponse (SVR) 12 weeks after planned end of therapy (SVR12) ofa 12-week or 24-week dual or triple regimen, including TMC435(150mg once daily) plus PSI7977 (400mg once daily) with orwithout ribavirin (RBV) (1000-1200mg/day) in HCV genotype1-infected subjects who are null responders to previouspeginterferon (PegINF/RBV) therapy or HCV treatment-naïve.Gastroenterology and HepatologyA Phase 3 Study with Asunaprevir and Daclatasvir (DUAL)for Null or Partial Responders to Peginterferon Alfa-2a andRibavirin (P/R), Intolerant or Ineligible to P/R Subjects andTreatment Naïve Subjects with Chronic Hepatitis C Genotype 1bInfection (AI447028)The study seeks to estimate efficacy, as determined by theproportion of subjects with a 12 week sustained viral response(SVR 12), defined as HCV RNA

Research Highlights continuedA Prospective, Longitudinal, and Multicenter Study to GetDefinitive Data on Diagnostic Performance of pCLE forIndeterminate Biliary StrictureWe are evaluating the diagnostic value of probe based confocallaser endomicroscopy for the diagnosis of benign or malignantbiliary strictures.PI: Michel Kahaleh, MDFunding: MaunaKea Tec, ParisAXIOS Stent and Delivery System for Endoscopic Drainageof Pancreatic Pseudocysts: A Multicenter, Prospective,Single-arm StudyWe are evaluating the safety and efficacy of a novel stent forthe endoscopic drainage of pancreatic pseudocysts. The uniquestent has a dog bone design to prevent migration of the stent,thus enabling safer and more efficient drainage of pseudocystduring endoscopic therapy.PI: Michel Kahaleh, MDFunding: Xlumena, Inc.Blood-based Biomarkers of Obesity-induced BreastInflammationThe overarching goal of this project is to determine if a noninvasivesignature of white adipose tissue inflammation canbe identified. A multifaceted strategy that includes plasmametabolite profiling is being employed.PI: Andrew J. Dannenberg, MDFunding: NIH/NCIChemokine 25-induced Signaling Suppresses Colon CancerInvasion and MetastasisWe identified the CCR9/CCL25 axis as an important prognosticmechanism for colorectal cancer as a mechanism preventingmetastasis lost in late stage tumors.PI: Steven Lipkin, MD, PhDFunding: NCI/ NSFmiR-23a Promotes the Transition from Indolent to InvasiveColorectal CancerPI: Felice Schnoll-Sussman, MDFunding: OnconomeBehavior and Lifestyle Changes in Barrett’s EsophagusSurvey of patients with Barrett’s esophagus to look at socialand relationship factors that may affect the quality of life andhealth behaviors, as well as patient’s attitudes about theirhealth behaviors.PI: Felice Schnoll-Sussman, MDFunding: NCIHereditary Colon Cancer SyndromesThe primary goal is to help create an infrastructure resourcethat can enable the identification of genetic causes of cancerand environmental modifiers of cancer risk and preventthe death from CRC in patients with hereditary colorectalsyndromes.PI: Felice Schnoll-Sussman, MDFunding: Bloomingdale’s Fund of the Macy’s FoundationThe objective of the present study is to establish the safety andefficacy of four administrations of PROCHYMAL in subjectsexperiencing treatment-refractory, moderate-to-severe Crohn’sdisease.PI: Ellen Scherl, MDFunding: Osiris TherapeuticsA Multicenter, Open-label Study to Evaluate the Safety ofPROCHYMAL ® (remestemcel-L) Intravenous Infusion inSubjects who have Received Previous Remestemcel-L InductionTreatment for Treatment-refractory Moderate-to-severeCrohn’s DiseaseThe objective of the study is to offer a defined course of openlabelPROCHYMAL treatment to all subjects who enroll in theparent study, Protocol 603, to evaluate the safety in subjectswith active Crohn’s disease who are resistant to standardCrohn’s disease therapies.PI: Ellen Scherl, MDFunding: Osiris TherapeuticsIdentification of Early Biomarkers/Targets for Cancer PreventionUsing Metabolomic ScreeningThe major goal of the project is to use metabolomics for theearly detection of experimental colorectal neoplasia. Based onpromising preclinical findings, efforts are under way to extendthis line of investigation to humans.PI: Andrew J. Dannenberg, MDFunding: NIH/NCIMolecular Determinants of Intestinal InflammationThis project seeks to elucidate the mechanisms that controlmucosal homeostasis with a focus on inflammation, stemcell biology and mucosal regeneration. The ultimate goal is todevelop new strategies to prevent or treat inflammatory boweldisease.PI: Andrew J. Dannenberg, MDFunding: New York Crohn’s FoundationObesity, Inflammation and Breast CancerThe mechanistic links between obesity, inflammation andbreast cancer are being defined. An improved understandingof mechanism is already providing the basis for experimentalinterventions in women with the long-term goal of reducing therisk of cancer.We identified microRNAs 23 and 27 as prognostic markers forcolon cancer.PI: Haiyuan Yu, PhD (Cornell University, Ithaca); Steven Lipkin,MD, PhDFunding: NCIThree-dimensional Reconstruction of Protein NetworksProvides Insight into Human Genetic DiseaseWe identified a new methodology using protein-interactomenetworks to classify genetic variants as causative mutations orbenign polymorphims.PI: Haiyuam Yu (Cornell University, Ithaca); Steven Lipkin, MD, PhDFunding: CTSC Pilot ProjectNovel Proteonomic Blood-based Serology for Colon CancerScreeningExamination of the accuracy of a novel serum protein-basedassay for detecting/ruling out colon cancer in subjectsundergoing routine colonoscopy and to assess the operatingcharacteristics of the assay in subjects with suspected orpreviously diagnosed colon cancer.PI: Felice Schnoll-Sussman, MDFunding: OnconomeA Phase 3, Randomized, Double-blind, Placebo-controlled,Parallel-group, Multicenter Study to Evaluate the Safety andEfficacy of Ustekinumab Induction Therapy in Subjects withModerately to Severely Active Crohn’s Disease Who Have Failedor Are Intolerant to TNF Antagonist Therapy (UNITI-1)This study examines ustekinumab (an antibody medication thatinhibits the inflammatory proteins IL-12 and IL-23) vs. a placebo(otherwise identical except without the ustekinumab antibody)given intravenously (by an IV) in adults with moderately toseverely active Crohn’s disease.PI: Ellen Scherl, MDFunding: Janssen Research and DevelopmentA Phase 3, Randomized, Double-blind, Placebo-controlled,Parallel-group, Multicenter Study to Evaluate the Safety andEfficacy of Ustekinumab Maintenance Therapy in Subjects withModerately to Severely Active Crohn’s Disease (IMUNITI)Study to determine whether additional ustekinumab treatmentis beneficial in patients with moderately to severely activeCrohn’s disease who initially had a clinical response to IVustekinumab in one of the 2 initial induction studies ([“UNITI-1”]or [“UNITI-2”]).PI: Ellen Scherl, MDFunding: Janssen Research and DevelopmentA Multicenter National Prospective Study of Pregnancy andNeonatal Outcomes in Women with Inflammatory BowelDiseaseThe purpose of this study is to determine whether the rates ofcongenital malformations, spontaneous abortion, preterm birthand small for gestational age (SGA) infants in a prospectivenational sample of women from the United States with IBDexposed to azathioprine/6MP or anti-TNF therapy are greaterthan those among IBD-affected women not exposed to thesemedications.PI: Ellen Scherl, MD, in collaboration with Dr. Uma Mahadevan-Velayos, UCSF Center for Colitis and Crohn’s Disease, CaliforniaFunding: Crohn’s Colitis Foundation of America Clinical AllianceProspective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Comparing REMICADE ® (infliximab) andPlacebo in the Prevention of Recurrence in Crohn’s DiseasePatients Undergoing Surgical Resection Who Are at anIncreased Risk of Recurrence (PREVENT)The purpose of this study is to evaluate the therapeutic benefit(prevention of clinical and endoscopic disease recurrence)and safety of infliximab in the treatment of patients who are atan increased risk of recurrence of active CD after ileocolonicresection.PI: Ellen Scherl, MDFunding: JanssenPI: Andrew J. Dannenberg, MDFunding: NIH/NCI; Breast Cancer Research Foundation;MSKCC Metastasis Research CenterThe Role of H. Pylori in Changing the Tumor Microenvironmentand Impact on Gastric Cancer CarcinogenesisObtaining biopsies of patients with H. pylori and gastric cancerto determine how the H. pylori infection can lead to gastriccancer, as well as provide information on possible interventiontreatments that can be administered prior to the developmentof advanced gastric cancer.A Phase III, Multicenter, Placebo-controlled, Randomized,Double-blind Study to Evaluate the Safety and Efficacy ofPROCHYMAL (ex vivo cultured adult human mesenchymalstem cells) Intravenous Infusion for the Induction of Remissionin Subjects Experiencing Treatment-refractory Moderate-tosevereCrohn’s DiseaseStrategies by which HCV Evaded the Innate Immune System inHumanized Liver MiceIn order to establish a chronic infection hepatitis C virus (HCV)needs to inactivate the innate immune response in hepatocytes.Several innate immune pathways have been implicated in HCV78 79

Research Highlights continuedinfection and for this project we focus on the RIG-I helicase andTLR7 signaling pathways, both of which can be inactivated bythe viral protease. By using human liver chimeric mice in whichprotease-resistant signaling proteins have been overexpressedin human hepatocytes, we examine if inactivation of thesepathways can prevent HCV from establishing infection.PI: Ype de Jong, MD, PhDFunding: NIDDKBuilding Care Bridges: Teaching Interdisciplinary Teams aboutTransitional CareDevelopment and implementation of educational curriculaand interventions that teach inter-professional teams thenecessary skills for effective communication, collaboration andcoordination of care at points of transition.PI: Sharda Ramsaroop, MDFunding: HRSA K01Screen for Factors that Influence Engraftment of FetalHepatoblasts and iPS-derived Hepatocyte-like Cells in MiceFetal human hepatoblasts and iPS-derived hepatocyte-likecells (iHLCs) share an immature phenotype. In contrast toadult human hepatocytes, both fetal hepatoblasts and iHLCsfail to repopulate livers of immunodeficient FAH-/- mice, thatsuffer from liver failure. We are screening lentiviral librariesexpressing human shRNAs or cDNAs in their ability to enhanceengraftment of both cell types in immunodeficient FAH-/- mice.PI: Ype de Jong, MD, PhDFunding: Helmsley Foundation pilot award (through TheRockefeller University)Research Supplements to Promote Diversity in Health-RelatedResearch/Improving the Management of Pain in Later LifeUtilizing 12 month longitudinal data for percutaneous coronaryintervention (PCI) patients, this study will determine if pain isa mediator of health behavior change over 12 months; assessbehavior change patterns over 12 months, stratifying for degreeof pain, depression and/or stress; and evaluate the effect ofpain on quality of life, combined major cardiac and neurologicmorbidity/mortality and hospitalizations over 12 months.PI: M. Carrington Reid, MD, PhD; Recipient: Peterson, Janey, EdDFunding: NIH/NIAGeriatrics and Palliative MedicineEdward R. Roybal Center for Research on Applied GerontologyCornell-Columbia Translational Research Institute on Pain inLater Life (TRIPLL)The grant creates a multi-institutional and interdisciplinarycollaboration focused on implementing innovative strategiesfor improving pain management among older adults.PI: M. Carrington Reid, MD, PhDFunding: NIH P30K24 Mid-Career Investigator Award in Patient-OrientedResearch in AgingThis program is intended to extend mentorship in agingresearch and to create a national mentorship program forjunior investigators in the field of elder abuse.PI: Mark Lachs, MDFunding: NIH K24Providing Care Along a Continuum: Geriatric Palliative CareTraining for Interdisciplinary TeamsThis grant fosters teaching, curriculum development andevaluation skills in training interdisciplinary providers ingeriatric palliative care.PI: Sonal Mehta, MDFunding: HRSA K01Treating Pain to Reduce Disability Among Older HomeHealth PatientsThe overall goal of this comparative effectiveness research(CER) study is to reduce disability among older home healthpatients by treating their pain more effectively. The study willcompare the effectiveness of usual care provided to older homehealth patients with activity-limited pain to usual care plusinstruction by physical therapists (PTs) in a cognitive-behavioralpain self-management program (CBPSM).PI: M. Carrington Reid, MD, PhD; Recipient: ChristopherMurtaugh, PhD, Visiting Nurse ServiceFunding: AHRQHartford Center of Excellence in Geriatric MedicineThe overarching goal of the Hartford Center of Excellence is toattract and train future academic leaders in geriatric medicine.PI: M. Carrington Reid, MDFunding: The John A. Hartford FoundationAdvancing the Quality of Palliative Care through ClinicianEducationThe goal of this work is to develop, implement and seek waysto sustain a palliative care educational program at NYP/WCthat will establish a campus-wide educational initiative thatwill complement and enhance the provision of palliative careservices.PI: Ronald Adelman, MDFunding: The Altman FoundationNYC Elder Abuse CenterThe NYC Elder Abuse Center is a collaborative approach toprovide a much-needed multidisciplinary team (MDT) of expertsto coordinate care and create solutions for the growing numberof complex cases of elder abuse in NYC.PIs: Mark Lachs, MD; Risa Breckman, LCSWFunding: Fan Fox and Leslie R. Samuels Foundation; BuckhantzFoundation; Gimbel Foundation; Jarvie Foundation; DHHSAdministration on Aging (sub-contract with UC-Irvine); Grace B.Kerr FoundationDeveloping Interdisciplinary Champions to Advance Hospital-Based Palliative CareThe project promotes the practice and principles of palliativecare throughout NYP/WC by developing and supportingpalliative care champions in nursing and social work in orderto expand exposure to, competencies in, and appreciation for,delivering quality care to patients with life-threatening illnessand their families.PI: Ronald Adelman, MDFunding: Fan Fox and Leslie R. Samuels Foundation; The NewYork Community TrustLiz Claiborne Center for Humanism in MedicineAn educational center for health care professionals andtrainees in multiple disciplines. Its mission is to enhance andintegrate the awareness, attitudes, knowledge, and skills ofthe principles of palliative care, and to promote the profile andpractice of medical humanism throughout the institution.PIs: Ronald Adelman, MD; Randi Diamond, MDFunding: Liz Claiborne/Art Ortenberg Foundation80 81

Research Highlights continuedHematology and Medical OncologyMolecular Targeting of Diffuse Large B-cell LymphomaEpigenetic Heterogeneity and Evolution in LeukemiaA Mouse Model for Human Gastrointestinal Stromal TumorEpigenetic Therapy for Diffuse Large B Cell LymphomaThe study seeks to establish the activity and safety of5’azacytidine (MTI) and MGCD0103 (HDI) combinationtherapy in patients with recurrent DLBCL, and correlateresponse with specific epigenetic signatures.PI: John Leonard, MDFunding: V FoundationDifferentiation Therapy for B-cell LymphomasThe goals of the study are to Identify the target genes of theBCL6-MTA3 complex; define the biochemical contributionof the BCL6-MTA3 complex to repression of differentiationrelated target genes; develop a peptidomimetic inhibitorof the BCL6-MTA3 interaction; and determine the antilymphomaimpact of MTA3 blockade in vitro and in vivo.PI: Ari Melnick, MDFunding: Burroughs Wellcome FundThis study is testing the spectrum of lymphomas responsive toRI-BPI; and translated RI-BPI for use in clinical trials.PI: Ari Melnick, MDFunding: NIH/NCITranscriptional Silencing by the Bcl-6 OncoproteinThe study seeks to determine the mechanism of actionof the BCL6 transcriptional repressor.PI: Ari Melnick, MDFunding: NIH/NCITargeting the Heat Shock Response for the Therapy of DLBCLThe goal of the study is to determine the mechanism ofaction of Hsp90 inhibitors in DLBCL, and the spectrumof B-cell lymphomas that respond to Hsp90 inhibitors.PI: Ari Melnick, MDFunding: NIH/NCIThe study hypothesizes that deregulation of the DNAmethylation machinery by IDH1, IDH2 and TET2 mutationsinduces a state of epigenetic instability in whichsubpopulations of leukemia cells acquire varying degreesof aberrant promoter methylation. We predict that thisdiversification continues as the disease progresses, leadingto a clonally heterogeneous neoplasm in which differentsubclones are characterized by distinct gene methylation andgene expression patterns.PI: Ari Melnick, MDFunding: NIH/NCI (PS-OC)Therapeutic Targeting of the MALT1 Protein forChemoresistant LymphomasThe research seeks to prove that MALT1 is a therapeutic targetin ABC-DLBCLs, and to develop small molecule inhibitors thatwill be translated for use in clinical trials.PI: Ari Melnick, MDFunding: Leukemia & Lymphoma SocietyThe project aims to investigate changes taking placeduring tumor development and progression with age inKitV558?/+ mice.PI: Joseph M. Scandura, MD, PhDFunding: NIH/NCI (Subcontract from MSKCC)Molecular Substrates of Translation at the SynapseThe goals are: to identify and characterize synaptically localizedmRNAs in mouse hippocampus; and to identify and characterizesynaptically localized microRNAs in mouse hippocampus.PI: Doron Betel, PhDFunding: NIH (subcontract from Scripps)Cellular Metabolism and Serum Metabolomic Profiling toIdentify Prognostic Markers and Novel Therapeutic Targets innon-Hodgkin LymphomaThe purpose of the study is to find new ways to detectlymphomas before they become an incurable and aggressivedisease and to find new cures by improving the currentlyavailable treatment. We want to detect lymphomas using a dropof blood that we will process to separate thousands of chemicalcomponents.PI: Leandro Cerchietti, MDFunding: Irma T. Hirschl TrustIdentification of Prognostic Markers and Novel TherapeuticTargets in non-Hodgkin Lymphoma Patients by ComprehensiveMetabolomicsWe propose to harness these methods to understand thebasic mechanisms mediating altered metabolic status of Bcell lymphomas and to develop diagnostic and therapeuticstrategies based on metabolic signatures.PI: Leandro Cerchietti, MDFunding: Doris DukeRole of HSF1 in the Physiology and Malignancy of GerminalCentersThe study seeks to determine whether genetic andpharmacological ablation of HSF1 affect GC formation andimmunoglobulin affinity maturation.PI: Leandro Cerchietti, MDFunding: American Society of HematologyGenetic and Epigenetic Basis of Relapse in Acute MyeloidLeukemiaNCI Mentored Clinical Scientist Research Career DevelopmentAward to Promote Diversity (K08).PI: Francine Garrett-Bakelman, MD, PhDFunding: NIH/NCI82 83

Research Highlights continuedSOP Development for Cabazitaxel Clinical TrialEnhancing BDNF Trafficking and Secretion in HDImmunologic and Pharmacologic Studies in AllotransplantTuberculosis Drug Accelerator ProgramThis contract includes a subcontract to Cornell University,Ithaca (Dr. Brian Kirby). This is a start-up contract fundingpreparation and development of SOP for the upcoming clinicaltrial. Prototype microfluidic device developed by Cornell will betested for further use in full clinical trial Cabaz_L_06056.PI: Paraskevi Giannakakou, PhDFunding: Sanofi AventisMechanism of Action and Resistance of Cabazitaxelin Prostate CancerThe study aims to determine the mechanism of action andresistance to Cabazitaxel; to investigate the molecularmechanism underlying the efficacy of Cabazitaxel in DocetaxelresistantProstate cancer patients; and to identify the CRPCpatient population that would best benefit from Cabazitaxeltreatment.PI: Paraskevi Giannakakou, PhDFunding: Sanofi AventisA Role for Elevated Autophagy in Survival and Chemoresistanceof Leukemia Stem CellsThe study will address whether autophagy represents a feasibletherapeutic target and/or sensitizes LSCs to induction therapy,diminishing the likelihood of relapse.PI: Monica Guzman, PhDFunding: NIH/NCIStrategies to Eliminate Chemoresistant Leukemia Stem CellsDuring RemissionThe long-term goal of this proposal is to improve therapeuticoutcomes in acute myeloid leukemia (AML) by ablating residualleukemia stem cells (LSCs) in patients who have achievedcomplete remission.PI: Monica Guzman, PhDFunding: Leukemia & Lymphoma SocietySignificance and Mechanisms of Genomic Diversity in AMLStem CellsWe hypothesize that LSCs represent a center of high genomicdiversity, which drives relapse and the emergence of refractoryAML clones. LSC diversity at single cell resolution has not beenexamined to date.PI: Duane Hassane, PhDFunding: Leukemia & Lymphoma SocietyWe will examine, using newly generated reagents that maximizedetection of endogenous BDNF (the bdnf-HA knockin mouse),how BDNF support of striatal neurons is impaired in HD.PI: Barbara Hempstead, MD, PhDFunding: CHDI Foundation Inc.Stem Cell Alterations in Lenalidomide Treated MyelomaPatientsThe overall goal of this proposal is to elucidate the mechanismsthat drive second primary malignancies (SPMs) in patients withmultiple myeloma (MM) undergoing long-term lenalidomidetreatment.PI: Ruben Niesvizky, MDFunding: Leukemia & Lymphoma SocietyBiophysical Activation of the Vascular Niche: Mechanisms forLeukemia Survival and RelapseThe project aims to investigate changes taking place duringtumor development and progression with age in KitV558?/+mice.PI: Joseph M. Scandura, MDFunding: NIH/NCI (subcontract)Next-Generation Sequencing to Evaluate TranscriptomicChanges Associated with H. pylori Infection and Gastric CancerCarcinogenesisThe study seeks to gain valuable insight into the gastricbacterial content in each patient. We will have identifiedcandidate pathways that may be responsible for gastric cancercarcinogenesis associated with chronic H. pylori infection andprovide a valuable dataset for future investigation of the hostpathogeninteraction.PI: Manish Shah, MDFunding: DeGregorio Family FoundationIntegration of Epigenetic and Genomic Changes in ChronicLymphocyticWe will perform microarray experiments, Mass Array Epitypingdata analysis, in vitro validation experiments.PI: Rita Shaknovich, MDFunding: Leukemia Research FoundationThe overall objective of the K24 is to develop a clinicalresearch program in transplantation that focuses ontransplant immunology and on transplant pharmacology/pharmacogenomics while preparing the next generation ofinvestigators in this area.PI: Koen van Besien, MDFunding: NIH/NCIThe Molecular Basis of Neuroendocrine Prostate Cancer(NEPC)The broad objectives are to discover the genetic alterationsfound in NEPC, identify therapeutically targetable somaticmutations, and develop new treatment strategies for patientswith NEPC.PI: Himisha Beltran, MDFunding: Prostate Cancer FoundationFractionated, Dual Targeted Radioimmunotherapy for FollicularLymphoma (FL)The project aims to determine the biodistribution, tumorlocalization and pharmacokinetics of radiolabeled epratuzumabtherapy, as well as any changes in targeting due topretreatment with veltuzumab, and to establish the safety andefficacy of fractionated 90Y-epratuzumab tetraxetan (anti-CD22)given in combination with veltuzumab (anti-CD20) in patientswith previously untreated, intermediate or high risk FL.PI: Peter Martin, MDFunding: NIH/NCIPilot ProjectThis is a Pilot Project that aims to stimulate mutual projectdevelopment between two campuses. It follows the lines ofresearch in a main PSOC grant and provides additional fundingfor the main project.PI: David M. Nanus, MDFunding: PS-OC Group, IthacaInfectious DiseasesMetabolosomes: The Organizing Principle of TB LatencyThis grant provides continuing support to test the idea thatMycobacterium tuberculosis is not just an unorganized bag ofmolecules, but rather, a highly structured cell that makes useof specific intracellular structures akin to metabolic organellesto enter and reside in an antibiotic tolerant state of latency.Knowledge of such structures holds the potential to shorten TBchemotherapies from months to days.PI: Kyu Y. Rhee, MD, PhDFunding: Bill and Melinda Gates FoundationThis grant provides additional support to ongoing efforts toaugment the TB drug development toolbox with state-of-theartmetabolomic profiling technologies. The specific goals ofsuch tools are to provide direct biochemical readouts of theintrabacterial fates and actions of new and existing TB drugswithin Mtb.PI: Kyu Y. Rhee, MD, PhDFunding: Bill and Melinda Gates FoundationEndothelial Progenitor Cells and the Pathogenesis of CerebralMalariaIn collaboration with investigators at the Noguchi MemorialInstitute of Medical Research (NMIMR) of the University ofGhana in Accra, the role of circulating endothelial progenitorcells in the pathogenesis of cerebral malaria is beinginvestigated. The goal is to gain a better understanding of therole of microvascular damage and repair in the pathogenesisof the disease. The study may provide information supportingthe use of novel augmentative therapies that promotemicrovascular repair mediated by circulating endothelialprogenitor cells.PI: Linnie M. Golightly, MDFunding: NIH R01A Non-invasive Cell Phone Imaging Probe for DiagnosingMalariaIn collaboration with Alberto Bilenca of Ben-Gurion Universityof the Negev in Israel, Dr. Golightly is working to develop acell phone imaging system that can non-invasively detectmalaria parasites in the blood. The system uses a polarizedlaser to detect hemozoin crystals indicative of malaria parasiteinfection, as well as micro-obstructions in the circulatorysystem that result from the infection. Ultimate testing of thedevice is planned in Ghana in collaboration with colleagues atthe NMIMR.PI: Linnie M. Golightly, MDFunding: Bill and Melinda Gates Foundation - Grand ChallengesSignaling a Stop to CholeraIn collaboration with John March, a Bio-Engineer at CornellUniversity, a novel cholera prophylactic is being developed. Thebacteria uses cell-to-cell signaling to coordinate its growthand virulence in the human gut. Strains of commensal bacteriathat naturally reside in the gut are being engineered to expresschemical signals used by cholera to abort the colonizationprocess and allow the pathogen to pass through the GI systemwithout causing symptoms. Ultimate testing is planned in Haiti.PI: Linnie M. Golightly, MDFunding: Bill and Melinda Gates Foundation - Grand Challenges84 85

Benefits of Universal Gown and Gloving (BUGG)NYP/Weill Cornell was one of 20 US hospitals that participatedin a multicenter, randomized-controlled trial of universalgown and gloving for the prevention of healthcare-associatedinfections in intensive care units.PI: David P. Calfee, MD; Co-Is: Michael Satlin, MD; David Berlin,MD (Pulmonary/Critical Care); Oren Friedman, MD (Pulmonary/Critical Care); and Kirsis Ham, NPFunding: Agency for Healthcare Research and Quality (AHRQ)persistent immune dysfunction due to a delay in ART initiationvs. a randomized control group of women receiving immediateART. We will also determine the effect of HIV and HIV/HPV coinfectionon the expression of genes that mediate the synthesis,catabolism, and signaling of prostaglandin E 2in cervical cellsobtained from a subset of the HIV-infected women in theEarly versus Deferred ART Cohort and a control group of HIVuninfectedwomen.PI: Daniel W. Fitzgerald, MD; Co-I: Andrew Dannenberg, MDFunding: NIH R01Cornell Clinical Trials UnitThe NIH-supported HIV clinical trials unit conducts trials in HIVtreatment and prevention, complications of HIV and its therapies,immune-based therapies, and important co-infections in bothHIV-infected and -uninfected individuals, such as hepatitis C,influenza, and human papillomavirus (HPV). New initiatives arestudies of pre-exposure prophylaxis (PrEP) for HIV preventionand newer investigational drugs for hepatitis C infection.PI: Roy Gulick, MD, MPH; Co-Is: Marshall Glesby, MD; IraJacobson, MD (Gastroenterology); Kristen Marks, MD; BruceSchackman, PhD (Public Health); Mary Vogler, MD; TimothyWilkin, MDFunding: NIH U01Doxycycline for COPD in HIV-Infected PatientsThis pilot study aims to test the hypothesis that the commonlyused antibiotic, doxycycline, will inhibit enzymes in the lungcalled matrix metalloproteinases, which are upregulatedin HIV-infected smokers and may contribute to acceleratedemphysema.PIs: Robert Kaner, MD (Department of Genetic Medicine;Division of Pulmonary and Critical Care); Marshall Glesby,MD, PhD. Co-Is: Thomas Walsh, MD; Dominic Falcone, PhD(Departments of Pathology, Cell Biology and Anatomy)Funding: NIH R34Regulation of T cell Activation in Leprosy and its ReversalReactionsThis grant provides support for research in Brazil on theregulation of T cell activation in leprosy and its reversal reactions.The aims are to: determine the role of leprosy diagnostic delayand disease progression on the frequency, severity, and responseto treatment of RR in leprosy patients in Natal, Brazil; anddetermine the extent to which the immunoregulatory moleculesof T cell activation contribute to the clinical phenotype of leprosydisease and development of RR.PI: Kathryn Dupnik, MD; Co-I: Warren Johnson, Jr., MDFunding: Burroughs WellcomeMedical EthicsNeuroethics and Disorders of Consciousness II: ExpandingResearch Infrastructure and ScholarshipWe seek to assess the scope of misdiagnosis and neglectof patients with disorders of consciousness, address theethical imperative to develop new measures of diagnosis andtreatment, and to aid in the development of the Center for theAdvanced Study of Brain Injury (CASBI) at Weill Cornell MedicalCollege and The Rockefeller University Hospital.PI: Joseph J. Fins, MDFunding: The Buster FoundationFemale Urogenital Schistosomiasis in Women in Rural TanzaniaThis project has enrolled approximately 900 adolescent girlsand women living in rural Tanzania and documented thatwomen with both S. haematobium and S. mansoni infectionshad an ~5 times greater odds of being HIV-infected than womenwithout schistosomiasis. Research is now underway to studyprospectively whether antecedent schistosomiasis increasesthe risk of HIV acquisition and to explore alterations in mucosalimmunity that cause the increased susceptibility to HIVinfection in women with schistosomiasis.PI: Jennifer A. Downs, MD; Co-Is: Warren D. Johnson, Jr., MD;Daniel W. Fitzgerald, MDFunding: Clinical and Translational Science Center (CTSC),WCMCNatural History and Pathogenesis of HPV/HIV Co-infectionin HaitiThis grant provides support to compare the natural historyof oncogenic HPV infection in HIV-1 infected women withuncontrolled HIV replication, low nadir CD4 count, andClinical and Translational Science AwardThe goal of this project is to support, advance, and promoteclinical and translational research enterprises at WCMC andcollaborating institutions.Role: Bioethicist and Head, Bioethics CorePI: Julianne L. Imperato-McGinley, MDFunding: NIHNephrology & HypertensionBypass Angioplasty Revascularization Investigation in Type 2Diabetes (BARI2D)In the Bari 2D trial, 2,368 patients with both T2DM and heartdisease were randomly assigned to undergo either promptrevascularization with intensive medical therapy or intensivemedical therapy alone, and to undergo either insulinsensitizationor insulin-provision therapy.Site PI: Phyllis August, MDFunding: NIH N01 (ACCORD)8687

Research Highlights continuedThe Action to Control Cardiovascular Risk in Diabetes StudyGroup; Effects of Intensive Glucose Lowering in Type 2 DiabetesIn the ACCORD Study, 10,000 T2DM, subjects were randomlyassigned to an intensive regimen for glycemic control orstandard therapy and followed for five years.Using mTOR Inhibitors in the Prevention of BK NephropathyThis is an open-label, randomized, prospective study to examinewhether substitution of Tacrolimus with Sirolimus, an mTORinhibitor, lowers BK viremia in post-transplant patients betterthan the typical reduction of calcineurin inhibition by Tacrolimus.options: strengthen the diuretic regimen, usually with addition of apotassium-sparing agent such as spironolactone; treat neurogenichypertension with combined alpha- and beta-blockade.PI: Samuel Mann, MDFunding: Medtronic Ardian, Inc.Biomolecular Markers Predictive/Diagnostic of RenalAllograft StatusThe main objective is to test the hypothesis that mRNA/miRNAexpression patterns of intraoperative renal allograft biopsies arepredictive of acute rejection and chronic allograft nephropathy.Site PI: Phyllis August, MDFunding: NIHTargeting Inflammation Using Salsalate for Type 2 DiabetesstageII (TNSAL –T2D)The primary objective of the study is to determine whethersalicylates represents a new pharmacological option fordiabetes management.Site Co-PI: Phyllis August, MDFunding: NIHKidney Disease in Type 2 Diabetes Mellitus: BiomarkerDiscovery and Novel TherapeuticsThe main objectives are development of a novel treatmentcombination of an oral vitamin D analogue and an angiotensinreceptor blocker for preventing progression of kidney diseasein patients with type 2 diabetes, and novel and noninvasivemolecular tests for identifying those at risk for progression andfor suggesting mechanisms for treatment success/failure.PI: Phyllis August, MDFunding: QNRF NPRPPIs: Darshana Dadhania, MD, MS; Sumit Mohan, MD, MPH(Collaborative Project with Columbia University)Funding: Pfizer, Inc.Intestinal Microbiota and Acute Rejection of Renal AllograftsThe overall objective is to discover an association betweenintestinal bacteria and rejection of transplanted kidneys.PI: John R. Lee, MDFunding: NIH/CTSCNebivolol vs. Metoprolol: Comparative Effects on Fatigue and QOLA frequently encountered side effect of beta-blockers is fatigue.Nebivolol, a new beta-blocker with vasodilating effects dueto increased secretion of nitric oxide, appears less likely tocause side effects such as fatigue, impairment of glucosemetabolism, and sexual dysfunction. This study is a doubleblindcrossover trial of nebivolol vs. metoprolol (the best-sellingbeta-blocker), 8 weeks on each drug, with the end points offatigue, and treadmill time.PI: Samuel Mann, MDFunding: Forest Research Institute, Inc.Biomolecular Markers of Renal Allograft StatusThe overall objective is to discover and validate biomarkersto predict acute rejection and chronic allograft nephropathyof human kidney transplant recipients using intragrafttranscriptome sequencing and to develop noninvasivebiomarkers of acute rejection and chronic allograft nephropathyby messengerRNA/microRNA profiling of urinary andperipheral blood cells.PI: Thangamani Muthukumar, MDFunding: NIH/NIAIDBiomolecular Markers for Safe Minimization ofImmunosuppressionThe aim of this project is to investigate whether urinary cell/peripheral blood cell/allograft mRNA/miRNA profiles areinformative of clinical outcomes in renal allograft recipientsrandomized to a standard dose tacrolimus vs. low dosetacrolimus regimen.PI: Manikkam Suthanthiran, MDFunding: NIH-2 R37PI: Manikkam Suthanthiran, MDFunding: QNRF NPRPPulmonary & Critical Care MedicineNeurophysiologic Studies of Neurological Disorders ofConsciousness Prospective Study of Survivors of CardiacArrest Treated with Therapeutic HypothermiaA clinical study of patients who survive cardiac arrest whoseneurologic injury is being treated with therapeutic hypothermiain our intensive care units.PI: Nicholas Schiff, MD; Co-I: David Berlin, MDFunding: James S. McDonnell FoundationPredictors of Oxidative Stress in Heart Failure Patients withCheyne-Stokes RespirationThe study investigates of the role of increased levels of oxidativestress in patients with heart failure and Cheyne-Stokesrespiration compared with healthy controls.PI: Ana C. Krieger, MD, MPHFunding: American Heart Association National Center; NIHA Multicenter, Phase 2, Open–label, Controlled, Extension Studyfor Stage 1 Subjects of Study A3921009 to Evaluate the LongtermSafety and Efficacy of CP–690,550 vs. Tacrolimus, whenCo–administered with Mycophenolate Mofetil in Renal AllograftRecipientsThis is a multicenter, Phase 2 study to evaluate the safety andefficacy of CP-690, 550 in renal transplant recipients.PI: Darshana Dadhania, MD, MSFunding: Pfizer, Inc.88Treatment of Resistant Hypertension: A SimplifiedMechanistic ApproachCurrent guidelines for treatment of resistant hypertension offeronly the general advice of increasing dosage or adding drugs. Ina new approach, focusing on targeting mechanisms underlyingresistant hypertension, an algorithm has been developed thatoffers a comprehensive and simplified treatment approach thatnarrows treatment choices to one or both of two treatmentFoxP3 Regulatory Network mRNA Profiles and Human RenalTransplant OutcomesThe central goal is to test the hypotheses that levels of mRNAfor Foxp3 and levels of mRNAs for a mechanistically linkedFoxp3 regulatory gene network are predictive of post-transplantallograft function, acute rejection severity and outcome andchronic allograft nephropathy.PI: Manikkam Suthanthiran, MDFunding: NIH89Acoustic Rhinometry in Pediatric Sleep ApneaThis study tests the difference between obstructive sleep apnea(OSA) and primary snoring groups during acoustic rhinometrymeasurements of the nasopharynx. Positional airway changeswere previously reported in adults with OSA, and furtherevaluation of the airway function in pediatric OSA is warranted.PI: Ana C. Krieger, MD, MPHFunding: NIH

Research Highlights continuedMechanisms of Endothelial Cell Dysfunction in Sleep ApneaThis research will investigate potential mechanisms leading to thedevelopment of vascular problems in patients with sleep apnea.PI: Ana C. Krieger, MD, MPHFunding: NIHSleep Bruxism and Central Sensitization in Myofascial Face PainThe purpose of this project is to evaluate the presence of sleeprelated bruxism in patients with myofascial face pain.PI (Weill Cornell Site): Ana C. Krieger, MD, MPHFunding: NIHRegulation of Vascular Thrombosis in Sleep ApneaThis study investigates the presence of a specific geneticpolymorphism in patients with sleep apnea as compared tohealthy controls. This polymorphism causes the production ofan alternative form of deaminase, which may alter patients’susceptibility to developing vascular thrombosis.PI: Ana C. Krieger, MD, MPHFunding: Robert Wood Johnson FoundationNational Institute of Neurological Disorders and Stroke Geneticsof Risk for Retinopathy among Qataris with Type 2 DiabetesThe research team aims to zero in on genetic locationsassociated with diabetes and find loci associated specificallywith diabetic retinopathy – the deterioration of the retinaas a symptom of diabetes. Drawing on the most advancedgenetic analysis approach, they will evaluate single nucleotidepolymorphisms – differences in DNA base pairs that show up asa disruption in expected patterns – among a sample of Qatarisubjects. This project is one part of a collaborative effort toanalyze diabetes at the genetic level in Qatar.PI: Ronald Crystal, MD, WCMC; Co-Lead PI: Abdulbari Bener,PhD, WCMC-QFunding: Qatar National Research Program’s (QNRF); NationalPriorities Research Fund (NPRP)Genetic Variability and Susceptibility to Type 2 Diabetes in theQatari PopulationThis study will segregate three – TCF7L2, FTO and CDKN2B–of the 15 known genes associated with type 2 diabetes and,using the information gathered from European populations,compare the functionality of these genes in Qatari diabetics.The drug Metaformin is a mainstay of therapy among Europeanpopulations, with its effectiveness among Europeans related inpart to another gene, SLC22A1 – the functionality of this drugwill also be tested among Qatari subjects.PI: Ronald Crystal, MD, WCMC (PI, New York); Co-Lead PI: LaithAbu-Raddad, PhD, WCMC-QFunding: Qatar National Research FundModulation of Genes Responsible for Cilia Length by Exposureto Cigarette Smoke.PI: Ann Tilley, MDFunding: NIH 1 K23 HL103837001RheumatologySelective Regulation of Macrophage ActivationThis project addresses the mechanisms that selectively regulateexpression of specific subsets of inflammatory macrophagegenes, allowing fine-tuning of distinct effector functions. Thelong-term goals are to understand mechanisms that selectivelyregulate macrophage effector functions important in humanautoimmune and inflammatory diseases and to utilize thisknowledge in development of new therapeutic approaches.PI: Xiaoyu Hu, BM, PhDFunding: NIH R01Signaling Cascades in Humoral Immunity and AutoimmunityThe project focuses on a novel protein termed IBP, a novel typeof activator for Rho GTPases, hypothesizing that IBP is a novelregulator of T cell activation and homeostasis which is criticalfor the prevention of autoimmune pathophysiology.PI: Alessandra Pernis, MDFunding: NIH R01; Alliance for Lupus ResearchInhibition of STAT3 and Inflammatory Cytokine ProductionThe long-term goals of this project are to elucidatemechanisms that control inflammatory cytokine productionin macrophages and dendritic cells, and to develop newtherapeutic approaches to modulating cytokine productionduring immune responses and inflammation.PI: Lionel Ivashkiv, MDFunding: NIH R01Vascular Quiescence and Stabilization in ImmunityThis project is testing the hypothesis that a dendritic cellsubpopulation regulates vascular quiescence and stabilizationin lymph nodes and that this vascular regulation is importantfor optimal immune responses.PI: Theresa Lu, MD, PhDFunding: NIH R01; Lupus Research InstituteInhibition of ROCK to Reverse T cell Dysfunction in SLEGiven that inhibition of ROCK activity is one of the keymechanisms responsible for the pleiotropic effects of statins,we will investigate the hypothesis that the ability of statins tointerfere with ROCK activation, if harnessed effectively, canexert beneficial effects in SLE.PI: Jane Salmon, MD; Alessandra Pernis, MDFunding: NIH R21; Lupus Research InstituteMedicalEducation9091

Residency Training ProgramThe NewYork-Presbyterian Hospital/Weill Cornell InternalMedicine Residency Program has a long-standing traditionof excellence in its commitment to training extraordinaryphysicians and academic scholars. The residency program’s36-month curriculum offers opportunities to learn all aspectsof clinical medicine with robust training in both inpatientand outpatient settings, providing care for an eclectic patientpopulation with a broad array of medical conditions. Residentsbenefit from working with world-renowned faculty at WeillCornell Medical College, as well as at our three affiliateinstitutions, Memorial Sloan-Kettering Cancer Center, Hospitalfor Special Surgery, and The Rockefeller University. Regardlessof their chosen career, our graduates are highly capablephysicians; be it as clinical educator, physician-scientist oracademic leader.The residency program places a strong emphasis onauthentic responsibility as a key element to learning both atthe bedside and in searching the evidence for best practice.In addition to the learning through supervised practice, theprogram provides creative conferences and workshops toenhance learning. Academic Time is a weekly 90-minutesession targeted to each year of training that uses aninteractive format with audience response clickers, realtimeliterature searching on iPads, and facilitated groupdiscussions with faculty experts. Education Units linked tooutpatient block time provide in-depth instruction on importanttopics like evidence based medicine, physical exam skills,and personalized patient-centered care. These two programscomplement Morning report, Chairman’s Conference, GrandRounds, Journal Club and M & M. The intellectual discoursewas expanded this year to include the Senior Seminar Series.Each of our PGY3 residents presents a 25-minute talk on a topicof their choice working with a faculty advisor to become anexpert on what is currently known on the issue. The senior talkshave been a fabulous addition.On the heels of our success with the 6 + 2 system (6 weeks ofrotation assignment followed by 2 weeks of outpatient practice,the Outpatient Pod has enriched the outpatient experienceof residents with increased continuity and newly addedperformance reports on clinical outcomes of each resident’spanel of patients. Under the guidance of Dr. Fran Ganz-Lord,residents now receive personalized reports on the outcomesof their patients: quality measures in patients with diabetesmellitus, screening for preventive services, and discussinglifestyle modifications.We have continued to grow our efforts around qualityimprovement and patient safety with the Chief Resident ofQuality and Safety now in its second year. Residents have beenactively engaged in highly visible changes in how we deliverpatient care to both improve efficiency and decrease waste. Oursimulation curriculum was expanded to include ultrasoundguidedbedside procedures including central lines andparacenteses led by Dr. Kirana Gudi and assisted by Dr. KapilRajwani and Dr. Alyson Fox.We continue to have many of our residents participatein research activities leading to national presentations andpublications. The four finalists from the David E. RogersResearch Competitions were Dr. Aaron Viny, Dr. Neha Mehta-Shah, Dr. Daneng Li, and Dr. Eugene Licht.Some of the high profile research efforts aided by our residentsare listed below.Batalden M, Warm E, Logio L. Beyond a Curricular Design ofConvenience: Replacing the Noon Conference with an AcademicHalf Day in Three Internal Medicine Residency Programs. AcadMed. 2013 May; 88 (5): 1-8.Logio LS, Gudi K, Cilmi S. Developmental core curriculum:A new model for Academic Time. Academic Internal MedicineInsight (in press).Logio LS, Zappetti D, Horowitz JM. Guiding residents throughthe fellowship selection and application Process. In: FicarolaRD, editor. The Toolkit Series: A Textbook for Internal MedicineEducation Programs 11 th Edition. Washington DC: Association ofProgram Directors in Internal Medicine (in press).Vertrees SM, Shuman AG, Fins JJ. Learning by Doing:Effectively Incorporating Ethics Education into ResidencyTraining. Journal of General Internal Medicine, 2012; online 21(November).National PresentationsMehta S, Hottensen D, Diamond R. Palliative Care 101 ForMedical Interns: The Palliative Care Education Unit. Posterpresented at the American Association for Hospice andPalliative Care 2013 Annual Assembly; New Orleans, LA.Fanucchi L, Cooke J, Logio L. An action oriented patient safetyconference model for the new millennium. Poster presentedat: 4 th Annual Integrating Quality Meeting of Association ofAmerican Medical Colleges, 2012 Jun 7-8; Chicago, IL.Carmel A, Fanucchi L, Lee J. “Bolus” and “Drip” qualityimprovement curricula for internal medicine residents. Posterpresented at: 35 th Annual Meeting of the Society for GeneralInternal Medicine, 2012 May 9-12; Orlando, FL.Ouchida K, Siegler E, Adelman R. Case presentation as a directobservation method to evaluate internal medicine residents?Systems-based practice competency. Presented at: the AnnualScientific Meeting of the American Geriatrics Society, 2012 May2-5; Seattle, WA.Publications:Muhamed Baljevic, Omar Abdel-Wahab, Raajit Rampal:Translocation (11;17) in de novo Myelodysplastic SyndromeNot Associated with Acute Myeloid or Acute PromyelocyticLeukemia. Acta Haematol, 2013;129:48-54.Rotman SR, Bishop TF: Proton Pump Inhibitor Use in the U.S.Ambulatory Setting, 2002-2009. Plos One|www.plosone.org,February 2013, Volume 8, Issue 2.Garment AR, Lee, WW, Harris C, Phillips-Caesar E.Development of a Structured Year-End Sign-Out Program in anAmbulatory Care Practice. JGIM 2013: 28;114-120.Fitzgerald, Daniel W., Karl Bezak, Oksana Ocheretina: TheEffect of HIV and HPV Coinfection on Cervical COX-2 Expressionand Systemic Prostaglandin E2 Levels. Published Online First,December 1, 2011; DOI:10.1158/1940-6207.CAPR-11-0496.Cancer Prev Res; 5 (1) January 2012.Zaniello, Ben A., Deborah A. Kessler, Katherine M. Vine:Seroprevalence of Chagas Infection in the Donor Population.PLOS|Neglected Tropical Diseases, a peer-reviewed, openaccess journal.The educational activities of the department continue to growand gain national reputation. Dr. Ernie Esquivel and Dr. AnthonyOgedegbe are now assistant Dr. Charles Bardes in managingthe third year medicine clerkship. Dr. Dana Zappetti coordinatesthe fourth year subinternship. We’ve continued to providesubinternships for the Weill Cornell - Qatar fourth years studentsas well. The residency program, led by Dr. Lia Logio, is assistedby a tremendous group of talented medical educators includingJudy Tung, B. Robert Meyer, Kirana Gudi, Susana Morales,Christina Harris, and Monika Harris. They were given a 10-yearaccreditation cycle (until 2022!). Ms. Cathy Jalali, MEd, joined theEducation Division and has added value in our efforts to improverounding practices, encourage critical thinking, and aided ourclinician educator faculty in their scholarship activities.This year, a number of core faculty were added to theleadership group to serve as resident advisors in preparationfor the ACGME’s Next Accreditation System: Dr. EugeniaSiegler, Dr. Jeff Silberzweig, Dr. Brian Bosworth, Dr. VishalDodia, and Dr. Dana Zappetti. 35 of our senior residentsmatched to highly competitive fellowship programs around thecountry, including a few who will stay on at Weill Cornell in oursubspecialty divisions.It has been another tremendously successful year for theprogram, even articulating a mission statement that guidesus as we adapt to the next wave of changes in healthcare andmedical education.• To cultivate extraordinary physicians who consistentlydemonstrate their unwavering dedication to each individualpatient in front of them• To encourage thinking anew about medicine in both itsscience and its art• To create a lifetime academic home for our medicalcommunity members92 93

Residents on the MoveJordan Nestor, MDI grew up uninsured, sought medical care through the clinics in one of the city’s public hospitals,and wanted to become a physician to increase healthcare access to the disenfranchised, such asthe Spanish-speaking Latinos in my community. I chose internal medicine when the relationshipbetween poor access to care, worsening of chronic illness, and the burden of disease to one’squality of life became clear to me; for example, when manageable diseases like hypertension anddiabetes go untreated and lead to complications, such as End Stage Renal Disease, with individualsrequiring long-term hemodialysis, a treatment regimen that is life altering. Unfortunately, theburden of chronic disease frequently falls on poor patient populations, disproportionately Latinoand African American communities. The opportunity to train in medicine at this time in our history,when we are expanding coverage to the uninsured while making efforts to improve healthoutcomes and control costs, is tremendously exciting.I feel fortunate to be training in this program wherethe priority is both the development of our clinicalacumen and delivering excellent patient care toall those we serve. As prudent, thoughtfulclinicians, we can all work towards eliminatinghealthcare disparities associatedwith limited access to care.Marcus D. Goncalves, MDI entered medicine to cure disease. Throughout my training as a physician-scientist, I have beenfascinated by the inner workings of the human body and invested in learning how to fix the problemsthat result in disease. My focus is on how the body stores energy and regulates metabolism which isimportant in conditions such as obesity, diabetes, and cardiovascular disease. Every day at NYP/WCwe see the toll that these chronic illnesses play on the lives of patients. As a resident, my goal is toobserve the complexities of patient care and identify areas that can be improved by my research in thefuture. Making people feel better is just a cherry on top.9495

Clara Tow, MDStarting my internal medicine residency training at NYP-WC, I knew I was entering anentirely new stage of my life that I could not even imagine. Joining the program has providedme with incredible knowledge and the ability to apply it towards helping others in the mostessential moments. More importantly, however, it has given me a new family that supplieslove, support, and teaching every step of the way. I could not be more grateful.Yecheskel Schneider, MDIn the beginning of intern year I felt almost like a fraud when I would walk the wards in my white coat.I’d ask myself if the program made a mistake and if they chose an imposter. But with mentoring fromexperienced faculty, camaraderie from co-residents and from the patience of patients, who take thetime to teach you how to care for them, fears and anxiety are transformed into confidence. You learn totrust what you know and seek help when you need it (and the help is always there). I am humbled thatI am surrounded by such knowledgeable attendings, compassionate residents and patients whom Ihave the privilege to serve. My white coat has never fit so well as it does right now.9697

Michael G. Knight, MDAs I walk through my front door, stethoscope in hand, a sense of uncertainty settles in as I headtowards another day on the wards. While I don’t know what clinical challenges await my arrival,I am certain that I will return home a stronger clinician. Whether it’s the patients whose lives I amprivileged to impact, the camaraderie of my fellow residents and faculty mentors, or the knowledgeI hope to gain as a clinician in training, I am certain that I will return home with a new sense: oneof complete satisfaction. At NYP/WC, I have the opportunity to make a positive impact in the livesof my patients who present from all walks of life, and the ability to advance my clinical training ina world class academic institution. As I prepare for a career at the intersection of clinical medicine,community advocacy, and executive leadership, the daily experiences that I have gained continueto fuel my passion for patient care, and the motivation to stand at the door every morning, ready foranother life changing experience.Heidi Charvet, MDEvery day of my training, I feel lucky to be part of such a wonderful internal medicine program.My co-residents are bright, energetic, and passionate young physicians who I consider an honor tohave as my life-long colleagues and friends. The faculty are enthusiastic about teaching and easilyapproachable. In addition to superb clinical training my experience at Cornell has been greatly enrichedthrough my participation in the Housestaff Quality Council (HQC). The HQC meets regularly with hospitalleadership and has an essential voice in the development of hospital policy and programs pertainingto patient safety. Through the HQC, I have had the opportunity to engage in patient safety and qualityimprovement projects with residents from all different specialties and with the mentorship of facultyat the leading edge of the field.9899

Current ResidentsCHIEF RESIDENTLee Shearer, Perelman School of Medicine at theUniversity of PennsylvaniaQUALITY IMPROVEMENT CHIEF RESIDENTBrian Eiss, Georgetown University School of MedicineSENIOR RESIDENTS (PGY3)Allison Waridibo, Faculty of Medicine, Imperial College London, UKDaniel Amoruso UMDNJ-New Jersey Medical SchoolErinn Ayres, University of Arizona College of MedicineMuhamed Baljevic, Weill Cornell Medical College, QatarKarl Bezak, Vanderbilt University School of MedicineIsaac Bowman, University of Texas Southwestern Medical Centerat DallasAugustine Chung, Case Western Reserve University Schoolof MedicineRobert Daly, Harvard Medical SchoolAnthony Daniyan, University of Miami School of MedicineMark Diamond, Washington University School of MedicineDavid Fernandez, State University of New York UpstateMedical UniversityTimothy Ferng, Wayne State University School of MedicineMichael Mulock, Jefferson Medical College of Thomas JeffersonUniversityKarla Nieves, University of Puerto Rico School of MedicineOlanma Okoji, George Washington University School of Medicineand Health SciencesJeffrey Okun, Albert Einstein College of Medicine, YeshivaVikram Palanivel, Perelman School of Medicine at the Universityof PennsylvaniaChiti Parikh, UMDNJ-Robert Wood Johnson Medical SchoolStephen Rotman, New York Medical CollegeKira Ryskina, Mount Sinai School of MedicineRachel Sanford, Harvard Medical SchoolLourdes Sanso, New York University School of MedicineDavid Seto, UMDNJ-New Jersey Medical SchoolMaryam Shafaee, Weill Cornell Medical College, QatarStephanie Tang, Northwestern University Feinberg Schoolof MedicineLouis Waldman, Perelman School of Medicine at theUniversity of PennsylvaniaFrances West, Jefferson Medical College of Thomas JeffersonUniversityCasey Wong, Weill Cornell Medical CollegeMicheas Zemedkun, Harvard Medical SchoolLaura Gingras, Emory University School of MedicineKati Glockenberg, Albert Einstein College of Medicine,Yeshiva UniversityLuke Godwin, Warren Alpert Medical School of Brown UniversityCeline Goetz, Loyola University of Chicago Stritch Schoolof MedicineMaday Gonzalez, Albert Einstein College of Medicine, YeshivaUniversityEric Goodman, Weill Cornell Medical CollegeRomona Kersellius, UMDNJ-Robert Wood Johnson MedicalSchoolDanny Khalil, Stony Brook University School of MedicineChrisann Kyi, Georgetown UniversityKevin Ma, Washington University School of Medicine in St. LouisFima Macheret, Mayo Medical SchoolEmily Marcus, Johns Hopkins University School of MedicineJonathan Mendelson, George Washington University School ofMedicine and Health SciencesTiago Miguel, New York University School of MedicineJamie Mullally, University of Rochester School of Medicine andDentistryNikola Natov, Tufts University School of Medicine UniversityAnil Punjabi, University of California, Los Angeles David GeffenSchool of MedicineMohini Aras, State University of New York-Downstate MedicalCenter College of MedicineKerri Aronson, State University of New York Upstate MedicalUniversityDaniel Bachman, State University of New York-DownstateMedical Center College of MedicineSheila Bharmal, Emory University School of MedicineJennifer Chester, Albert Einstein College of Medicine,Yeshiva UniversityErica Chu, Baylor College of MedicineShirley Cohen, University of Michigan Medical SchoolAmanda DeMauro, University of Michigan Medical SchoolVinicius Domingues, Universidade Estácio de Sá, Rio de Janeiro,BrazilScott Drutman, New York University School of MedicineJason Dukes, Columbia University College of Physiciansand SurgeonsAndrew Dunbar, New York Medical CollegeGuillermo Espinoza, New York University School of MedicineJohn Ferrarone, New York Medical CollegeMarcus Goncalves, Perelman School of Medicine at the Universityof PennsylvaniaSergey Gurevich, Medical College of WisconsinHoratio Holzer, Weill Cornell Medical CollegeJessica Furst, Albert Einstein College of Medicine,Yeshiva UniversityTimothy Glew, Tulane University School of MedicineJonathan Gordin, Weill Cornell Medical CollegeParag Goyal, University of Massachusetts Medical SchoolElizabeth Greig, University of Miami School of MedicineLeon Igel, Albert Einstein College of Medicine, Yeshiva UniversityKunal Karia, Virginia Commonwealth UniversityScott Kramer, Weill Cornell Medical CollegeJoseph Krepp, Stony Brook University School of MedicineFrank Lin, Albany Medical CollegeAmy Loden, University of Missouri School of MedicineLenette Lu, Case Western Reserve University School of MedicineSharayne Mark, University of Rochester School of Medicineand DentistryJoseph Marmora, Loyola University of Chicago StritchSchool of MedicineAdrian Mei, New York Medical CollegeJohn Morris, University of Maryland School of MedicineJUNIOR RESIDENTS (PGY2)Kathryn Arbour, Weill Cornell Medical CollegeAmiran Baduashvili, Stony Brook University School of MedicineThomas Baker, Temple University School of MedicineGeorge Bao, University of California, Los Angeles David GeffenSchool of MedicineMichael Bender, University of Rochester School of Medicine andDentistryDavid Bennett, UMDNJ-Robert Wood Johnson Medical SchoolMichael Berlin, Albert Einstein College of Medicine, YeshivaUniversityAnjori Bhatia, Stony Brook University School of MedicineSheng Cai, Washington University School of Medicine in St. LouisHeidi Charvet, New York Medical CollegeRowland Chavez, Albert Einstein College of Medicine, YeshivaUniversityClaiborne Childs, Georgetown UniversityMallory Delehanty, Weill Cornell Medical CollegeCelia Egan, New York Medical CollegeAlexandra Racanelli, Virginia Commonwealth University Schoolof MedicineMonica Saumoy, Weill Cornell Medical CollegeKatherine Saunders, Weill Cornell Medical CollegeYecheskel Schneider, New York University School of MedicineMichael Scordo, UMDNJ-New Jersey Medical SchoolClara Tow, Weill Cornell Medical CollegeSurafel Tsega, Weill Cornell Medical CollegeSantosha Vardhana, New York University School of MedicineAshwin Vasan, University of Michigan Medical SchoolBrian West, Mount Sinai School of MedicineDavid Wise, Perelman School of Medicine at the Universityof PennsylvaniaKevin Wood, University of Kansas School of MedicineINTERN RESIDENTS (PGY1)Sarah Adkins, Columbia University College of Physicians andSurgeonsMohamed Al-Kazaz, Weill Cornell Medical College - QatarYulian Khagi, Saint Louis University School of MedicineMichael Knight, Case Western Reserve University School ofMedicineJames Kuo, University of Washington School of MedicineChrystal Landry, Stony Brook University School of MedicineRichard Leiter, Northwestern University Feinberg Schoolof MedicineEmily Lu, Emory University School of MedicineElizabeth Maina, Tulane University School of MedicinePatrick McNair, University of South Florida College of MedicineSaif Muhsin, College of Medicine, University of Baghdad, IraqJordan Nestor, Albert Einstein College of Medicine, YeshivaUniversityAleksey Novikov, Warren Alpert Medical School of BrownUniversityMarcia Paddock, University of Washington School of MedicineStephen Perazzelli, SUNY-Downstate Medical Center College ofMedicineArgelis Rivera, Albert Einstein College of Medicine, YeshivaUniversity100 101

John Ruffino, Weill Cornell Medical CollegeGERIATRICSDaniel Sanchez, Mount Sinai School of MedicineMatthew Schoenfeld, New York Medical CollegeAdam Schwartz, Mount Sinai School of MedicineKaartiga Sivanesan, Vanderbilt University School of MedicineErinn AyresNewYork-Presbyterian/Weill Cornell Medical CenterLouis WaldmanYale University, New Haven, CTRichard Wang, Weill Cornell Medical CollegeRui Wang, Sichuan University, Chengdu, ChinaBethel Woldu, University of Colorado Denver School of MedicineGASTROENTEROLOGYKarl BezakHospital of the University of Pennsylvania, Philadelphia, PANeeha Zaidi, Mount Sinai School of MedicineWilliam Zhang, New York University School of MedicineKunal KariaNewYork-Presbyterian/Weill Cornell Medical CenterScott KramerNew York University Langone Medical Center, New York, NYSubspecialty Fellowship & Other ProfessionalPursuitsOlanma OkojiSt. Luke’s Hospital, New York, NYJeffrey OkunMontefiore Medical Center, New York, NYCARDIOLOGYTimothy GlewBeth Israel Medical Center, New York, NYStephen RotmanBrigham and Women’s Hospital, Boston, MAINFECTIOUS DISEASESCLASSICAL CHINESE ACUPUNCTURE APPRENTICESHIPJonathon GordinUCLA Medical Center, Los Angeles, CAParag GoyalNewYork-Presbyterian/Weill Cornell Medical CenterGENERAL INTERNAL MEDICINEKira RyskinaHospital of the University of Pennsylvania, Philadelphia, PAAllison WaridiboNew York University Langone Medical Center, New York, NYLenette LuMassachusetts General Hospital, Boston, MADavid SetoWang Ju-yi Applied Channel Theory Research Center, Beijing,ChinaJoseph KreppGeorgetown University Hospital, Washington, DCFrank LinNewYork-Presbyterian/Weill Cornell Medical CenterSharayne MarkHospital of the University of Pennsylvania, Philadelphia, PAJoseph MarmoraLoyola University Health System, Maywood, ILMichael MulockUniversity of Pittsburgh Medical Center, Pittsburgh, PACasey WongBarnes-Jewish Hospital at Washington University Medical Center,St. Louis, MOMicheas ZemedkunGeorgetown University Hospital, Washington, DCCRITICAL CARESamantha BrennerStanford University Medical Center, Palo Alto, CAHEMATOLOGY AND MEDICAL ONCOLOGYMuhamed BaljevicMD Anderson Cancer Center, Houston, TXSheng CaiMemorial Sloan-Kettering Cancer Center, New York, NYRobert DalyUniversity of Chicago Medical Center, Chicago, ILAnthony DaniyanMemorial Sloan-Kettering Cancer Center, New York, NYMark DiamondHospital of the University of Pennsylvania, Philadelphia, PAPeter ForsbergNewYork-Presbyterian/Weill Cornell Medical CenterDanny KhalilMemorial Sloan-Kettering Cancer Center, New York, NYNeha Mehta ShahMemorial Sloan-Kettering Cancer Center, New York, NYRachel SanfordMD Anderson Cancer Center, Houston, TXNEPHROLOGYSamantha DiazDuke University Hospital, Durham, NCPULMONARY AND CRITICAL CARE MEDICINELourdes SansoNewYork-Presbyterian/Weill Cornell Medical CenterMae WestNewYork-Presbyterian/Weill Cornell Medical CenterRHEUMATOLOGYDavid FernandezHospital for Special Surgery, New York, NYOther Professional PursuitsACADEMIC APPOINTMENTSElizabeth GreigAssistant Clinical Professor of Medicine, University of NorthCarolina, Chapel Hill, NCAcademic Clinical PracticeAmy LodenInstructor of Medicine, Associate Program Director Primary CareTrack, Washington, University in St. Louis Academic ClinicalPracticeDaniel AmorosoNewYork-Presbyterian/Weill Cornell Medical CenterAcademic HospitalistIsaac BowmanMemorial Sloan-Kettering Cancer Center, New York, NYAcademic HospitalistTimothy FerngMemorial Sloan-Kettering Cancer Center, New York, NYAcademic HospitalistAdrian MeiNewYork-Presbyterian/Weill Cornell Medical CenterAcademic HospitalistENDOCRINOLOGYJessica FurstColumbia University Medical Center/New York Presbyterian, NewYork, NYLeon IgelNewYork-Presbyterian/Weill Cornell Medical CenterMaryam ShafaeeMD Anderson Cancer Center, Houston, TXSantosha VardhanaMemorial Sloan-Kettering Cancer Center, New York, NYDavid WiseMemorial Sloan-Kettering Cancer Center, New York, NYGLOBAL HEALTH LEADERSHIPVikram PalanivelMassachusetts General Hospital, Boston, MAJohn MorrisGeorgetown University Hospital, Washington, DCAcademic HospitalistKarla NievesMemorial Sloan-Kettering Cancer Center, New York, NYAcademic Hospitalist102 103

FellowshipsThe Department of Medicine offers a variety of fellowshiptraining opportunities in each of our divisions. All of ourfellowships emphasize clinical and research training. Theseprograms provide a challenging educational experience underthe supervision and guidance of noted experts in their fields anddemonstrate our commitment to ensuring that our physiciansin-trainingemerge as tomorrow’s leaders in their chosen fields.ADVANCED HEART FAILURE CARDIOLOGY TRANSPLANTThe Fellowship Program in the Maurice R. and Corinne P.Greenberg Division of Cardiology at Weill Cornell Medical College/New York-Presbyterian Hospital is a one year ACGME-accreditedprogram that prepares highly qualified candidates for careers inAdvanced Heart Failure and Transplant Cardiology. This fellowshipwill train fellows in the management of the advanced congestiveheart failure patient population. This includes patients with: acutedecompensated heart failure (left and right), destination or bridgeto transplant mechanical assist devices, acute support devices,perioperative high risk conventional cardiac surgery, approved andinvestigational catheter or mini surgical valvular interventions;those needing evaluation for, and those who already underwentheart transplantation. An added strength of the program is indepthtraining of the evaluation and management of pulmonaryhypertension and exposure to patients with WHO Groups 1-5PH. Cardiac Transplantation training portion occurs at NewYorkPresbyterian Hospital-Columbia Medical Center. Highlights ofthis program include a strong collaboration with colleagues fromcardiac imaging, catheterization lab (including structural heartdisease program), electrophysiology, cardiothoracic surgery,cardiac anesthesia, rheumatology and oncology.Program Director: Evelyn Horn, MDProgram Coordinator: Lisa Brooks, (212) 746-2218Duration of Training: 1 yearNumber of Positions: 12012-2013 FellowMaria Karas, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)CARDIOLOGYUnder the auspices of the Maurice R. and Corinne P. GreenbergDivision of Cardiology, this three or four-year programprepares highly qualified candidates for careers in investigativeand clinical cardiology. Our fellows receive comprehensiveexperience in all major clinical and laboratory aspects ofcontemporary cardiology under the close supervision of fulltimestaff. In addition, each fellow is expected to participate inone or more areas of ongoing research during their training.Clinical care is the focus of the first two years, while the thirdand fourth years involve a more intensive, mentored experiencein a particular clinical subspecialty or in basic research. Anadditional year (or more) of training/research in a subspecialtyarea can be arranged, as indicated/appropriate.Program Director: Erica C. Jones, MDProgram Coordinator: Lisa Brooks, (212) 746-2218Duration of Training: 3 yearsNumber of Positions: 192012-2013 FellowsSubhi Al-Aref, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Nisha Bavalia, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Konstantinos Charitakis, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Grace Chung, MDUniversity of ChicagoBrian Cullingford, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Roderick Deano, MDUniversity of ChicagoAbiola Dele-Michael, MD, MPHUniversity of MichiganBobby Ghosh, MDUniversity of MichiganSattar Gojraty, MDUniversity of PennsylvaniaAlbert Jung, MD, PhDNewYork-Presbyterian Hospital (Weill Cornell Campus)Ryan Kaple, MDMassachusetts General HospitalAlexander Mauskop, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Lynn Punnoose, MDBrigham and Women’s HospitalJoshua Schulman-Marcus, MDNewYork-Presbyterian Hospital (Columbia Campus)Ashish M. Shah, MDNewYork-Presbyterian Hospital (Columbia Campus)Samuel Volo, MDBrigham and Women’s HospitalJoshua Weisbrot, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)David Yang, MDBrigham and Women’s HospitalCLINICAL CARDIAC ELECTROPHYSIOLOGY (CCEP)This fellowship within the Maurice R. and Corinne P. GreenbergDivision of Cardiology provides advanced training in all aspectsof invasive electrophysiology. Fellows attain expertise in catheterablation of complex arrhythmias, including atrial fibrillationand ventricular tachycardias, as well as device implantationand management, with an emphasis on implantable defibrillatorsand cardiac resynchronization. The core of the fellowshipconsists of rotations in the Invasive Electrophysiology Laboratory,but fellows also rotate through the device clinic and inpatientand outpatient consultations. Fellows also participate in theongoing basic and clinical research programs conducted withinthe electrophysiology laboratory.Program Director: Jim W. Cheung, MDProgram Coordinator: Lisa Brooks, (212) 746-2218Duration of Training: 1 yearNumber of Positions: 42012-2013 FellowsSeth Bender, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Joshua Liez, MDUniversity of Pennsylvania Health System105Faisal Siddiqi, MDYale-New Haven HospitalMichelle Spotnitz, MDUMDNJ-Robert Wood JohnsonINTERVENTIONAL CARDIOLOGYA one-year advanced training fellowship in all aspectsof interventional cardiology is also available through theMaurice R. and Corinne P. Greenberg Division of Cardiology.The program emphasizes a systematic, evidence-basedapproach to diagnostic and therapeutic coronary procedures,and enables fellows to develop expertise in pre- and postproceduralpatient care in both inpatient and outpatientsettings. Fellows are trained to perform percutaneous coronaryinterventions using state-of-the-art technologies, and areexpected to participate in active clinical research efforts.Program Director: Robert Minutello, MDProgram Coordinator: Lisa Brooks, (212) 746-2218Duration of Training: 1 yearNumber of Positions: 22012-2013 FellowsPraveen Khanna, MDYale New Haven HospitalSean R. Wilson, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)CARDIOLOGY BROOKLYN PROGRAMProgram Director: Ciprian Nedelcu, MDProgram Coordinator: Julie C. Quinonez, (718) 250-6952Duration of Training: 3 yearsNumber of Positions: 62012-2013 Fellows:Mohammad Ansari, MDBeth Israel Medical CenterCesar Ayala-Rodriguez, MDThe Brooklyn Hospital Medical CenterSameer Kaul, MDWyckoff Heights Medical CenterThe Brooklyn Hospital Medical CenterKhurram Liaqat, MDThe Brooklyn Hospital Medical CenterUmesh Mishra, MDThe Brooklyn Hospital Medical CenterPawan Sarda, MDThe Brooklyn Hospital Medical Center

ENDOCRINOLOGY, DIABETES, AND METABOLISM2012-2013 FellowsThis program is a comprehensive two-year training programthat provides unique, in-depth clinical and academic experiencein the field of endocrinology. Endocrine fellows receive a widerange of didactic instruction and clinical training in the inpatientand ambulatory facilities of three premier medical institutions:NewYork-Presbyterian Hospital, Memorial Sloan-KetteringCancer Center and the Hospital for Special Surgery. The firstyear of the fellowship focuses on intensive clinical training,while the second year emphasizes clinical, translational orbasic research. Our fellows are actively involved in shaping theireducation, gain ‘hands-on’ experience teaching residents andmedical students and receive individualized instruction fromnationally renowned clinicians and researchers. As appropriate,fellows may continue their training with an optional third yeardevoted to further research.Pamela Eliach, MDSt. Luke’s HospitalDaniel Fish, MDWeill Cornell Medical Center, Department of SurgeryUrania Rappo, MD, PharmDNew York University School of MedicineDaniel Shirley, MDUniversity of Colorado Health Sciences CenterStephen Williams, MDMount Sinai Medical CenterHEMATOLOGY AND MEDICAL ONCOLOGYProgram Director: David Brillon, MDProgram Coordinator: Helen Carey, (212) 746-9939Duration of Training: 2 yearsNumber of Positions: 42012–2013 FellowsJosé Alemán, MD, PhDNewYork-Presbyterian Hospital (Weill Cornell Campus)Samim Enayat, MDUniversity of VirginiaJames Flory, MD, MSCENewYork-Presbyterian Hospital (Weill Cornell Campus)Oksana Lewis, MDMontefiore Medical CenterGASTROENTEROLOGY AND HEPATOLOGYThis three-year program attracts some of the best andbrightest trainees who are interested in pursuing a career inacademic medicine. Currently, two fellows are accepted intothe program annually. The first year is largely consultative, andfellows maintain a weekly ambulatory patient practice. Secondyearfellows are expected to be involved in basic or clinicalresearch. Third year fellows continue the research projectsdeveloped in their second year, and have an opportunity topursue specific areas of interest in inflammatory bowel disease,hepatology, liver transplantation, and cancer screening andprevention. Over the course of their training, fellows generallyperform more than 600 upper endoscopies, 300 colonoscopiesand a significant number of EUS (endoscopic ultrasound) andERCPs (endoscopic retrograde cholangio pancratography).Program Director: Brian Bosworth, MDProgram Coordinator: Ming Su, (646) 962-4700Duration of Training: 3 yearsNumber of Positions: 72012-2013 FellowsMichelle Cohen, MDNewYork-Presbyterian Hospital (Columbia Campus)Nikhil Kumta, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Melissa Rosen, MDMount Sinai Medical CenterAmir Soumekh, MDMount Sinai Medical CenterEthan Weinberg, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)GERIATRIC MEDICINEThis comprehensive fellowship program integrates outstanding,nationally recognized academic and clinical resources with thegoal of training future clinical and academic leaders in geriatricmedicine. Clinical training occurs in all appropriate geriatricsettings: acute hospitals, long-term care facilities, patients’homes, hospices, continuing care communities and ambulatoryclinics. The second year of training focuses on completingan independent research project. Fellows can participate ina third year of training as clinician-researchers or clinicianeducatorsthrough our Hartford Center of Excellence. One-yearfellowship positions also become available from time to time forthose unable to do the second year. Board certification can beobtained after completing a one-year fellowship.Program Director: Barrie Raik, MDProgram Coordinator: Quincy Leon, (212) 746-3539Duration of Training: 2 yearsNumber of Positions: 42012-2013 FellowsSonica Bhatia, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Kiran Rayalam, MDWyckoff Heights Medical CenterWei Wang, MDBronx Lebanon Hospital CenterHEALTH SERVICES RESEARCHThe goal of the T32 fellowship training program funded bythe Agency for Healthcare Research and Quality is to trainpost-residency physicians to conduct interdisciplinary healthservices research. The objective is to train new physicianinvestigatorsto become independent researchers, usingmethodologically rigorous approaches to meet emerginghealth services research priorities: specifically, improving theeffectiveness and outcomes of clinical practice, improvingour ability to provide high-quality, cost-effective care, andassessing the effectiveness of health systems changeson outcomes, quality, cost and access to healthcare. Theprogram emphasizes theoretical, methodological and practicefoundations in health services research, clinical research andbehavior sciences to enable physician-investigators to conductresearch that will improve practice. A special emphasis of theprogram is to train researchers from diverse backgrounds,imparting the skills to address health concerns and challengesfaced by minority populations in our unique urban environment.Graduates from our program are principal or co-principalinvestigators on grants totaling more than $67 million.Program Director: Mary E. Charlson, MDAdministrator of Educational Programs:Suzan Toro, (646) 962-5060Duration of Training: 2 yearsNumber of Positions: Number variesThis three-year fellowship attracts outstanding fellowsfrom a large national pool. First-year fellows rotate throughthe multiple clinical subspecialty services at NewYork-Presbyterian/Weill Cornell. The second year is devoted tosupervised laboratory and/or clinical research. During thethird year, fellows consolidate their educational experiencesin the diagnosis and management of hematologic/neoplasticdisorders, and continue research training.Program Director: Ronald Scheff, MDProgram Coordinator: Sarah Ahmad, (212) 746-6702Duration of Training: 3 yearsNumber of Positions: 182012-2013 FellowsJohn Allan, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Nancy Chan, MDRobert Wood Johnson University Hospital - University of Medicineand Dentistry of New JerseyJohn Chapin, MDAlbert Einstein College of Medicine - Montefiore Medical CenterElan Diamond, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Bishoy Faltas, MDRochester University General HospitalSatyajit Kosuri, MDSUNY Downstate Medical CenterEmil Kuriakose, MDUniversity of Texas Southwestern Medical CenterAdriana Rossi, MDThomas Jefferson University HospitalSarah Rutherford, MDThomas Jefferson University HospitalAshish Saxena, MD, PhDAlbert Einstein College of Medicine - Montefiore Medical CenterYael Zack, MDAlbert Einstein College of Medicine - Montefiore Medical CenterArun Jesudian, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Veerawat Phongtankuel, MDTemple University Hospital106 107

INFECTIOUS DISEASESDesigned to foster clinical and academic excellence, thisfellowship provides individualized training through facultyguidance, clinical rotations, mentored research and didacticcourse work. Graduates of the program are highly qualified forthe practice of infectious diseases medicine, bench and clinicalresearch, and for leadership roles in medicine. The minimumfellowship duration is two years (ACGME-required); however,most fellows complete three years of training. Inpatient andambulatory care are emphasized during the first year. Thesecond and third years of fellowship emphasize clinical andbasic laboratory research, both at home and abroad in Haiti,Brazil, Ghana and Tanzania. Fellows also have the opportunityto pursue master’s degrees in clinical epidemiology andclinical investigation at Weill Cornell.Program Director: Kristen Marks, MDProgram Coordinator: Marisol Valentin, (212) 746-7602Duration of Training: 2 yearsNumber of Positions: 62012-2013 FellowsBisrat Abraham, MD, MPHThe Johns Hopkins HospitalAshita Batavia, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Leah Burke, MDYale-New Haven HospitalDaniel Eiras, MDMount Sinai Medical CenterFlonza Isa, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Matt McCarthy, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)NEPHROLOGYFellows receive clinical training to treat patients withcomplicated acid-base and fluid and electrolyte problems,hypertension, acute and chronic kidney diseases, and renalfailure requiring replacement therapy with dialysis and kidneytransplantation. Our fellows benefit from the vast clinical andresearch resources of the NewYork-Presbyterian Hospital, WeillCornell Medical College, the Rogosin Kidney Center and theMemorial Sloan-Kettering Cancer Center. Fellows undertakea minimum of six months of dedicated elective time in clinicalor bench research.Program Director: Phyllis August, MDProgram Coordinator: Frances Gillen, (212) 746-0822Duration of Training: 2 yearsNumber of Positions: 82012-2013 FellowsShuang-Ying BaoNew York Medical College (Richmond)Sean Campbell, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Layla Kamal, MDStaten Island University HospitalDinesh Kannabhiran, MBBSSt. Joseph Mercy Health System, Ann Arbor, MichiganJohn Lee, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Swati Mehta, MBBSSUNY Upstate Medical UniversityPatricia Myers-Gurevitch, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Dhaval Patel, MDRobert Wood Johnson University Hospital - University of Medicineand Dentistry of New JerseyGuan Xu, MDUniversity of Texas Southwestern Medical Center108 109

Jyoti Mathad, MD: An International Fellowship inIndia Compares Two tests for TuberculosisPULMONARY DISEASE AND CRITICAL CARE MEDICINEThis three-year training program offers a structuredcurriculum encompassing rotations in a variety of medicaland surgical intensive care units, pulmonary consultation,pulmonary pathology, sleep medicine and an ambulatorypulmonary office setting. Fellows are supervised by theDivision’s renowned clinical faculty and participate in clinicalor bench research in a wide breath of areas pertaining to thepractice of pulmonary and critical care medicine.Program Director: Dana Zappetti, MDProgram Coordinator: Diane Hawkins, (212) 746-2908Duration of Training: 3 yearsNumber of Positions: 152012-2013 FellowsAdviteeya N. Dixit, MBBSRochester General HospitalCaroline Gulati, MDUniversity of Pennsylvania Medical CenterMary E. Harris, MDAlbert Einstein College of Medicine/Montefiore Medical CenterJustina M. Hessel, MDAlbert Einstein College of Medicine/Montefiore Medical CenterDavid H. Kung, MDYale-New Haven HospitalJulio A. Lanfranco Molina, MDUniversity of Miami/Jackson Memorial HospitalLaura J. Libby, MDSt. Vincent’s Hospital & NewYork-Presbyterian Hospital (WeillCornell Campus)Lindsay Lief, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Sarah O’Bierne, MDNew York UniversityDorothy Ryan, MBBCh, BAOMater Misericordiae HospitalEugene Shostak, MDLahey Clinic Medical CenterRHEUMATOLOGYThe Hospital for Special Surgery (HSS) rheumatology fellowshipcombines broad-based, in-depth clinical and researchexperiences to deliver superb training to medical professionals.The clinical experience focuses on outpatient rheumatologyclinics and inpatient Rheumatic Disease Unit (HSS), andinpatient consultative services at NewYork-PresbyterianHospital and Memorial Sloan-Kettering Cancer Center.In addition, fellows have access to clinics in office-basedorthopedics and other musculoskeletal areas (osteoporosis,neuromuscular disease, radiology and rehabilitation). They alsoparticipate in divisional research advancing knowledge in thebasic and clinical sciences.Program Director: Anne R. Bass, MDProgram Coordinator: Amy Broffman, (212) 774-2189Duration of Training: 3 years (years 1 and 2 are ACGMEaccredited)Number of Positions: 92012-2013 FellowsElana Bernstein, MDMassachusetts General HospitalSoumya Chakravarty, MD, PhDNewYork-Presbyterian Hospital (Weill Cornell Campus)Reena Khianey, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Susan Kim, MDNewYork-Presbyterian Hospital (Weill Cornell Campus)Lindsay Lally, MDNew York-Presbyterian Hospital (Weill Cornell Campus)Konstantinos Loupasakis, MDTufts UniversitySonali Narain, MDTufts UniversityDanielle Ramsden-Stein, MDGreenwich HospitalLauren Wong, MDYale-New Haven HospitalDr. Jyoti Mathad (left) in India with colleagues.I chose NYP/WCMC for my fellowship because of its history of groundbreaking research in thebasic science and clinical management of tuberculosis. With the support and expertise availableto me through the Division of Infectious Diseases and the Center for Global Health, I have forgeda new collaboration between WCMC and Byramjee Jeejeebhoy Medical College in Pune, a majorcity in India’s Maharashtra state.Tuberculosis (TB) kills 500,000 women every year. In India, which leads the world in TB cases,three-quarters of the women suffering from the disease are of childbearing age, between 15 and45. The typical patient carries the infection, unknowingly, for years. When pregnancy suppressesher immune system – a process that we still don’t fully understand – the infection is twice aslikely to spread. The disease threatens the life of the woman, her baby, and the other children shecares for. Detecting latent TB before it reactivates is crucial to reducing both maternal and infantmortality, especially in India, which accounts for 20 percent of maternal deaths worldwide.For the past 3 years, I have examined the performance of two different latent TB tests – thetuberculin skin test (TST) and the newer interferon gamma release assay (IGRA) – in pregnantand recent postpartum women in Pune. Our preliminary data suggests that the TST, the mostwidely used TB screening test in the world, does not reliably diagnose latent TB infection duringpregnancy. The IGRA detected almost twice as many latent TB infections as the TST. Every year,there are over 200 million pregnancies in the world, 25 percent of which occur in one of the 22high-burden TB countries. Based on our research, the TST may be missing the diagnosis in up to50 percent of these women. Many young women in TB-endemic countries access health care onlyonce in their lives: during pregnancy. It is vital for us to accurately screen and treat them for TBduring that visit, which may be our only opportunity.Last year, I was awarded a Global Health Fellowship by the Weill Cornell Medical CollegeCenter for Clinical and Translational Research (CTSC) to continue my work in India for the nexttwo years. The goal of this fellowship is to better understandthe immunology of pregnancy as it relates to TB. We are usingflow cytometry to measure additional cytokine concentrations inpatient samples after ex vivo exposure to TB antigens. These datawill describe the immune status of women at various gestationalstages, which may help explain why pregnant women are at highrisk for developing TB postpartum. Eventually, our work may leadto the identification of specific biomarkers in pregnancy to predictthe development of active TB postpartum.110111

AlumniMargaret A. Hamburg, MDCommissioner of Food and DrugsUnited States of AmericaInternship and residency is like no other experience. I’ll never forget those first days on the medical floors at whatwas then called New York Hospital – Cornell Medical Center, not knowing what situation would need to be managed,who was going to be presenting with what symptoms – and recognizing that I was now the one wearing the name tagthat said “Dr.”. But the training was superb, and my fellow residents and I learned what we needed, not only to survive,but to do our jobs and do them well. We gained both the knowledge and the clinical skills required to practice internalmedicine.But my experiences as a resident taught me much more. They taught me to be humble, resilient, and optimistic.They taught me that I was capable of stepping up and taking responsibility – indeed that I was expected to do so. Theytaught me to think through problems and defend my decisions. And perhaps most important, they taught me that nomatter how difficult the night – the morning always comes. These skills and this perspectivehave served me well in everything I have done since.As a medical student, I had watched with dismay as a mysterious new illness emerged. Bythe time I was a resident in New York City in the mid 1980s, there were many patients with HIV/AIDS to take care of, but we had no effective treatments – and little seemed on the horizon.We could offer neither cure nor hope. For a young, idealistic doctor like myself, nothing couldhave been worse.Those early days of HIV/AIDS also brought many lessons. The epidemic opened my eyes tothe importance of research and global health, the need for an integrated health care systemthat harnesses the full continuum of medicine, science and public health, and that some ofthe greatest challenges in medicine exist at the interface of a broader set of social, ethical,political and legal concerns.And it was those challenges that drew me to public health, and to a career in governmentand public service. To this day, I am grateful that my experience as an intern and residentat New York Hospital—Cornell Medical Center provided the knowledge and life lessons thatprepared me for such a career.Christine Laine, MD, MPHEditor, Annals of Internal MedicineI clearly remember the elation I felt when I opened my Match Day envelope and saw the words, “New York Hospital-Cornell.” New York Hospital was unquestionably the place where I wanted to train and it did not disappoint. Training atNew York Hospital meant learning to care for a patient population that was tremendously diverse – socioeconomically,ethnically, and clinically. There were actually times when rounds brought us from royalty in one hospital bed to a homelessperson in the next. It also meant working alongside the world’s best physicians. Carol Storey-Johnson, my clinicalattending, taught me that outpatient general medicine and outpatient care were every bit as challenging and professionallyrewarding as inpatient subspecialty medicine. But not all of these outstanding physicians were faculty, many were myco-residents. Running across York Avenue in scrubs from hospital housing to hospital, we developed as professionals andforged friendships that have lasted decades. Work rounds, morning report, and chief’s rounds were intellectually stimulatingexperiences – even after sleepless nights spent caring for more than afew very sick patients. My residency class was the first group to live throughresident work hours regulations. Years before these regulations spread toother locales, we struggled with their implementation at New York Hospital.We were also the first group for whom passing the internal medicine boardsdidn’t mean certification for life. I am proud when I hear of the impressiveachievements of my New York Hospital colleagues. At New York Hospital Ilearned clinical medicine, developed the “art of medicine” skills necessaryto truly care for a wide array of patients, and built the foundation for the restof my professional life. Of course, there also was the beauty of training in aplace where you could have any kind of food delivered to the MICU – even if itwas 2 AM! I didn’t fully appreciate this benefit until I found myself in Bostonfor fellowship where the only 2 AM dining option was the hospital vendingmachine. I often think it would be really nice to have my career bring me backto New York Hospital one day.Financial Reportand Donors112

2012 Financial ReportThe Department of Medicine continued to experience solid financial growth in fiscal year 2012 with total operatingfunds equaling $220.5 million as compared with $201.0 million in fiscal year 2011.The Department’s clinical enterprise revenue increased by 14.9% over fiscal year 2011 and accounts for approximately52% of the total sources of funds. As a result, patient care activities, as measured by annual outpatient visits and WorkRVUs increased in fiscal year 2012 to 215,782 and 75,745 respectively.The Department’s research grants activity held steady in 2012 with funding of $35.6 million. Industry sponsoredresearch increased by 8.6% in 2012 to $8.8 million.Medical education mission activities, which encompasses medical student education, the internal medicine residencyprogram, and our 10 fellowship education programs continued to be a priority for the Department of Medicine during fiscalyear 2012. The Department’s budget for these educational activities is approximately $12.5 million annually.The Department’s largest expense is its faculty, management, and staff costs which consume almost 60% of its totalannual budget. The remaining 40% of expenses is distributed among direct expenses (24%), indirect expenses (9%),malpractice liability insurance (3%), and miscellaneous expenses (4%).Annual Clinical Revenue Trend (In Millions)120$114.2M$99.4M100$85.2M$79.3M80604020Clinical Revenue by Division (In Millions)Cardiology$25.1M - 22.0%Hematology/Oncology$41.7M - 36.0%Gastroenterology & Hepatology$16.7M - 15.0%Hospital Medicine $4.4M - 4.0%Women’s Health $3.4M - 3.0%Endocrinology $3.0M - 3.0%Infectious Disease $2.0M - 2.0%Geriatrics $1.4M - 1.0%Nephrology & Hypertension $1.2M - 1.0%Other $4.3M - 4.0%WCIMA $6.4M - 6.0%Pulmonary $4.7M - 4.0%Sources of Funds (In Millions)Clincal Services$114.2M - 52.0%Hospital Funding $28.1M - 13.0%College Funding $5.4M - 2.0%Research Grants$36.0M - 16.0%Uses of Funds (In Millions)FacultyCompensation$97.5M - 44.0%Non Faculty Compensation$36.1M - 16.0% Malpractice $5.7M - 3.0%Direct Overhead$52.7M - 24.0%02009 2010 2011 2012*Includes Infusion RevenueTotal Clincial Revenue: $114.2 MillionOther $10.4M - 5.0%All Sources of Funds: $220.5 MillionEndowments andDiscretionary Funds$17.4M - 8.0%All Funds by Division Total Revenue (In Millions)Cardiology $39.0M - 18.0%Clinical Trials $8.8M - 4.0%Gastroenterology & Hepatology$30.4M - 14.0%Total Use of Funds: $220.5 MillionNephrology & Hypertension $6.3M - 3.0%Indirect Overhead$20.2M - 9.0%Other $8.1M - 4.0%Annual Outpatient Visits225,000210,000195,275195,000184,319 184,507180,000215,782Annual wRVU Trend800,000700,000599,975600,000549,376500,000400,000*666,717751,745Geriatrics $8.3M - 4.0%300,000Hospital Medicine $9.5M - 4.0%Endocrinology $4.9M - 2.0%165,000200,000Pulmonary $7.9M - 4.0%Infectious Disease $15.7M - 7.0%150,0002009 2010 2011 2012100,0002009 2010 2011 2012Hematology/Oncology$72.4M- 33.0%WCIMA $9.7M - 4.0%Women’s Health $5.1M - 2.0%Other $9.8M - 4.0%Total Revenue: $219.0 Million*wRVU means Work Relative Value Units114115

2012 Financial Report continued2012 DonorsFund For MedicineResearch and Grant Expenditures Trend (In Millions)4035302520151050$27.0M$8.2M$18.9M2008 2009 2010 2011 2012■ Direct Funding$26.0M$5.1M$20.4M$31.0M$7.8M$23.2M$36.0M$9.5M$26.3M■ Indirect Cost Recovery$36.0M$9.0M$26.7MClinical Trials Revenue (In Millions)Hematology/Oncology$5.5M - 62.0%Other $0.3M - 3.0%Geriatrics $1.8M - 5.0%Gastroenterology &Hepatology$4.5M - 13.0%Endocrinology $0.3M - 1.0%Research and Grants (In Millions)CEESR $3.6M - 10.0%Cardiology $0.8M - 9.0%Total Clinical Trials Revenue: $8.8 MillionHematology/Oncology$10.7M - 30.0%Cardiology $3.9M - 11.0%Total: $36.0 MillionGastroenterology & Hepatology$2.2M - 25.0%Infectious Disease$8.5M - 24.0%Pulmonary $0.6M - 2.0%Nephrology & Hypertension$1.7M - 5.0%The Fund For Medicine raises money to support critical resources and innovative programs in education, patient care andbiomedical research at New York-Presbyterian Hospital and Weill Cornell Medical College. These resources and programsenable our physicians and scientists to carry on a long tradition of excellence in medicine with the ultimate goal in mind:to provide superior patient care to the communities they serve. The Department of Medicine thanks all those who have givenor directed gifts to the Fund For Medicine.Ms. Harriet AbramsonMurray AlonThe Murray Alon CharitableFoundationAnonymousThe Applebaum Foundation Inc.Mr. Stanley J. ArkinStanley J. Arkin FoundationMs. Vera J. AryehMary E. BarrettMs. Rena BartosThe Beir FoundationBenson Dakota Trust LLCMr. Charles E. BinderDr. Jane E. BramWilliam B. & Jane E. BramFoundationDr. Barry D. BrauseMs. Rita S. BrauseRoberta C. BrauseMr. Michael T. BrennanBrownington FoundationMr. Clyde BrownstoneBrownstone Family FoundationJohn B. Caddell, IIICaddell Dry Dock and RepairCo., Inc.Mrs. John L. CadyColeman Family CharitableFoundationConnecticut CommunityFoundationDr. Joseph T. CookeD’Agostino FoundationDears Foundation, Inc.Mr. & Mrs. Robert J. EastonFranklyn Ellenbogen Jr.Memorial FoundationMarjorie EllenbogenEnterprise FoundationMr. Herbert FeinbergMr. Richard FeldsteinFeldstein Family CharitableFoundationA. J. FioreWilliam T. Foley FoundationMr. Sanford FreimanMrs. Helene GleemanMr. Michael I. GlickMr. John A. GriffinHarrison Medical GroupMr. Joel HoffmanMr. and Mrs. Henry H. Hoyt, Jr.Mrs. Mary O. HughesArlene JacobiThe Jewish Communal FundMs. Joan KavochkaCharles & Lucille King FamilyFoundationDiana KingCarol L. KlapperMs. Joan KronMr. Bernard LatermanMr. Seth LevenMs. Emily M. LinMr. Robert E. LintonLinton FoundationMs. Camille LiptenClaire S. LordThe Grace R. and Alan D. MarcusFoundationMex-Am Cultural Foundation, Inc.Mr. Brent M. MoweryOceanic Heritage FoundationSylvan and Ann OestreicherFoundation, Inc.Sabino S. PaceShekhar PalekarMs. Vita L. PellettieriDr. Allen R. RadinJudi Rappoport BlitzerMr. Michael H. RatnerMichael and Marilyn Ratner FundMr. Richard RoobMelissa B. RovelliEstate of Lisa SabinMr. Eric SchorrMarvin SchwartzMarvin & Joyce S. Schwartz FundMr. Edward B. ShermanMs. Helene SilvermanIrene and Sidney B. SilvermanCharitable FundMr. Sidney B. SilvermanMr. Daniel SobaMrs. Melissa SorosRobert SorosJudith and Fred StollMr. Joseph H. ThalJoseph and Sheila ThalFoundationMrs. Bertha WeiserMs. Dana A. WeissMr. Judah WiederkehrWinston Foundation, Inc.Dr. James F. WittmerMr. Jordan E. Yaret116 117

Friends of MedicineThe Department of Medicine is deeply grateful to individuals who have generously contributed to furthering the department’sinitiatives in patient care, education of physician-scientists, and bench-to-bedside research breakthroughs. We thank all of thosedonors who have given or directed gifts as Friends of Medicine. There are a large number of contributors, former patients andfriends, who have given donations below the level of $100. Due to space limitations we cannot list these donors but do express oursincerest thanks for their loyal support.1stdibs.com72nd Street MedicalAssociates, P.C.9611 Owners Corp.Mr. Harrison AaronAbbott LaboratoriesAbettor FoundationMr. Jerry AbramowitzMs. Harriet AbramsonMs. Joan AbrutynAccess Capital FoundationDr. Alberto M. AcostaMrs. Lynn D. AdamsMrs. Margot AdamsMr. Geoffrey P. AdamsonEthel & Philip AdelmanCharitable Foundation, Inc.Ms. Lois AdelmanDr. Ronald AdelmanMr. Benny AdlerMr. Sami AdranlyAdvanced ResearchFoundation, Inc.Mr. Arthur AederAgrifuel CorporationMr. Maxim AkivisMr. Muhammad A. Al-AgilMr. Aaron AlbertMr. Edward AlbertMs. Karen AlbertJanice AlexanderMr. Guillaume P. AlixAll Point Insurance Agency, LLCMs. Rosemary D. AlloccoChristine Alnemy GuideMurray AlonThe Murray Alon CharitableFoundationMr. and Mrs. Jerome AlpernMr. Bruce AlpertMr. Michael S. AlpertAnne AltchekMr. David J. AlwadishAmerican Watch AssociationAmiel Restaurant Partners, LLCMs. Susan AmighiMs. Emily R. AmilhussinMrs. Fran AmirsalehMs. June AmmiratiMrs. Madeline AnbinderHolly Andersen Heart FoundationMs. Linn AndersonMr. David AngstreichAnn-Louise JewellersAnonymousThe Applebaum Foundation Inc.Appleman Foundation, Inc.Mrs. Anne ArkelMs. Louise ArkelArkin Family FoundationMr. Stanley J. ArkinStanley J. Arkin FoundationMr. Stanley S. ArkinGaro ArmenThe Graham Arnold CharitableFundMs. Nancy AryehMs. Vera J. AryehMr. and Mrs. George AschMary AscheimAstellas/Polaris ManagementPartnersDr. Robert C. and Veronica AtkinsFoundationVeronica Atkins-MersentesLily Auchincloss Foundation, Inc.Mrs. Sherri R. Axelrod FreemanMr. Alan AydinMs. Shelley AzapianMarvin Azrak & Sons FoundationBB & M Subs, Inc.Dr. Paul BachnerMr. John BaiMr. Stuart D. BakerDr. Katherine BallisMrs. Jeanette L. BarberDr. Medha G. BarbhaiyaMrs. Carol A. BardDr. Christopher L. BarleyDr. John T. BarnardMr. Richard BarnetMarlene BarocasMr. Charles A. BarragatoMr. Joseph P. BarreriroMs. Mary E. BarrettMr. Martin BarronMs. Barbara T. BartlettMr. James R. BartlettMr. Robert T. BartlettMr. Walter BartnerMr. Gregory BartonMs. Rena BartosMr. Brian BassukMr. Gregory BassukMs. Jennifer M. BassukDr. Paul M. BasukMr. Keith BatesMr. Alix BaudinMs. Susan M. BauerMr. Jeffrey BaumlMr. Ronald B. BeatsonMr. Cory BeckerMs. Dotty BeckwithBecton Dickinson and CompanyMr. Harry BedaMr. Peter M. BedevianMr. Louis BegleyThe Beir FoundationMr. Paul J. BeispelMr. Steven BeispelMr. Sanford A. BellMr. William M. BellamyMs. Maura A. BelliveauDr. Paul C. BellmanMrs. Lorinda BelloneMoshe BenenfeldFrances and Benjamin BenensonFoundation, Inc.Mr. and Mrs. Frederick C. BenensonMr. John H. BenischBenson Dakota Trust LLCMr. Ross H. BenthienMr. Neal BergmanDeborah Berke & PartnersArchitects LLPMr. Andrew BermanMr. Martin L. BermanBerman Private FoundationMr. Sanford BernhardtBernsohn & Fetner, LLCMs. Stacee BernsteinHani N. BeyhumAvanish R. BhavsarMr. Howard BienenfeldMr. Joseph BiggersMr. Charles E. BinderMrs. Phyllis BinderMs. Heather BinenDeborah A. BiolsiMrs. Lynne B. BirdMs. Alexandra M. BirnbaumMr. Joseph BishopMrs. Elizabeth BlaneyMr. Clifford BlazeMr. Raymond A. BleserMr. Jerry BlickmanMs. Judi R. BlitzerJames A. BlockBlogHerMr. Thomas BlonskiThe Bloomingdale’s Fund ofMacy’s FoundationBlue Hill Road Leshkowitz & Co.Dr. David S. BlumenthalMr. Steven BoalMrs. Stefni BogardMr. Scott L. BokMr. Caesar BonisMs. Barbara BorozanDr. Brian P. BosworthMr. Allan S. BotterMrs. Unn J. BoucherMrs. Kathryn BourlandDr. Carla Boutin-FosterMr. Steven BoxerMr. Haig J. BoyadjianMr. James J. BoylanThe Braewold FundSholeh BrahimyDr. Jane E. BramWilliam B. & Jane E. BramFoundationMr. Joseph BrancatoMrs. Ilene BrandonStacey Braun Associates, Inc.Ms. Rita S. BrauseDr. Barry D. BrauseRoberta C. BrauseMr. Michael T. BrennanNereyda G. BrennerBridgewood FieldwaterFoundationBrink’s IncorporatedBristol-Myers Squibb CompanyHoustonBristol-Myers Squibb FoundationMs. Kimberly BroadwaterBroadway Video, Inc.Mr. Hugh BroderMr. Scott BroderMr. Gary BrooksMrs. Patricia A. BrooksMrs. Shari R. BrooksShari and Gary Brooks FamilyFundMr. Russell A. BroomeBrown Brothers Harriman & Co.Brown Family EndowmentThe Brown Family FoundationMs. Ariana S. BrownMs. Arline BrownMs. Barbara BrownMr. Bart B. BrownMr. Tony BrownWilliam Brown FoundationBrownington FoundationMs. Marcy BrownsonMr. Clyde BrownstoneBrownstone Family FoundationMs. Tracy L. BroxmeyerMs. Doris BryMs. Hillary BrylkaVladimir & Araxia BuckhantzFoundationMs. Karen C. BulmanMr. Nicholas BurgerMr. Robert BurgerRobert & Judith BurgerPhilanthropic FundMr. William L. BurkeMr. Randall BurkertPamela BurksMr. Chet J. BurrosMs. Naomi BushmanMr. Denis ButkovicMr. Samuel C. ButlerMr. Roy ButlerCJohn B. Caddell, IIICaddell Dry Dock andRepair Co., Inc.Mrs. John L. CadyMr. Charles CaffrayMr. Charles C. Cahn, Jr.Mr. Peter CalabrettaMr. David P. CalfeeMr. Edward W. CallahanJean CammarataCampari AmericaCancer Research and TreatmentFund, Inc.Cancer Support TeamMrs. Melissa CantinIris & B. Gerald CantorFoundationMs. Iris CantorMrs. Ariane CaparellaCardiology AssociatesFoundationCardiology Consultants of NY, PCCardiovascular Prevention andTherapeutics of New YorkMr. James W. CarlinMr. Anthony Carlos, Jr.Mr. Philip J. CarraherMr. Edward CarrollMr. Mark S. CasadyMr. George S. CaseSara CassMr. Anthony CassanoCatholic Charities of theArchdiocese of Atlanta, Inc.Mr. Al CelleriCeltic Cottage Pub & Patio Bar, Inc.Center for Cancer PreventionResearch, Inc.Mr. Bruce P. ChandlerMr. Kevin ChangThe Chapman Family CharitableTrustMrs. Blythe A. ChaseMr. David ChasenChristine ChavelJennifer Y. Chen EvansDr. Mark CherchesMr. Richard M. CieriMr. William J. CieslaMrs. Cynthia CintronLiz Claiborne & Arthur OrtenbergFoundationMr. Henry N. ClamanMr. Allen M. ClarkMr. Gary L. ClarkMr. Kevin W. ClarkMr. Francis J. ClarkeMs. Raynelle A. ClauserMs. Dolores M. ClaytonMr. Edward C. CloseMrs. Agnes CoakleyMrs. DuPre C. CochranCode, LLCMr. David CoffeenMr. John D. CoffinMr. Joel I. CohenMr. Michael M. CohenDr. Richard P. CohenBetsy and Alan CohnFoundation, Inc.Ms. Betsy CohnDr. Morton ColemanMrs. Anne B. CollinsMr. David C. CollinsColon Cancer CoalitionFoundationCommerce Gift Incentives, Inc.Communities Foundation of TexasThe Community Foundation ofWestern North CarolinaConnecticut CommunityFoundationThe Connell CompanyMr. Grover ConnellMr. John J. ConnollyMs. Irene ConnorsMs. Sophie C. ConsagraMr. Anthony J. ConstantiniMr. John N. ConynghamJohn N. Conyngham III & Lou C.Conyngham Family CharitableFoundationMs. Gail M. CookeDr. Joseph T. CookeMr. Barry C. CooperMs. Esther CooperMr. Herbert L. CooperDr. Gerald J. CordaniCornell Club of New YorkMr. Mark A. Corrado118 119

2012 Donors continuedMrs. Valier T. CortalanoMs. Catherine CorwenCosmos Queens, Ltd.Mr. Douglas D. CoughranMs. Kathy CoveyMr. John P. CovielloMr. Wilbur CowettPatricia J. CoxJ. Fletcher Creamer FoundationMr. Pierre CremieuxMs. Catherine CristinoMs. Mary S. CrossThe Crystal Family FoundationMr. J. Timothy CummingMr. F. Allan CurranMrs. Margaret H. CurryDMr. Max D’AgostinoD’Agostino FoundationFilomen M. D’AgostinoGreenberg Foundation Corp.Dalessandro FoundationMr. Raymond T. DalioMr. Mark F. DaltonMrs. Anna L. DaneckerMr. Andrew DarcyDartmouth CollegeMr. Joseph F. DashMr. Mike DaumMr. William H. DavidMr. Adam DavisDears Foundation, Inc.Decorative Things, LLCMr. William G. DeFabiisGerard DeGregoris, Jr., EsquireMs. Diane Del Mauro GorinMr. Craig DeliziaDelizia RestaurantMr. Donald L. DellDella Rosa Family FoundationDr. Byron P. DemopoulosMr. Alexander B. DensonMr. Joseph DepaolaDr. Maria T. DeSanchoMs. Ariella DeutschMrs. Lori DeutschMr. Martin DeutschDr. Richard B. DevereuxMr. Richard A. DevineMrs. Ginny B. DeVriesElizabeth A. DewDiamond Baratta Design, Inc.Diamond CellarMs. Pamela S. DicksteinMs. Domenica DiFilippiMr. Ernest J. DiGiovanniMr. Daniel DiLorenzoPeter Di Natale & Associates, Inc.Mrs. Gail L. DoboshMr. Laurence D. DoboshMs. Michele DochartyMr. Daniel DodgeDollies Making A DifferenceCarlos & Carmen DominguezFoundationMrs. Carmen M. DominguezMr. Edward DominguezMr. John F. DonahueAngelo Donghia FoundationMr. Derek M. D’OnofrioMr. John DonovanMr. John F. DorchJerome and Laura DorfmanCharitable FoundationLaura DorfmanMr. Ronald G. DouglasMr. Andrew DowiczMr. John D. DreherMr. Arthur DresnerJacqueline DryfoosDTM Drafting & ConsultingServices, Inc.Mr. Terence DugganMr. Robert D. DukeMrs. Walter G. DunningtonDr. Timothy C. DuttaDuty Free Americas, Inc.EE.C. ContractingEarth University FoundationMr. and Mrs. Robert J. EastonMrs. Susan L. EconomouMs. Claire EdersheimCarol B. EinigerMr. Roger W. EinigerMr. L. C. Einwick, Jr.Mr. John A. Eitel, Jr.EKA Brokerage Services, Inc.Franklyn Ellenbogen Jr.Memorial FoundationMarjorie EllenbogenEMcision LimitedMr. Howard EmeryEnterprise FoundationEntertainment IndustryFoundationEpstein Teicher PhilanthropiesMr. Irving EskenaziMs. Meredith EstessMs. Valerie EstessDr. Arthur T. EvansEdward P. Evans FoundationMr. Paul EwigFFacility Merchandising Inc.Ms. Sarah FalgoustMr. Frank FarinellaMr. Joseph FashanoArthur and Eve FastenbergPhilanthropic FundThe Feeney GroupMr. Keith FeeneyMrs. Rosemary S. FeeneyDr. Oliver T. FeinMr. Herbert FeinbergDr. Dmitriy N. FeldmanMr. Robert C. FeldmanFeldstein Family CharitableFoundationMr. Richard FeldsteinMs. Ruth FeldsteinMr. Steven FerjentsikMs. Jaime FernandMr. Jeffrey FiddelmanMs. Leonore FiddlemanFidelity Charitable Gift FundFieldland Investment CompanyMs. Ilene FineMr. Jack FinkelsteinFink’s Jewelers, Inc.Mrs. Anne FinneganA. J. FioreMrs. Edmee FirthNicholas and Edmee FirthCharitable FoundationMr. Barry L. FisherDr. Jeffrey D. FisherMr. Jack FishmanFitz & CompanyMs. Kerri FitzgeraldTerry FitzpatrickMr. Patrick FixterMr. John FlanaganMr. Daniel FleuryFlink FundMr. Steve FlinkMr. Matthew FogelsonWilliam T. Foley FoundationMrs. Kathleen ForsbergMs. Linda D. FosterMrs. Sara M. FosterMr. Tim FosterMrs. Arlene M. FoxMs. Lissete A. FoxClaire & Meyer Frank andLeann Frank CharitableFoundation, Inc.Mrs. Claire W. FrankThomas W. and Claire W. FrankFundMr. Ben H. FrankelMr. John FrankelDr. Richard H. FrankelMr. Robert R. FrederickMr. William E. FredericksMr. Laurence G. FreemanMr. Gary B. FreidmanMr. Gary D. FriedmanMr. Peter R. FriedmanMr. Scott FriedmanFriedman Circle FundMr. Sanford FreimanMrs. Kathy H. FrickerMr. Robert FrumkesMr. Adam FuttermanGG & G Wholesales Jewelry LLCMr. Mario J. GabelliGabelli FundMiller GaffneyGalane Cleaners, Inc.G. GallagherMr. David GallaiGamco Investors, Inc.Sheila E. GarganoAudrey M. GatinsMr. Michael GaviserDr. Mitchell L. GaynorDr. Elaine GeeMr. Bruce S. GelbLawrence M. Gelb Foundation, Inc.Mr. Nicholas GelberMr. Leslie GenattGenentech, Inc.Genentech USAGenslerMr. Peter A. GeorgescuGeorgescu Family FoundationMr. Angelos GeorgopoulosMs. Joan B. GewurzThe Giammalva Family FoundationMs. Akimi L. GibsonGilead Sciences, Inc.Mrs. Joan GilesMr. John GillinMr. Zachary GilmanMs. Barbara GimbelBernard F. & Alva B. GimbelFoundation, Inc.Bruce A. Gimbel FoundationDr. David Nelson GimbelMr. Morton GinsbergMr. Michael O. GittlesohnMrs. Ginny GlasserMr. Joshua GlassmanMr. Matthew GlassmanMr. Adam C. GlazerPeter H. GleasonMrs. Helene GleemanMr. Thomas GlennDr. Marshall J. GlesbyMr. Michael I. GlickMs. Judith L. GlikDr. Laurie H. GlimcherMs. Barbara GodardMs. Carole GodinMr. Alan E. GoldbergMr. Jon GoldbergMr. Jules E. GoldbergCharlotte GoldblattMs. Leslie E. GoldblattMs. Theresa GoldenMs. Dorothy T. GoldmanMr. Edward GoldmanGoldman Sachs & Co.Goldman Sachs & Co. MatchingGift ProgramGoldman Sachs GivesMs. Elizabeth D. GoldsmithMr. Herman C. GoldsmithMr. Dan R. GoldsteinMr. Walter R. GonzalesMr. Anthony C. GoochMrs. Anne T. GordonThe Kenny Gordon FoundationMs. Vivien GordonDr. Kenneth J. GorelickDr. Delia GorgaMs. Eileen F. GouldMs. Monica GrahamMr. Lawrence GrassiMr. Michael GreenDr. Burton J. GreenbergGreenberg Medical ResearchInstitute, Inc.The David and Alan Greene FamilyFoundationMr. Michael C. GreeneMs. Stephanie GriffinMr. John A. GriffinMiss Jeanne A. GrifoMichael and Donna GrohmanGrohman Family FundMs. Renee GrossMr. Andrew GrossmanDr. Melanie C. GrossmanMr. Paul GroudasGuardian Service Industries, Inc.Mr. James GuckertSubhash C. GulatiMr. Gregory P. GuliaMs. R. Denise GundertMs. Cathy GunnellsMr. Robert H. GutheilMr. Bruce GutkinMr. and Mrs. Andrew GyenesAndrew & Maeve GyenesCharitable FundThe Deborah Gyenes RevocableLiving TrustHHackers for HopeMrs. Esther HaddadNaseem HaffarMr. Jerome HaimsJerome Haims Realty, Inc.Mr. Martin HalbfingerMr. Ross A. HalperinMrs. Doris HambroMs. Ruth HamerMr. Jeff HamiltonMr. Richard C. HamlinKerry HanifinMrs. Marie S. HanleyMr. Joseph P. HanleyMs. Hope HanlonMr. Daniel HannafinGeorge and Caryn Harb FundMr. George HarbMr. James HarbMrs. Elizabeth A. HarbaughThe Harjen Charitable FoundationMr. David T. HarmonMr. James A. HarmonMs. Katherine HarpootlianMary W. Harriman FoundationMs. Pamela HarrisMrs. Shirley D. HarrisShirley D. Harris TrustHarrison Medical GroupHarry’s Italian Pizza BarJohn A. Hartford FoundationDr. Barry J. HartmanMrs. Lorraine HarveyMr. Frank H. HawrylakHealthcare Quality Strategies, Inc.Healthy Corner Pharmacy, Inc.The Hearst CorporationMs. Ellen HebertMrs. Charlene HeffernanMs. Dorothy J. HegerMrs. Elsie HeinemanMrs. Linda G. HeinemanMr. Melvin L. HeinemanMrs. Drue HeinzMrs. Susan K. Held120 121

2012 Donors continuedHellring Lindeman Goldstein &Siegel, LLPMr. H. Monroe Helm, IIILeona and Harry B. HelmsleyFoundation Inc.Hemenway & Barnes LLPDr. Barbara L. HempsteadMr. Craig HendersonMrs. Jennifer HentelMr. Paul A. HerdMr. Donald C. HerringDr. Edmund M. HerroldCharles Hertzig FoundationMr. and Mrs. Saul HertzigMr. and Mrs. Morton E.HertzmarkHess Foundation Inc.Ms. Allison L. HicksMr. Michael HigginsHighside Capital Management, LPHillmann DiBernardo LeiterCastelliThe Hirsch Family CharitableFundShay and George HirschMs. Linda B. HirschsonThe Hitchcock FoundationY.C. Ho/Helen and MichaelChiang FoundationMr. Franklin Warren Hobbs, IVMs. Joan G. HobenMs. Susan HochbaumDr. Eugenia S. HochmanJohn A. and Ann M. HockeyRevocable TrustDr. John A. HockeyMrs. Gerry HodesMr. Leonard B. HodesRobert and Gerry Hodes FamilyFundHoelscher Family FoundationMr. Gregory HoelscherMr. Joel HoffmanMr. John B. HoffmannThe Nancy and John HoffmannFoundationDr. Esther Ho-KungMr. Seth H. HollanderMs. Joanne HomseyMarjorie HonickmanMr. John E. HonkalaMr. James E. HookMr. Robert A. HorneMr. John T. HorneyHospital for Special SurgeryMr. Thomas J. HostomskyMrs. Patricia HouriganAnne C. HowardAnne H. HowatMr. John M. HowellMr. and Mrs. Henry H. Hoyt, Jr.Ms. Suzanne C. HoytMavourneen A. HubbardMrs. Mary O. HughesHughes Family FoundationMrs. Mary P. HulitarLeslie HuntDr. James R. HurleyMr. Andrew HusebyMs. Kathryn H. HutchisonIIacobellis Various DonorsIBEC Building CorporationICAP Service North America, LLCMr. Mark ImowitzMrs. Elaine M. IncorvaiaIngram Yuzek Gainen Carroll &Bertolotti, LLPMs. Tracy F. InmanMrs. Barbara InraDr. Lawrence A. InraInsurance Industry CharitableFoundation, Inc.JMr. Michael JaberMr. Philip JaberMs. Arlene JacobiMr. and Mrs. Bruce JacobsMrs. Lois M. JacobsMrs. Rosalind JacobsDr. Ira M. JacobsonDr. Michael W. JacobsonMr. Raymond JaegerMr. Nitinkumas S. JainMr. Ronald M. JakubekDr. Ann A. JakubowskiMs. Nancy B. JamesNancy Barlow James Rev TrustJames Free JewelersMs. Brooke JanisThe Brooke Janis Living TrustMrs. Frances M. JansenJanssen Services, Inc. (Johnson &Johnson)Janssen Services, LLCDr. Charles I. JarowskiEric Javits Family FoundationMs. Jocelyn JavitsJB Precious JewelsThe Jeep StoreJefferies & Company, Inc.Jenemi Associates, Inc.Jewelers of America, Inc.The Jewish Communal FundJJG Foundation Inc.Ms. Joan K. LangeMs. Betsey L. JohnsonDr. Warren D. Johnson, Jr.Dr. Erica C. JonesMrs. Helayne JonesMr. and Mrs. Kenneth J. JonesMrs. Rory JonesJones Lang Lasalle AmericasJoodayoh Inc.JRT Realty Group, Inc.KMs. Linda Kabumoto-GrasMr. Nathan R. KalikowMr. Gary KalksteinKalkstein & Johnson, P.C.Kalosieh, Shackil & Meola, CPAS,PAMrs. Willys S. KalsMr. Albert KalterMr. Craig KaplanMs. Rita J. KaplanRita J. & Stanley H. Kaplan FamilyFoundationMrs. Shari KaplanHoward Karasik, Attorney at LawMrs. Susan KargerMr. Mark KatzmanMr. Neil R. KatzmanMrs. Patti KatzmanMs. Joan KavochkaDr. Bonnie P. KeelerMs. Marie KeenanDr. Robert O. KenetMr. James C. KennedyMrs. Maureen M. KennedyBreene M. KerrGrayce B. Kerr Fund, Inc.Mr. John C. KicksMr. Gerald H. KielMs. Bitiye KimyagarovaMr. Alexandre Kindler-MulitzNils A. KindwallCharles & Lucille King FamilyFoundationDiana KingThe Kingsberg FoundationMr. Harold J. KingsbergMs. Glenda KirbyMr. Jay M. KlahrCarol L. KlapperHildabeth KleinMr. Jeffrey KleinDr. Ludwig KleinDori KleinmanMs. Tama B. KlosekLouis & Rose Klosk FundBeryl KoblinMr. Robert S. KobyMrs. Rosemary KobyMr. Ben KoenigMr. David KoeppelMs. Karen KondekMr. Cody K. KondoMr. Richard KoppelmanMs. Juliet B. KornetzLorraine A. KostyraMs. Alexandra E. KoturMr. Reed KrakoffMr. Alan KramerJamie KravitzMs. Brenda M. KrepolMr. Michael F. KristoffMs. Joan KronMs. Barbara L. KrongelAlice KulickAlice L. Kulick FoundationRajan KundraKweit, Mantell & DeLucia, LLPLDr. Mark S. LachsMr. Cory LaingMrs. Jeanne D. LalliMs. Kristin C. LandauMr. and Mrs. W. Loeber LandauDr. Brian R. LandzbergMr. Christopher LaneMs. Joan K. LangeMrs. Sandra LanskyMr. Len LantychTerri LantychMr. Bernard LatermanMegan LaughlinMs. Anita J. LawMr. Elliot LawrenceDr. Marlene A. LazarThe Lazarus Charitable TrustMr. Charles P. LazarusMs. Adriana LebowitzMrs. Laurie Z. LedermanMs. Annie Meng-Lun LeeMs. Regina LeeRegina A. Lee 2004 RevocableTrustMs. Susan J. LeitnerMr. Robert L. LenznerDr. John P. LeonardMrs. Leah S. LeonardDr. Bruce B. LermanMr. David B. LernerMrs. Karen LeshMr. Yitzchok LeshinskyMr. Craig LevaMr. William Levant, Jr.Mr. Seth LevenDr. Lawrence F. LevinMr. and Mrs. Irwin LevineLaurence Levine CharitableFund, Inc.Mr. Martin LevineMr. Matthew LevineRonelle LevineMs. Vilma M. LevineMs. Constance B. LevinsonLevinson Living TrustMs. Esther LevitinMr. Arthur J. Levitt, Jr.Mr. Laurence R. LevyMr. Robert LewinMr. Irwin LewisDr. Daniel M. LibbyAnnabelle LiebermanLifetime Brands, Inc.Liljenquist and Beckstead of VA.Ms. Emily M. LinMr. Richard J. LinMr. Robert E. LintonLinton FoundationSandra LipskyMs. Camille LiptenMrs. Lini LiptonMr. Laurent LislmachioMrs. Gloria LissMr. Marty LissDr. Harold LitvakMrs. Marina E. Livanos ColettisThe Lloyd Family GST ExemptTrustMr. Gilbert F. LloydDr. Veronica M. LofasoMr. Bonnell M. LombardiLonghill Charitable FoundationMs. Anna LongobardoMs. Petra LopezDr. Jorge A. Lopez-OvejeroClaire S. LordMr. Daniel LotaMr. Anthony G. LoucasDonna LowMs. Nancy L. LoweMr. Hugh P. LowensteinHugh and Sandy LowensteinCharitable FundMr. George T. LowyMr. Edward J. LudwigMr. John LuekenMrs. Joy C. LukeMs. Kristen Michelle Luksa-HawkinsThe Lymphoma FoundationMr. Michael J. LyonsLyons Family FundMs. Barbara B. LyskiMs. Anne LytleMM.A.C. AIDS FundSandra MabrittoMrs. June C. MacdonaldMrs. Jane MackMs. Lisa M. MackMacy’s Corporate ServicesGail MagaliffMagowan Family FoundationMr. Stephen Magyera, IIIDr. Richard J. MahlerMr. David MalkinMr. Richard J. MaloneyMr. Joseph M. MandelMr. Lewis R. MandelMs. Elizabeth MannMr. Michael D. MannDr. Samuel J. MannAmy S. MannMr. and Mrs. Burt ManningMr. Amir ManocherianAmir & Rosita ManocherianFamily FoundationMrs. Bernice ManocherianMs. Beverly D. MansonMarann FundMr. Thomas I. MarcossonMrs. Deana MarcusThe Grace R. and Alan D. MarcusFoundationJerome C. Marcus FundMr. Jerry C. MarcusSherri and Sam MarcusCharitable FundMr. Stephen MarescoMariner Investment Group, Inc.Alissa J. MarkDr. Steven M. MarkowitzMs. Lois B. MarksMarmur Dermatology &Cardiology, PLLCEllen R. MarramDr. Franklin MarshMr. Michael MarshMrs. Yvonne MarshYvonne and Michael Marsh FamilyFoundationMr. Alexander MarsonMs. Mary MartellMs. Myla J. Martin122 123

2012 Donors continuedMrs. Roberta M. MathewsMr. Dean W. MatheyMiss Patricia J. MatsonMatsu Fusion Restaurant, Inc.Mr. Kevin MatthewsMr. William MayerDr. Sarah J. McAleerYvonne McCalla FoundationMcCobb Landscape ArchitectMr. Mark J. McCooeyMrs. Marilyn L. McGillMrs. Wanda McGovernMr. John I. McGuireMr. Kevin R. McHaleMr. David L. McKissockMs. Gregory McLaughlinMcLaughlin Family FoundationMr. Geoffrey McNallyMrs. Rosalee M. McNamaraDr. Todd McNiffMD Lieberman FoundationMediq Learning, LLCMs. Deborah S. MelincoffMr. Bruce L. MellionDr. Ellen M. MellowMrs. Nursuna E. MemecanMenaker and Herrmann, LLPMr. Jack MendelsonMr. Paul R. MendelsohnPaul R. Mendelsohn FundMr. Robert B. MenschelMerckMercury CommunicationsGroup, LLCMr. Timothy A. MerjosRuth P. Merrill TrustMs. Barbara V. MethMetropolitan Baptist ChurchMetropolitan Planning &ManagementMex-Am Cultural Foundation,Inc.Mr. Lance MeyerowichMr. Richard MeyerowichMr. Gordon MichaelsonMid Hudson Medical GroupMidas Chain, Inc.Mr. Charles R. MiersMs. Jean M. MigdalMs. Florence R. MilanoMr. Matthew P. MilazzoMs. Ellen MilbergMr. Guy M. MillerMiller FoundationMrs. Rona V. MillerMrs. Sharon MillerMr. Stuart A. MillerMrs. Beatrice C. MinionMr. Joseph MontesanoDr. Anne MooreMrs. Nina MooreMr. Richard A. Moore, Jr.Sir Thomas R. MooreJerry Nagler, MDMr. Stuart NagourneyNAS Consulting Corp.Dr. Thomas W. NashNational Philanthropic TrustNature’s Cure Pharmacy Inc.Mr. Jeffrey NedelmanNejame, Lafay, Jancha, Ahmed,Barker, Joshi & Moreno P.A.Ms. Cindy E. NelsonMr. Darius NematiNeptune Ale House LLCThe Dorothy and ArnoldNeustadter FoundationMs. Dorothy NeustadterNew York Cardiology Associates,P.C.New York City Cyclones Inc.The New York Community TrustMrs. Judith B. NewboldMs. Martha G. O’NeillShane O’NeillMr. Aharon OrlanskyMr. Arthur OrtenbergMs. Marcia A. OsgoodOsprey Real Estate LLCMr. Richard M. OssoffPP H Custom Woodworking Corp.Sabino S. PaceAmol PachnandaMr. John PaciMs. Carolyn Padial-MuncanDr. Soo Mee PakJuana PalancoShekhar PalekarMrs. Beverly PankenEva A. PetersonMr. Robert C. PetittiMrs. Rosemarie PetrocelliMs. Stacey M. PetrowerMs. Karen A. PettifordMr. Richard PhillipsMr. Pablo PickDr. Sean P. PickeringMr. Philip PierceMr. Henry A. PincusMr. Matthew S. PincusPincus Family FundMr. Robert L. PlancherPlaza 400 Owners Corp.Mr. Robert F. PlotczykPolaris Management PartnersMrs. Nancy T. PolevoyCynthia H. PolskyHazen Polsky FoundationBrenda G. RambeauMrs. Jill A. RamirezMr. Gary RancourtMs. Karen RandMs. Susie RappaportDr. Irwin RappaportJudi Rappoport BlitzerMichael and Marilyn Ratner FundMr. Michael H. RatnerMr. Norman D. RauMr. Francisco F. RealeMs. Mary ReddReem Bridals, LLCMr. John R. ReeseMr. Robert J. RegerDr. Bonnie S. ReichmanDr. Brendan M. ReillyResearch Fund for Waldenstrom’sLtd.Dr. Benjamin A. RosenbergDr. Howard E. RosenbergMr. Peter RosenbergMs. Alice RosenwaldRuth and Samuel J. RosenwasserCharitable TrustLeo Rosner Foundation, Inc.Mr. Peter RosowDr. Albert M. RossMr. Philip N. RossMr. Spencer RossMelissa B. RovelliMs. Maida K. RubinMs. Catherine M. Moraetis Mrs. Virginia C. NewmanPaper Products, LLCChris PomboRex Energy Operating Corp.Morgan StanleyMr. Philip A. NewmanMr. Roger ParadisoMr. John PomerantzMs. Nancy F. RheingroverSMorgan Stanley Smith Barney Mr. Duncan L. NiederauerMr. Brian ParkJoann PowellMr. Jack RichardMr. Ray MortensonMr. Bernard NoblePark 55 Medical Associates, P.C.Ms. Catherine M. PriceJack Richard FundS. Forest Company, Inc.Mr. Peter MortimerMr. Jerry V. NoyceDr. Herbert M. ParnesMr. James PriceRichemont Latin America & Robert & Barbara SablowskyCaribbean, LLCFoundationMs. Shirley MossDr. Irwin NydickDr. Robert ParnesDr. R. A. Rees PritchettMr. Harold B. RichmanMr. Robert SablowskyMr. Russell J. MotchkavitzNYP Medical House StaffMr. Walfrido B. PatawaranProstate Cancer FoundationEsther M. RidderMrs. Barbara B. SacksMr. Brent M. MoweryMr. Jeffrey D. PattersonProtestant Cooperative MinistryRevocable Trust Esther M. Ridder Mr. Dan SaidelMr. Gary MuehlemannOMs. Michele PaukerPsychists Inc.Mr. Scott RiskinMr. Samuel A. SaidelKurt Munkacsi and Nancy JeffriesMr. William I. PaukerMr. Daniel PurdomDr. Ellen K. RitchieSalix Pharmacueticals, Inc.Mr. Jack MuradMrs. Francine OberstMr. and Mrs. Andrew M. PaulMr. David N. RobertsSamlyn Capital LLCKaushik MuraliOceanic Heritage Foundation Andrew M. Paul Family FundQJill A. RobertsMr. Matthew SamuelMr. Donald B. MurphyMr. James O’ConnorMs. Elizabeth T. PeabodyMs. Linda RobertsMr. Steve SamuelMs. Jeanne M. MurphyMr. John O’ConnorMs. Barbara PeckQuantia Communications, Inc.Ms. Robin R. RobertsDr. Abraham SandersKatherine John MurphyDr. Michael W. O’DellMs. Alice N. PellMr. Miguel Alberto QuesadaThe Robertson Foundation The Mara and Ricky SandlerFoundationMr. William P. O’DonnellMs. Vita L. PellettieriFoundationMrs. Elizabeth RobinsonMs. Bernadette E. MurraySylvan and Ann Oestreicher Mr. Matthew H. PeltzRMr. Ricky SandlerRock Central Services, Inc.Ms. Elizabeth MurrayFoundation, Inc.Ms. Pamela A. PerezMr. Leo B. SanfaconMs. Anita K. RoeMrs. Frances A. MurrayMs. Eileen O’HaraCaroline S. PerkinBeth RabinMrs. Marie Santa CroceRogosin InstituteMusicians Emergency Fund Inc. Old Broadway Hotel, Inc.Perkin FundDr. Asher Z. RabinowitzMs. Betty SantangeloMr. Christopher RollinsOld Westbury Golf & Country ClubMalva RabinowitzMs. Elsa A. SantosFoundation, Inc.Mr. David E. PerlinMr. Adam RonzoniNMr. Lawrence A. RaderMs. Margaret SantryMr. John J. O’LoughlinDr. Francis S. PerroneMr. Richard RoobDr. Allen R. RadinThe Saramar Charitable FundDr. Sonja K. OlsenMrs. Gail M. PershesMr. Joseph D. RosaMs. Marcia NadGwenn A. RamageCarol SardOne Love One HeartMr. Richard W. PershingMs. Christina RoseMs. Donna B. NadlerMrs. Elizabeth I. Peters124 125Jack RudinLouis & Rachel Rudin FoundationMr. William C. RudinSara de C. Ruth TrustMr. Phillip A. RutmanMr. Daniel E. RyanMr. Charles SarowitzMs. Edythe SatzMs. Gina SauroCynthia W. SavageMs. Katherine R. SavitsDr. Bernhard D. SaxeMs. Christine ScalleyMs. Tara M. ScalzaMr. Herb ScannellDr. Bruce R. SchackmanDr. Andrew I. SchaferMr. Charles S. ScheidtSchenker Family FoundationThe Schiff FoundationMr. David T. SchiffMr. Craig SchlangerStanley L. Schlessinger, DDSMr. Mark F. SchmitMr. David Z. SchneiderMs. Alicia A. SchoendorfMr. Eric SchorrMr. Leslie J. SchreyerSchwab Charitable FundDavid Schwartz Foundation, Inc.Mr. Howard SchwartzMarvin & Joyce S. Schwartz FundMr. Marvin SchwartzPhyllis and Howard SchwartzPhilanthropic FundMrs. Phyllis SchwartzMr. Richard J. SchwartzMs. Susan E. SchwartzMs. Diana SchwatkaSchwinghammer Lighting, LLCMs. Glenda ScottSDA FoundationSea Breeze FordThe Seaport Group LLCMrs. Lucille SedgeleyMr. Gary L. SeeversSeevers Family FoundationMrs. Bonnie H. SelfeMs. Barbara SerotaServices for the Underserved Inc.

Chairman’s OfficeChairmanAndrew I. Schafer, MDTel: (212) 746-4720Executive Vice Chair for Clinical AffairsBrendan M. Reilly, MDTel: (212) 746-6420Administrative ManagerBeverly BorgTel: (212) 746-4720AdministrationChief Administrative Officer &Vice Chair for Business AffairsTipton (Tip) FordTel: (212) 746-4271Associate Administrator,Faculty & Staff SupportNancy BennettTel: (212) 746-4007Associate Administrator,Budget & AccountingPeter KamTel: (212) 746-4007Residency OfficeVice Chair for EducationDirector, Internal MedicineResidency ProgramLia Logio, MDTel: (212) 746-4749Residency Program ManagerMargie DalyTel: (212) 746-4749Divisional OfficesCardiologyBruce B. Lerman, MD, ChiefAnn Matier, AdministratorTel: (212) 746-2176Clinical Epidemiology and EvaluativeSciences ResearchMary E. Charlson, MD, ChiefSuzan Toro, AdministratorTel: (646) 962-5060Clinical PharmacologyMarcus M. Reidenberg, MD, ChiefTel: (212) 746-6227Emergency MedicineNeal E. Flomenbaum, MD, ChiefGeorgia Rose, AdministratorTel: (212) 746-0780Endocrinology, Diabetes & MetabolismJulianne Imperato-McGinley, MD, ChiefThomas Cunningham, AdministratorTel: (212) 746-1503Gastroenterology & HepatologyIra M. Jacobson, MD, ChiefDebbie Dimanche, AdministratorTel: (646) 962-4778Geriatrics & Palliative CareRonald D. Adelman, MD, Co-ChiefMark S. Lachs, MD, MPH, Co-ChiefMary Anderson, AdministratorTel: (212) 746-1733Hematology and Medical OncologyDavid M. Nanus, MD, ChiefPaula Goldstein, AdministratorTel: (212) 746-4550128Hospital MedicineArthur T. Evans, MD, MPH, Chief, andVice Chair of Faculty DevelopmentMary Elizabeth Kelser, AdministratorTel: (212) 746-4910Infectious DiseasesRoy M. Gulick, MD, MPH, ChiefMufida Rosiana, AdministratorTel: (212) 746-4914Iris Cantor Women’s Health CenterOrli R. Etingin, MD, DirectorEllen Connelly, AdministratorTel: (212) 821-0558Medical EthicsJoseph J. Fins, MD, ChiefCathleen Acres, AdministratorTel: (212) 746-1126Nephrology and HypertensionManikkam Suthanthiran, MD, ChiefAnita Mesi, AdministratorTel: (212) 746-4430Pulmonary & Critical Care MedicineJoseph T. Cooke, MD, ChiefMalika Maddison, AdministratorTel: (212) 746-2858RheumatologyMary K. Crow, MD, ChiefLaughlin Rice, AdministratorTel: (646) 797-8487Weill Cornell Internal MedicineAssociatesJudy Tung, MD, Medical DirectorDiego Arias, Practice ManagerTel: (212) 746-2395Daniel Splitgerber, AdministratorTel: (212) 746-4371If you wish to have your name removed from lists to receive fundraisingrequests supporting NewYork-Presbyterian Hospital in the future,please either write to us at Director of Operations, Office of Development,NewYork-Presbyterian Hospital, 525 East 68th Street, Box 123, New York,NY 10065, call 866-959-5605, or e-mail optoutnyp@nyp.org. If you alsowish to be removed from lists to receive fundraising requests supportingWeill Cornell Medical College. please either write to us at Privacy Office,Weill Cornell Medical College, 1300 York Avenue, Box 303, New York,NY 10065, call 866-841-2420, or e-mail optoutwcmc@med.cornell.edu .New York-Presbyterian Fund, Inc.A copy of our latest financial report may be obtained by writing to: Officeof Development, New York-Presbyterian Fund, Inc., 525 East 68th Street,Box 123, New York, NY 10065. If you are a resident of one of these states,you may obtain financial information directly from the state agency or asindicated:FLORIDA – A COPY OF THE OFFICIAL REGISTRATION AND FINANCIALINFORMATION MAY BE OBTAINED FROM THE DIVISION OF CONSUMERSERVICES BY CALLING TOLL-FREE, 1-800-435-7352 (800-HELP-FLA)WITHIN THE STATE. REGISTRATION DOES NOT IMPLY ENDORSEMENT,APPROVAL, OR RECOMMENDATION BY THE STATE. FloridaRegistration #CH34509. GEORGIA - A full and fair description of theprograms of NewYork-Presbyterian Fund, Inc. and our financial statementsummary is available upon request at the office and phone numberindicated above. MARYLAND – For the cost of copies and postage, Officeof the Secretary of State, State House, Annapolis, MD 21401. MICHIGAN –MICS No.: CS-45810 MISSISSIPPI – The organization’s official registrationand financial information may be obtained from the Mississippi Secretaryof State’s office by calling 1-888-236-6167. Registration by the Secretaryof State does not imply endorsement. NEW JERSEY – INFORMATIONFILED WITH THE ATTORNEY GENERAL CONCERNING THIS CHARITABLESOLICITATION AND THE PERCENTAGE OF CONTRIBUTIONS RECEIVEDBY THE CHARITY DURING THE LAST REPORTING PERIOD THAT WEREDEDICATED TO THE CHARITABLE PURPOSE MAY BE OBTAINEDFROM THE ATTORNEY GENERAL OF THE STATE OF NEW JERSEY BYCALLING (973) 504-6215 AND IS AVAILABLE ON THE INTERNET AT www.njconsumeraffairs.gov/ocp.htm#charity. REGISTRATION WITH THEATTORNEY GENERAL DOES NOT IMPLY ENDORSEMENT. NEW YORK –Office of the Attorney General, Department of Law, Charities Bureau, 120Broadway, New York, NY 10271. NORTH CAROLINA – Financial informationabout this organization and a copy of its license are available from thesate solicitation licensing branch at 1888-830-4989. The license is not anendorsement by the state. PENNSYLVANIA – The official registration andfinancial information of NewYork-Presbyterian Fund, Inc. may be obtainedfrom the Pennsylvania Department of State by calling toll-free, withinPennsylvania, 1-800-732-0999. Registration does not imply endorsement.VIRGINIA – Virginia State Office of Consumer Affairs, Department ofAgricultural and Consumer Services, PO Box 1163, Richmond, VA 23218.WASHINGTON – Charities Division, Office of the Secretary of State,State of Washington, Olympia, WA 98504-0422, 1-800-332-4483. WESTVIRGINIA – Residents may obtain a summary of the registration andfinancial documents from the Secretary of State, State Capitol, Charleston,WV 25305. Registration with any of these state agencies does not implyendorsement, approval or recommendation by any state.Managing Editor-WriterAssociate Director of CommunicationsSuzanne RossDepartment of MedicineDesignerSundberg Design, Inc.PhotographyRoger Tully ProductionsContributing PhotographyRichard I. DeWittRobert EsselBud GlickPatricia KuharicAmelia PanicoSpecial Thanks to:Eva AllenDoug BanquerBeverly BorgMargie DalyDivision AdministratorsJ. Chris FollmerTipton FordDr. Monica R. GaidhaneShaun GillenPeter KamOffice of the ChairmanAtya PearsonJuliette PhillipsJoann PowellMonica PrabudossDr. Andrew I. SchaferSilva SergenianDr. Jae-Hyuck ShimGreg SundbergNadine SylvainRoger TullyNoli Ann VegaKaren WongDr. Glimcher Lab MembersDr. Lipkin Lab MembersDr. Melnick Lab MembersDr. Suthanthiran Lab Members