GEA Pharma Systems Small Scale Solid Dosage R&D A complete ...

Totally Contained, Completely FlexibleHigh Shear GranulatorsThe Aeromatic-Fielder & Collette High Shear Mixer andGranulator are multi-purpose processors equally suitable forhigh speed dispersion of dry powders, aqueous or solventgranulations, effervescent production and melt pelletization.PharmaConnect which enables diverse GEA developmentequipment to be docked into a single ‘plug and play’ modulewith full cGMP compliance.Process OverviewAt the heart of the production plant are PharmaConnect ® andFlexstream. PharmaConnect ® is GEA’s innovative, modulargranulation and blending system offering an unbeatable rangeof process types and capacities; FlexStream is the worldleading process technology for spray granulation and pelletcoating, delivering unbeatable benefits in terms of greaterproductivity, lower running costs and a robust and scaleableprocess.Containment Valves & DisposableContainment InterfacesThe system includes examples of both rigid and disposableproduct transfer technology offering containment down to lownanogram levels. These options include: the disposableHicoflex ® system with significantly lower capital and runningcosts compared with rigid IBC technology and rapid productchangeover for improved plant utilization; the unique, modularBuck ® MC valve with its simple design that enables completecontainer-to-container transfer flexibility; and the Buck ® TCValve, the highest performing split valve available in the marketplace. By introducing a wash step prior to valve separation, theBuck ® TC Valve is capable of performance to the low nanogramlevel.Integrated ApproachAll of these technologies are brought together for an integratedprocess system that mimics the hundreds of large-scale plantsprovided by GEA Pharma Systems globally. It epitomises theapproach of ensuring customers receive the same technologyfrom the laboratory through to production, using the samecontainment and process technologies to ensure seamless scaleupand the most flexible blend of process capabilities.7