Activities - Benjamin-Mills

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AN ASPIRIN ASSAYWM68 Calculate the purity of the aspirin tablet, using Table 1.Assay 1 Assay 2 Assay 3Mass of specimen tube + aspirin powder/gMass of specimen tube after pouring out aspirin powder/gMass of aspirin used/gVolume of sodium hydroxide solution used/cm 3Amount of sodium hydroxide used/molAmount of aspirin which reacted with sodium hydroxide/molMass of aspirin which reacted with sodium hydroxide/gAspirin in powder used/%Table 1Evaluating your results and proceduresa What is the percentage error in your measurement of the mass ofaspirin used and in the volume of sodium hydroxide solution used?b Identify any stages in your procedure which could have led to errors.Comment on the range of answers obtained for your three assays.c Bearing in mind the sources of error you have discussed above, howmany significant figures do you think you are justified in using forthe percentage of aspirin in the powder?9 Accurately weigh one aspirin tablet. Use your assay results to calculate themass of aspirin contained in the tablet. Suggest why the mass of the tabletand the mass of aspirin may be different. Why do you think the tablets aredescribed as ‘300 mg’ tablets?AS LEVEL„ Salters Advanced Chemistry 2000 – see Copyright restrictions151
WM8Which product shoulda pharmaceuticalcompany develop?In the exercise that follows, you are asked to take onthe role of a manager in a pharmaceutical companyhelping to make decisions about which products yourcompany should develop.General informationIt is a very long process from the initial discovery of a compound which hassome pharmacological activity to the final marketing of a medicine. At any onetime, several different compounds may be available for further development, butthe process is so expensive that a company must select only a limited number ofcompounds for further investigation.Policies are reviewed at regular intervals and the progress of work on any onecompound will be scrutinised at several key stages of development.In this exercise, you need to be organised into groups which representdifferent management groups in a company. Some of the groups will make an‘initial technological and economic appraisal’ of two potential pharmaceuticals;the other groups will make a ‘second technological and economic appraisal’ ofthe same two compounds.Initial technological and economic appraisalThis is the stage at which the compounds under review have been identified,synthetic routes have been established and some preliminary testing for activityand toxicity is complete. The research division of the company have put forwardtwo compounds, AP1011 and H2202, to be considered for further development.You must consider the evidence available and produce, for each of thesecompounds, a summary of the arguments for and against taking up the option offurther development work. Since the company budget may only allow for workon one of these, you should also recommend which seems the more promisingcompound to develop.Second technological and economic appraisalThis comes after further development has been carried out. For the purpose ofthe exercise, it is assumed that the company adopted both compounds at theearlier stage and has since completed clinical trials and further studies of thebehaviour of the compound in the body. Once again, the available evidencemust be examined to produce a summary of the points for and againstproceeding with each of the compounds, and you must recommend whichshould be developed and marketed.When the evaluations have been completed, groups which have made theinitial appraisal should compare their conclusions with groups which made thesecond appraisal.152AS LEVEL„ Salters Advanced Chemistry 2000 – see Copyright restrictions
Page 1 and 2: WM1The origins anddevelopment of th
Page 4 and 5: THE ORIGINS AND DEVELOPMENT OF THE
Page 6 and 7: WM2Extraction of salicylicacidIn th
Page 8 and 9: WM3Investigating thechemistry of th
Page 10 and 11: INVESTIGATING THE CHEMISTRY OF THE
Page 12 and 13: INTERPRETATION OF THE MASS SPECTRUM
Page 14 and 15: WM5.1A preparation of aspirinThis a
Page 16 and 17: USING SPECTROSCOPYWM5.2100908070100
Page 20 and 21: WHICH PRODUCT SHOULD A PHARMACEUTIC
Page 22 and 23: WHICH PRODUCT SHOULD A PHARMACEUTIC
Page 24: WM9Check your notes onWhat’s in a

Activities - Benjamin-Mills

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