Nieuwsbrief Academische Werkplaats Angst - GGZ inGeest

Nieuwsbrief Academische Werkplaats AngstDecember 2012Int J Psychophysiol. 2012 Apr;84(1):33-8. doi:10.1016/j.ijpsycho.2012.01.005. Epub 2012 Jan 23.Determinants of salivary evening alpha-amylase in a largesample free of psychopathology.Veen G, Giltay EJ, Vreeburg SA, Licht CM, Cobbaert CM, Zitman FG,Penninx BW.SourceDepartment of Psychiatry, VU University Medical Center,Amsterdam, The Netherlands. G.Veen@ggzingeest.nlAbstractOBJECTIVE:Recently, salivary alpha-amylase (sAA) has been proposed as asuitable index for sympathetic activity and dysregulation of theautonomic nervous system (ANS). Although determinants of sAAhave been described, they have not been studied within the samestudy with a large sample size without potential disturbances ofpsychopathology. In this paper, we report about correlates ofevening sAA in saliva.METHODS:In 487 participants (mean age=42.9years, 59.8% female) withoutlifetime psychiatric disorders from the Netherlands Study ofDepression and Anxiety (NESDA), sociodemographic, health andsampling determinants of sAA levels were examined usingmultivariable linear regression analysis. sAA was measured in twosaliva samples that participants collected in the late evening, at22:00h and 23:00h, after which these were averaged.RESULTS:In multivariate analysis, age (β=0.20, p