2006 Abstracts - American Society of Animal Science

115 The effect of feed antimicrobial on the prevention andtreatment of E coli K88 diarrhoea in young piglets. F. Omogbenigunand E. Beltranena*, Alberta Agriculture, Food and Rural Development,Edmonton, AB. Canada T6H 5T6., Edmonton, AB. Canada.A total of 342 Hypor crossbred weanlings (20 ± 1 d) were used in a 35d trial to evaluate the effects of feed antimicrobial on the prevention andtreatment of non-induced, with confirmed naturally-occurring E. coli K88 diarrhoea in a university nursery facility. The dietary treatmentswere: basal (control) diet containing zinc oxide (3,000 parts per million(ppm) at Phase 1 and 1,000 ppm at Phases 2 and 3); Flavomycin ® 4 (12mg/kg diet bambermycin at Phases 1, 2, and 3); Neo-terramycin ® 50/50(220 mg/kg diet neomycin sulphate, 220 mg/kg diet oxytetracyclinehydrochloride at Phases 1, 2, and 3); Tylan ® (44 mg/kg diet tylosinphosphate at Phases 1, 2, and 3); increased zinc oxide level (3,000 ppmat Phase 1 and 1,500 ppm at Phases 2 and 3). There were eight pigs perpen and eight pens per treatment. The test diets were offered in threedifferent feeding phases from weaning; a non-medicated common dietwas offered during the last week of the trial to avoid conflicting with theadministration of the water-soluble ileitis vaccine. Pigs were weighedand scored for symptoms of diarrhoea at the beginning and end of eachfeeding phase. There was no treatment effect on ADFI, ADG and G:F(P > 0.05) for each feeding phase or the overall trial. Pigs fed the medicateddiets had better scores (P < 0.05) for the lack of incidence ofdiarrhoea, cleanliness of the anal area, and fewer clinical symptoms ofdehydration than those fed the non-medicated, control diet. The use ofzinc oxide led to the lowest cost per kg BW gained.In summary, no benefit in animal performance and merely a slight improvementin physical appearance resulted from antimicrobial inclusionin nursery diets for pigs affected by E. coli K 88. The dietary inclusionof zinc oxide was the most cost-effective strategy compared to thetested drug inclusions.Table 1.0 - 35dpostwean Control Flavo neo-terra Tylosin ZnO SEADFI, g 388 393 391 399 419 23ADG, g 334 342 337 341 365 18G:F 0.86 0.88 0.87 0.85 0.87 0.02Key Words: Pigs, Antimicrobials, Performance116 Growth performance of nursery pigs fed BIOSAF ® yeastalone or in combination with in–feed antimicrobial. B. M.Hildabrand*, T. E. Burkey, K. A. Skjolaas, S. S. Dritz, B. J. Johnson,and J. E. Minton, Kansas State University, Manhattan.Previous research with Saccharomyces cerevisiae (BIOSAF ® ) yeasthas lead to the hypothesis that BIOSAF ® may alter the intestinalmicrobiota in the pig by interacting with or even binding to potentialpathogens in the gut. This may be a mechanism by which BIOSAF ®could improve the growth rate and overall health of young swine. In thecurrent study, 280 weaned pigs (initial BW 5.66 kg) were used in a 28 dgrowth study to evaluate the effects of feeding carbadox (CARB),BIOSAF ® (0.4%), and the combination of CARB and BIOSAF ®(0.15%) in nursery pig diets. Pigs were blocked by sex and BW andassigned randomly to one of the following four dietary treatments:Control (CTL; no added CARB or BIOSAF ® ), CARB (CTL diet plusCARB), BIOSAF ® (0.4%), or CARB + BIOSAF ® (0.15%). Therewere ten pens per treatment and seven pigs per pen. Treatments wereapplied in both Phase I (d 0 to 14) and Phase II (d 15 to 28) diets.Overall (d 0 to 28), pigs fed CARB had greater ADG than CTL, and pigsfed the diet supplemented with 0.4% BIOSAF ® (P < 0.03 and 0.01 vs.CTL and BIOSAF ® , respectively). Over this same period, pigs fed thecombination diet (CARB + BIOSAF ® ) had greater (P < 0.04) ADGthan CTL pigs and pigs fed BIOSAF ® alone. In addition, over the 28 dperiod, pigs fed CARB and CARB + BIOSAF ® had greater (P < 0.05)ADFI than CTL or BIOSAF ® fed pigs. F/G was not affected by treatment.In summary, BIOSAF ® alone failed to enhance growth comparedto CTL. Also, we did not observe interactions of BIOSAF ® with CARBto improve pig growth beyond that of CARB. It is possible that theinteractive effects of BIOSAF ® reported for other in-feed antibiotics toenhance growth does not include CARB, or perhaps interactive effectsare only observed when CARB itself exerts a more potent stimulationof ADG in nursery pigs.Key Words: Antimicrobials, Yeast, Nursery pigs117 Growth performance of nursery pigs fed BIOSAF ® in combinationwith in–feed antimicrobials. B. M. Hildabrand*, T. E.Burkey, K. A. Skjolaas, S. S. Dritz, B. J. Johnson, and J. E. Minton,Kansas State University, Manhattan.Results from previous studies indicate that yeast may interact with infeedantibiotics to stimulate growth performance in nursery pigs to agreater extent than antibiotics alone. However, these effects may bedependent on differences in yeast cultures, processing and yeast activityas well as the specific antimicrobial used. The objective of the currentexperiment was to evaluate the effects of feeding traditional antimicrobialsalone or in combination with Saccharomyces cerevisiae(BIOSAF ® ) yeast in nursery pig diets. In the current study, 240 weanedpigs (initial BW 6.12 kg) were used in a 28 d growth study. Pigs wereblocked by sex and BW and assigned randomly to one of the followingfive dietary treatments: CTL (control diet; no added antimicrobials),NT (CTL diet plus Neo-Terra), DEN (CTL diet plus Denagard PLUS),NT+BIO (CTL diet plus NT and 0.15% BIOSAF ® ), or DEN+BIO(CTL diet plus DEN and 0.15% BIOSAF ® ). There were eight pens pertreatment and six pigs per pen. Treatments were applied in both PhaseI (d 0 to 14) and Phase II (d 15 to 28) diets. Overall (d 0 to 28), pigs fedDEN+BIO had greater ADG than all other treatments (P < 0.05) andpigs fed NT, DEN and NT+BIO had greater (P < 0.05) ADG than CTLpigs. For the same period, DEN+BIO pigs had greater (P < 0.05) ADFIthan CTL and NT-fed pigs, but similar ADFI compared to DEN andNT+BIO. In addition, over the entire 28 d experiment, DEN+BIO-fedpigs maintained greater (P < 0.05) F/G over CTL and DEN-fed pigs.However, F/G was similar between DEN+ BIO, NT+BIO and NT fedpigs. In summary, BIOSAF ® fed in combination with DEN enhancedthe growth response of nursery pigs beyond the growth advantage ofDEN alone. The interaction of BIOSAF with in-feed antibiotics is generallyconsistent with other reports. Factors affecting the presence andmagnitude of the interaction of BIOSAF ® and antibiotics to enhance thegrowth response remain to be elucidated.Key Words: Yeast, Antimicrobials, Nursery pigs38