GEA Pharma Systems Small Scale Solid Dosage R&D A complete ...

Single-Pot ProcessingSingle-Pot Technology offers a choice of mixing, granulationand drying options integrated into one processing vessel.For development purposes, the Collette UltimaPro 10 and 25has the processing batches capacities of 1 to 9kg. All keycharacteristics, granulation and drying options of the Single-PotProcessor are available for these R&D machines. Both are compact,mobile machines which are easyto install because of a Plug & Play concept.Compact and Cost-Effective ProcessingSingle-Pot technology is a very compact technology achieved byincorporating several processing steps into one machine. Thisreduces the capital cost of the equipment as well as the cGMP &technical space required for granule production andtherefore the overall project cost.Flexible ProcessingWhether for standard wet granulation, melt granulation,pelletizing or effervescent production, combined with vacuum ormicrowave drying, a single-pot processor can achieve the requiredresult. The swinging bowl option enhances this flexibility evenfurther by its capability to process older formulations to a highquality standard. With easy and efficient cleaning, using a CIPsystem, quick product changeover is achievable.UltimaPro combines high-sheargranulation with highly efficient vacuumand microwave drying technologies.The result: the ultimate flexibility for bothpharmaceutical R&D and production.Single Pot Processing - ideal for:- Ecological, organic solvent-based soliddosage processing: UltimaPro-Eco- Efficient processing of effervescentformulations (especially water-basedreaction method): UltimaPro-FZ- High containment solid dosage processingfor oncology, hormone and other highlypotent products: UltimaPro-HCContained ProcessingBecause of its very nature, a single-pot process is a containedprocess. No transfers are required between process steps, exceptfor loading the raw materials and unloading the dry granules. Thisis not only beneficial for protecting the operators from potentproducts, but also for protecting the products from externalinfluences such as heat, light or moisture. Specific solutions areavailable for product loading and discharging to achieve thedesired level of containment for the whole process10